Cited by 5,866Cell death mechanisms and regulationCancer-related Molecular PathwaysDeath, Funerary Practices, and Mourning

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Death Receptors: Signaling and Modulation

Ashkenazi, Avi, Dixit, Vishva M.·1998·Science

DOI 10.1126/science.281.5381.1305

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Abstract

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

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Crossref · 10.1126/science.281.5381.1305

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Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
Mechanisms and Genes of Cellular Suicide
Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,469
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Self-citation

Show all 91 references

Research works printed but not linked: 10

Boise L. H., Thompson C. B., ibid. 274, 67 (1996);
Winoto A., ibid. 9, 365 (1997).
Nagata S., ibid. 88, 355 (1997).
Pan G., et al., ibid. 277, 815 (1997).
Rothe M., Pan M. G., Henzel W. J., Ayres T. M., Goeddel D. V., ibid. 83, 1243 (1995).
Kelliher M., et al., ibid. 8, 297 (1998).
Ahmad M., et al., Cancer Res. 57, 615 (1997).
M. J. Martinez-Lorenzo et al. Eur. J. Immunol. in press.
Jeramias I., Herr I., Boehler T., Debatin K. M., ibid. 28, 143 (1998).
Lacey D. L., et al., ibid. 93, 165 (1998).

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Cho, S., Lee, Y. H., Park, H.-S., Ryoo, K., Kang, K. W., Park, J., Eom, S. J., Kim, M., Chang, T.-S., Choi, S.-Y., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005561200 · Cited by 400
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Liu, B., Fan, Z., Edgerton, S. M., Deng, X.-S., Alimova, I. N., Lind, S. E., & Thor, A. D. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8814 · Cited by 392
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Maria, R. D., Zeuner, A., Eramo, A., Domenichelli, C., Bonci, D., Grignani, F., Srinivasula, S. M., Alnemri, E. S., Testa, U., & Peschle, C. (1999) · Nature · doi:10.1038/46809 · Cited by 390
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Nagane, M., Pan, G., Weddle, J. J., Dixit, V. M., Cavenee, W. K., & Huang, H. (2000) · PubMed · Cited by 387
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Cisplatin nephrotoxicity: molecular mechanisms.
Hanigan, M. H., & Devarajan, P. (2003) · PubMed · Cited by 384
Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
Mantovani, A., Locati, M., Vecchi, A., Sozzani, S., & Allavena, P. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01941-x · Cited by 383
The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
Jobin, C., & Sartor, R. B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c451 · Cited by 382
Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat
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Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis
Mancini, M., Machamer, C. E., Roy, S., Nicholson, D. W., Thornberry, N. A., Casciola-Rosen, L. A., & Rosen, A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.603 · Cited by 379
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Gene defect in ectodermal dysplasia implicates a death domain adapter in development
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Caspase 8 small interfering RNA prevents acute liver failure in mice
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The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis.
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Caspases — An update
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Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
Cuello, M. A., Ettenberg, S. A., Clark, A. S., Keane, M., Posner, R. H., Nau, M. M., Dennis, P. A., & Lipkowitz, S. (2001) · PubMed · Cited by 370
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Self-citation
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Cell death induced by the Fas/Fas ligand pathway and its role in pathology
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Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways
Yin, X. (2000) · Cell Research · doi:10.1038/sj.cr.7290045 · Cited by 315
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Chou, C.-C., Yang, J., Lu, H.-F., Ip, S., Lo, C., Wu, C., Lin, J.-P., Tang, N.-Y., Chung, J., Chou, M.-J., et al. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0808-y · Cited by 312
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Schmidt‐Ullrich, R., Dent, P., Grant, S., Mikkelsen, R. B., & Valerie, K. C. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)153[0245:stacrr]2.0.co;2 · Cited by 311
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Miyoshi, H., Rust, C., Roberts, P. J., Burgart, L. J., & Gores, G. J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70461-0 · Cited by 317
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Bálint, É., & Vousden, K. H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2128 · Cited by 315
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Mollinedo, F., & Gajate, C. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.10.003 · Cited by 326
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Kaplowitz, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80414-6 · Cited by 309
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Burnett, S. H., Kershen, E. J., Zhang, J., Zeng, L., Straley, S. C., Kaplan, A. M., & Cohen, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903442 · Cited by 307
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Lankat–Buttgereit, B., & Göke, R. (2009) · Biology of the Cell · doi:10.1042/bc20080191 · Cited by 315
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Foo, R., Mani, K. M., & Kitsis, R. N. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24569 · Cited by 312
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Brouard, S., Berberat, P. O., Tobiasch, E., Seldon, M. P., Bach, F. H., & Soares, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108317200 · Cited by 306
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Martínez‐Lorenzo, M. J., Anel, A., Gamen, S., Monleón, I., Lasierra, P., Larrad, L., Piñeiro, A., Álava, M. A., & Naval, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1274 · Cited by 306
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Authors: Ashkenazi, A., & Dixit, V. M.
Affiliations: Genentech (US)
ORCID: Ashkenazi, Avi
Dixit, Vishva M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1305-1308
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1305
OpenAlex: W2025128734
Cited by: 5,866
References: 91
Citations by year: 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
FWCI: 26.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
MeSH terms: Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand

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