Cited by 5,866Cell death mechanisms and regulationCancer-related Molecular PathwaysDeath, Funerary Practices, and Mourning

The DOI matches its Crossref record; 87 of the 91 references it cites were found in a registry or an index.

Death Receptors: Signaling and Modulation

Ashkenazi, Avi, Dixit, Vishva M.·1998·Science

DOI 10.1126/science.281.5381.1305

Open this paper in CoChat — free account

Abstract

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

Integrity signals

Registry

Crossref · 10.1126/science.281.5381.1305

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
Mechanisms and Genes of Cellular Suicide
Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,469
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Self-citation

Flagged first, then by citations

Show all 91 references

4 of the 91 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

Boise L. H., Thompson C. B., ibid. 274, 67 (1996);
Winoto A., ibid. 9, 365 (1997).
Nagata S., ibid. 88, 355 (1997).
Pan G., et al., ibid. 277, 815 (1997).
Rothe M., Pan M. G., Henzel W. J., Ayres T. M., Goeddel D. V., ibid. 83, 1243 (1995).
Kelliher M., et al., ibid. 8, 297 (1998).
Ahmad M., et al., Cancer Res. 57, 615 (1997).
M. J. Martinez-Lorenzo et al. Eur. J. Immunol. in press.
Jeramias I., Herr I., Boehler T., Debatin K. M., ibid. 28, 143 (1998).
Lacey D. L., et al., ibid. 93, 165 (1998).

Sorted by citations

Items 401–500 of 1,023

Activation of caspases-8 and -10 by FLIPL
Boatright, K. M., Cristina, D. E. I. S., Denault, J., Sutherlin, D. P., & Salvesen, G. S. (2004) · Biochemical Journal · doi:10.1042/bj20040809 · Cited by 242
Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity
Ricci, M., Jin, Z., Dews, M., Yu, D., Thomas‐Tikhonenko, A., Dicker, D. T., & El‐Deiry, W. S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8541-8555.2004 · Cited by 241
Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas
Subauste, M. C., von Herrath, M., Planat‐Benard, V., Chamberlain, C. E., Chuang, T., Chu, K., Bokoch, G., & Hahn, K. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9725 · Cited by 241
Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS
Wu, Y., Bressette, D., Carrell, J., Kaufman, T. M., Feng, P., Taylor, K., Gan, Y., Cho, Y. H., Garcia, A., Gollatz, E., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005224200 · Cited by 241
Activation of the NF-κB pathway by Caspase 8 and its homologs
Chaudhary, P. M., Eby, M. T., Jasmin, A., Kumar, A., Liu, L., & Hood, L. (2000) · Oncogene · doi:10.1038/sj.onc.1203812 · Cited by 241
RIP3, a Novel Apoptosis-inducing Kinase
Sun, X., Lee, J., Navas, T. A., Baldwin, D. T., Stewart, T. A., & Dixit, V. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16871 · Cited by 240
Self-citation
The modulation of host cell apoptosis by intracellular bacterial pathogens
Gao, L., & Kwaik, Y. A. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01784-4 · Cited by 240
Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions
Ashkenazi, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80420 · Cited by 240
Self-citation
TRAIL-induced signalling and apoptosis
MacFarlane, M. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(02)00422-8 · Cited by 240
Necrotic Death Pathway in FAS Receptor Signaling
Matsumura, H., Shimizu, Y., Ohsawa, Y., Kawahara, A., Uchiyama, Y., & Nagata, S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1247 · Cited by 242
Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1β Production
Man, S. M., Tourlomousis, P., Hopkins, L., Monie, T. P., Fitzgerald, K. A., & Bryant, C. E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301581 · Cited by 239
Apoptosis regulators and their role in tumorigenesis
Zörnig, M., Hueber, A., Baum, W., & Evan, G. I. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00031-2 · Cited by 243
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
Phillips, A. C., Ernst, M. K., Bates, S., Rice, N. R., & Vousden, K. H. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80387-1 · Cited by 239
Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Wu, G. S., Burns, T. F., Zhan, Y.-A., Alnemri, E. S., & El‐Deiry, W. S. (1999) · PubMed · Cited by 238
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
Pellegrini, M., Belz, G. T., Bouillet, P., & Strasser, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336198100 · Cited by 240
Regulation Mechanism of Selective Atresia in Porcine Follicles: Regulation of Granulosa Cell Apoptosis during Atresia
MANABE, N., Goto, Y., MATSUDA‐MINEHATA, F., Inoue, N., Maeda, A., Sakamaki, K., & Miyano, T. (2004) · Journal of Reproduction and Development · doi:10.1262/jrd.50.493 · Cited by 238
Improving T Cell Therapy for Cancer
Leen, A. M., Rooney, C. M., & Foster, A. E. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141527 · Cited by 240
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
Yang, L., Mashima, T., Sato, S., Mochizuki, M., Sakamoto, H., Yamori, T., Oh‐hara, T., & Tsuruo, T. (2003) · PubMed · Cited by 238
Defining Characteristics of Types I and II Apoptotic Cells in Response to TRAIL
Özören, N., & El‐Deiry, W. S. (2002) · Neoplasia · doi:10.1038/sj.neo.7900270 · Cited by 236
Control of the Cell Death Pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-Related Caspase Activator
Kanuka, H., Sawamoto, K., Inohara, N., Matsuno, K., Okano, H., & Miura, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80386-x · Cited by 236
Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications
Shankar, S., & Srivastava, R. K. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.03.002 · Cited by 235
Drug-induced Liver Injury.
David, S., & Hamilton, J. P. (2010) · PubMed · Cited by 235
How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis
Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234
Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas
Kauer, T. M., de Figueiredo, J. L., Hingtgen, S., & Shah, K. (2011) · Nature Neuroscience · doi:10.1038/nn.3019 · Cited by 234
Nuclear Factor-κB Activation: A Question of Life or Death
Shishodia, S., & Aggarwal, B. B. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.1.028 · Cited by 235
Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8
Kim, Y. M., Kim, T., Chung, H., Talanian, R. V., Yin, X., & Billiar, T. R. (2000) · Hepatology · doi:10.1053/jhep.2000.18291 · Cited by 236
The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases
Wang, X. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00105.x · Cited by 232
The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells
Sade, H., Krishna, S., & Sarin, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309924200 · Cited by 232
Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway
Perumal, E., Gunadharini, D. N., Kalimuthu, S., Banudevi, S., Arunkumar, R. S., Selvanesan, B. C., Sharmila, G., & Arunakaran, J. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.10.008 · Cited by 233
Glucose Uptake and Glycolysis Reduce Hypoxia-induced Apoptosis in Cultured Neonatal Rat Cardiac Myocytes
Malhotra, R., & Brosius, F. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12567 · Cited by 232
FADD Is Required for DR4- and DR5-mediated Apoptosis
Kuang, A. A., Diehl, G. E., Zhang, J., & Winoto, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000284200 · Cited by 231
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2–ASK1 signals
Wu, Y., Fan, Y., Xue, B., Luo, L., Shen, J., Zhang, S., Jiang, Y., & Yin, Z. (2006) · Oncogene · doi:10.1038/sj.onc.1209576 · Cited by 233
Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells
Dayem, A. A., Choi, H.-Y., Kim, J., & Cho, S. (2010) · Cancers · doi:10.3390/cancers2020859 · Cited by 232
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.
Hao, C., Bèguinot, F., Condorelli, G., Trencia, A., Meir, E. G. V., Yong, V. W., Parney, I. F., Roa, W., & Petruk, K. C. (2001) · PubMed · Cited by 230
Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics
Devarajan, P., Mishra, J., Supavekin, S., Patterson, L. T., & Steven Potter, S. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.09.012 · Cited by 229
Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways
Rieux‐Laucat, F., Deist, F. L., & Fischer, A. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401190 · Cited by 229
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
Ruder, B., Atreya, R., & Becker, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081887 · Cited by 228
Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways
Zhang, X. D., Gillespie, S., & Hersey, P. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.187.3.2 · Cited by 228
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
Kawane, K., Fukuyama, H., Yoshida, H., Nagase, H., Ohsawa, Y., Uchiyama, Y., Okada, K., Iida, T., & Nagata, S. (2003) · Nature Immunology · doi:10.1038/ni881 · Cited by 230
Reactive oxygen intermediates in TNF signaling
Garg, A. K., & Aggarwal, B. B. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00207-9 · Cited by 227
Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo
Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K. X., & Kitsis, R. N. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00777.2002 · Cited by 230
A Mechanism of Cell Survival
Wang, X., DeFrances, M. C., Dai, Y., Pediaditakis, P., Johnson, C., Bell, A., Michalopoulos, G. K., & Zarnegar, R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00439-2 · Cited by 225
Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells
Trivedi, R., & Mishra, D. P. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00069 · Cited by 229
Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway
Ovcharenko, D., Kelnar, K., Johnson, C. D., Leng, N., & Brown, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1484 · Cited by 225
TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer
Walczak, H. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01066.x · Cited by 233
A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis
Cavalcante, G. C., Schaan, A. P., Cabral, G. F., Santana-da-Silva, M. N., Pinto, P., Vidal, A. F., & Ribeiro‐dos‐Santos, Â. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174133 · Cited by 233
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
Yan, M., Marsters, S. A., Grewal, I. S., Wang, H., Ashkenazi, A., & Dixit, V. M. (2000) · Nature Immunology · doi:10.1038/76889 · Cited by 222
Self-citation
Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice
Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C., & Kitsis, R. N. (2003) · Circulation · doi:10.1161/01.cir.0000101920.72665.58 · Cited by 223
Herpes Simplex Virus Inhibits Apoptosis through the Action of Two Genes, Us5 and Us3
Jerome, K. R., Fox, R., Chen, Z., Sears, A. E., Lee, H.-Y., & Corey, L. (1999) · Journal of Virology · doi:10.1128/jvi.73.11.8950-8957.1999 · Cited by 222
Rho kinase in the regulation of cell death and survival
Shi, J., & Wei, L. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0009-7 · Cited by 254
Caspase activation cascades in apoptosis
Logue, S. E., & Martin, S. J. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360001 · Cited by 221
The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase
Lin, Y., Devin, A., Cook, A., Keane, M., Kelliher, M. A., Lipkowitz, S., & Liu, Z.-G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6638-6645.2000 · Cited by 221
Heat shock proteins – modulators of apoptosis in tumour cells
Creagh, E. M., Sheehan, D., & Cotter, T. G. (2000) · Leukemia · doi:10.1038/sj.leu.2401841 · Cited by 222
Drug Resistance in Melanoma: Mechanisms, Apoptosis, and New Potential Therapeutic Targets
Grossman, D., & Altieri, D. C. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1013123532723 · Cited by 220
Pathways to caspase activation
Wang, Z., Liu, Y., & Cui, Y. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.04.001 · Cited by 219
Role of apoptosis in atherosclerosis and its therapeutic implications
Stoneman, V. E. A., & Bennett, M. R. (2004) · Clinical Science · doi:10.1042/cs20040086 · Cited by 220
Differential expression and regulation of chemokines JE, KC, and IP-10 gene in primary cultured murine hepatocytes
Wang, H., Gao, X., Fukumoto, S., Tademoto, S., Sato, K., & Hirai, K. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199911)181:2 · Cited by 45
Biological activity studies on organotin(IV)+ complexes and parent compounds
Pellerito, C., Nagy, L., Pellerito, L., & Szorcsik, A. (2006) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2005.12.025 · Cited by 218
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells
Mao, X., Yu, C. R., Li, W. H., & Li, W. (2008) · Cell Research · doi:10.1038/cr.2008.86 · Cited by 218
Neuronal Apoptosis in Neurodegeneration
Okouchi, M., Ekshyyan, O. Y., Maracine, M., & Aw, T. Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1511 · Cited by 222
Current concepts in apoptosis: The physiological suicide program revisited
Chowdhury, I., Tharakan, B., & Bhat, G. K. (2006) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-006-0041-3 · Cited by 223
Early Mitochondrial Activation and Cytochrome c Up-regulation during Apoptosis
Chandra, D., Liu, J.-W., & Tang, D. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207622200 · Cited by 217
An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes
Hueber, A., Bernard, A., Hérincs, Z., Couzinet, A., & He, H. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf022 · Cited by 217
Histone deacetylase inhibitors and cell death
Zhang, J., & Zhong, Q. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1656-6 · Cited by 229
Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis
Gajate, C., del Canto-Jañez, E., Acuña, A. U., Amat‐Guerri, F., Geijo‐Barrientos, E., Santos-Beneit, A. M., Veldman, R. J., & Mollinedo, F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040213 · Cited by 223
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
Sodeman, T. C., Bronk, S. F., Roberts, P. J., Miyoshi, H., & Gores, G. J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g992 · Cited by 215
Caffeic Acid Phenethyl Ester Induces Apoptosis by Inhibition of NFκB and Activation of Fas in Human Breast Cancer MCF-7 Cells
Watabe, M., Hishikawa, K., Takayanagi, A., Shimizu, N., & Nakaki, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306040200 · Cited by 214
Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.
Mathiasen, I. S., Lademann, U. A., & Jäättelä, M. (1999) · PubMed · Cited by 214
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213
Death receptor signals to the mitochondria
Khosravi‐Far, R. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.11.1173 · Cited by 219
The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse
Canbay, A. E., Feldstein, A. E., Baskin-Bey, E. S., Bronk, S. F., & Gores, G. J. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060129 · Cited by 215
Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells
Luther, K. M., Haar, L., McGuinness, M., Wang, Y., Lynch, T. L., Phan, A., Song, Y., Shen, Z., Gardner, G., Kuffel, G. R., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.04.012 · Cited by 213
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells
Yang, W.-L. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1379 · Cited by 217
Molecular Recognition by a Binary Code
Fellouse, F. A., Li, B., Compaan, D. M., Peden, A. A., Hymowitz, S. G., & Sidhu, S. S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.03.041 · Cited by 216
Apoptosis by dietary factors: the suicide solution for delaying cancer growth
Khan, N., Afaq, F., & Mukhtar, H. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl243 · Cited by 212
The Domains of Apoptosis: A Genomics Perspective
Reed, J. C., Doctor, K. S., & Godzik, A. (2004) · Science s STKE · doi:10.1126/stke.2392004re9 · Cited by 213
Key Apoptotic Pathways for Heat-Induced Programmed Germ Cell Death in the Testis
Hikim, A. P. S., Lue, Y., Yamamoto, C. M., Vera, Y., Rodriguez, S., Yen, P. H., Soeng, K., Wang, C., & Swerdloff, R. S. (2003) · Endocrinology · doi:10.1210/en.2003-0175 · Cited by 215
Apoptosis induced by death receptors
Schneider, P., & Tschopp, J. (2000) · Pharmaceutica Acta Helvetiae · doi:10.1016/s0031-6865(99)00038-2 · Cited by 213
Death receptors and melanoma resistance to apoptosis
Ivanov, V. N., Bhoumik, A., & Ronai, Z. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206456 · Cited by 210
Mechanisms of retinal ganglion cell injury and defense in glaucoma
Qu, J., Wang, D., & Grosskreutz, C. L. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.04.002 · Cited by 209
MECHANISMS OF APOPTOSIS THROUGH STRUCTURAL BIOLOGY
Yan, N., & Shi, Y. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131040 · Cited by 212
Locoregional Apo2L/TRAIL Eradicates Intracranial Human Malignant Glioma Xenografts in Athymic Mice in the Absence of Neurotoxicity
Roth, W., Isenmann, S., Naumann, U., Kügler, S., Bähr, M., DICHGANS, J., Ashkenazi, A., & Weller, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1693 · Cited by 209
Self-citation
Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis
Harper, N. W., Hughes, M. A., MacFarlane, M., & Cohen, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303399200 · Cited by 209
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
Forcet, C., Ye, X., Granger, L., Corset, V., Shin, H., Bredesen, D. E., & Mehlen, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051378298 · Cited by 208
Platelets in tissue repair: control of apoptosis and interactions with regenerative cells
Gawaz, M., & Vogel, S. (2013) · Blood · doi:10.1182/blood-2013-05-468694 · Cited by 217
Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics
Chaudhry, G.-E.-S., Akim, A. M., Sung, Y. Y., & Muhammad, T. S. T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.842376 · Cited by 221
Apoptosis in rheumatoid arthritis
Baier, A., Meineckel, I., Gay, S., & Pap, T. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200305000-00015 · Cited by 208
Apoptosis in the anucleate platelet
Leytin, V. (2011) · Blood Reviews · doi:10.1016/j.blre.2011.10.002 · Cited by 207
Caspase Mechanisms
Salvesen, G. S., & Riedl, S. J. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-1-4020-6554-5_2 · Cited by 206
Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
Buendia, B., Santa-Maria, A., & Courvalin, J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.11.1743 · Cited by 206
Mechanisms mediating caspase activation in cell death
Kumar, S. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400600 · Cited by 206
Regulation of TNF‐α with a focus on rheumatoid arthritis
Moelants, E. A. V., Mortier, A., Damme, J. V., & Proost, P. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.15 · Cited by 207
Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol
Fulda, S., & Debatin, K. (2004) · Oncogene · doi:10.1038/sj.onc.1207630 · Cited by 205
Arsenic trioxide–induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL
Liu, Q., Hilsenbeck, S. G., & Gazitt, Y. (2003) · Blood · doi:10.1182/blood-2002-10-3231 · Cited by 205
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
Thomis, D. C., Marktel, S., Bonini, C., Traversari, C., Gilman, M. Z., Bordignon, C., & Clackson, T. (2001) · Blood · doi:10.1182/blood.v97.5.1249 · Cited by 204
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
Wang, H., Marsters, S. A., Baker, T., Chan, B., Lee, W. P., Fu, L. L., Tumas, D. B., Yan, M., Dixit, V. M., Ashkenazi, A., et al. (2001) · Nature Immunology · doi:10.1038/89782 · Cited by 204
Self-citation
Reactive oxygen species are downstream products of TRAF-mediated signal transduction
Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103074200 · Cited by 203
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells
Liu, J.-J. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.2087 · Cited by 203
Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways
Devarajan, P., Savoca, M., Castaneda, M. P., Park, M. S., Esteban-Cruciani, N., Kalinec, G. M., & Kalinec, F. (2002) · Hearing Research · doi:10.1016/s0378-5955(02)00634-2 · Cited by 202
The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): An up-to-date cell-specific review
Galani, V., Tatsaki, E., Bai, M. C., Kitsoulis, P., Lekka, M. E., Νάκος, Γ., & Kanavaros, P. (2010) · Pathology - Research and Practice · doi:10.1016/j.prp.2009.12.002 · Cited by 203

Authors: Ashkenazi, A., & Dixit, V. M.
Affiliations: Genentech (US)
ORCID: Ashkenazi, Avi
Dixit, Vishva M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1305-1308
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1305
OpenAlex: W2025128734
Cited by: 5,866
References: 91
Citations by year: 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
FWCI: 26.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
MeSH terms: Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Death Receptors: Signaling and Modulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks