Cited by 5,866Cell death mechanisms and regulationCancer-related Molecular PathwaysDeath, Funerary Practices, and Mourning

The DOI matches its Crossref record; 87 of the 91 references it cites were found in a registry or an index.

Death Receptors: Signaling and Modulation

Ashkenazi, Avi, Dixit, Vishva M.·1998·Science

DOI 10.1126/science.281.5381.1305

Open this paper in CoChat — free account

Abstract

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

Integrity signals

Registry

Crossref · 10.1126/science.281.5381.1305

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
Mechanisms and Genes of Cellular Suicide
Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,469
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Self-citation

Flagged first, then by citations

Show all 91 references

4 of the 91 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

Boise L. H., Thompson C. B., ibid. 274, 67 (1996);
Winoto A., ibid. 9, 365 (1997).
Nagata S., ibid. 88, 355 (1997).
Pan G., et al., ibid. 277, 815 (1997).
Rothe M., Pan M. G., Henzel W. J., Ayres T. M., Goeddel D. V., ibid. 83, 1243 (1995).
Kelliher M., et al., ibid. 8, 297 (1998).
Ahmad M., et al., Cancer Res. 57, 615 (1997).
M. J. Martinez-Lorenzo et al. Eur. J. Immunol. in press.
Jeramias I., Herr I., Boehler T., Debatin K. M., ibid. 28, 143 (1998).
Lacey D. L., et al., ibid. 93, 165 (1998).

Sorted by citations

Items 501–600 of 1,023

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma
Chen, Q., Gong, B., Mahmoud-Ahmed, A. S., Zhou, A., Hsi, E. D., Hussein, M. A., & Almasan, A. (2001) · Blood · doi:10.1182/blood.v98.7.2183 · Cited by 202
Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4
Chuntharapai, A., Dodge, K., Grimmer, K., Schroeder, K. A., Marsters, S. A., Koeppen, H., Ashkenazi, A., & Kim, K. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4891 · Cited by 203
Self-citation
Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain
Young, C., Klocke, B. J., Tenkova, T. I., Choi, J., Labruyere, J., Qin, Y.-Q., Holtzman, D. M., Roth, K. A., & Olney, J. W. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401277 · Cited by 201
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells
Mukherjee, B., Kessinger, C. W., Kobayashi, J., Chen, B. P. C., Chen, D. J., Chatterjee, A., & Burma, S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.01.011 · Cited by 207
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury
Pu, J., Yuan, A., Shan, P., Gao, E., Wang, X., Wang, Y., Lau, W. B., Koch, W. J., Ma, X., & He, B. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs011 · Cited by 200
Renal Inflammation and Fibrosis: A Double-edged Sword
Black, L. M., Lever, J. M., & Agarwal, A. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419852932 · Cited by 203
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis.
Roth, W., Isenmann, S., Nakamura, M., Platten, M., Wick, W., Kleihues, P., Bähr, M., Ohgaki, H., Ashkenazi, A., & Weller, M. (2001) · PubMed · Cited by 200
Self-citation
A Central Role for Death Receptor-Mediated Apoptosis in the Rejection of Tumors by NK Cells
Screpanti, V., Wallin, R. P. A., Ljunggren, H., & Grandien, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2068 · Cited by 200
Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis
Odabaei, G., Chatterjee, D., Jazirehi, A. R., Goodglick, L., Yeung, K. C., & Bonavida, B. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91005-6 · Cited by 200
The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression.
Li, F., & Altieri, D. C. (1999) · PubMed · Cited by 199
Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells
Claudio Napoli, A., Quehenberger, O., de Nigris, F., Abete, P., Glass, C. K., & Palinski, W. (2000) · The FASEB Journal · doi:10.1096/fj.99-0986com · Cited by 199
IL-21 Induces the Apoptosis of Resting and Activated Primary B Cells
Mehta, D. S., Wurster, A. L., Whitters, M. J., Young, D. A., Collins, M. A., & Grusby, M. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4111 · Cited by 198
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Kar, S., Beesley, J., Olama, A. A. A., Michailidou, K., Tyrer, J. P., Kote‐Jarai, Z., Lawrenson, K., Lindström, S., Ramus, S. J., Thompson, D. J., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1227 · Cited by 200
Apoptosis in rheumatoid arthritis
Tak, P. P., & Firestein, G. S. (1999) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8741-0_9 · Cited by 198
Ubiquitin-mediated Degradation of the Proapoptotic Active Form of Bid
Breitschopf, K., Zeiher, A. M., & Dimmeler, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001083200 · Cited by 198
Peripartum cardiomyopathy: A comprehensive review
Abboud, J., Murad, Y., Chen-Scarabelli, C. A., Saravolatz, L. I. I., & Scarabelli, T. M. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.08.005 · Cited by 196
Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials
Yu, L., Zhu, G., Zhang, Z., Yu, Y., Zeng, L., Xu, Z., Weng, J., Xia, J., Li, J., & Pathak, J. L. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01969-1 · Cited by 200
Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation
Haridas, V., Higuchi, M., Jayatilake, G. S., Bailey, D. J., Mujoo, K., Blake, M. E., Arntzen, C. J., & Gutterman, J. U. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101619098 · Cited by 202
Annexin V Staining Due to Loss of Membrane Asymmetry Can Be Reversible and Precede Commitment to Apoptotic Death
Hammill, A. M., Uhr, J. W., & Scheuermann, R. H. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4581 · Cited by 196
Targeted Induction of Apoptosis in Cancer Management: The Emerging Role of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor Activating Agents
Rowinsky, E. K. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.2889 · Cited by 196
Apoptosis-detecting radioligands: current state of the art and future perspectives
Lahorte, C., Vanderheyden, J., Steinmetz, N. D., de Wiele, C. V., Dierckx, R. A. J. O., & Slegers, G. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1555-4 · Cited by 195
The Role of Apoptosis in Normal and Abnormal Embryonic Development
Brill, A. G., Torchinsky, A. M., Carp, H., & Toder, V. (1999) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1020541019347 · Cited by 195
The kiss of death: promises and failures of death receptors and ligands in cancer therapy
Daniel, P., Wieder, T., Sturm, I., & Schulze‐Osthoff, K. (2001) · Leukemia · doi:10.1038/sj.leu.2402169 · Cited by 198
ARC Inhibits Cytochrome c Release From Mitochondria and Protects Against Hypoxia-Induced Apoptosis in Heart-Derived H9c2 Cells
Ekhterae, D., Lin, Z., Lundberg, M. S., Crow, M. T., Brosius, F. C., & Núñez, G. (1999) · Circulation Research · doi:10.1161/01.res.85.12.e70 · Cited by 195
Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells
Gimenez‐Bonafé, P., Tortosa, A., & Pérez‐Tomás, R. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909788166600 · Cited by 194
Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L–induced apoptosis of human acute leukemia cells
Wen, J., Nimmanapalli, R., Nguyen, D. N., Perkins, C. L., Worthington, E., & Bhalla, K. N. (2000) · Blood · doi:10.1182/blood.v96.12.3900 · Cited by 194
The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer
Kovbasnjuk, O. N., Mourtazina, R., Baibakov, B. A., Wang, T., Elowsky, C. G., Choti, M. A., Kane, A. V., & Donowitz, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506474102 · Cited by 194
Reovirus-Induced Apoptosis Is Mediated by TRAIL
Clarke, P., Meintzer, S. M., Gibson, S. B., Widmann, C., Garrington, T. P., Johnson, G. L., & Tyler, K. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8135-8139.2000 · Cited by 193
An auxiliary mode of apoptotic DNA fragmentation provided by phagocytesPreprint
McIlroy, D., Tanaka, M., Sakahira, H., Fukuyama, H., Suzuki, M., Yamamura, K., Ohsawa, Y., Uchiyama, Y., & Nagata, S. (2000) · Genes & Development · doi:10.1101/gad.14.5.549 · Cited by 194
Molecular determinants of retinal ganglion cell development, survival, and regeneration
Isenmann, S. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00027-2 · Cited by 192
The Regulation of Ovarian Granulosa Cell Death by Pro- and Anti-apoptotic Molecules
MATSUDA‐MINEHATA, F., Inoue, N., Goto, Y., & MANABE, N. (2006) · Journal of Reproduction and Development · doi:10.1262/jrd.18069 · Cited by 193
Programmed Cell Death, from a Cancer Perspective: An Overview
Mishra, A. P., Salehi, B., Sharifi‐Rad, M., Pezzani, R., Kobarfard, F., Sharifi‐Rad, J., & Nigam, M. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0329-9 · Cited by 200
Glutamine-dependent Antiapoptotic Interaction of Human Glutaminyl-tRNA Synthetase with Apoptosis Signal-regulating Kinase 1
孝彦, 八., 小三郎, 前., 輝明, 林., Park, H., Park, H.-S., Choi, E.-J., & Kim, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006189200 · Cited by 196
Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate
Domen, J., & Weissman, I. L. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01464-1 · Cited by 192
Deciphering the pathways of germ cell apoptosis in the testis
Hikim, A. P. S., Lue, Y., Diaz-Romero, M., Yen, P. H., Wang, C., & Swerdloff, R. S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00193-6 · Cited by 192
ACTIVATION OF MITOCHONDRIAL APOPTOTIC PATHWAYS IN HUMAN RENAL ALLOGRAFTS AFTER ISCHEMIA-REPERFUSION INJURY
Castaneda, M. P., Swiatecka‐Urban, A., Mitsnefes, M. M., Feuerstein, D., Kaskel, F. J., TELLIS, V. A., & Devarajan, P. (2003) · Transplantation · doi:10.1097/01.tp.0000069835.95442.9f · Cited by 192
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
MacFarlane, M., Harper, N. W., Snowden, R. T., Dyer, M. J. S., Barnett, G., Pringle, J. H., & Cohen, G. M. (2002) · Oncogene · doi:10.1038/sj.onc.1205853 · Cited by 192
Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis
You, B. R., Moon, H. J., Han, Y. H., & Park, W. H. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.02.034 · Cited by 197
A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies
Hotte, S. J., Hirte, H. W., Chen, E. X., Siu, L. L., Le, L., Corey, A. E., Iacobucci, A., MacLean, M., Lo, L., Fox, N. L., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1416 · Cited by 191
The Role of Nitric Oxide in Cancer: Master Regulator or NOt?
Khan, F. H., Dervan, E., Bhattacharyya, D. D., McAuliffe, J. D., Miranda, K. M., & Glynn, S. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249393 · Cited by 201
Coral Thermal Tolerance: Tuning Gene Expression to Resist Thermal Stress
Bellantuono, A. J., Granados‐Cifuentes, C., Miller, D. J., Hoegh‐Guldberg, O., & Rodríguez‐Lanetty, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050685 · Cited by 203
The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy.
de Almagro, M. C., & Vucic, D. (2012) · PubMed · Cited by 190
Melanoma Genetics and Therapeutic Approaches in the 21st Century: Moving from the Benchside to the Bedside
Hocker, T. L. H., Singh, M. K., & Tsao, H. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.226 · Cited by 196
Antioxidants, programmed cell death, and cancer
Lopaczynski, W., & Zeisel, S. H. (2001) · Nutrition Research · doi:10.1016/s0271-5317(00)00288-8 · Cited by 189
Cancer Metabolism and the Evasion of Apoptotic Cell Death
Sharma, A., Boise, L., & Shanmugam, M. (2019) · Cancers · doi:10.3390/cancers11081144 · Cited by 202
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
Gurney, A. L., Marsters, S. A., Huang, A. J. Y., Pitti, R. M., Mark, M. R., Baldwin, D. T., Gray, A. M., Dowd, P., Brush, J., Heldens, S., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80093-1 · Cited by 189
Self-citation
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
Nakano, H., Komazawa‐Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9803 · Cited by 189
Death receptors as targets in cancer
Micheau, O., Shirley, S., & Dufour, F. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12238 · Cited by 189
The Structure of FADD and Its Mode of Interaction with Procaspase-8
Carrington, P. E., Sandu, C., Wei, Y., Hill, J. M., Morisawa, G., Huang, T., Gavathiotis, E., Wei, Y., & Werner, M. H. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.018 · Cited by 188
Necroptosis, tumor necrosis and tumorigenesis
Liu, Z.-G., & Jiao, D. (2020) · Cell Stress · doi:10.15698/cst2020.01.208 · Cited by 194
A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction
Park, Y. C., Ye, H., Hsia, C. Y., Segal, D., Rich, R. L., Liou, H.-C., Myszka, D. G., & Wu, H. (2000) · Cell · doi:10.1016/s0092-8674(00)80889-2 · Cited by 188
Death receptors: Targets for cancer therapy
Mahmood, Z., & Shukla, Y. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.12.011 · Cited by 187
Death Receptors in Liver Biology and Pathobiology
Faubion, W. A., & Gores, G. J. (1999) · Hepatology · doi:10.1002/hep.510290101 · Cited by 191
Death receptor-mediated apoptosis and the liver
Yoon, J., & Gores, G. J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00209-x · Cited by 193
Viruses and apoptosis
Thomson, B. J. (2001) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2001.iep195.x · Cited by 190
Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
Srinivas, P., Gopinath, G., Banerji, A., Dinakar, A., & Gopala, S. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.20031 · Cited by 186
Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells
Chang, X., Yang, B. F., Asadi, N., Bèguinot, F., & Hao, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202946200 · Cited by 186
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
Zhang, H., Xu, Q., Krajewski, S., Krajewska, M., Xie, Z., Fuess, S., Kitada, S., Pawłowski, K., Godzik, A., & Reed, J. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2597 · Cited by 186
Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic
Wold, W. S. M., Doronin, K., Tóth, K., Kuppuswamy, M. N., Lichtenstein, D. L., & Tollefson, A. E. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80064-8 · Cited by 186
Pathophysiological Mechanisms in Osteoarthritis Lead to Novel Therapeutic Strategies
Malemud, C. J., Islam, N., & Haqqi, T. M. (2003) · Cells Tissues Organs · doi:10.1159/000070573 · Cited by 185
Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors
Ray, S. K., Hogan, E. L., & Banik, N. L. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00152-8 · Cited by 185
Inhibition of endothelial cell survival and angiogenesis by protein kinase A
Kim, S., Bakre, M. M., Yin, H. X., & Varner, J. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14268 · Cited by 185
p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site
Liu, X., Yue, P., Khuri, F. R., & Sun, S.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1195 · Cited by 184
Translocation of Bim to the Endoplasmic Reticulum (ER) Mediates ER Stress Signaling for Activation of Caspase-12 during ER Stress-induced Apoptosis
Morishima, N., Nakanishi, K., Tsuchiya, K., Shibata, T., & Seiwa, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408493200 · Cited by 184
Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart
Bae, S., Xiao, Y., Guo-hu, L., Casiano, C. A., & Zhang, L. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00005.2003 · Cited by 184
The cell biology of aging
DiLoreto, R., & Murphy, C. T. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1084 · Cited by 192
Targeting death-inducing receptors in cancer therapy
Takeda, K., Stagg, J., Yagita∥, H., Okumura, K., & Smyth, M. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210374 · Cited by 187
Apoptotic signaling cascades
Ashe, P. C., & Berry, M. D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00016-2 · Cited by 186
Multiple myeloma
Sirohi, B., & Powles, R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15736-x · Cited by 190
Tumor Necrosis Factor α Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of Cytochrome c Oxidase
Samavati, L., Lee, I., Mathes, I., Lottspeich, F., & Hüttemann, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801954200 · Cited by 186
A Decision Between Life and Death During TNF-α-Induced Signaling
Gupta, S. (2002) · Journal of Clinical Immunology · doi:10.1023/a:1016089607548 · Cited by 186
Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10
Somayajulu, M., McCarthy, S., Hung, M.-Y., Sikorska, M., Borowy‐Borowski, H., & Pandey, S. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.021 · Cited by 189
A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation
Henis‐Korenblit, S., Levy-Strumpf, N., Goldstaub, D., & Kimchi, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.496-506.2000 · Cited by 183
An oncological view on the blood–testis barrier
Bart, J., Groen, H. J. M., van der Graaf, W. T. A., Hollema, H., Hendrikse, N. H., Vaalburg, W., Sleijfer, D. T., & de Vries, E. G. E. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00776-3 · Cited by 183
Fas–Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis
Volpe, E., Sambucci, M., Battistini, L., & Borsellino, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00382 · Cited by 197
The atomic-resolution structure of human caspase-8, a key activator of apoptosis
Watt, W., Koeplinger, K. A., Mildner, A. M., Heinrikson, R. L., Tomasselli, A. G., & Watenpaugh, K. D. (1999) · Structure · doi:10.1016/s0969-2126(99)80180-4 · Cited by 182
Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling
Wajant, H., & Scheurich, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00064-9 · Cited by 182
Mechanisms of fenretinide-induced apoptosis
Hail, N., Kim, H. J., & Lotan, R. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9289-3 · Cited by 182
APRIL-Deficient Mice Have Normal Immune System Development
Varfolomeev, E. E., Kischkel, F. C., Martin, F., Seshasayee, D., Wang, H., Lawrence, D. A., Olsson, C., Tom, L., Erickson, S. L., French, D. M., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.997-1006.2004 · Cited by 182
Self-citation
Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis.
Tucker, A. S., Headon, D. J., Schneider, P., Ferguson, B. M., Overbeek, P., Tschopp, J., & Sharpe, P. T. (2000) · Development · doi:10.1242/dev.127.21.4691 · Cited by 211
Caspase-2 Can Trigger Cytochrome c Release and Apoptosis from the Nucleus
Paroni, G., Henderson, C. J., Schneider, C., & Brancolini, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112338200 · Cited by 181
Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure
Razavi, H. M., HAMILTON, J., & Feng, Q. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.11.006 · Cited by 182
Apoptotic death sensor: an organelle's alter ego?
Bratton, S. B., & Cohen, G. M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01718-1 · Cited by 181
Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor
Papoff, G., Häusler, P., Eramo, A., Pagano, M. G., Leve, G. D., Signore, A., & Ruberti, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.38241 · Cited by 181
Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis
Elliott, J. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00242-x · Cited by 181
Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury.
Chong, Z. Z., Li, F., & Maiese, K. (2005) · PubMed · doi:10.14670/hh-20.299 · Cited by 181
Induction of Apoptosis and Antiproliferative Activity of Naringenin in Human Epidermoid Carcinoma Cell through ROS Generation and Cell Cycle Arrest
Ahmad, M. S., Siddiqui, S., Jafri, A., Ahmad, S., Afzal, M., & Arshad, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110003 · Cited by 181
Bid-induced Cytochrome c Release Is Mediated by a Pathway Independent of Mitochondrial Permeability Transition Pore and Bax
Kim, T., Zhao, Y., Barber, M. J., Kuharsky, D. K., & Yin, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003370200 · Cited by 181
Morte Celular por Apoptose
Grivicich, I., Regner, A., & da Rocha, A. B. (2007) · Revista Brasileira de Cancerologia · doi:10.32635/2176-9745.rbc.2007v53n3.1801 · Cited by 180
Cell death regulation: A new way for natural products to treat osteoporosis
Li, Z., Li, D., Chen, R., Gao, S., Xu, Z., & Li, N. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106635 · Cited by 183
A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis
Seol, D., & Billiar, T. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2072 · Cited by 178
The Ectodermal Dysplasia Receptor Activates the Nuclear Factor-κB, JNK, and Cell Death Pathways and Binds to Ectodysplasin A
Kumar, A., Eby, M. T., Sinha, S. K., Jasmin, A., & Chaudhary, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008356200 · Cited by 178
The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
Roshan, M. H. K., Tambo, A., & Pace, N. P. (2016) · International Journal of Inflammation · doi:10.1155/2016/1532832 · Cited by 181
The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.
Perkins, C. L., Fang, G., Kim, C. N., & Bhalla, K. N. (2000) · PubMed · Cited by 177
Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells
Liu, T., Brouha, B., & Grossman, D. (2004) · Oncogene · doi:10.1038/sj.onc.1206978 · Cited by 176
Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis
Obeng, E. A., & Boise, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502685200 · Cited by 175
The role of ARK in stress-induced apoptosis in Drosophila cells
Zimmermann, K. C., Ricci, J., Droin, N. M., & Green, D. R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.20112068 · Cited by 175
The Caspase Pathway in Noise-Induced Apoptosis of the Chinchilla Cochlea
Nicotera, T. M., Hu, B. H., & Henderson, D. (2003) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-002-3038-2 · Cited by 175
Reovirus-Induced Apoptosis Requires Activation of Transcription Factor NF-κB
Connolly, J. L., Rodgers, S. E., Clarke, P., Ballard, D. W., Kerr, L. D., Tyler, K. L., & Dermody, T. S. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.2981-2989.2000 · Cited by 174
ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
Baik, J. Y., Liu, Z., Jiao, D., Kwon, H., Yan, J., Kadigamuwa, C., Choe, M., Lake, R. G., Kruhlak, M. J., Tandon, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23004-3 · Cited by 177

Authors: Ashkenazi, A., & Dixit, V. M.
Affiliations: Genentech (US)
ORCID: Ashkenazi, Avi
Dixit, Vishva M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1305-1308
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1305
OpenAlex: W2025128734
Cited by: 5,866
References: 91
Citations by year: 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
FWCI: 26.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
MeSH terms: Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Death Receptors: Signaling and Modulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks