Cellular and molecular mechanisms of sarcopenia: The S100B perspective
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Abstract Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise healthy people. The pathogenesis of primary sarcopenia is not completely understood. Herein, we review the essentials of the cellular and molecular mechanisms of skeletal mass maintenance; the alterations of myofiber metabolism and deranged properties of muscle satellite cells (the adult stem cells of skeletal muscles) that underpin the pathophysiology of primary sarcopenia; the role of the Ca 2+ ‐sensor protein, S100B, as an intracellular factor and an extracellular signal regulating cell functions; and the functional role of S100B in muscle tissue. Lastly, building on recent results pointing to S100B as to a molecular determinant of myoblast–brown adipocyte transition, we propose S100B as a transducer of the deleterious effects of accumulation of reactive oxygen species in myoblasts and, potentially, myofibers concurring to the pathophysiology of sarcopenia.
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gApN induces the expression of MyoD that allows myoblast proliferation and differentiation.
“Second, gApN induces the expression of MyoD that allows myoblast proliferation and differentiation [56,69,70].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [70]
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Research works printed but not linked: 2
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- Authors
- Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- Donato, Rosario
- ORCID
- Venue
- Journal of Cachexia Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2018-11-30
- Volume
- 9
- Issue
- 7
- Pages
- 1255-1268
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC6351675
- OpenAlex
- W2903461337
- Cited by
- 114
- References
- 152
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 13 · 2020: 16 · 2019: 5 · 2018: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondazione Cassa di Risparmio di Perugia (2016‐0136.021, 2012.0241.021, 2015.0325.021)
- Associazione Italiana per la Ricerca sul Cancro (17581)
- French Muscular Dystrophy Association (16812, 12992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- sarcopenia, S100B, satellite cells, calcium-sensing proteins, reactive oxygen species, aging, muscle stem cells
- MeSH terms
- Humans, Biomarkers, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Sarcopenia, S100 Calcium Binding Protein beta Subunit
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