Cited by 5,866Cell death mechanisms and regulationCancer-related Molecular PathwaysDeath, Funerary Practices, and Mourning

The DOI matches its Crossref record; 87 of the 91 references it cites were found in a registry or an index.

Death Receptors: Signaling and Modulation

Ashkenazi, Avi, Dixit, Vishva M.·1998·Science

DOI 10.1126/science.281.5381.1305

Open this paper in CoChat — free account

Abstract

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

Integrity signals

Registry

Crossref · 10.1126/science.281.5381.1305

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
Mechanisms and Genes of Cellular Suicide
Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,469
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Self-citation

Flagged first, then by citations

Show all 91 references

4 of the 91 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

Boise L. H., Thompson C. B., ibid. 274, 67 (1996);
Winoto A., ibid. 9, 365 (1997).
Nagata S., ibid. 88, 355 (1997).
Pan G., et al., ibid. 277, 815 (1997).
Rothe M., Pan M. G., Henzel W. J., Ayres T. M., Goeddel D. V., ibid. 83, 1243 (1995).
Kelliher M., et al., ibid. 8, 297 (1998).
Ahmad M., et al., Cancer Res. 57, 615 (1997).
M. J. Martinez-Lorenzo et al. Eur. J. Immunol. in press.
Jeramias I., Herr I., Boehler T., Debatin K. M., ibid. 28, 143 (1998).
Lacey D. L., et al., ibid. 93, 165 (1998).

Sorted by citations

Items 301–400 of 1,023

Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis
Xanthoudakis, S., Roy, S., Rasper, D., Hennessey, T., Aubin, Y., Cassady, R., Tawa, P., Ruel, R., Rosen, A., & Nicholson, D. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2049 · Cited by 305
Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes
McLauchlan (2000) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.2000.00201.x · Cited by 303
RNA Viruses: ROS-Mediated Cell Death
Reshi, L., Su, Y.-C., & Hong, J. (2014) · International Journal of Cell Biology · doi:10.1155/2014/467452 · Cited by 314
Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro
MacFarlane, M., Merrison, W., Bratton, S. B., & Cohen, G. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200317200 · Cited by 303
Molecular biomarkers in acute myeloid leukemia
Prada‐Arismendy, J., Arroyave-Ospina, J. C., & Röthlisberger, S. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.08.005 · Cited by 317
Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy
Godwin, P., Baird, A., Heavey, S., Barr, M. P., O'Byrne, K. J., & Gately, K. A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00120 · Cited by 312
Mechanisms underlying hypoxia-induced neuronal apoptosis
Banasiak, K. J., Xia, Y., & Haddad, G. G. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00011-3 · Cited by 306
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
Mocarski, E. S., Upton, J. W., & Kaiser, W. J. (2011) · Nature reviews. Immunology · doi:10.1038/nri3131 · Cited by 309
Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
Canbay, A. E., Higuchi, H., Bronk, S. F., Taniai, M., Sebo, T. J., & Gores, G. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35953 · Cited by 302
Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish
Long, Q., Huang, H., Shafizadeh, E., Liu, N., & Lin, S. (2000) · Nature Cell Biology · doi:10.1038/35019592 · Cited by 300
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x L
Huang, D. C. S., Hahne, M., Schroeter, M., Frei, K., Fontana, A., Villunger, A., Newton, K., Tschopp, J. F., & Strasser, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14871 · Cited by 300
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
Häcki, J., Egger, L., Monney, L., Conus, S., Rossé, T., Fellay, I., & Borner, C. (2000) · Oncogene · doi:10.1038/sj.onc.1203592 · Cited by 303
Formononetin: A Review of Its Anticancer Potentials and Mechanisms
Tay, K. C., Tan, L. T., Chan, C. K., Hong, S. L., Chan, K., Yap, W. H., Pusparajah, P., Lee, L., & Goh, B. H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00820 · Cited by 306
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
Doi, T. S., Marino, M. W., Takahashi, T., Yoshida, T., Sakakura, T., Old, L. J., & Obata, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2994 · Cited by 299
Characterization of a Previously Unidentified Viral Protein in Porcine Circovirus Type 2-Infected Cells and Its Role in Virus-Induced Apoptosis
Liu, J., Chen, I., & Kwang, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.8262-8274.2005 · Cited by 298
Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities
Plati, J., Bucur, O., & Khosravi‐Far, R. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21707 · Cited by 301
The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis
Priatel, J. J., Chui, D., Hiraoka, N., Simmons, C. J. T., Richardson, K. B., Page, D. M., Fukuda, M., Varki, N. M., & Marth, J. D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80180-6 · Cited by 295
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways
Liou, A. K. F., Clark, R. S. B., Henshall, D. C., Yin, X., & Chen, J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00005-4 · Cited by 295
Effect of Long-Term Estrogen Deprivation on Apoptotic Responses of Breast Cancer Cells to 17 -Estradiol
Song, R., Mor, G., Naftolin, F. N., McPherson, R. A., Song, J., Zhang, Z., Yue, W., Wang, J., & Santen, R. J. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1714 · Cited by 293
Cascading effects of stressors and inflammatory immune system activation: Implications for major depressive disorder
Anisman, H. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0902 · Cited by 292
Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus
Stenqvist, A., Nagaeva, O., Baranov, V. I., & Mincheva‐Nilsson, L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301885 · Cited by 292
Apoptosome dysfunction in human cancer
Hajra, K. M., & Liu, J. R. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000045786.98031.1d · Cited by 291
Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases
Tang, M., Chen, Z., Wu, D., & Chen, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26954 · Cited by 292
Losing heart: the role of apoptosis in heart disease—a novel therapeutic target?
Gill, C., Mestril, R., & Samali, A. (2002) · The FASEB Journal · doi:10.1096/fj.01-0629com · Cited by 292
Cell surface Death Receptor signaling in normal and cancer cells
Özören, N., & El‐Deiry, W. S. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00131-1 · Cited by 292
The Role of Natural Killer Cells in Autoimmune Diseases
Küçüksezer, U. C., Çetin, E. A., Esen, F., Tahralı, İ., Akdeniz, N., Gelmez, M. Y., & Deniz, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622306 · Cited by 304
Annexin 1: more than an anti-phospholipase protein
Parente, L., & Solito, E. (2004) · Inflammation Research · doi:10.1007/s00011-003-1235-z · Cited by 288
Cdc2 Phosphorylation of BAD Links the Cell Cycle to the Cell Death Machinery
Konishi, Y., Lehtinen, M. K., Donovan, N., & Bonni, A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00524-5 · Cited by 291
Regulation of death receptor-mediated apoptosis pathways
Schmitz, I., Kirchhoff, S., & Krammer, P. H. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00048-0 · Cited by 287
Speed kills: cellular and molecular bases of methamphetamine‐induced nerve terminal degeneration and neuronal apoptosis
Cadet, J. L., Jayanthi, S., & Deng, X. (2003) · The FASEB Journal · doi:10.1096/fj.03-0073rev · Cited by 286
IFN-γ Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression
Sedger, L. M., Shows, D. M., Blanton, R. A., Peschon, J. J., Goodwin, R. G., Cosman, D. J., & Wiley, S. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.920 · Cited by 286
Progression of Atheroma
Geng, Y., & Libby, P. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000031341.84618.a4 · Cited by 285
p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells
Narayanan, B. A., Geoffroy, O. J., Willingham, M. C., Re, G. G., & Nixon, D. W. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00323-1 · Cited by 286
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF‐R1 activation by endogenous membrane‐anchored TNF
Grell, M., Zimmermann, G., Gottfried, E., Chen, C., Grünwald, U., Huang, D. C. S., Lee, Y. W., Dürkop, H., Engelmann, H., Scheurich, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3034 · Cited by 284
Regulated Commitment of TNF Receptor Signaling
Pimentel‐Muiños, F. X., & Seed, B. (1999) · Immunity · doi:10.1016/s1074-7613(00)80152-1 · Cited by 282
TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure
Ramesh, G., & Reeves, W. B. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00101.2003 · Cited by 281
Cisplatin Induces Apoptosis in LLC-PK1 Cells via Activation of Mitochondrial Pathways
Park, M. S., Leon, M. D., & Devarajan, P. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134858 · Cited by 281
TRAIL/Apo-2L: Mechanisms and Clinical Applications in Cancer
Srivastava, R. K. (2001) · Neoplasia · doi:10.1038/sj.neo.7900203 · Cited by 279
Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling
Kelley, R. F., Tótpál, K., Lindstrom, S. H., Mathieu, M. A., Billeci, K. L., DeForge, L. E., Pai, R., Hymowitz, S. G., & Ashkenazi, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410660200 · Cited by 279
Self-citation
Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand
Varfolomeev, E. E., Maecker, H. L., Sharp, D. A., Lawrence, D. A., Renz, M. E., Vucic, D., & Ashkenazi, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509560200 · Cited by 278
Self-citation
Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy
Karunagaran, D., Rashmi, R., & Kumar, T. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053202081 · Cited by 278
Neuronal Apoptosis After CNS Injury: The Roles of Glutamate and Calcium
Zipfel, G. J., Babcock, D., Lee, J., & Choi, D. W. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.857 · Cited by 281
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
Ermolaeva, M., Michallet, M., Papadopoulou, N., Utermöhlen, O., Kranidioti, K., Kollias, G. A., Tschopp, J., & Pasparakis, M. (2008) · Nature Immunology · doi:10.1038/ni.1638 · Cited by 277
Regulated Cell Death: Signaling and Mechanisms
Ashkenazi, A., & Salvesen, G. S. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013226 · Cited by 289
Self-citation
Apoptosis in ischemic heart disease
Teringová, E., & Toušek, P. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1191-y · Cited by 276
Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature
Millimouno, F. M., Dong, J., Liu, Y., Li, J., & Li, X. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0136 · Cited by 276
Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells
Arango, D., Wilson, A. J., Shi, Q., Corner, G. A., Aranes, M., Nicholas, C., LESSER, M. L., Mariadason, J. M., & Augenlicht, L. H. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602215 · Cited by 273
Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2
Ungewickell, A., Bhaduri, A., Rios, E. J., Reuter, J., Lee, C. S., Mah, A., Zehnder, A. M., Ohgami, R. S., Kulkarni, S., Armstrong, R. J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3370 · Cited by 281
Interdimer processing mechanism of procaspase‐8 activation
Chang, D. W.-W., Xing, Z., Capacio, V. L., Peter, M. E., & Yang, X. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg414 · Cited by 278
Keratin-Dependent, Epithelial Resistance to Tumor Necrosis Factor-Induced Apoptosis
Caulı́n, C., Ware, C. F., Magin, T. M., & Oshima, R. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.1.17 · Cited by 271
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis
Schempp, C. M., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Kiss, J., Termeer, C., Gilb, B., Kaufmann, T., Borner, C., Sleeman, J. P., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205190 · Cited by 271
Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells
Xia, P., Wang, L., Gamble, J. R., & Vadas, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34499 · Cited by 271
Apoptosis in sepsis: a new target for therapeutic exploration
Oberholzer, C., Oberholzer, A., Clare-Salzler, M. J., & Moldawer, L. L. (2001) · The FASEB Journal · doi:10.1096/fj.00-058rev · Cited by 273
The Type III Inositol 1,4,5-Trisphosphate Receptor Preferentially Transmits Apoptotic Ca2+ Signals into Mitochondria
Mendes, C. C. P., Gomes, D. A., Thompson, M., Souto, N. C., Góes, T. S., Goes, A. M., Rodrigues, M. Â., Gomez, M. V., Nathanson, M. H., & Leite, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506623200 · Cited by 270
Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
Kong, A. T., Yu, R., Chen, C., Mandlekar, S., & Primiano, T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976458 · Cited by 272
TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase
Fan, J., Frey, R. S., & Malik, A. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18696 · Cited by 271
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
Nakata, S., Yoshida, T., Horinaka, M., Shiraishi, T., Wakada, M., & Sakai, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207830 · Cited by 268
CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl–positive human leukemia cells to apoptosis due to antileukemic drugs
Fang, G., Kim, C. N., Perkins, C. L., Nimmanapalli, R., Winton, E. F., Wittmann, S., & Bhalla, K. N. (2000) · Blood · doi:10.1182/blood.v96.6.2246 · Cited by 268
The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol‐lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis
Palinski, W., & Claudio Napoli, A. (2002) · The FASEB Journal · doi:10.1096/fj.02-0226rev · Cited by 272
The death domain superfamily: a tale of two interfaces?
Weber, C. H., & Vincenz, C. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01905-3 · Cited by 271
Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity
Hughes, P., Belz, G. T., Fortner, K. A., Budd, R. C., Strasser, A., & Bouillet, P. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.017 · Cited by 271
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
Mader, J. S., Salsman, J., Conrad, D., & Hoskin, D. W. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0077 · Cited by 266
Death Receptor Regulation and Celecoxib-Induced Apoptosis in Human Lung Cancer Cells
Liu, X., Yue, P., Zhou, Z., Khuri, F. R., & Sun, S. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh322 · Cited by 266
Differential Secretion of Fas Ligand- or APO2 Ligand/TNF-Related Apoptosis-Inducing Ligand-Carrying Microvesicles During Activation-Induced Death of Human T Cells
Monleón, I., Martínez‐Lorenzo, M. J., Monteagudo, L. V., Lasierra, P., Taulés, M., Iturralde, M., Piñeiro, A., Larrad, L., Álava, M. A., Naval, J., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6736 · Cited by 265
Elevated Akt Activity Protects the Prostate Cancer Cell Line LNCaP from TRAIL-induced Apoptosis
Nesterov, A., Lu, X., Johnson, M., Miller, G. J., Ivashchenko, Y., & Kraft, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005196200 · Cited by 265
Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells
Kaushal, G. P., Kaushal, V., Hong, X., & Shah, S. V. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00026.x · Cited by 263
Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes
Li, J., Bombeck, C. A., Yang, S., Kim, Y., & Billiar, T. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17325 · Cited by 264
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262
Self-citation
Molecular Mechanisms of Apoptosis in Cerebral Ischemia: Multiple Neuroprotective Opportunities
Nakka, V. P., Gusain, A., Mehta, S. L., & Raghubir, R. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8013-9 · Cited by 270
Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL
Gibson, S. B., Oyer, R. J., Spalding, A. C., Anderson, S. M., & Johnson, G. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.205-212.2000 · Cited by 258
In stent restenosis: bane of the stent era
Mitra, A., & Agrawal, D. K. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.025742 · Cited by 257
A mathematical model of caspase function in apoptosis
Fussenegger, M., Bailey, J. E., & Varner, J. D. (2000) · Nature Biotechnology · doi:10.1038/77589 · Cited by 259
Direct Activation of Bax Protein for Cancer Therapy
Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H., & Zhou, J. (2015) · Medicinal Research Reviews · doi:10.1002/med.21379 · Cited by 260
Specific Cleavage of Mcl-1 by Caspase-3 in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis in Jurkat Leukemia T Cells
Weng, C., Li, Y., Xu, D., Shi, Y., & Tang, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412819200 · Cited by 255
The Cascade Hypothesis of Keratoconus
Kenney, M. C., & Brown, D. J. (2003) · Contact Lens and Anterior Eye · doi:10.1016/s1367-0484(03)00022-5 · Cited by 259
Nitric Oxide as a Pro-apoptotic as well as Anti-apoptotic Modulator
Choi, B.-M., Pae, H., Jang, S. I., Kim, Y., & Chung, H. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.1.116 · Cited by 256
Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells
Delaney, C. L., Cheng, H.-L., & Feldman, E. L. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199912)41:4 · Cited by 253
Increased TNF-α-Induced Apoptosis in Lymphocytes from Aged Humans: Changes in TNF-α Receptor Expression and Activation of Caspases
Aggarwal, S., Gollapudi, S. V. S., & Gupta, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2154 · Cited by 252
Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys
D’Amico, G., Frascaroli, G., Bianchi, G., Transidico, P., Doni, A., Vecchi, A., Sozzani, S., Allavena, P., & Mantovani, A. (2000) · Nature Immunology · doi:10.1038/80819 · Cited by 252
Noncaspase proteases in apoptosis
Johnson, D. (2000) · Leukemia · doi:10.1038/sj.leu.2401879 · Cited by 251
Nitric oxide, cell signaling and cell death
Blaise, G. A., Gauvin, D., Gangal, M., & Authier, S. (2005) · Toxicology · doi:10.1016/j.tox.2004.11.032 · Cited by 250
Distinguishing modes of cell death using the ImageStream® multispectral imaging flow cytometer
George, T. C., Basiji, D. A., Hall, B. E., Lynch, D. H., Ortyn, W. E., Perry, D. J., Seo, M. J., Zimmerman, C. A., & Morrissey, P. (2004) · Cytometry Part A · doi:10.1002/cyto.a.20048 · Cited by 251
Hormonal regulation of male germ cell development
Ruwanpura, S. M., McLachlan, R. I., & Meachem, S. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0025 · Cited by 250
The Apoptosome: Heart and Soul of the Cell Death Machine
Chinnaiyan, A. M. (1999) · Neoplasia · doi:10.1038/sj.neo.7900003 · Cited by 264
Physiological Roles of ASK1-Mediated Signal Transduction in Oxidative Stress- and Endoplasmic Reticulum Stress-Induced Apoptosis: Advanced Findings from ASK1 Knockout Mice
Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K., & Ichijo, H. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196218 · Cited by 249
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression
Lee, J. H., Khor, T. O., Shu, L., Su, Z., Fuentes, F., & Kong, A. T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.008 · Cited by 254
Caspases Disrupt the Nuclear-Cytoplasmic Barrier
Faleiro, L. J., & Lazebnik, Y. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.5.951 · Cited by 249
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
Wertz, I. E., Newton, K., Seshasayee, D., Kusam, S., Lam, C., Zhang, J., Popovych, N., Helgason, E., Schoeffler, A. J., Jeet, S., et al. (2015) · Nature · doi:10.1038/nature16165 · Cited by 254
Self-citation
Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of $alpha;-tocopherol
Ochiai, T., Ohno, S., Soeda, S., Tanaka, H., Shoyama, Y., & Shimeno, H. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.02.067 · Cited by 246
Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release
Koya, R. C., Fujita, H., Shimizu, S., Ohtsu, M., Takimoto, M., Tsujimoto, Y., & Kuzumaki, N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15343 · Cited by 251
RIP kinases as modulators of inflammation and immunity
He, S., & Wang, X. (2018) · Nature Immunology · doi:10.1038/s41590-018-0188-x · Cited by 250
Specific Caspase Pathways Are Activated in the Two Stages of Cerebral Infarction
Benchoua, A., Guégan, C., Couriaud, C., Hosseini, H., Sampaı̈o, N., Morin, D., & Onténiente, B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07127.2001 · Cited by 246
Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy
Grisendi, G., Bussolari, R., Cafarelli, L., Peták, I., Rasini, V., Veronesi, E., Santis, G. D., Spano, C., Tagliazzucchi, M., Barti-Juhász, H., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1865 · Cited by 247
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Hopkins-Donaldson, S., Bodmer, J.-L., Bourloud, K. B., Brognara, C. B., Tschopp, J., & Gross, N. (2000) · PubMed · Cited by 245
Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside
Kochanek, P. M., Clark, R. S. B., Ruppel, R. A., Adelson, P. D., Bell, M. J., Whalen, M. J., Robertson, C., Satchell, M. A., Seidberg, N. A., Marion, D. W., et al. (2000) · Pediatric Critical Care Medicine · doi:10.1097/00130478-200007000-00003 · Cited by 245
Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor
Raoul, C., Henderson, C. E., & Pettmann, B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.1049 · Cited by 244
Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis
Shu, L., Cheung, K., Khor, T. O., Chen, C., & Kong, A. T. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9239-y · Cited by 247
Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation
Gilbert, S., Loranger, A., Daigle, N., & Marceau, N. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102130 · Cited by 245
The role of the Bcl-2 protein family in cancer
Coultas, L., & Strasser, A. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00129-3 · Cited by 243
Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart
Chao, W. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00995.2008 · Cited by 246

Authors: Ashkenazi, A., & Dixit, V. M.
Affiliations: Genentech (US)
ORCID: Ashkenazi, Avi
Dixit, Vishva M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1305-1308
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1305
OpenAlex: W2025128734
Cited by: 5,866
References: 91
Citations by year: 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
FWCI: 26.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
MeSH terms: Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Death Receptors: Signaling and Modulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks