Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

Fast gapped-read alignment with Bowtie 2

Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

MUSCLE: multiple sequence alignment with high accuracy and high throughput

Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662

HTSeq—a Python framework to work with high-throughput sequencing data

Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985

Predicting effective microRNA target sites in mammalian mRNAs

Agarwal, V., Bell, G. W., Nam, J.-W., & Bartel, D. P. (2015) · eLife · doi:10.7554/elife.05005 · Cited by 7,318

The biogenesis, biology and characterization of circular RNAs

Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823

Metazoan MicroRNAs

Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Kopp, F. B., & Mendell, J. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.011 · Cited by 3,574

Regulation of microRNA function in animals

Gebert, L. F. R., & MacRae, I. J. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0045-7 · Cited by 2,284

The Biogenesis, Functions, and Challenges of Circular RNAs

Li, X., Yang, L. C., & Chen, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,060

The expanding regulatory mechanisms and cellular functions of circular RNAs

Chen, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0243-y · Cited by 1,726

Past, present, and future of circRNAs

Patop, I. L., Wüst, S., & Kadener, S. (2019) · The EMBO Journal · doi:10.15252/embj.2018100836 · Cited by 1,237

Circular RNAs: Characterization, cellular roles, and applications

Liu, C., & Chen, L. (2022) · Cell · doi:10.1016/j.cell.2022.04.021 · Cited by 1,094

RNA in cancer

Goodall, G. J., & Wickramasinghe, V. O. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00306-0 · Cited by 1,090

Noncoding RNA:RNA Regulatory Networks in Cancer

Chan, J. J., & Tay, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051310 · Cited by 1,032

Circular RNA-protein interactions: functions, mechanisms, and identification

Huang, A., Zheng, H., Wu, Z., Chen, M., & Huang, Y. (2020) · Theranostics · doi:10.7150/thno.42174 · Cited by 914

microRNAs in action: biogenesis, function and regulation

Shang, R., Lee, S., Senavirathne, G., & Lai, E. C. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00611-y · Cited by 897

Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance

Li, J., Sun, D., Pu, W., Wang, J., & Peng, Y. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.01.012 · Cited by 805

Circular RNA and its mechanisms in disease: From the bench to the clinic

Han, B., Chao, J., & Yao, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.010 · Cited by 788

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Zhang, M., Zhao, K., Xu, X., Yang, Y., Yan, S., Wei, P., Liu, H., Xu, J., Xiao, F., Zhou, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06862-2 · Cited by 747

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Li, B., Zhu, L., Lu, C., Wang, C., Wang, H., Jin, H., Ma, X., Cheng, Z., Yu, C., Wang, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20527-z · Cited by 697

Long noncoding RNAs in cancer metastasis

Liu, S. J., Dang, H. X., Lim, D. A., Feng, F. Y.-C., & Maher, C. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00353-1 · Cited by 653

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

Kleaveland, B., Shi, C. Y., Stefano, J., & Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.05.022 · Cited by 610

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

He, A. T., Liu, J., Li, F., & Yang, B. B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00569-5 · Cited by 567

Circbank: a comprehensive database for circRNA with standard nomenclature

Liu, M., Wang, Q., Shen, J., Yang, B. B., & Ding, X. (2019) · RNA Biology · doi:10.1080/15476286.2019.1600395 · Cited by 561

Widespread and Functional RNA Circularization in Localized Prostate Cancer

Chen, S., Huang, V., Xu, X., Livingstone, J., Soares, F., Jeon, J., Zeng, Y., Hua, J. T., Petricca, J., Guo, H., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.025 · Cited by 544

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Wu, P., Mo, Y., Miao, P., Tang, T. F., Zhong, Y. M., Deng, X., Xiong, F., Guo, C. J., Wu, X., Li, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1147-3 · Cited by 538

Specific expression and functions of circular RNAs

Mısır, S., Wu, N., & Yang, B. B. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00948-7 · Cited by 493

Targeting mitochondria-located circrna scar alleviates nash via reducing mros output

Zhao, Q., Liu, J., Deng, H., Ma, R., Liao, J.-Y., Liang, H., Hu, J., Li, J., Guo, Z., Cai, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.009 · Cited by 469

circRNAs in Cancer

Patop, I. L., & Kadener, S. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.11.007 · Cited by 469

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

Su, M., Xiao, Y., Ma, J., Tang, Y., Tian, B., Zhang, Y., Xu, L., Wu, Z., Yang, D., Zhou, Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1002-6 · Cited by 463

Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice

Huang, S., Li, X., Zheng, H., Si, X., Li, B., Wei, G., Li, C., Chen, Y., Chen, Y., Liao, W., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.038361 · Cited by 454

Small and long non-coding RNAs: Past, present, and future

Chen, L., & Kim, V. N. (2024) · Cell · doi:10.1016/j.cell.2024.10.024 · Cited by 461

A 360° view of circular RNAs: From biogenesis to functions

Wilusz, J. E. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1478 · Cited by 446

The emerging roles and functions of circular RNAs and their generation

Yu, C., & Kuo, H. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0523-z · Cited by 443

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Garikipati, V. N. S., Verma, S. K., Cheng, Z. A., Liang, D., Truongcao, M. M., Cimini, M., Yue, Y., Huang, G., Wang, C., Benedict, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11777-7 · Cited by 428

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Cheng, Z., Yu, C., Cui, S., Wang, H., Jin, H., Wang, C., Li, B., Qin, M., Yang, C. G., He, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11162-4 · Cited by 419

CircRNA: a rising star in gastric cancer

Li, R., Jiang, J., Shi, H., Qian, H., Zhang, X., & Xu, W. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03345-5 · Cited by 415

CircRNAs and cancer: Biomarkers and master regulators

Arnaiz, E., Solé, C., Manterola, L., Iparraguirre, L., Otaegui, D., & Lawrie, C. H. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.12.002 · Cited by 411

A map of human circular RNAs in clinically relevant tissues

Maass, P. G., Glažar, P., Memczak, S., Dittmar, G., Hollfinger, I., Schreyer, L., Sauer, A. V., Toka, O., Aiuti, A., Luft, F. C., et al. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1582-9 · Cited by 391

CircRNAs: role in human diseases and potential use as biomarkers

Verduci, L., Tarcitano, E., Strano, S., Yarden, Y., & Blandino, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03743-3 · Cited by 382

Extracellular Vesicle–Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

Yang, L., Han, B., Zhang, Z., Wang, S., Bai, Y., Zhang, Y., Tang, Y., Du, L., Xu, L., Wu, F., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.045765 · Cited by 376

Is plasticity of synapses the mechanism of long-term memory storage?

Abraham, W. C., Jones, O. D., & Glanzman, D. L. (2019) · npj Science of Learning · doi:10.1038/s41539-019-0048-y · Cited by 398

Screening for functional circular RNAs using the CRISPR–Cas13 system

Li, S., Li, X., Xue, W., Zhang, L., Yang, L.-Z., Cao, S.-M., Lei, Y.-N., Liu, C.-X., Guo, S.-K., Shan, L., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-01011-4 · Cited by 365

Circular RNAs open a new chapter in cardiovascular biology

Aufiero, S., Reckman, Y. J., Pinto, Y. M., & Creemers, E. E. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0185-2 · Cited by 355

Review on circular RNAs and new insights into their roles in cancer

Tang, X., Ren, H., Guo, M., Qian, J., Yang, Y., & Gu, C. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.018 · Cited by 358

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Dube, U., Del-Aguila, J. L., Li, Z., Budde, J. P., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M. V., Farias, F., Norton, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0501-5 · Cited by 345

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

Hanniford, D., Ulloa-Morales, A. J., Karz, A., Berzoti-Coelho, M. G., Moubarak, R. S., Sánchez‐Sendra, B., Kloetgen, A., Dávalos, V., Imig, J., Wu, P., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.007 · Cited by 348

Molecular roles and function of circular RNAs in eukaryotic cells

Holdt, L. M., Kohlmaier, A., & Teupser, D. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2688-5 · Cited by 347

Aging, melatonin, and the pro- and anti-inflammatory networks

Hardeland, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051223 · Cited by 337

Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Liu, Z., Zhou, Y., Liang, G., Ling, Y., Tan, W., Tan, L., Andrews, R., Zhong, W., Zhang, X., Song, E., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1287-1 · Cited by 336

133 Translation and transforming activity of a circular RNA from human papillomavirus

Zhao, J., Lee, E. E., Kim, J., Yang, R., Chamseddin, B. H., Ni, C., Gusho, E., Xie, Y., Chiang, C., Buszczak, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10246-5 · Cited by 325

Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease

Piwecka, M., Rajewsky, N., & Rybak-Wolf, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00809-y · Cited by 320

Biogenesis and Functions of Circular RNAs Come into Focus

Xiao, M., Ai, Y., & Wilusz, J. E. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.12.004 · Cited by 316

Biogenesis and Regulatory Roles of Circular RNAs

Yang, L. C., Wilusz, J. E., & Chen, L. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-125117 · Cited by 308

Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription

Chen, Q., Wang, H., Li, Z., Li, F., Liang, L., Zou, Y., Shen, H., Li, J., Xia, Y., Cheng, Z., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.027 · Cited by 295

Role of circular RNAs in brain development and CNS diseases

Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281

Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein

Cheng, X., Zhang, L., Zhang, K., Zhang, G., Hu, Y., Sun, X., Zhao, C., Li, H., Li, Y. M., & Zhao, J. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-212056 · Cited by 280

The emerging functions and roles of circular RNAs in cancer

Qu, S., Liu, Z., Yang, X., Zhou, J., Yu, H., Zhang, R., & Li, H. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.022 · Cited by 281

Circular RNA in cancer

Conn, V. M., Chinnaiyan, A. M., & Conn, S. J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00721-7 · Cited by 300

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

Santer, L., Bär, C., & Thum, T. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.07.001 · Cited by 279

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

Min, L., Zhu, S., Chen, L., Liu, X., Wei, R., Zhao, L., Yang, Y., Zhang, Z., Kong, G., Li, P., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1643670 · Cited by 272

Circular RNAs (circRNAs) in Health and Disease

Haque, S., & Harries, L. W. (2017) · Genes · doi:10.3390/genes8120353 · Cited by 272

Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

Rogalska, M. E., Vivori, C., & Valcárcel, J. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00556-8 · Cited by 284

Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals

Ji, P., Wu, W., Chen, S., Zheng, Y., Zhou, L. M., Zhang, J., Cheng, H., Jin, Y., Zhang, S., Yang, P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.078 · Cited by 265

Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction

Liu, C., Ge, H., Liu, B.-H., Dong, R., Shan, K. Y., Chen, X., Yao, M.-D., Li, X., Yao, J., Zhou, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814874116 · Cited by 260

circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Sun, Y., Wang, W., Zeng, Z., Chen, T.-Q., Han, C., Pan, Q., Huang, W., Fang, K., Sun, L.-Y., Zhou, Y.-F., et al. (2019) · Blood · doi:10.1182/blood.2019000802 · Cited by 244

Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk

Smillie, C. L., Sirey, T., & Ponting, C. P. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1447542 · Cited by 243

A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p

Li, M., Ding, W., Tariq, M., Chang, W., Zhang, X., Xu, W., Hou, L., Wang, Y., & Wang, J. (2018) · Theranostics · doi:10.7150/thno.27285 · Cited by 236

Circular RNA and Alzheimer’s Disease

Akhter, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_19 · Cited by 234

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

Fan, C., Li, Y., Lan, T., Wang, W., Long, Y., & Yu, S. Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.006 · Cited by 227

Best practice standards for circular RNA research

Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T. B., Irimia, M., Kadener, S., Kristensen, L. S., Legnini, I., Morlando, M., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01487-2 · Cited by 238

Circular RNAs: emerging cancer biomarkers and targets

Zhang, Y., Liang, W., Zhang, P., Chen, J., Qian, H., Zhang, X., & Xu, W. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0624-z · Cited by 225

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

Stoll, L., Sobel, J., Rodriguez‐Trejo, A., Guay, C., Lee, K., Venø, M. T., Kjems, J., Laybutt, D. R., & Regazzi, R. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.010 · Cited by 223

Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Hong, X.-H., Liu, N., Liang, Y., He, Q., Yang, X., Lei, Y., Zhang, P., Zhao, Y., He, S., Wang, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01149-x · Cited by 223

Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

Zhao, X., Cai, Y., & Xu, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163926 · Cited by 225

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

Zhu, P., Zhu, X., Wu, J., He, L., Lu, T., Wang, Y., Liu, B., Ye, B., Sun, L., Fan, D., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0297-6 · Cited by 219

Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

Lou, J., Hao, Y., Lin, K., Lyu, Y., Chen, M., Wang, H., Zou, D., Jiang, X., Wang, R., Jin, D., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01253-y · Cited by 221

m6A-dependent biogenesis of circular RNAs in male germ cells

Tang, C., Xie, Y., Yu, T., Liu, N., Wang, Z., Woolsey, R. J., Tang, Y., Zhang, X., Qin, W., Zhang, Y., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0279-8 · Cited by 207

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway

Yan, B., Zhang, Y., Liang, C., Liu, B., Ding, F., Wang, Y., Zhu, B. T., Zhao, R., Yu, X., & Li, Y. (2020) · Theranostics · doi:10.7150/thno.42259 · Cited by 203

Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Okholm, T. L. H., Sathe, S., Park, S. S., Kamstrup, A. B., Rasmussen, A. M., Shankar, A., Chua, Z. M., Fristrup, N., Nielsen, M. M., Vang, S., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00812-8 · Cited by 204

Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis

Guo, Y., Guo, Y., Chen, C., Fan, D., Wu, X., Zhao, L., Shao, B., Sun, Z., & Ji, Z. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01372-0 · Cited by 202

Circular RNAs: a new frontier for cancer diagnosis and therapy

Zhang, M., & Xin, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0569-5 · Cited by 199

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Long, F., Lin, Z., Li, L., Ma, M., Lu, Z., Jing, L., Li, X., & Lin, C. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01318-6 · Cited by 198

The biogenesis and regulation of animal microRNAs

Kim, H., Lee, Y.-Y., & Kim, V. N. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00805-0 · Cited by 201

Circular RNAs as Therapeutic Agents and Targets

Holdt, L. M., Kohlmaier, A., & Teupser, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01262 · Cited by 189

Functional role of circular RNAs in cancer development and progression

Ng, W. L., Mohidin, T. B. M., & Shukla, K. (2018) · RNA Biology · doi:10.1080/15476286.2018.1486659 · Cited by 185

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Nicolet, B. P., Engels, S., Aglialoro, F., van den Akker, E., Lindern, M. V., & Wolkers, M. C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky721 · Cited by 188

Improved circRNA Identification by Combining Prediction Algorithms

Hansen, T. B. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00020 · Cited by 181

The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

Wen, G., Zhou, T., & Gu, W. (2020) · Protein & Cell · doi:10.1007/s13238-020-00799-3 · Cited by 183

Reconstruction of full-length circular RNAs enables isoform-level quantification

Zheng, Y., Ji, P., Chen, S., Hou, L., & Zhao, F. (2019) · Genome Medicine · doi:10.1186/s13073-019-0614-1 · Cited by 171

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Bhat, A. A., Younes, S. N., Raza, S. S., Zarif, L., Nisar, S., Ahmed, I., Mir, R., Kumar, S., Sharawat, S. K., Hashem, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01175-9 · Cited by 172

Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Yang, X., Ye, T., Liu, H., Lv, P., Duan, C., Wu, X., Jiang, K., Lu, H., Ding, X., Peng, E., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01300-8 · Cited by 169

Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease

Lu, Y., Tan, L., & Wang, X. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00361-0 · Cited by 168

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling

Gu, Y., Wang, Y., He, L., Zhang, J., Zhu, X., Liu, N., Wang, J., Lu, T., He, L., Tian, Y., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01435-2 · Cited by 165

Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas

He, J., Huang, Z., He, M., Liao, J., Zhang, Q., Wang, S., Xie, L., Ouyang, L., Koeffler, H. P., Yin, D., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1120-1 · Cited by 163

Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis

Zhu, Z., Rong, Z., Luo, Z., Yu, Z., Zhang, J., Qiu, Z., & Huang, C. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1054-7 · Cited by 159

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Katon, J. M., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0192-1 · Cited by 161

CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

Zhang, Y., Jiang, J., Zhang, J., Shen, H., Wang, M., Guo, Z., Zang, X., Shi, H., Gao, J., Cai, H., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01390-y · Cited by 158

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

Zhang, L., Zhou, Q., Qiu, Q., Hou, L., Wu, M., Li, J., Li, X., Lü, B., Cheng, X., Liu, P., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1080-5 · Cited by 154

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition

Zimmerman, A. J., Hafez, A. K., Amoah, S. K., Rodriguez, B. A., Dell’Orco, M., Lozano, E., Hartley, B. J., Alural, B., Lalonde, J., Chander, P. N., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0653-4 · Cited by 153

Landscape of Noncoding RNA in Prostate Cancer

Hua, J. T., Chen, S., & He, H. H. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.08.004 · Cited by 152

Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges

Jost, I., Shalamova, L. A., Gerresheim, G. K., Niepmann, M., Bindereif, A., & Roßbach, O. (2018) · RNA Biology · doi:10.1080/15476286.2018.1435248 · Cited by 150

Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression

Li, H., Yang, F., Hu, A., Wang, X., Fang, E., Chen, Y., Li, D., Song, H., Wang, J., Guo, Y., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910835 · Cited by 149

Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression

Sang, M., Meng, L., Sang, Y., Liu, S., Ding, P., Ju, Y., Liu, F., Gu, L., Lian, Y., Li, J., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.03.049 · Cited by 149

Cutting out circular RNAs

Jasny, B. R. (2017) · Science · doi:10.1126/science.357.6357.1250-m

Impact of Cdr1as and miR-7 network on synaptic transmission of mouse cortical neurons

Cerda, C. (2023) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-41654

Regulatory circles

Yates, D. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.118 · Cited by 3

miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent mannerPreprint

Cerda, C., Kim, S. J., Thomas, G., Farsi, Z., Zolotarov, G., Georgii, E., Woehler, A., Piwecka, M., & Rajewsky, N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525729 · Cited by 3

The history and function of a circular RNA

Cerda, C., Scoyni, F., Zolotarov, G., Bhaskar, P., León-Periñán, D., Kjems, J., & Rajewsky, N. (2026) · Nature Communications · doi:10.1038/s41467-026-71822-0 · Cited by 5