Cited by 330Regulation of Appetite and ObesityEating Disorders and BehaviorsAdipokines, Inflammation, and Metabolic Diseases

How Palatable Food Disrupts Appetite Regulation

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Erlanson‐Albertsson, Charlotte·2005·Basic & Clinical Pharmacology & Toxicology

Abstract

Abstract: Appetite regulation is part of a feedback system that controls the energy balance, involving a complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in peripheral organs. Hunger signals may be generated in peripheral organs (e.g. ghrelin) but most of them are expressed in the hypothalamus (neuropeptide Y, orexins, agouti‐related peptide, melanin concentrating hormone, endogenous opiates and dopamine) and are expressed during situations of energy deficiency. Some satiety signals, such as cholecystokinin, glucagon‐like peptide 1, peptide YY and enterostatin are released from the digestive tract in response to food intake. Others, such as leptin and insulin, are mobilized in response to perturbations in the nutritional state. Still others are generated in neurones of the hypothalamus (α‐melanocyte‐stimulating hormone and serotonin). Satiety signals act by inhibiting the expression of hunger signals and/or by blunting their effect. Palatable food, i.e. food rich in fat and sugar, up‐regulates the expression of hunger signals and satiety signals, at the same time blunting the response to satiety signals and activating the reward system. Hence, palatable food offsets normal appetite regulation, which may explain the increasing problem of obesity worldwide.

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Crossref · 10.1111/j.1742-7843.2005.pto_179.x

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  • The hedonic system is implicated in overeating, particularly in the current environment of unlimited access to a high variety of highly palatable and energy dense foods.

    “It is largely recognized that the hedonic system is implicated in overeating, particularly in the current environment of unlimited access to a high variety of highly palatable and energy dense foods [114].”

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Research works printed but not linked: 3

  1. Batterham, R. L., M. A. Cohen, S. M. Ellis, C. W. Le Roux, D. J. Withers, G. S. Frost, M. A. Ghatei & S. R. Bloom: Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 2003, 349, 941-948.
  2. Farooqi, I. S. & S. O'Rahilly: Monogenic human obesity syn- dromes. Recent Prog. Horm. Res. 2004, 59, 409-424.
  3. Tritos, N. A. & E. Maratos-Flier: Two important systems Clark, J. Deeds, et al.: Identification and expression cloning trating hor- mone. Neuropeptides 1999, 33, 339-349.

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Authors
Erlanson‐Albertsson, C.
Affiliations
Lund University (SE)
Corresponding author
Erlanson‐Albertsson, Charlotte
Venue
Basic & Clinical Pharmacology & Toxicology
Publisher
Wiley
Published
2005-07
Volume
97
Issue
2
Pages
61-73
ISSN
  • 1742-7835 (ISSN-L)
  • 1742-7843
OpenAlex
W2161715455
Cited by
330
References
158
Citations by year
2026: 6 · 2025: 11 · 2024: 18 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 23 · 2014: 25 · 2013: 18 · 2012: 20
FWCI
1.47
Type
journal article
Language
en
Open access
Locations
  • Basic & Clinical Pharmacology & Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
appetite regulation, palatable food, energy balance, hunger signals, satiety signals, hypothalamus, ghrelin, leptin, insulin, neuropeptide Y, orexin, cholecystokinin, glucagon-like peptide-1, peptide YY, enterostatin, melanin-concentrating hormone, serotonin, reward systems, obesity
MeSH terms
Animals, Appetite Regulation, Food Preferences, Humans, Hunger, Reward, Satiety Response, Behavior, Addictive

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