Neuropeptide Y Distribution in the Rat Brain

Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., Polak, J. M.·1983·Science

Open this paper in CoChat — free account

Abstract

A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.6136091

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605
Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia
Crofford, L. J., Pillemer, S. R., Kalogeras, K. T., Cash, J. M., Michelson, D., Kling, M. A., Sternberg, E. M., Gold, P. W., Chrousos, G. P., & Wilder, R. L. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371105 · Cited by 508
Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis
Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501
Neuropeptide Y: a stressful review
Reichmann, F., & Holzer, P. (2016) · Neuropeptides · doi:10.1016/j.npep.2015.09.008 · Cited by 490
Genetic variation in human NPY expression affects stress response and emotion
Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., et al. (2008) · Nature · doi:10.1038/nature06858 · Cited by 455
Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo
Klausberger, T., Márton, L. F., Baude, A., Roberts, J. D. B., Magill, P. J., & Somogyi, P. (2004) · Nature Neuroscience · doi:10.1038/nn1159 · Cited by 393
Hormonal regulation of food intake
Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372
Self-citation
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358
How Palatable Food Disrupts Appetite Regulation
Erlanson‐Albertsson, C. (2005) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2005.pto_179.x · Cited by 330
Ivy Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity
Fuentealba, P., Begum, R., Capogna, M., Jinno, S., Márton, L. F., Csicsvari, J., Thomson, A., Somogyi, P., & Klausberger, T. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.034 · Cited by 255
Classification of NPY-Expressing Neocortical Interneurons
Karagiannis, A., Gallopin, T., Dávid, C., Battaglia, D., Geoffroy, H., Rossier, J., Hillman, E. M. C., Staiger, J. F., & Cauli, B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0058-09.2009 · Cited by 256
Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: Coexistence with neuropeptide Y neurons, and effects alzheimer‐type dementia
Chan‐Palay, V. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902600205 · Cited by 254
Studies of the Secretion of Corticotropin-Releasing Factor and Arginine Vasopressin into the Hypophysial-Portal Circulation of the Conscious Sheep
Engler, D., Pham, T., Fullerton, M. J., Ooi, G., Funder, J. W., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000125141 · Cited by 235
Neuropeptide Y: Direct and indirect action on insulin secretion in the rat
Moltz, J. H., & McDonald, J. K. (1985) · Peptides · doi:10.1016/0196-9781(85)90443-7 · Cited by 213
Sleep and Movement Differentiates Actions of Two Types of Somatostatin-Expressing GABAergic Interneuron in Rat Hippocampus
Katona, L., Lapray, D., Viney, T. J., Oulhaj, A., Borhegyi, Z., Micklem, B. R., Klausberger, T., & Somogyi, P. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.007 · Cited by 169
Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility
Manfredi-Lozano, M., Roa, J., & Tena-Sempere, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.008 · Cited by 162
Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y
Bowers, M. E., Choi, D. C., & Ressler, K. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.004 · Cited by 155
The homeostatic role of neuropeptide Yin immune function and its impact on mood and behaviour
Farzi, A., Reichmann, F., & Holzer, P. (2015) · Acta Physiologica · doi:10.1111/apha.12445 · Cited by 145
Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus
Ferraguti, F., Klausberger, T., Cobden, P., Baude, A., Roberts, J. D. B., Szucs, P., Kinoshita, A., Shigemoto, R., Somogyi, P., & Dalezios, Y. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2547-05.2005 · Cited by 137
Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
Kishi, T., Aschkenasi, C. J., Choi, B. J., Lopez, M. E., Lee, C. E., Liu, H., Hollenberg, A. N., Friedman, J. M., & Elmquist, J. K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20432 · Cited by 119
Emotion Processing, Major Depression, and Functional Genetic Variation of Neuropeptide Y
Mickey, B. J., Zhou, Z., Heitzeg, M. M., Heinz, E., Hodgkinson, C. A., Hsu, D. T., Langenecker, S. A., Love, T. M., Peciña, M., Shafir, T., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.197 · Cited by 115
Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep: II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing’s syndrome of endogenous depression and anorexia nervosa
Liu, J. P., Clarke, I. J., Funder, J. W., & Engler, D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117121 · Cited by 81
The corticotropin–release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis
Engler, D., Redei, E., & Kola, I. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0376 · Cited by 79
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Central administration of neuropeptide Y reduces α-melanocyte-stimulating hormone-induced cyclic adenosine 5′-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
Sarkar, S., & Lechan, R. M. (2003) · Endocrinology · doi:10.1210/en.2002-220675 · Cited by 63
Neuropeptide Y: History and Overview
Tatemoto, K. (2004) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-18764-3_1 · Cited by 52
Self-citation
Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex
Vollmer, L. L., Schmeltzer, S., Schurdak, J., Ahlbrand, R., Rush, J., Dolgas, C. M., Baccei, M. L., & Sah, R. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4955-13.2016 · Cited by 45
“Neuropeptide Y (NPY), a 36 aa peptide, is widely expressed in the CNS (Adrian et al., 1983; Allen et al., 1983) and regulates physiological and behavioral responses such as stress and anxiety, fear, learning and memory, control of blood pressure, and sympathetic activity (Heilig and Widerlöv, 1995; Eaton et al., 2007…”
Background
Calcitonin gene‐related peptide in the amygdaloid complex of the rat: Immunohistochemical and quantitative distribution, and drug effects on calcium dependent, potassium‐evoked in vitro release
Haring, C., Humpel, C., Skofitsch, G., Krobath, J., Javorsky, F., & Saria, A. (1991) · Synapse · doi:10.1002/syn.890080404 · Cited by 20

Authors: Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1983-08-26
Volume: 221
Issue: 4613
Pages: 877-879
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6136091
OpenAlex: W2064110992
Cited by: 1,096
References: 0
FWCI: 19.39
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Neuropeptide Y Distribution in the Rat Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cited by

Metadata

Record

About these checks

Data sources