The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
Open accessAbstract
Help the Aged: Muscle function declines with age, as does neurogenesis in certain brain regions. Two teams analyzed the effects of heterochronic parabiosis in mice. Sinha et al. (p. 649 ) found that when an aged mouse shares a circulatory system with a youthful mouse, the aged mouse sees improved muscle function, and Katsimpardi et al. (p. 630 ) observed increased generation of olfactory neurons. In both cases, Growth Differentiation Factor 11 appeared to be one of the key components of the young blood.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The first study42 focused on the monomeric forms of GDF11 and myostatin and showed that they cumulatively decrease in abundance in serum with aging42,44.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [42]
In the citing paper
“Importantly, there are monomeric (12.5 kDa) and dimeric (25 kDa) forms of both myostatin and GDF11, which were not distinguished using the cross-reacting antibodies in these studies42,43.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [42]
In the citing paper
“Accumulation of DNA damage in these stem cells can also be detected using single-cell gel electrophoresis assays38,40.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [38]
In the citing paper
“aged HSCs and muscle stem cells (also called satellite cells) show an increased number of nuclear foci that stain for the phosphorylated form of the variant histone H2A.X (γH2A.X)36–38, which serves as a marker of DNA double-strand breaks39.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [38]
In the citing paper
“A recent parabiosis study further demonstrated the potential to correct DNA damage accumulated in aging mouse satellite cells via circulating systemic factors, with associated improvement of stem cell and tissue functions38.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [38]
In the citing paper
“Intriguingly, at least part of the ‘rejuvenating’ effect of a young systemic environment appears related to the higher levels of circulating growth differentiation factor 11 (GDF11) and oxytocin present in young blood as compared to aged38,166,168,169.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [38]
In the citing paper
“Heterochronic parabiosis (a technique that links the circulatory systems of an old and young animal) can “rejuvenate” several hallmarks of aging in an old mouse (Conboy et al., 2005; Sinha et al., 2014).”
From The Aging Epigenome (2016) · cites this paper as Sinha et al., 2014
In the citing paper
“Many of the molecular signatures of aging, including stem cell exhaustion, altered intercellular signaling, and a loss of genome integrity, are reversed in an old mouse as a result of heterochronic parabiosis, suggesting that the epigenome and gene expression could also be restored to a more youthful state by this treatment (Rando and Chang, 2012; Sinha et al., 2014)”
From The Aging Epigenome (2016) · cites this paper as Sinha et al., 2014
In the citing paper
“Studies on heterochronic parabiosis and plasma exchange in animals have demonstrated that circulating proteins can have a causal influence on ageing phenotypes across the body, including in skeletal muscle107,108, heart109 and brain15,110–112.”
From Measuring biological age using omics data (2022) · cites this paper as [108]
In the citing paper
“Old mice exhibit a decrease in circulating levels of the growth hormone GDF-11, and restoring GDF-11 levels in the old mouse was sufficient for much of the benefit for muscle function (Sinha et al., 2014).”
From Programmed cell death in aging (2015) · cites this paper as Sinha et al., 2014
In the citing paper
“Old mice exhibit a decrease in circulating levels of the growth hormone GDF-11, and restoring GDF-11 levels in the old mouse was sufficient for much of the benefit for muscle function (Sinha et al., 2014).”
From Programmed cell death in aging (2015) · cites this paper as Sinha et al., 2014
In the citing paper
“Replenishing the circulatory system with young blood has been shown to rejuvenate peripheral organs and reverse functional deficits in animals (Sinha et al, 2014).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Sinha et al, 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
The Comet Assay for DNA Damage and Repair: Principles, Applications, and Limitations
Collins, A. R. (2004) · Molecular Biotechnology · doi:10.1385/mb:26:3:249 · Cited by 2,892
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Self-citationIncreased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
γH2AX: a sensitive molecular marker of DNA damage and repair
Mah, L.-J., El-Osta, A., & Karagiannis, T. C. (2010) · Leukemia · doi:10.1038/leu.2010.6 · Cited by 1,557
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037
Self-citationLoffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948
Self-citationThe aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677
Cited by
Sorted by citations
Items 101–200 of 829
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
Yousef, H., Conboy, M. J., Morgenthaler, A., Schlesinger, C., Bugaj, L., Paliwal, P., Greer, C., Conboy, I. M., & Schaffer, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3851 · Cited by 113
Olson, K. A., Beatty, A. L., Heidecker, B., Regan, M. C., Brody, E. N., Foreman, T. M., Kato, S., Mehler, R. E., Singer, B. S., Hveem, K., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv385 · Cited by 117
Role of Oxidative Stress in Ocular Diseases: A Balancing Act
Shu, D. Y., Chaudhary, S., Cho, K., Lennikov, A., Miller, W. P., Thorn, D. C., Yang, M., & McKay, T. B. (2023) · Metabolites · doi:10.3390/metabo13020187 · Cited by 120
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
Moretti, I., Ciciliot, S., Dyar, K. A., Abraham, R., Murgia, M., Agatea, L., Akimoto, T., Bicciato, S., Forcato, M., Pierre, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms12397 · Cited by 115
Supraphysiological levels of GDF11 induce striated muscle atrophy
Hammers, D. W., Merscham‐Banda, M., Hsiao, J. Y., Engst, S., Hartman, J. J., & Sweeney, H. L. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607231 · Cited by 120
Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 117
Gan, K. J., & Südhof, T. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902672116 · Cited by 114
Cellular and molecular mechanisms of sarcopenia: The S100B perspective
Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12363 · Cited by 114
“…nding that growth differentiation factor 11 (GDF11), a myostatin homologue, might support muscle trophism and regeneration and contrast muscle aging 80 was dampened by reports showing that, on the contrary, GDF11 levels increases with age and inhibits muscle regeneration, behaving like…”
Mei, W., Xiang, G., Li, Y., Li, H., Xiang, L., Lu, J., Xiang, L., Dong, J., & Liu, M. (2016) · Molecular Therapy · doi:10.1038/mt.2016.160 · Cited by 113
Shen, G., Zhou, H.-B., Zhang, H., Chen, B., Liu, Z., Yuan, Y., Zhou, X., & Xu, Y. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.015 · Cited by 112
Structural basis for potency differences between GDF8 and GDF11
Walker, R. G., Czepnik, M., Goebel, E. J., McCoy, J. C., Vujić, A., Cho, M., Oh, J., Aykul, S., Walton, K. L., Schang, G., et al. (2017) · BMC Biology · doi:10.1186/s12915-017-0350-1 · Cited by 115
Self-citationMyostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs
Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting
Zimmers, T. A., Jiang, Y., Wang, M., Liang, T. W., Rupert, J. E., Au, E. D., Marino, F. E., Couch, M. E., & Koniaris, L. G. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0639-9 · Cited by 112
Mechanisms of Cachexia in Chronic Disease States
Yoshida, T., & Delafontaine, P. (2015) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000511 · Cited by 117
Regulation of inflammation as an anti‐aging intervention
Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15061 · Cited by 110
Geroprotectors: A Unified Concept and Screening Approaches
Moskalev, A., Chernyagina, E., Kudryavtseva, A. V., & Shaposhnikov, M. V. (2017) · Aging and Disease · doi:10.14336/ad.2016.1022 · Cited by 110
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104
MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview
Diamanti‐Kandarakis, E., Dattilo, M., Μacut, D., Duntas, L. H., Gonos, E. S., Goulis, D. G., Kanaka‐Gantenbein, C., Καπετάνου, Μ., Koukkou, E. G., Lambrinoudaki, I. V., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1061 · Cited by 105
Rodgers, B. D., & Eldridge, J. A. (2015) · Endocrinology · doi:10.1210/en.2015-1628 · Cited by 104
TGF-β superfamily signaling in testis formation and early male germline development
Young, J. C., WAKITANI, S., & Loveland, K. L. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.029 · Cited by 114
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
Ho, T. T., Dellorusso, P. V., Verovskaya, E. V., Bakker, S. T., Flach, J., Smith, L. K., Ventura, P. B., Lansinger, O. M., Hérault, A., Zhang, S. Y., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210223 · Cited by 101
Ozek, C., Krolewski, R. C., Buchanan, S. M., & Rubin, L. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-35716-6 · Cited by 99
Du, G., Shao, Z., Wu, J., Yin, W., Li, S.-H., Wu, J., Weisel, R. D., Tian, J., & Li, R. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0593-y · Cited by 100
Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A. J., Baras, A. S., Karim, B. O., Kim, A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905722116 · Cited by 96
Cancer Cachexia: New Insights and Future Directions
Mariean, C. R., Tiucă, O. M., Mariean, A., & Cotoi, O. S. (2023) · Cancers · doi:10.3390/cancers15235590 · Cited by 112
Prediction of sarcopenia using a combination of multiple serum biomarkers
Kwak, J. Y., Hwang, H., Kim, S., Choi, J. Y., Lee, S.-M., Bang, H., Kwon, E., Lee, K., Chung, S. G., & Kwon, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-26617-9 · Cited by 97
Young capillary vessels rejuvenate aged pancreatic islets
Almaça, J., Molina, J., Drigo, R. A. E., Abdulreda, M. H., Jeon, W. B., Berggren, P., Caicedo, A., & Nam, H. G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414053111 · Cited by 95
Balistreri, C. R., Madonna, R., Melino, G., & Caruso, C. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.004 · Cited by 93
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
Lee, K. Y., Singh, M. K., Ussar, S., Wetzel, P., Hirshman, M. F., Goodyear, L. J., Kispert, A., & Kahn, C. R. (2015) · Nature Communications · doi:10.1038/ncomms9054 · Cited by 95
Self-citationExtracellular vesicles and aging
Robbins, P. D. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.12.03 · Cited by 93
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
Baker, N., Wade, S., Triolo, M., Girgis, J., Chwastek, D., Larrigan, S., Feige, P., Fujita, R., Crist, C. G., Rudnicki, M. A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.010 · Cited by 96
L’honoré, A., Commère, P., Négroni, E., Pallafacchina, G., Friguet, B., Drouin, J., BUCKINGHAM, M. E., & Montarras, D. (2018) · eLife · doi:10.7554/elife.32991 · Cited by 94
Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues
Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 91
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective
Pandya, V. A., & Patani, R. (2019) · Brain · doi:10.1093/brain/awz360 · Cited by 86
Association of Donor Age and Sex With Survival of Patients Receiving Transfusions
Edgren, G., Ullum, H., Rostgaard, K., Erikstrup, C., Sartipy, U., Holzmann, M. J., Nyrén, O., & Hjalgrim, H. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.0890 · Cited by 89
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis
Chen, Y., Pu, Q., Ma, Y., Zhang, H., Ye, T., Zhao, C., Huang, X., Ren, Y., Qiao, L., Liu, H., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.019 · Cited by 92
Aging and brain rejuvenation as systemic events
Bouchard, J. J., & Villeda, S. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12969 · Cited by 90
Switching roles: the functional plasticity of adult tissue stem cells
Wabik, A., & Jones, P. H. (2015) · The EMBO Journal · doi:10.15252/embj.201490386 · Cited by 84
Stem cells: Aging and transcriptional fingerprints
Keyes, B. E., & Fuchs, E. V. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201708099 · Cited by 84
Regulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 89
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
Jones, J. E., Cadena, S. M., Gong, C., Wang, X., Chen, Z., Wang, S. X., Vickers, C., Chen, H., Lach‐Trifilieff, E., Hadcock, J. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.044 · Cited by 87
Escape of hair follicle stem cells causes stem cell exhaustion during aging
Zhang, C., Wang, D., Wang, J., Wang, L., Qiu, W., Kume, T., Dowell, R. D., & Yi, R. (2021) · Nature Aging · doi:10.1038/s43587-021-00103-w · Cited by 87
Molecular insights of exercise therapy in disease prevention and treatment
Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 95
Blood-Borne Revitalization of the Aged Brain
Castellano, J. M., Kirby, E. D., & Wyss-Coray, T. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1616 · Cited by 83
Dong, J., Dong, Y., Chen, Z., Mitch, W. E., & Zhang, L. (2016) · Kidney International · doi:10.1016/j.kint.2016.07.029 · Cited by 83
Suh, J., Kim, N.-K., Lee, S., Eom, J., Lee, Y., Park, J., Woo, K. M., Baek, J., Kim, J., Ryoo, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916034117 · Cited by 87
Role of growth differentiation factor 11 in development, physiology and disease
Zhang, Y., Wei, Y. S., Liu, D., Liu, F., Li, X. A., Pan, L., Pang, Y., & Chen, D. (2017) · Oncotarget · doi:10.18632/oncotarget.20258 · Cited by 84
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Henrot, P., Blervaque, L., Dupin, I., Zysman, M., Estèves, P., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13103 · Cited by 88
Ximerakis, M., Holton, K. M., Giadone, R. M., Ozek, C., Saxena, M., Santiago, S., Adiconis, X., Dionne, D. A., Nguyễn, L., Shah, K. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00373-6 · Cited by 81
Self-citationAnti-Aging Strategies Based on Cellular Reprogramming
Ocampo, A., Reddy, P., & Belmonte, J. C. I. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.005 · Cited by 80
Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Kim, M., Miller, C. M., Shadrach, J. L., Wagers, A. J., & Serwold, T. F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403158 · Cited by 74
Self-citationThe TGF-β Family inCaenorhabditis elegansPreprint
Savage‐Dunn, C., & Padgett, R. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022178 · Cited by 76
Translating the Science of Aging into Therapeutic Interventions
Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78
Hwang, A. B., & Brack, A. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.008 · Cited by 83
Fife, E., Kostka, J., Kroc, Ł., Guligowska, A., Pigłowska, M., Sołtysik, B. K., Kaufman‐Szymczyk, A., Fabianowska‐Majewska, K., & Kostka, T. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0888-y · Cited by 77
Discovery of bone morphogenetic proteins – A historical perspective
Sampath, T. K., & Reddi, A. H. (2020) · Bone · doi:10.1016/j.bone.2020.115548 · Cited by 76
Oh, J., Sinha, I., Tan, K. Y., ROSNER, B. A., Dreyfuss, J. M., Gjata, O., Tran, P. H., Shoelson, S. E., & Wagers, A. J. (2016) · Aging · doi:10.18632/aging.101098 · Cited by 78
Self-citationAdipose Tissue Senescence and Inflammation in Aging is Reversed by the Young Milieu
Ghosh, A. K., O’Brien, M., Mau, T., Qi, N., & Yung, R. L. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly290 · Cited by 73
Contribution of muscle satellite cells to sarcopenia
Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74
Harper (2016) · doi:10.1161/circresaha.116.307962 · Cited by 74
Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q., & Su, D. (2018) · The FASEB Journal · doi:10.1096/fj.201800059r · Cited by 74
Self-citationHamaguchi, M., Muramatsu, R., Fujimura, H., Mochizuki, H., Kataoka, H., & Yamashita, T. (2019) · eLife · doi:10.7554/elife.41869 · Cited by 75
Li, H., Li, Y., Xiang, L., Zhang, J., Zhu, B., Xiang, L., Dong, J., Liu, M., & Xiang, G. (2017) · Diabetes · doi:10.2337/db17-0086 · Cited by 74
Alway, S. E., Bennett, B. T., Wilson, J. C., Sperringer, J., Mohamed, J. S., Edens, N. K., & Pereira, S. L. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00674.2014 · Cited by 73
Kiss, T., Tarantini, S., Csípő, T., Balasubramanian, P., Nyúl‐Tóth, Á., Yabluchanskiy, A., Wren, J. D., Garman, L., Huffman, D. M., Csiszár, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00180-6 · Cited by 75
Zotter‐Tufaro, C., Mascherbauer, J., Duca, F., Koell, B., Aschauer, S., Kammerlander, A. A., Panzenboeck, A., Sadushi‐Kolici, R., Bangert, C., Laimer, D., et al. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.01.010 · Cited by 74
Zhao, Y., Li, J., Liu, H., Xi, Y., Xue, M., Liu, W., Zhuang, Z., & Lei, M. (2015) · BMC Genomics · doi:10.1186/s12864-015-1580-7 · Cited by 72
Stem cell therapy for neurological disorders: A focus on aging
Nguyen, H., Zarriello, S., Coats, A. B., Nelson, C., Kingsbury, C., Gorsky, A., Rajani, M., Neal, E. G., & Borlongan, C. V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.011 · Cited by 74
Lack of evidence for GDF 11 as a rejuvenator of aged skeletal muscle satellite cells
Hinken, A. C., Powers, J. M., Luo, G., Holt, J. A., Billin, A. N., & Russell, A. J. (2016) · Aging Cell · doi:10.1111/acel.12475 · Cited by 71
Ma, J., Zhang, L., He, G., Tan, X., Jin, X., & Li, C. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.08.004 · Cited by 73
Biological strategies for osteoarthritis: from early diagnosis to treatment
Weber, A. E., Bolia, I. K., & Trasolini, N. A. (2020) · International Orthopaedics · doi:10.1007/s00264-020-04838-w · Cited by 70
Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.10.006 · Cited by 71
Sarcopenia: An Endocrine Disorder?
McKee, A. M., Morley, J. E., Matsumoto, A. M., & Vinik, A. I. (2017) · Endocrine Practice · doi:10.4158/ep171795.ra · Cited by 72
Whittemore, K., Derevyanko, A., Martinez, P., Serrano, R., Pumarola, M., Bosch, F., & Blasco, M. A. (2019) · Aging · doi:10.18632/aging.101982 · Cited by 69
van Beek, H., Kirkwood, T. B. L., & Bassingthwaighte, J. B. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0079 · Cited by 77
Growth Differentiation Factor-15 in Immunity and Aging
Pence, B. D. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.837575 · Cited by 68
Horbelt, D., Boergermann, J. H., Chaikuad, A., Alfano, I., Williams, E., Lukonin, I., Timmel, T., Bullock, A. N., & Knaus, P. I. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.604397 · Cited by 70
Geroconversion of aged muscle stem cells under regenerative pressure
Sousa-Victor, P., Perdiguero, E., & Muñoz-Cánoves, P. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965072 · Cited by 68
The systemic environment: at the interface of aging and adult neurogenesis
Smith, L. K., White, C., & Villeda, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2715-8 · Cited by 70
Zheng, L., Shi, S., Lu, M., Fang, P., Pan, Z., Zhang, H., Zhou, Z., Zhang, H., Mou, M., Huang, S., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03166-1 · Cited by 73
Deshmukh, A. S., Cox, J., Jensen, L. J., Meissner, F., & Mann, M. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00720 · Cited by 68
The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging
Zhu, P., Zhang, C., Gao, Y., Wu, F., Zhou, Y., & Wu, W.-S. (2019) · Nature Communications · doi:10.1038/s41467-019-10479-4 · Cited by 66
Stem cell aging in the skeletal muscle: The importance of communication
Hong, X., Campanario, S., Ramírez‐Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz‐Cánoves, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101528 · Cited by 73
Zhang, R., Chen, H., & Liu, D. (2015) · Cell Systems · doi:10.1016/j.cels.2015.09.002 · Cited by 70
Rich, B., Scadeng, M., Yamaguchi, M., Wagner, P. D., & Breen, E. C. (2017) · The Journal of Physiology · doi:10.1113/jp273994 · Cited by 68
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells
Dai, Z., Song, G., Balakrishnan, A., Yang, T., Yuan, Q., Möbus, S., Weiss, A., Bentler, M., Zhu, J., Jiang, X., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318812 · Cited by 67
Guerra, A., Oikonomidou, P. R., Sinha, S., Zhang, J., Presti, V. L., Hamilton, C. R., Breda, L., Casu, C., La, P., Martins, A. C., et al. (2019) · Blood · doi:10.1182/blood.2019001057 · Cited by 64
Systemic problems: a perspective on stem cell aging and rejuvenation.
Conboy, I. M., Conboy, M. J., & Rebo, J. (2015) · Aging · doi:10.18632/aging.100819 · Cited by 58
Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease
Liang, R. H.-S., & Ghaffari, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14194 · Cited by 69
GDF11 Improves Angiogenic Function of EPCs in Diabetic Limb Ischemia
Zhang, J., Li, Y., Li, H., Zhu, B., Wang, L., Guo, B., Xiang, L., Dong, J., Liu, M., & Xiang, G. (2018) · Diabetes · doi:10.2337/db17-1583 · Cited by 67
The Mechanism of Stem Cell Aging
Mi, L., Hu, J., Li, N., Gao, J., Huo, R., Peng, X., Zhang, N., Liu, Y., Zhao, H., Liu, R., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10317-5 · Cited by 64
The Fountain of Youth: A tale of parabiosis, stem cells, and rejuvenation
Conese, M., Carbone, A., Beccia, E., & Angiolillo, A. (2017) · Open Medicine · doi:10.1515/med-2017-0053 · Cited by 65
Harper, S. C., Johnson, J. P., Borghetti, G., Zhao, H., Wang, T., Wallner, M., Kubo, H., Feldsott, E. A., Yang, Y., Joo, Y., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312955 · Cited by 63
Novel myostatin-specific antibody enhances muscle strength in muscle disease models
Muramatsu, H., Kuramochi, T., Katada, H., Ueyama, A., Ruike, Y., Ohmine, K., Shida-Kawazoe, M., Miyano-Nishizawa, R., Shimizu, Y., Okuda, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81669-8 · Cited by 64
Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis
Alonso‐Martín, S., Rochat, A., Mademtzoglou, D., Morais, J., de Reyniès, A., Aurade, F., Chang, T. H., Zammit, P. S., & Relaix, F. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00058 · Cited by 65
Fight to the bitter end: DNA repair and aging
Chen, Y., Geng, A., Zhang, W., Qian, Z. Y., Wan, X., Jiang, Y., & Mao, Z. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101154 · Cited by 63
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice
Zhou, Y., Ju, H., Hu, Y., Li, T., Chen, Z., Si, Y., Sun, X., Shi, Y., & Fang, H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02760-7 · Cited by 63
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 64
Metadata
- Authors
- Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., Hirshman, M. F., Lebowitz, J., Shadrach, J. L., Cerletti, M., Kim, M.-J., Serwold, T., Goodyear, L. J., Rosner, B., Lee, R. T., & Wagers, A. J.
- Affiliations
- Joslin Diabetes Center (US)
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Sinha, Manisha
- Jang, Young C.
- Wagers, Amy J.
- ORCID
- Venue
- Science
- Published
- 2014-05-09
- Volume
- 344
- Issue
- 6184
- Pages
- 649-652
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4104429
- OpenAlex
- W1998004606
- Cited by
- 824
- References
- 25
- Citations by year
- 2026: 31 · 2025: 43 · 2024: 43 · 2023: 52 · 2022: 57 · 2021: 56 · 2020: 66 · 2019: 68 · 2018: 80 · 2017: 94 · 2016: 98 · 2015: 93 · 2014: 42
- FWCI
- 41.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- American Heart Association
- Abbott Laboratories
- Glenn Foundation for Medical Research
- Amgen
- Eli Lilly and Company
- Colgate-Palmolive Company
- Brigham and Women's Hospital
- Harvard University
- National Institutes of Health (1dp2od004345-01)
- Harvard Stem Cell Institute
- National Institute on Aging (R01AG033053, R01AG032977, R01AG040019)
- National Heart, Lung, and Blood Institute (U01HL100402)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK036836)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042238)
- National Institute of Dental and Craniofacial Research (T32DE007057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- GDF11, muscle aging, skeletal muscle regeneration, heterochronic parabiosis, satellite cells, muscle stem cells, genome stability, exercise capacity
- MeSH terms
- Age Factors, Aging, Animals, Male, Mice, Inbred C57BL, Parabiosis, Regeneration, Rejuvenation, Muscle, Skeletal, Bone Morphogenetic Proteins, Myoblasts, Skeletal, Mice, Growth Differentiation Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
