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Exosomal circEhmt1 Released from Hypoxia‐Pretreated Pericytes Regulates High Glucose‐Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway

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Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer

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Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System

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Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex

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Circular RNA s: Methodological challenges and perspectives in cardiovascular diseases

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The Role of Circular RNAs in Immune-Related Diseases

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circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

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Emerging functions of circular RNA in aging

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Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease

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RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery

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MicroRNA-7: expression and function in brain physiological and pathological processes

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Specific and sensitive detection of CircRNA based on netlike hybridization chain reaction

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Role of RNA modifications in brain and behavior

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Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer

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The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

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CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression

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Recent research progress on circular RNAs: Biogenesis, properties, functions, and therapeutic potential

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Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities

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Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity

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Functions of Circular RNA in Human Diseases and Illnesses

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CircBA9.3 supports the survival of leukaemic cells by up-regulating c-ABL1 or BCR-ABL1 protein levels

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High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

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A New World of Biomarkers and Therapeutics for Female Reproductive System and Breast Cancers: Circular RNAs

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Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

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Diverse lncRNA mechanisms in brain development and disease

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Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role

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Red Light-Initiated Cross-Linking of NIR Probes to Cytoplasmic RNA: An Innovative Strategy for Prolonged Imaging and Unexpected Tumor Suppression

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CircRNA: a rising star in plant biology

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Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis

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Molecular functions and biological roles of long non‐coding RNAs in human physiology and disease

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Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression

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Deep learning models for disease-associated circRNA prediction: a review

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The nuclear export of circular RNAs is primarily defined by their length

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Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation

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Prospect of Circular RNA in Hepatocellular Carcinoma: A Novel Potential Biomarker and Therapeutic Target

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FUS‐induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR‐142‐3p in lung cancer

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Exosomal miR-107 antagonizes profibrotic phenotypes of pericytes by targeting a pathway involving HIF-1α/Notch1/PDGFRβ/YAP1/Twist1 axis in vitro

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Biological roles and therapeutic potential of circular RNAs in osteoarthritis

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To kill a microRNA: emerging concepts in target-directed microRNA degradation

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microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease

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Circular RNAs: The Brain Transcriptome Comes Full Circle

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Circular RNA expression and function in the brain

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Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia

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RNA structures in alternative splicing and back‐splicing

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Circular RNAs as Potential Theranostics in the Cardiovascular System

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Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

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Long non-coding RNAs in vascular biology and disease

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Methods for analysis of circular RNAs

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CircAST: Full-Length Assembly and Quantification of Alternatively Spliced Isoforms in Circular RNAs

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Circular RNAs in digestive system cancer: potential biomarkers and therapeutic targets.

Sheng, J., Liu, L., Wang, M.-R., & Li, P. (2018) · Europe PMC (PubMed Central) · Cited by 57

Preferential production of RNA rings by T4 RNA ligase 2 without any splint through rational design of precursor strand

Chen, H., Cheng, K., Liu, X., An, R., Komiyama, M., & Liang, X. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa181 · Cited by 58

CircRNA–miRNA networks in regulating bone disease

Huang, W., Wu, Y., Qiao, M., Xie, Z., Cen, X. B., Huang, X., & Zhao, Z. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30625 · Cited by 56

hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis

Xu, P., Zhang, J., Wang, M., Liu, B., Li, R., Li, H., Zhai, N., Liu, W., Lv, C., & Song, X. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.045 · Cited by 56

A circular twist on microRNA regulation

Bezzi, M., Guarnerio, J., & Pandolfi, P. P. (2017) · Cell Research · doi:10.1038/cr.2017.136 · Cited by 56

A lariat-derived circular RNA is required for plant development in Arabidopsis

Cheng, J., Zhang, Y., Li, Z., Wang, T., Zhang, X., & Zheng, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-017-9182-3 · Cited by 56

Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1β signaling

Wang, H., Li, Z., Gao, J., & Liao, Q. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.041 · Cited by 55

Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

Najafi, S., Zarch, S. M. A., Majidpoor, J., Pordel, S., Aghamiri, S., Rasul, M. F., Asemani, Y., Vakili, O., Mohammadi, V., Movahedpour, A., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.166 · Cited by 56

Molecular functions and specific roles of circRNAs in the cardiovascular system

Holdt, L. M., Kohlmaier, A., & Teupser, D. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.05.002 · Cited by 55

Current status and potential role of circular RNAs in neurological disorders

Lu, S., Yang, X. F., Wang, C., Chen, S., Lu, S., Yan, W., Xiong, K., Liu, F., & Yan, J. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14724 · Cited by 57

The regulatory functions of circular RNAs in osteosarcoma

Soghli, N., Qujeq, D., Yousefi, T., & Soghli, N. (2020) · Genomics · doi:10.1016/j.ygeno.2020.03.024 · Cited by 55

Circular RNA: A novel potential biomarker for skin diseases

Wu, X., Xiao, Y., Ma, J., & Wang, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104841 · Cited by 55

circMbl Functions in cis and in trans to Regulate Gene Expression With Impacts on Physiology

Pamudurti, N. R., Patop, I. L., Krishnamoorthy, A., Bartok, O., Maya, R., Lerner, N., Ashwal-Fluss, R., Konakondla, J. V. V., Beatus, T., & Kadener, S. (2021) · Cell Reports · doi:10.1016/j.celrep.2022.110740 · Cited by 54

Substoichiometric action of long noncoding RNAs

Unfried, J. P., & Ulitsky, I. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00911-1 · Cited by 54

A novel circRNA-miRNA association prediction model based on structural deep neural network embedding

Guo, L.-X., You, Z., Wang, L., Yu, C.-Q., Zhao, B.-W., Ren, Z.-H., & Pan, J. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac391 · Cited by 54

Identification of circRNAs linked to Alzheimer's disease and related dementias

Puri, S., Hu, J., Sun, Z., Lin, M., Stein, T. D., Farrer, L. A., Wolozin, B. L., & Zhang, X. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12960 · Cited by 54

Circles in the heart and cardiovascular system

Lim, T. B., Lavenniah, A., & Foo, R. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz227 · Cited by 54

Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome

Ma, Z., Zhao, H., Zhang, Y., Liu, X., & Hao, C. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05122-y · Cited by 53

Current understanding of epigenetics in atopic dermatitis

Schmidt, A. D., & Strong, C. D. G. (2021) · Experimental Dermatology · doi:10.1111/exd.14392 · Cited by 56

CircRNAs in Plants

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Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells

Chen, T., Talló-Parra, M., Cao, Q. M., Kadener, S., Böttcher, R., Pérez‐Vilaró, G., Boonchuen, P., Somboonwiwat, K., Díez, J., & Sarnow, P. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008346 · Cited by 54

Circular RNAs in cardiovascular diseases

Mei, X., & Chen, S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107991 · Cited by 55

A Bi-Directional Competitive Interaction between CircHomer1 and Homer1b within the Orbitofrontal Cortex Regulates Reversal Learning

Hafez, A. K., Zimmerman, A. J., Papageorgiou, G., Chandrasekaran, J., Amoah, S. K., Lin, R., Lozano, E., Pierotti, C. E., Dell’Orco, M., Hartley, B. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.110282 · Cited by 52

Circular RNAs in cell differentiation and development

Timoteo, G. D., Rossi, F., & Bozzoni, I. (2020) · Development · doi:10.1242/dev.182725 · Cited by 52

The physiological function of long-noncoding RNAs

Chen, H., & Shan, G. (2020) · Non-coding RNA Research · doi:10.1016/j.ncrna.2020.09.003 · Cited by 51

Circular RNA in Diseased Heart

Wang, Y., & Liu, B. (2020) · Cells · doi:10.3390/cells9051240 · Cited by 51

The emerging roles of exosomal circRNAs in diseases

Guo, X., Tan, W., & Wang, C. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02485-6 · Cited by 51

Viruses join the circular RNA world

Tan, K., & Lim, Y. (2020) · FEBS Journal · doi:10.1111/febs.15639 · Cited by 51

Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma

Liang, L., Zhang, Z., Qin, X., Gao, Y., Zhao, P., Liu, J., & Zeng, W. (2019) · Melanoma Research · doi:10.1097/cmr.0000000000000595 · Cited by 50

The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders

Zaiou, M. (2020) · Cells · doi:10.3390/cells9061473 · Cited by 50

Circular RNA circZNF566 Promotes Hepatocellular Carcinoma Progression by Sponging miR-4738-3p and Regulating TDO2 Expression

Li, S., Weng, J., Song, F., Li, L., Xiao, C. W., Yang, W., Zhu, Z., & Xu, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-020-2616-8 · Cited by 51

Silencing of circular RNA ANRIL attenuates oxygen–glucose deprivation and reoxygenation-induced injury in human brain microvascular endothelial cells by sponging miR-622

Jiang, S., Zhao, G., Lu, J. K., Jiang, M., Wu, Z., Huang, Y., Huang, J., Shi, J., Jin, J., Xu, X., et al. (2020) · Biological Research · doi:10.1186/s40659-020-00295-2 · Cited by 50

Interactions and links among the noncoding RNAs in plants under stresses

Zhou, X., Cui, J., Meng, J., & Luan, Y. (2020) · Theoretical and Applied Genetics · doi:10.1007/s00122-020-03690-1 · Cited by 50

Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA

Liu, B., Liu, N., Zhu, X., Yang, L., Ye, B., Li, H., Zhu, P., Lu, T., Tian, Y., & Fan, Z. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00680-1 · Cited by 49

Regulation of microRNA by circular RNA

Singh, S., Sinha, T., & Panda, A. C. (2023) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1820 · Cited by 50

Deep learning of the back-splicing code for circular RNA formation

Wang, J., & Wang, L. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz382 · Cited by 48

Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats

Yoshimoto, R., Rahimi, K., Hansen, T. B., Kjems, J., & Mayeda, A. (2020) · iScience · doi:10.1016/j.isci.2020.101345 · Cited by 48

An in vivo strategy for knockdown of circular RNAs

Pamudurti, N. R., Patop, I. L., Krishnamoorthy, A., Ashwal-Fluss, R., Bartok, O., & Kadener, S. (2020) · Cell Discovery · doi:10.1038/s41421-020-0182-y · Cited by 49

ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway

Meng, L., Liu, S., Liu, F., Sang, M., Ju, Y., Fan, X., Gu, L., Li, Z., Geng, C., & Sang, M. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.08.015 · Cited by 48

CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis–angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF

Ji, H., Cui, X., Yang, Y., & Zhou, X. (2021) · Aging · doi:10.18632/aging.202791 · Cited by 48

The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer

Hansen, E. B., Fredsøe, J., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., et al. (2022) · Genome Medicine · doi:10.1186/s13073-021-01009-3 · Cited by 50

Identification of Potential Immune-Related circRNA–miRNA–mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection

Xiu, Y., Jiang, G., Zhou, S., Diao, J., Liu, H., Su, B., & Li, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00731 · Cited by 47

Cutting out circular RNAs

Jasny, B. R. (2017) · Science · doi:10.1126/science.357.6357.1250-m

Impact of Cdr1as and miR-7 network on synaptic transmission of mouse cortical neurons

Cerda, C. (2023) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-41654

Regulatory circles

Yates, D. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.118 · Cited by 3

miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent mannerPreprint

Cerda, C., Kim, S. J., Thomas, G., Farsi, Z., Zolotarov, G., Georgii, E., Woehler, A., Piwecka, M., & Rajewsky, N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525729 · Cited by 3

The history and function of a circular RNA

Cerda, C., Scoyni, F., Zolotarov, G., Bhaskar, P., León-Periñán, D., Kjems, J., & Rajewsky, N. (2026) · Nature Communications · doi:10.1038/s41467-026-71822-0 · Cited by 5