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Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC
Abstract
The protein encoded by the c- MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein–2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.
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Metadata
- Authors
- Wu, K.-J., Polack, A., & Dalla-Favera, R.
- Venue
- Science
- Published
- 1999-01-29
- Volume
- 283
- Issue
- 5402
- Pages
- 676-679
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050563044
- Cited by
- 326
- References
- 3
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- closed
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