Cysteine depletion induces pancreatic tumor ferroptosis in mice

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Genomic analyses identify molecular subtypes of pancreatic cancer

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Thioketal-Incorporated Biodegradable Lipid Nanoparticles Deliver mRNA to Ductal Epithelial Cells for Improved Pancreatic Cancer Treatment

Qiu, X., Yang, Y., Ma, Q., Zheng, B., Chen, Z., Wu, F., Zhou, B., & Xiong, H. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c19387 · Cited by 14

CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARγ-dependent manner.

Tao, P., Jiang, Y., Wang, H., & Gao, G. (2021) · PubMed Central · doi:10.11817/j.issn.1672-7347.2021.210413 · Cited by 14

Prognostic Model and Nomogram Construction Based on a Novel Ferroptosis-Related Gene Signature in Lower-Grade Glioma

Zhao, J., Liu, Z., Zheng, X., Gao, H., & Li, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.753680 · Cited by 14

Research progress of ferroptosis in glaucoma and optic nerve damage

Huang, S., Liu, K., Su, Y., Wang, F., & Feng, T. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04545-7 · Cited by 14

Identification of a novel gene signature with regard to ferroptosis, prognosis prediction, and immune microenvironment in osteosarcoma

Zheng, D., Xia, K., Wei, Z., Wei, Z., & Guo, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.944978 · Cited by 14

Research progress on ferroptosis in gliomas (Review)

Bo, Y., Mu, L., Yang, Z., Li, W., & Jin, M. (2023) · Oncology Letters · doi:10.3892/ol.2023.14169 · Cited by 14

Targeting Ferroptosis as an Advance Strategy in Cancer Therapy

Muluh, T. A., Fu, Q., Ai, X., Wang, C., Chen, W., Zheng, X., Wang, W., Wang, M., Shu, X., & Ying, Y. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0608 · Cited by 15

Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer

Lin, Y., Tsai, Y.-C., Li, C., Wei, T.-T., Wang, J.-L., Lin, B.-W., Wu, Y., Wu, S., Lin, S.-C., & Lin, S.-C. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103358 · Cited by 14

IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer

Wu, D., Wang, Z., Zhang, Y., Yang, Y., Yang, Y., Zu, G., Yu, X., Chen, W., Qin, Y., Xu, X., et al. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024153 · Cited by 14

A comprehensive review of ferroptosis in environmental pollutants-induced chronic obstructive pulmonary disease

Jiang, X., Peng, Z., He, B., Li, S., & Huang, Q. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177534 · Cited by 14

Glutathione Peroxidases: An Emerging and Promising Therapeutic Target for Pancreatic Cancer Treatment

Iglesias-Matesanz, P., Lacalle-González, C., Lopez-Blazquez, C., Otieno, M. O., García‐Foncillas, J., & Martínez‐Useros, J. (2024) · Antioxidants · doi:10.3390/antiox13111405 · Cited by 17

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Schneider, A. T., Koppe, C., Crouchet, É., Papargyriou, A., Singer, M. T., Büttner, V., Keysberg, L. S., Szydlowska, M., Jühling, F., Moehlin, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56493-7 · Cited by 14

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein

Yang, L., An, X., Yang, S., Lin, X., Chen, Z., Xue, Q., Chen, X., Wang, Y., Yan, D., Chen, S., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07895-4 · Cited by 14

Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity

Rattigan, K. M., Zarou, M. M., & Helgason, G. V. (2023) · Blood · doi:10.1182/blood.2022018258 · Cited by 16

Multi-platform-based characterization of ferroptosis in human colorectal cancer

Zhong, Y., Zhang, W., Yu, H., Lin, L., Gao, X., He, J., Li, D., Chen, Y., Zeng, Z., Xu, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104750 · Cited by 14

Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome

Zhang, X., Liu, J., Bai, C., Fan, Y., Song, H., Huang, Z., Li, Y., & Luo, T. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156777 · Cited by 15

Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets

Dominiak, A., Chełstowska, B., & Nowicka, G. (2025) · Cancers · doi:10.3390/cancers17142341 · Cited by 15

Targeting Ferroptosis as the Achilles’ Heel of Breast Cancer: Mechanisms and Therapeutic Opportunities from a Comprehensive Systematic Review

Szulc, A., & Woźniak, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209902 · Cited by 17

Amino acid-based biomaterials for modulation of cell behaviors: from mechanisms to biomedical applications

Liu, M., Chen, J., Li, H., Ma, Y., Xiao, Q., Ding, J., Li, J., & Chen, X. (2026) · Chemical Society Reviews · doi:10.1039/d5cs01504a · Cited by 15

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

Wang, Z., Li, B., Tang, P., Yan, F., Wang, S., Leng, G., Dawa, P., Chen, Y., Guo, Y., Yang, P., et al. (2026) · MedComm – Oncology · doi:10.1002/mog2.70068 · Cited by 14

Artemisia argyi H.Lév. & Vaniot essential oil induces ferroptosis in pancreatic cancer cells via up-regulation of TFR1 and depletion of γ-glutamyl cycle

Zhang, N., Zhang, J., Cui, W., Wu, D., Zhang, J., Wei, B., Qu, L., & Xu, X. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105522 · Cited by 13

Clinical Evaluation of the Pancreatic Cancer Microenvironment: Opportunities and Challenges

Szczepanski, J. M., Rudolf, M. A., & Shi, J. (2024) · Cancers · doi:10.3390/cancers16040794 · Cited by 15

Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies

Li, Y., Li, X., & Li, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1360638 · Cited by 15

Bifidobacterium longum GL001 alleviates rat intestinal ischemia–reperfusion injury by modulating gut microbiota composition and intestinal tissue metabolism

Tang, J., Zhao, M., Miao, X., Chen, H., Zhao, B., Wang, Y., Guo, Y., Wang, T., Cheng, X., Ruan, H., et al. (2024) · Food & Function · doi:10.1039/d3fo03669c · Cited by 13

A multi-mode Rhein-based nano-platform synergizing ferrotherapy/chemotherapy-induced immunotherapy for enhanced tumor therapy

Zhu, X., Xie, L., Tian, J., Jiang, Y., Song, E., & Song, Y. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.03.030 · Cited by 13

Relationship of mTORC1 and ferroptosis in tumors

Liao, H., Wang, Y., Zou, L., Fan, Y., Wang, X., Tu, X., Zhu, Q., Wang, J., Liu, X., & Dong, C. (2024) · Discover Oncology · doi:10.1007/s12672-024-00954-w · Cited by 14

Brucella rough RB51 infection activates P53-Slc7a11-Gpx4/GSH pathway to induce ferroptosis to attenuate the intracellular survival on macrophages

Hu, H., Zhang, G., Tian, M., Yin, Y. B., Bao, Y., Guan, X., Ding, C., & Yu, S. (2024) · Veterinary Microbiology · doi:10.1016/j.vetmic.2024.110224 · Cited by 13

NRF2 inhibits RSL3 induced ferroptosis in gastric cancer through regulation of AKR1B1

Li, X., Qian, J., Xu, J., Bai, H., Yang, J., & Chen, L. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114210 · Cited by 13

tRF-Gly-GCC in Atretic Follicles Promotes Ferroptosis in Granulosa Cells by Down-Regulating MAPK1

Pan, Y., Gan, M., Wu, S., He, Y., Feng, J., Jing, Y., Li, J., Chen, Q., Tong, J., Kang, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169061 · Cited by 13

MDH2 Promotes Hepatocellular Carcinoma Growth Through Ferroptosis Evasion via Stabilizing GPX4

Yu, W., Li, Y., Gao, C., Li, D., Chen, L., Dai, B., Yang, H., Han, L., Deng, Q., & Bian, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111604 · Cited by 13

Mitochondria-targeted ratiometric fluorescent imaging of cysteine

Wei, Y., Lin, B., Shu, Y., & Wang, J. (2021) · The Analyst · doi:10.1039/d1an00758k · Cited by 13

The Role of Ferroptosis Signature in Overall Survival and Chemotherapy of Pancreatic Adenocarcinoma

Wei, W., Hu, Q., Li, W., Li, M., Dong, S., Peng, Y., Yin, J., Lu, Y., Liu, L., & Zhao, Q. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0594 · Cited by 13

Protein tyrosine phosphatase 1 protects human pancreatic cancer from erastin-induced ferroptosis

Huang, X.-D., Xiao, F., Guo, Y., Sun, Y., Zhang, Y., & Shi, X.-J. (2022) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2021.11.048 · Cited by 13

Systematic toxicological analysis of the effect of salinity on the physiological stress induced by triphenyltin in Nile tilapia

Li, Z., Xing, S., Li, P., He, S., Cao, Z., Wang, X., Cao, X., Liu, B., & You, H. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106441 · Cited by 13

Role of ferroptosis in fibrosis diseases

Sun, Z., Zou, X., Bao, M., Huang, Z., Lou, Y., Zhang, Y., & Huang, P. C. (2023) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2023.04.024 · Cited by 14

Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway

Yang, Y., Zhang, Z., Wen, Y. C., Xiong, L., Huang, Y.-P., Wang, Y., & Liu, K. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i11.1668 · Cited by 13

Polyamines buffer labile iron to suppress ferroptosis

Sharma, P., Keys, H. R., Mansell, R. P., Stark, J., Girard, L., Ausler, C., Anderson, R., Müller, S., Imada, S., Pires, I. S., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.040 · Cited by 7

Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase

Lin, C., Lin, Y.-T., Chen, S.-Y., Setayeshpour, Y., Chen, Y., Dunn, D., Nguyen, T., Mestre, A. A., Banerjee, A., Guruprasad, L., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci190215 · Cited by 12

Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes

Tam, E., Reno, C., Nguyen, K. D., Cho, S., & Sweeney, G. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305167 · Cited by 11

A cascading-response fluorescent probe for real-time pH monitoring during cysteine-depletion process in pancreatic cancer cells

Qin, X., Zhang, S., Guo, X., Liu, X., & Shen, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1062781 · Cited by 12

TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response

Zhang, J., Sun, W., Yan, W., Kong, X., Shen, T., Laubach, K., Chen, M., & Chen, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-022-05529-7 · Cited by 12

Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus)

Wang, J., Chen, Y., Wang, X., Sun, Y., Jiang, M., Ye, Y., Wu, H., Lu, Y., Zhong, H., Wu, Y., et al. (2024) · Environmental Toxicology · doi:10.1002/tox.24276 · Cited by 12

Pancreatic ductal adenocarcinoma cells reshape the immune microenvironment: Molecular mechanisms and therapeutic targets

Zhao, Y., Qin, C., Chen, L., Li, Z., Zhao, B., Li, T., Zhang, X., & Wang, W. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189183 · Cited by 14

Therapeutic potential of synthetic and natural iron chelators against ferroptosis

Prabhune, N. M., Ameen, B., & Prabhu, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03640-4 · Cited by 15

Reconnoitering the role of Lipid Metabolites in Ferroptosis

Raju, M. V., Chandrasekaran, M. K., Ahalliya, R. M., & Kanniappan, G. V. (2024) · Advances in Redox Research · doi:10.1016/j.arres.2024.100117 · Cited by 12

Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment

Ravari, N. R., Sadri, F., Mahdiabadi, M. A., Mohammadi, Y., Ourang, Z., & Rezaei, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1522873 · Cited by 14

The intersection of ferroptosis and non-coding RNAs: a novel approach to ovarian cancer

Jiang, Y., Saeed, T. N., Alfarttoosi, K. H., Bishoyi, A. K., Rekha, M. M., Kundlas, M., Jain, B., Rizaev, J. A., Taher, W. M., Alwan, M., et al. (2025) · European journal of medical research · doi:10.1186/s40001-025-02559-7 · Cited by 13

Ferroptosis as an Emerging Target in Diabetic Osteoporosis

Li, C., Gong, H., Zhang, Y., Shi, P., Liu, S., & Zhang, Q. (2025) · The FASEB Journal · doi:10.1096/fj.202500415r · Cited by 13

Prognostication of Pancreatic Cancer Using The Cancer Genome Atlas Based Ferroptosis-Related Long Non-Coding RNAs

Li, J., Zhang, J., Tao, S., Hong, J., Zhang, Y., & Chen, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.838021 · Cited by 12

The Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends?

Tan, S., Kong, Y., Xian, Y., Gao, P., Xu, Y., Wei, C., Lin, P., Ye, W., Li, Z., & Zhu, X. M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.938677 · Cited by 14

Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer

Jiménez‐Alonso, J. J., Guillén-Mancina, E., Calderón‐Montaño, J. M., Jiménez-González, V., Díaz-Ortega, P., Burgos‐Morón, E., & López‐Lázaro, M. (2022) · Nutrients · doi:10.3390/nu14163378 · Cited by 12

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Cai, B., Luo, L., Chen, X., Zhao, X., He, J., Chen, H., Wan, P., Chen, D., & Pan, J. (2023) · Food & Function · doi:10.1039/d3fo00009e · Cited by 12

Protective Effect of Compound Tongluo Decoction on Brain Vascular Endothelial Cells after Ischemia‐Reperfusion by Inhibition of Ferroptosis Through Regulating Nrf2/ARE/SLC7A11 Signaling Pathway

Li, P., Wang, Z., Zhao, T. T., Cheng, X., Zhang, Z., Wang, J., Wang, S., Huang, R., & Hui, Z. (2023) · Advanced Biology · doi:10.1002/adbi.202300416 · Cited by 12

Temporal regulation of genetic programs governing multiple cell death during myocardial ischemia-reperfusion injury

Pang, Q., Meng, X., Zhou, Z., You, L., Yuan, J., Feng, Q., & Zhu, B. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1632867 · Cited by 12

Analyte-Induced p K a -Tunable Hemicyanine Dual-Locked Molecular Platform for In Vivo Tumor Precision Imaging

Lv, Z., Huang, J., Wang, J., Xu, J., Feng, H., Shen, X., & Chen, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06353 · Cited by 11

Discovery of the cysteine dynamics during the development and treatment of diabetic process by fluorescent imaging

Wang, K., Yao, K., Chen, X., Wen, D.-K., Qin, Y., Hu, Z.-G., & Yang, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102660 · Cited by 11

Protocol of CRISPR-Cas9 knockout screens for identifying ferroptosis regulators

Yang, X. P., Duan, S., Li, Z., Wang, Z., Kon, N., Zhang, Z., & Gu, W. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102762 · Cited by 11

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

Yu, D., Liang, J., Widlund, H. R., & Puigserver, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114484 · Cited by 11

Circ_BBS9 as an early diagnostic biomarker for lung adenocarcinoma: direct interaction with IFIT3 in the modulation of tumor immune microenvironment

Peng, D., Liang, M., Li, L., Yang, H., Fang, D., Chen, L., & Guan, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1344954 · Cited by 11

A glutathione-activatable near-infrared fluorescent probe with a large Stokes shift for imaging 4T1 tumor and its ferroptosis

Han, L., Wu, S.-P., Yang, J.-H., Mao, G., Chen, T., Wang, Q., & Zhang, G. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.111658 · Cited by 11

Fighting ischemia-reperfusion injury: Focusing on mitochondria-derived ferroptosis

Tian, L., Liu, Q., Guo, H. W., Zang, H., & Li, Y. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101974 · Cited by 15

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Zhang, Z., Xu, H., He, J., Hu, Q., Liu, Y., Xu, Z., Lou, W., Wu, W., Zhang, L., Pu, N., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07330-8 · Cited by 14

Based on GSH aggregating AIE and disaggregating ACQ to achieve non-competitive discriminative detection of Cys and GSH in living cells

Huang, P., Zhang, W., Huo, F., & Yin, C. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111163 · Cited by 11

Ferroptosis: the potential key roles in idiopathic pulmonary fibrosis

Song, L., Fusheng, G., & Man, J. (2025) · European journal of medical research · doi:10.1186/s40001-025-02623-2 · Cited by 11

D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione

Homma, T., Osaki, T., Kobayashi, S., Sato, H., & Fujii, J. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-143 · Cited by 11

TRPM4 and TRPV2 are two novel prognostic biomarkers and promising targeted therapy in UVM

Wang, J., Qiao, S., Liang, S., Qian, C., Dong, Y., Pei, M., Wang, H., & Wan, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.985434 · Cited by 11

Progress in the study of ferroptosis in cancer treatment: State-of-the-Art

Wang, D. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110348 · Cited by 11

Endogenous cysteine fluorescence monitoring and its deployment in tumour demarcation

Yue, Y., Zhao, T., Ma, K., Huo, F., & Yin, C. (2022) · Chemical Communications · doi:10.1039/d1cc06765f · Cited by 11

Nanotechnology for tumor ferroptosis

Wang, Z., Xu, H., Li, M., Lei, S., Cai, Y., Wu, Y., Lin, J., & Huang, P. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100222 · Cited by 10

Ferroptosis: New Strategies and Ideas for the Treatment of Pancreatic Ductal Adenocarcinoma

Yang, C., Dong, Q., Bao, H., Ge, Y., Xu, Z., Li, J., Jiang, X., Xu, Y., & Zhong, X. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2901045 · Cited by 12

Mechanism of targeting the mTOR pathway to regulate ferroptosis in NSCLC with different EGFR mutations

Wu, C., Zhong, R., Wei, T., Jin, Y., He, C., Li, H., & Cheng, Y. (2024) · Oncology Letters · doi:10.3892/ol.2024.14431 · Cited by 13

Cyclopeptide RA-V from Rubia yunnanensis restores activity of Adagrasib against colorectal cancer by reducing the expression of Nrf2

Jiang, Z.-Z., Ye, S.-Q., Wu, Y., Zhou, C., Cao, F., & Tan, N. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107252 · Cited by 12

CircCOL5A1 is involved in proliferation, invasion, and inhibition of ferroptosis of colorectal cancer cells via miR‐1287‐5p/SLC7A11

Wang, J., Zhang, Z., Zhuang, J., Kang, D., & Song, W. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23772 · Cited by 11

Emerging role of tumor microenvironmental nutrients and metabolic molecules in ferroptosis: Mechanisms and clinical implications

Li, D., Zhang, Z., & Wang, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117406 · Cited by 10

Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK

Yang, D., Yang, D., Song, Y. W., Liu, J., Wang, Y., Feng, X., Zeng, X., Chen, Q., Li, J., & Dan, H. (2024) · Journal of Dental Research · doi:10.1177/00220345241280257 · Cited by 10

Reciprocal regulation between ferroptosis and STING-type I interferon pathway suppresses head and neck squamous cell carcinoma growth through dendritic cell maturation

Li, M., Jin, S., Ma, H., Yang, X., & Zhang, Z. (2025) · Oncogene · doi:10.1038/s41388-025-03368-2 · Cited by 14

ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction

Jin, J. J., Dong, Y., Huang, Y., Wu, L., Yu, L., Sun, Y., Zhou, Q., Yin, H., & Gu, W. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05005-1 · Cited by 10

Transcriptomic analysis reveals that selenium-enriched Lactobacillus plantarum alleviates high -salinity stress in common carp through lipid metabolism and ferroptosis signalling pathways

Shang, X., Che, X., Geng, L., Zhang, Q., Wei, H., Li, W., Shi, X., & Xu, W. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118690 · Cited by 12

Quinazolinone derivatives as potential anti‑tumor agents: Structural features and molecular mechanisms in inducing cell death (Review)

Li, J., Yang, Y., Wang, L., Liu, Q., Kang, X., & Yang, Y. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5646 · Cited by 10

PGM3 inhibition shows cooperative effects with erastin inducing pancreatic cancer cell death via activation of the unfolded protein response

Zerbato, B., Gobbi, M., Ludwig, T., Brancato, V., Pessina, A., Brambilla, L., Wegner, A., & Chiaradonna, F. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1125855 · Cited by 10

Prediction of Prognosis and Chemotherapeutic Sensitivity Based on Cuproptosis-Associated lncRNAs in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Zhou, J., Xu, L., Zhou, H. H., Wang, J., & Xing, X. (2023) · Genes · doi:10.3390/genes14071381 · Cited by 10

Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma

Ali, A. H., Chianese, U., Papulino, C., Toraldo, A., Abakar, M. E. A., Passaro, E., Cennamo, R., Gaudio, N. D., Altucci, L., & Benedetti, R. (2022) · Cancers · doi:10.3390/cancers14153799 · Cited by 10

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexiaPreprint

Ferrer, M., Mourikis, N., Davidson, E. E., Kleeman, S. O., Zaccaria, M., Habel, J., Rubino, R., Flint, T. R., Connell, C. M., Lukey, M. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.17.528937 · Cited by 10

KCNA1 promotes the growth and invasion of glioblastoma cells through ferroptosis inhibition via upregulating SLC7A11

Wang, W., Zhang, Y., Li, X., Qinzi, E., Jiang, Z., Shi, Q., Huang, Y., Wang, J., & Huang, Y. (2024) · Cancer Cell International · doi:10.1186/s12935-023-03199-9 · Cited by 9

Hijacking cysteine metabolism for reversing hydrogen sulfide production in enhanced ferroptosis therapy

Xu, X., Wang, F., Luo, R., & Lei, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151774 · Cited by 9

Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

Yamauchi, T., Okano, Y., Terada, D., Yasukochi, S., Tsuruta, A., Tsurudome, Y., Ushijima, K., Matsunaga, N., Koyanagi, S., & Ohdo, S. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00352-4 · Cited by 9

Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8+ T cells

Qin, T., Chen, C., Lu, J., Zheng, X., Zhai, X., Yang, Y., Zhao, Z., Hao, J., Yang, K., Ye, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1490845 · Cited by 9

Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells

Wang, X., Zhang, T., Wang, S., Shi, H., Dong, H. Y., Huang, Y., Lai, W., Hu, Y., & Yue, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03117-3 · Cited by 9

Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches

Zhou, X., Tian, L., Xiong, W., Li, Y., & Liu, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1568246 · Cited by 9

Ferroptosis-mediated immune responses in osteoporosis

Wang, X., Yike, W., Gongwen, L., & Xu, Y. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.011 · Cited by 11

Integrating network pharmacology and transcriptomics reveals that Bushen Huoxue recipe ameliorates ferroptosis and apoptosis in granulosa cells by regulating PI3K/Akt signaling pathway in premature ovarian insufficiency mice

Huang, Y., Zhu, M., Zhang, Z., Liu, Z., Li, F., Hu, R., Geng, Y., Song, Y., Ma, W., Dong, H., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120057 · Cited by 9

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Li, M., Yu, X., Liu, Y., Ouyang, S., Wu, L., Chen, X., Yu, H. J., Chen, H., Lian, S., Li, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202504470 · Cited by 9

MicroRNAs at the crossroads of exercise and ferroptosis: a regulatory bridge

Lin, Z. J., & Feng, Z. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01766-0 · Cited by 11

High temperatures and antibacterial plant additives change the fermentation quality, free amino acids and lactic acid bacteria fermentation type in Caragana Korshinskii silage

Zhou, T., Lei, X., Luo, Y., Ou, Y., Tian, S., Xie, Y., Zheng, Y., Sun, H. Y., & Yang, F. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04153-7 · Cited by 10

Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy

Zhou, Z., Cai, Y., Yuan, H., Chen, Q., Zhao, S. W., Yang, J., Liu, M., Arreola, A. X., Ren, Y., Xu, C., et al. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0268 · Cited by 10

Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communication

Sorokin, O., Hause, F., Wedler, A., Alakhras, T., Bauchspiess, T., Dietrich, A., Günther, W. F., Guha, C., Obika, K. B., Kraft, J., et al. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02161-6 · Cited by 14

Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis

Huang, H., van Sligtenhorst, M., de Vries-Smits, A. M. M., Gulersonmez, C. M. C., Stigter, E. C. A., Dansen, T. B., & Burgering, B. M. T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02760-x · Cited by 10

Deep-NIR to NIR-II hemicyanine fluorophore scaffolds with dual optically tunable sites for in vivo multiplexed imaging

Liu, Q., Li, Z., Huang, Y., Lin, Z., Shen, X., & Chen, H. (2025) · Chemical Science · doi:10.1039/d5sc06690e · Cited by 9

Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations

Hafner, P., Keller, S. J., Chen, X., Alrawashdeh, A. Y., Jumaa, H., Nollmann, F. I., Besson, S., Kemming, J., Gorka, O., Das, T., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02563-7 · Cited by 10

Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment

Ma, J., Bhardwaj, V., Lobie, P. E., & Pandey, V. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02620-x · Cited by 10

Ferroptotic cell death and cancer

Kiberstis, P. A. (2020) · Science · doi:10.1126/science.368.6486.42-m · Cited by 1

Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer

(2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2020-054 · Cited by 2

“Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import”Preprint

Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/827972 · Cited by 2

Abstract 5711: Therapeutic induction of tumor-selective ferroptosis in models of pancreatic cancer

Badgley, M. A., DelGiorno, K. E., Wahl, G. M., Lyssiotis, C. A., & Olive, K. P. (2020) · Cancer Research · doi:10.1158/1538-7445.am2020-5711

The critical role of cysteine import and metabolism in pancreatic cancer

Badgley, M. A. (2017) · doi:10.7916/d8db8dhx