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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Genomic analyses identify molecular subtypes of pancreatic cancer

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The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance

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An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells

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Current understanding of ferroptosis in the progression and treatment of pancreatic cancer

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Ferroptosis and renal fibrosis: A new target for the future (Review)

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Insights on Ferroptosis and Colorectal Cancer: Progress and Updates

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Protein arginine methyltransferase 8 regulates ferroptosis and macrophage polarization in spinal cord injury via glial cell‐derived neurotrophic factor

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Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy

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Metabolic Response to Androgen Deprivation Therapy of Prostate Cancer

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A nanocarbon-enabled hybridization strategy to construct pharmacologically cooperative therapeutics for augmented anticancer efficacy

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Catabolism of extracellular glutathione supplies cysteine to support tumours

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Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer

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Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer

Kerimoglu, B., Lamb, C., McPherson, R. D., Ergen, E., Stone, E. M., & Ooi, A. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0661 · Cited by 19

Is There a Connection between the Metabolism of Copper, Sulfur, and Molybdenum in Alzheimer’s Disease? New Insights on Disease Etiology

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Microenvironment immune response induced by tumor ferroptosis—the application of nanomedicine

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A vinyl-decorated covalent organic framework for ferroptotic cancer therapy via visible-light-triggered cysteine depletion

Guan, Q., Zhou, L., Zhou, W. D., & Dong, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01815b · Cited by 20

Discovery and optimization of 2-(trifluoromethyl)benzimidazole derivatives as novel ferroptosis inducers in vitro and in vivo

Fang, Y., Tan, Q., Zhou, H., Xu, J., & Gu, Q. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114905 · Cited by 19

Ferroptosis: a dual-edged sword in tumour growth

Zhao, X., Li, X., & Xu, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1330910 · Cited by 21

Cystathionine‐gamma‐lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy

Lancien, M., Gueno, L., Salle, S., Mérieau, E., Bériou, G., Nguyen, T. H., Abidi, A., Dilek, N., Solomon, P., Poschmann, J., et al. (2021) · Cancer Science · doi:10.1111/cas.14862 · Cited by 19

Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine

Yamamoto, K., Opina, A. C. L., Sail, D., Blackman, B. N., Saito, K., Brender, J., Malinowski, R. M., Seki, T., Oshima, N., Crooks, D. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90921-0 · Cited by 19

A novel dual-functional fluorescent probe for imaging viscosity and cysteine in living system

Fu, M., Wang, K., Ma, Q., Zhu, J., Bian, M., & Zhu, Q. X. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob02116h · Cited by 18

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer

Zhang, C., Ding, J., Lim, K. S., Zhou, W., Miao, W., Wu, S., Liu, H., Huang, D., Chen, C., He, H., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-23-2796 · Cited by 18

Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway

Kong, X., Wei, P., Meng, L., Yu, Z., Liu, X., Li, M., Zou, Y., Li, J., & Wu, G. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117873 · Cited by 18

Initial evaluation of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate (FSPG) PET/CT imaging in patients with head and neck cancer, colorectal cancer, or non-Hodgkin lymphoma

Park, S. Y., Mosci, C., Kumar, M., Wardak, M., Koglin, N., Bullich, S., Mueller, A., Berndt, M., Stephens, A. W., Chin, F. T., et al. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00678-2 · Cited by 18

ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

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Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome

Hansen, A. W., & Venkatachalam, K. V. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101529 · Cited by 23

Ferroptosis: potential targets and emerging roles in pancreatic diseases

Huang, Z., Ma, Y., Sun, Z., Cheng, L., & Wang, G. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03625-x · Cited by 19

Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis

Li, Y., Ma, M., Wang, X., Li, J., Fang, Z., Li, J., Yang, B., Lu, Y., Xu, X., & Li, Y. (2023) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2023.2300508 · Cited by 22

UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis

Fan, M., Huo, S., Guo, Y., Wang, R., Hao, W., Zhang, Z., Wang, L., & Zhao, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113808 · Cited by 18

Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

Vinciguerra, G. L. R., Capece, M., Bonetti, L. R., Nigita, G., Calore, F., Rentsch, S., Magistri, P., Ballarin, R., Benedetto, F. D., Distefano, R., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01740-4 · Cited by 18

Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations

Zaugg, J., López‐Tello, J., Musiał, B., Vaughan, O. R., Fowden, A. L., Albrecht, C., & Sferruzzi-Perri, A. N. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05192-5 · Cited by 24

Mycobacterium tuberculosis infection induces a novel type of cell death: Ferroptosis

Wang, J., Cao, H., Xie, Y., Xu, Z., Li, Y., & Luo, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117030 · Cited by 18

Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment

Wang, Y., Chen, Q., Luo, Y., Qu, Y., Li, X., Song, H., Li, C., Zhang, Y., Sun, T., & Jiang, C. (2024) · ACS Nano · doi:10.1021/acsnano.4c13425 · Cited by 18

Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

Nishida, H., Okada, M., Yang, L., Takano, T., Tabata, S., Soga, T., Ho, D. M., Chung, J., Minami, Y., & Yoo, S. K. (2021) · eLife · doi:10.7554/elife.59809 · Cited by 17

The Role of Stroma in Cancer MetabolismPreprint

Kimmelman, A. C., & Sherman, M. H. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041540 · Cited by 19

Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis

Liu, X., Huang, Z., Chen, Q., Chen, K., Liu, W., Liu, G., Chu, X., Li, D., Ma, Y., Tian, X., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02035-x · Cited by 17

Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors

Chen, Y., Xu, W., Jin, H., Zhang, M., Liu, S., Liu, Y., & Zhang, H. (2024) · ACS Nano · doi:10.1021/acsnano.4c08083 · Cited by 19

CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis

Yao, H., Ge, J., Chen, J., Tang, X., Li, C., Hu, X., Ahmed, A. A., Pu, Y., Zhou, G., Zhang, T., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03295-w · Cited by 23

Bioinspired Dual‐Ionic‐Site Single‐Atom Nanozymes for Synergistic Ferroptosis/Cuproptosis and Enhanced Immune Checkpoint Blockade Therapy

Yang, L., Pan, M., Hu, H., Liu, F., Jiang, M., Ning, S., Chen, X., Zhang, Z., Yu, X., & Xu, L. (2025) · Small · doi:10.1002/smll.202501076 · Cited by 22

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

Zhou, B., Li, J., Wu, A., Wang, X., Cheng, L., Yang, G., Gao, D., & Zhu, C. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1587986 · Cited by 18

Chronic Heat Stress Caused Lipid Metabolism Disorder and Tissue Injury in the Liver of Huso dauricus via Oxidative-Stress-Mediated Ferroptosis

Zhang, Y., Li, Y., Wang, R., Wang, S., Sun, B., Cao, D., Sun, Z., Lv, W., Bo, M., & Zhang, Y. (2025) · Antioxidants · doi:10.3390/antiox14080926 · Cited by 20

Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma

Salem, S., Han, T., Alchoueiry, M., Mahmoud, N., Bzeih, W., Chami, J., Khabibullin, D., Mansour, H., Tang, Y., Ho, T. H., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03562-2 · Cited by 20

Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications

Dai, Z., Liu, J., Zeng, L., Shi, K., Peng, X., Jin, Z., Zheng, R., & Zeng, C. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100049 · Cited by 23

Haem Oxygenase-1, Ferroptosis and Disorders—A Narrative Review

Pham, J., Refesse, M., Saeed, A., & Latunde-Dada, G. O. (2025) · Nutrients · doi:10.3390/nu17243921 · Cited by 18

High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer

Wang, H., Chen, S., Kang, W., Ding, B., Cui, S., Zhou, L., Zhang, N., Luo, H., Wang, M., Zhang, F., et al. (2023) · Discover Oncology · doi:10.1007/s12672-023-00634-1 · Cited by 18

The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application

Fu, S., Xu, S., & Zhang, S. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188893 · Cited by 18

CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway

Zhao, Y., Ma, R., Wang, C., Hu, R., Wu, W., Sun, X., Chen, B., Zhang, W., Chen, Y., Zhou, J., et al. (2023) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2023.101919 · Cited by 17

Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins

Zhao, Y., Jiang, B., Huang, D., Lou, J., Li, G., Liu, J., Duan, F., Yuan, Y., & Su, X. (2023) · PeerJ · doi:10.7717/peerj.15786 · Cited by 17

Immunometabolism: a new dimension in immunotherapy resistance

Xiao, C., Xiong, W., Xu, Y., Zou, J. P., Zeng, Y., Liu, J., Peng, Y., Hu, C., & Wu, F. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1012-z · Cited by 18

Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment

Yang, J., & Gu, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1283465 · Cited by 19

Ferrous sulfate combined with ultrasound emulsified cinnamaldehyde nanoemulsion to cause ferroptosis in Escherichia coli O157:H7

Sun, J., Shen, Q.-J., Pan, J.-N., Zheng, X., Yu, T., & Zhou, W.-W. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.106884 · Cited by 17

Nanoparticles targeting OPN loaded with BY1 inhibits vascular restenosis by inducing FTH1-dependent ferroptosis in vascular smooth muscle cells

Zhang, Y., Zheng, B.-Y., Zhang, Q.-F., Zhao, Y., Yu, Q.-M., Liu, X., Ding, S.-Y., Qian, S.-S., Wu, H., Wu, Q.-Y., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122613 · Cited by 17

A Λ -Ir( iii )-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1

Zhu, L., Wang, X., Tian, T., Chen, Y., Du, W., Wei, W., Zhao, J., Guo, Z., & Wang, X. (2024) · Chemical Science · doi:10.1039/d4sc00422a · Cited by 17

Injectable hybrid hydrogels enable enhanced combination chemotherapy and roused anti-tumor immunity in the synergistic treatment of pancreatic ductal adenocarcinoma

Zhou, H., Wang, W., Cai, Z., Jia, Z.-Y., Li, Y., He, W., Li, C., & Zhang, B. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02646-7 · Cited by 17

Multifunctional single-component photosensitizers as metal-free ferroptosis inducers for enhanced photodynamic immunotherapy

Fang, L., Meng, Q., Wang, J., Tu, Y., Hong, Q., Diao, Y., Li, W., Wen, H., Jin, F., Hang, L., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.034 · Cited by 17

Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma

Ruze, R., Chen, Y., Song, J., Xu, R., Yin, X., Xu, Q., Wang, C., & Zhao, Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217162 · Cited by 18

The role of non-apoptotic cell death in the treatment and drug-resistance of digestive tumors

Yang, Y., Bai, L., Liao, W., Feng, M., Zhang, M., Wu, Q., Zhou, K., Wen, F., Lei, W., Zhang, N., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112678 · Cited by 17

Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates

Yang, F., Sun, S., Wang, S., Guo, J., Liu, X., Ge, N., & Wang, G. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i1.1 · Cited by 18

Cysteine-based biomolecules regulate cellular copper- and redox-homeostasis

Maiti, B. K., & Singh, M. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216442 · Cited by 16

Amino acids metabolism: a potential target for cancer treatment

Ren, S., Zhou, X., Wang, Z., & Yuan, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02523-3 · Cited by 19

The mechanism and progress of ferroptosis in pancreatic cancer

Bao, Z., Hou, X.-B., Li, H.-L., Mao, Y., & Wang, W. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151919 · Cited by 17

Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury

Dong, S., Hu, M., Huang, J., Chen, L., Sun, X., Yao, Z., Tong, X., Jin, W.-J., & Zhang, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355766 · Cited by 16

Knockdown of the SELENOK gene induces ferroptosis in cervical cancer cells

Abdurahman, A., Li, Y., Jia, S.-Z., Xu, X.-W., Lin, S., Ouyang, P., He, Z. J., Zhang, Z.-H., Liu, Q., Xu, Y., et al. (2023) · Metallomics · doi:10.1093/mtomcs/mfad019 · Cited by 16

Facile synthesis of poly(disulfide)s through one-step oxidation polymerization for redox-responsive drug delivery

Zhang, R., Nie, T., Wang, L., He, D., Yang, K., Zhang, C., & Wu, J. (2023) · Biomaterials Science · doi:10.1039/d3bm00461a · Cited by 16

Carnosine attenuates renal ischemia–reperfusion injury by inhibiting GPX4-mediated ferroptosis

Wang, H., Guo, S., Wang, B., Liu, X., Gao, L., Chen, C., & Wu, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110850 · Cited by 16

NaYF4:Yb/Er@Mn3O4@GOX Nanocomposite for Upconversion Fluorescence Imaging and Synergistic Cascade Cancer Therapy by Apoptosis and Ferroptosis

Chen, Y., Li, H., Hou, B., Wu, A., Wu, W., Li, C., Wang, H., Chen, D., & Wang, X. (2023) · Small · doi:10.1002/smll.202304438 · Cited by 16

D-A-D type based NIR fluorescence probe for monitoring the cysteine levels in pancreatic cancer cell during ferroptosis

Qin, J., Wang, J., Bian, Y., & Shao, C. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107260 · Cited by 16

Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects

Zeng, J., Zhang, X., Lin, Z., Zhang, Y., Yang, J., Dou, P., & Liu, T. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00498-3 · Cited by 16

GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy

Liao, Z., Wen, E., & Feng, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02425-4 · Cited by 16

Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway

Xiao, H., Chen, C., Yuan, X., Yang, L., Zheng, Y., Jin, Y., Huang, S. M., Liang, J., Yuan, S., Li, M., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117529 · Cited by 16

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Zhang, F., Huang, B., Xu, Y., Cao, G., Shen, M., Liu, C., & Luo, J. (2025) · Advanced Science · doi:10.1002/advs.202415814 · Cited by 17

Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction

Jin, G., Han, W., Duan, T., Xue, Z., Song, C., Xu, Y., & Yu, M. Z. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01559-0 · Cited by 16

Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma

Thakur, G., Kumar, R., Kim, S.-B., Lee, S.-Y., Lee, S., & Rho, G. (2021) · Biomedicines · doi:10.3390/biomedicines9020178 · Cited by 16

Pharmacological Targeting of Ferroptosis in Cancer Treatment

Roushandeh, A. M., Roudkenar, M. H., Valashedi, M. R., Nikoo, A., Najafi-Ghalehlou, N., Tomita, K., Kuwahara, Y., & Sato, T. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666211202091523 · Cited by 17

MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis−Starvation therapy in triple negative breast cancer

Wang, D., Fang, W., Huang, C., Chen, Z., Nie, T., Wang, J., Luo, L., & Xiao, Z. (2021) · Smart Materials in Medicine · doi:10.1016/j.smaim.2021.12.008 · Cited by 16

The Complex Roles of Redox and Antioxidant Biology in CancerPreprint

Hayashi, M., Okazaki, K., Papgiannakopoulos, T., & Motohashi, H. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041546 · Cited by 16

An emerging double‑edged sword role of ferroptosis in cardiovascular disease (Review)

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Western diet promotes the progression of metabolic dysfunction‐associated steatotic liver disease in association with ferroptosis in male mice

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Cysteine Depletion-Initiated Redox Imbalance Evokes Ferroptosis and Pyroptosis for Enhanced Pancreatic Cancer Therapy

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Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

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Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma

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Quantitative reactive cysteinome profiling reveals a functional link between ferroptosis and proteasome-mediated degradation

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Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application

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Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

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Crosstalk Between Microbiome and Ferroptosis in Diseases: From Mechanism to Therapy

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