Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis
Abstract
Specialization in brain neurogenic niche The adult mammalian brain generates neurons from the subventricular zone (SVZ). In mice, Paul et al. were able to link environmental signals with the type of neurons that are generated and showed that anatomical subspecialization occurrs in the SVZ. Neural circuits that respond to hunger or satiety enervate a subregion of the SVZ and retune the production of new olfactory neurons just from that portion of the subventricular niche. Science , this issue p. 1383
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Spatially distinct pools of adult V-SVZ NSCs can be regulated by physiological states and distant neural circuits.
“Moreover, spatially distinct pools of adult V-SVZ NSCs can be regulated by physiological states and distant neural circuits (Paul et al., 2017), highlighting the importance of regional differences between the lateral and septal walls regarding intrinsic NSC identity, as well as for niche signals in regulating stem cell behavior.”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Paul et al., 2017
Spatially distinct pools of NSCs can sense and respond to different local and long-range physiological signals to generate different types of OB interneurons.
“Indeed, spatially distinct pools of NSCs can sense and respond to different local and long-range physiological signals to generate different types of OB interneurons (Paul et al., 2017), and V-SVZ NSCs are promptly recruited upon injury or under pathological conditions (Chaker et al., 2016).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Paul et al., 2017
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“Examples include the increased generation of granule cells in the DG after physical activity or the modulation of adult SVZ neurogenesis by hormonal changes or in response to hypothalamic innervation (Kempermann et al., 1997; Paul et al., 2017; Shingo et al., 2003).”
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“In vivo, ICI 204448 increases cell proliferation in the SVZ without modifying the expression of neuroblasts [74].”
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“NSCs reside mainly in a dormant, quiescent state, and the quiescent NSCs proliferate as an adaption to environmental cues such as feeding and exercise [52–54].”
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Versatile strategies for adult neurogenesis: avenues to repair the injured brain
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“Adult neurogenesis in rodents may not be restricted to the SVZ and SGZ, as it was also reported in other brain regions such as the hypothalamus, substantia nigra, and amygdala (Lie et al., 2002; Zhao et al., 2003; Paul et al., 2017; Jurkowski et al., 2020).”
BackgroundExploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments
Sánchez-Gomar, I., Geribaldi‐Doldán, N., Santos-Rosendo, C., Sanguino-Caneva, C., Carrillo-Chapman, C., Moreno, O. F., Camacho, J. L. V., Quiroz, E. N., & Verástegui, C. (2024) · Biomolecules · doi:10.3390/biom14030335 · Cited by 15 · see citing works
“Thus, hunger and satiety processing may regulate adult neurogenesis by modulating activity through a connection between the hypothalamus and SVZ that enables on-demand neurogenesis in response to physiology and environmental cues [113].”
Backgrounddel Águila, Á., Adam, M., Ullom, K., Shaw, N., Qin, S., Ehrman, J. M., Nardini, D., Salomone, J. R., Gebelein, B. A., Lü, Q., et al. (2022) · Development · doi:10.1242/dev.200028 · Cited by 15 · see citing works
Could a Different View of Quiescence Help Us Understand How Neurogenesis Is Regulated?
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Homemade: building the structure of the neurogenic niche
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“Many studies have reported on the characteristics, origin, and differentiation potential of NSCs [27–30].”
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Amodeo, V., Davies, T. J., Martínez-Segura, A., Clements, M., Ragdale, H. S., Bailey, A., dos Santos, M. S., MacRae, J. I., Mokochinski, J. B., Kramer, H., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.03.021 · Cited by 10 · see citing works
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“…NPC fates are in large part regulated by the surrounding environment and neighbouring cells, such as the choroid plexus and cerebral spinal fluid (Silva-Vargas et al., 2016), endothelial cells (Paredes et al., 2021), microglia (Matarredona et al., 2018) and axonal innervation (Paul et al., 2017).”
BackgroundmiR-17∼92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages
Favaloro, F., DeLeo, A. M., Delgado, A. C., & Doetsch, F. K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111773 · Cited by 7 · see citing works
Integrative single-cell transcriptomics clarifies adult neurogenesis and macroglia evolutionPreprint
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“NSCs are a heterogeneous population of progenitors committed to generate specific neuron types and, at least in adults, are regulated by distinct conditions and neuronal circuits 80–85 .”
BackgroundThe Critical Balance Between Quiescence and Reactivation of Neural Stem Cells
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“…cues include the presence of nutrients and feeding behaviour triggering hypothalamic-derived signals that control activation of a V-SVZ NSC subsets [50], and physical exercise such as running, which activates quiescent SGZ radial NSCs and has since long known to increase numbers of neurons in the…”
In vivo live imaging of postnatal neural stem cells
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Neural Stem Cells, Differentiation, and Migration
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Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
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“Pools of adult V-SVZ in spatially different regions can be regulated by different stimuli and distant neural circuits (381).”
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“Paul et al. (2017) discovered that the Nkx2.”
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Food odour recognition adjusts systemic metabolism to nutrient availability
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Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCs
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“It is known that hypothalamic, dopaminergic and serotonergic axons as well as striatal neurons innervate the SVZ niche [93, 94, 95, 96].”
BackgroundRegulation of neural stem cells by innervating neurons
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“Given the existing body of work connecting POMC + neurons with feeding behavior (Aponte et al., 2011 ; Zeltser et al., 2012 ), Paul and colleagues assessed how changes in feeding behav - ior affect SVZ NPCs fates via the POMC neuron activity (Paul et al., 2017 ).”
InfluentialHeterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone
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“This diversity can be regulated by internal states such as food intake or pregnancy (Paul et al. 2017; Chaker et al. 2023), such that the sub-type composition of adult-generated neurons is continually fine-tuned in response to ongoing organismal changes.”
Neural circuits of the mammalian main olfactory bulb
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Giving birth gives birth to neurons
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Quiescent neural stem cells transiently become ‘neurons’ to coordinate reactivationPreprint
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Yetişkin Memeli Beyninde Nörogenez ve Koku Duyusu ile İlişkisi
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“42,43 Such an effect may also occur during lactation and would require much more intensive sampling to detect and characterize.”
Synaptogenesis in the adult CNS—olfactory system
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Food consumption increases cell proliferation in the python brain
Habroun, S. S., Schaffner, A. A., Taylor, E. N., & Strand, C. R. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.173377 · Cited by 2 · see citing works
“Differential regulation of neural cell proliferation can occur in mice, where fasting decreased proliferation of distinct pools of neural stem cells in the sub-ventricular zone (Paul et al., 2017).”
BackgroundInfluential
- Authors
- Paul, A., Chaker, Z., & Doetsch, F.
- Affiliations
- Columbia University (US)
- University of Basel (CH)
- Corresponding author
- Doetsch, Fiona
- Venue
- Science
- Published
- 2017-06-30
- Volume
- 356
- Issue
- 6345
- Pages
- 1383-1386
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2625985854
- Cited by
- 137
- References
- 26
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 14 · 2020: 20 · 2019: 22 · 2018: 14 · 2017: 8
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH Office of the Director (award313486, NINDS NS053884, award313487, NINDS NS074039, award313488, NINDS F31NS089252)
- NYSTEM (award313489, C024287)
- University of Basel (award313491)
- The Leona M. and Harry B. Helmsley Charitable Trust (award313490)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- hypothalamus, adult neural stem cells, subventricular zone, olfactory bulb neurogenesis, neurogenic niche
- MeSH terms
- Animals, Hypothalamus, Neural Pathways, Lateral Ventricles, Mice, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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