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IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
Abstract
Activation of the transcription factor nuclear factor kappa B (NF-κB) by inflammatory cytokines requires the successive action of NF-κB–inducing kinase (NIK) and IκB kinase–α (IKK-α). A widely expressed protein kinase was identified that is 52 percent identical to IKK-α. IκB kinase–β (IKK-β) activated NF-κB when overexpressed and phosphorylated serine residues 32 and 36 of IκB-α and serines 19 and 23 of IκB-β. The activity of IKK-β was stimulated by tumor necrosis factor and interleukin-1 treatment. IKK-α and IKK-β formed heterodimers that interacted with NIK. Overexpression of a catalytically inactive form of IKK-β blocked cytokine-induced NF-κB activation. Thus, an active IκB kinase complex may require three distinct protein kinases.
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Metadata
- Authors
- Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V.
- Venue
- Science
- Published
- 1997-10-31
- Volume
- 278
- Issue
- 5339
- Pages
- 866-870
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997509253
- Cited by
- 1,181
- References
- 3
- FWCI
- 56.41
- Type
- journal article
- Language
- en
- Open access
- closed
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