Cited by 114Muscle Physiology and DisordersNutrition and Health in AgingS100 Proteins and Annexins

Cellular and molecular mechanisms of sarcopenia: The S100B perspective

Open access
Riuzzi, Francesca, Sorci, Guglielmo, Arcuri, Cataldo, Giambanco, Ileana, Bellezza, Ilaria, Minelli, Alba, Donato, Rosario·2018·Journal of Cachexia Sarcopenia and Muscle

Abstract

Abstract Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise healthy people. The pathogenesis of primary sarcopenia is not completely understood. Herein, we review the essentials of the cellular and molecular mechanisms of skeletal mass maintenance; the alterations of myofiber metabolism and deranged properties of muscle satellite cells (the adult stem cells of skeletal muscles) that underpin the pathophysiology of primary sarcopenia; the role of the Ca 2+ ‐sensor protein, S100B, as an intracellular factor and an extracellular signal regulating cell functions; and the functional role of S100B in muscle tissue. Lastly, building on recent results pointing to S100B as to a molecular determinant of myoblast–brown adipocyte transition, we propose S100B as a transducer of the deleterious effects of accumulation of reactive oxygen species in myoblasts and, potentially, myofibers concurring to the pathophysiology of sarcopenia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/jcsm.12363

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 2

  1. [4]Fuggle N, Shaw S, Dennison E, Cooper C. Sarcopenia. Best Pract Res Clin Rheumatol 2017; 31: 218– 242. 29224698 PMC5768235
  2. [94]Garbuglia M, Verzini M, Giambanco I, Spreca A, Donato R. Effects of calcium‐binding proteins (S100a0, S100a, S100b) on desmin assembly in vitro. FASEB J 1996; 10: 317– 324. 8641565

Cited by

Sorted by citations

Authors
Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R.
Affiliations
University of Perugia (IT)
Corresponding author
Donato, Rosario
Venue
Journal of Cachexia Sarcopenia and Muscle
Publisher
Wiley
Published
2018-11-30
Volume
9
Issue
7
Pages
1255-1268
ISSN
  • 2190-5991 (ISSN-L)
  • 2190-6009
OpenAlex
W2903461337
Cited by
114
References
152
Citations by year
2026: 7 · 2025: 17 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 13 · 2020: 16 · 2019: 5 · 2018: 1
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fondazione Cassa di Risparmio di Perugia (2016‐0136.021, 2012.0241.021, 2015.0325.021)
  • Associazione Italiana per la Ricerca sul Cancro (17581)
  • French Muscular Dystrophy Association (16812, 12992)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords
sarcopenia, S100B, satellite cells, calcium-sensing proteins, reactive oxygen species, aging, muscle stem cells
MeSH terms
Humans, Biomarkers, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Sarcopenia, S100 Calcium Binding Protein beta Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review