The DOI matches its Crossref record; 87 of the 91 references it cites were found in a registry or an index.
Death Receptors: Signaling and Modulation
Abstract
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.
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“Extrinsic apoptosis is an RCD modality initiated by perturbations of the extracellular microenvironment [265–268].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [265]
Citations
Cites
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Self-citation
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Metadata
- Authors
- Ashkenazi, A., & Dixit, V. M.
- Affiliations
- Genentech (US)
- Venue
- Science
- Published
- 1998-08-28
- Volume
- 281
- Issue
- 5381
- Pages
- 1305-1308
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025128734
- Cited by
- 5,866
- References
- 91
- Citations by year
- 2026: 42 · 2025: 63 · 2024: 61 · 2023: 87 · 2022: 84 · 2021: 96 · 2020: 116 · 2019: 116 · 2018: 142 · 2017: 126 · 2016: 158 · 2015: 177 · 2014: 171 · 2013: 196 · 2012: 191
- FWCI
- 26.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
- Keywords
- death receptors, apoptosis, signal transduction, cell number regulation, programmed cell death
- MeSH terms
- Animals, Humans, Neoplasms, Receptors, Cell Surface, Signal Transduction, Antigens, CD, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Member 25, Receptors, TNF-Related Apoptosis-Inducing Ligand
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