Cited by 5,866Cell death mechanisms and regulationCancer-related Molecular PathwaysDeath, Funerary Practices, and Mourning

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Death Receptors: Signaling and Modulation

Ashkenazi, Avi, Dixit, Vishva M.·1998·Science

DOI 10.1126/science.281.5381.1305

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Abstract

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

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Authors: Ashkenazi, A., & Dixit, V. M.
Affiliations: Genentech (US)
ORCID: Ashkenazi, Avi
Dixit, Vishva M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-08-28
Volume: 281
Issue: 5381
Pages: 1305-1308
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5381.1305
OpenAlex: W2025128734
Cited by: 5,866
References: 91
Citations by year: 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
FWCI: 26.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
MeSH terms: Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand

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