Network biology concepts in complex disease comorbidities

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Error and attack tolerance of complex networks

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Diabetic Retinopathy

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Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

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Temporal networks

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Biological robustness

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The Genetic Landscape of a Cell

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Computing topological parameters of biological networks

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Deep patient: An unsupervised representation to predict the future of patients from the electronic health records

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Missing heritability and strategies for finding the underlying causes of complex disease

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Uncovering disease-disease relationships through the incomplete interactome

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The pre-therapeutic classification of co-morbidity in chronic disease

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The mystery of missing heritability: Genetic interactions create phantom heritability

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A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

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Hsp90 as a capacitor of phenotypic variation

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Metformin—mode of action and clinical implications for diabetes and cancer

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Diabetic kidney disease

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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

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Personalized medicine: Time for one-person trials

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Copy number variation in human health, disease, and evolution

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Diabetic retinopathy

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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

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Pleiotropy in complex traits: challenges and strategies

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The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

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Quantitative Analyses of SMN1 and SMN2 Based on Real-Time LightCycler PCR: Fast and Highly Reliable Carrier Testing and Prediction of Severity of Spinal Muscular Atrophy

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Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

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Genomic analysis of regulatory network dynamics reveals large topological changes

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Causes and consequences of comorbidity

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A copy number variation map of the human genome

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Comorbidity or multimorbidity: what's in a name? A review of literature

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Understanding multicellular function and disease with human tissue-specific networks

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Towards a theory of biological robustness

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Differential network biology

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Next-generation proteomics: towards an integrative view of proteome dynamics

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p53 Dynamics Control Cell Fate

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Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

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Chronic obstructive pulmonary disease

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High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

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The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

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The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?

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Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

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Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

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A Dynamic Network Approach for the Study of Human Phenotypes

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Comparative Genomics of Centrality and Essentiality in Three Eukaryotic Protein-Interaction Networks

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Pervasive Sharing of Genetic Effects in Autoimmune Disease

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Human disease classification in the postgenomic era: A complex systems approach to human pathobiology

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Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

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Network dynamics and cell physiology

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Integrative approaches for finding modular structure in biological networks

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Abundant Pleiotropy in Human Complex Diseases and Traits

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Genetic insights into common pathways and complex relationships among immune-mediated diseases

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On the binding affinity of macromolecular interactions: daring to ask why proteins interact

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Cryptic genetic variation: evolution's hidden substrate

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A robustness-based approach to systems-oriented drug design

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High‐Betweenness Proteins in the Yeast Protein Interaction Network

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Deep phenotyping for precision medicine

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High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

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Three functional variants of IFN regulatory factor 5 ( <i>IRF5</i> ) define risk and protective haplotypes for human lupus

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Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

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Rewiring of Genetic Networks in Response to DNA Damage

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Applying mass spectrometry-based proteomics to genetics, genomics and network biology

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Tissue-specific alternative splicing remodels protein-protein interaction networks

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Finding the sources of missing heritability in a yeast cross

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Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

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The many faces of pleiotropy

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Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients

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Mass Spectrometry–Based Proteomics and Network Biology

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Dynamic Complex Formation During the Yeast Cell Cycle

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Smoking Intensity, Duration, and Cessation, and the Risk of Rheumatoid Arthritis in Women

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Single-cell technologies for monitoring immune systems

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Human Copy Number Variation and Complex Genetic Disease

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Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2

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Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

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Triggers and drivers of autoimmunity: lessons from coeliac disease

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The dynamic control of signal transduction networks in cancer cells

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Genomic analysis of essentiality within protein networks

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Pervasive robustness in biological systems

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Tissue specificity and the human protein interaction network

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Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

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Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system

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Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases

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Probing genetic overlap among complex human phenotypes

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Credible Mendelian Randomization Studies: Approaches for Evaluating the Instrumental Variable Assumptions

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Health and population effects of rare gene knockouts in adult humans with related parents

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Decanalization and the origin of complex disease

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Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

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Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

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Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

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Unravelling the human genome–phenome relationship using phenome-wide association studies

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