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From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice
Abstract
After intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III β-tubulin) and were able to activate the transcription factor cAMP response element–binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications.
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Metadata
- Authors
- Brazelton, T. R., Rossi, F. M. V., Keshet, G. I., & Blau, H. M.
- Venue
- Science
- Published
- 2000-12
- Volume
- 290
- Issue
- 5497
- Pages
- 1775-1779
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970895440
- Cited by
- 1,676
- References
- 2
- FWCI
- 30.58
- Type
- journal article
- Language
- en
- Open access
- closed
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