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Melatonin and ferroptosis: Mechanisms and therapeutic implications

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ARID3A enhances chemoresistance of pancreatic cancer via inhibiting PTEN-induced ferroptosis

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Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies

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Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

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Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters

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Unexpected dual-functional cyanine fluorophores: NIR multifunctional fluorescent probes for simultaneous monitoring of mitochondrial cysteine /viscosity during kidney ferroptosis in vivo

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Ferroptosis resistance in cancer: recent advances and future perspectives

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m6A-driven NAT10 translation facilitates fatty acid metabolic rewiring to suppress ferroptosis and promote ovarian tumorigenesis through enhancing ACOT7 mRNA acetylation

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PD-L1 protects tumor-associated dendritic cells from ferroptosis during immunogenic chemotherapy

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Cancer metabolism and dietary interventions

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Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy

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Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

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High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer

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Membrane transporters in cell physiology, cancer metabolism and drug response

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Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds

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Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

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Recent advances in the development of metallodrugs for cancer chemoimmunotherapy

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Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

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SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment

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Menin‑MLL inhibitors induce ferroptosis and enhance the anti‑proliferative activity of auranofin in several types of cancer cells

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The DUBA-SLC7A11-c-Myc Axis is Critical for Stemness and Ferroptosis

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Nanoscintillator‐Mediated X‐Ray‐Triggered Boosting Transformation of Fe3+ into Fe2+ for Enhancing Tumor Ferroptosis/Immunotherapy

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Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro

Tang, J., Zeng, J., Chen, L., Wang, M., He, S., Muhmood, A., Chen, X., Huang, K., & Gan, F. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04560 · Cited by 36

Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer Radiotherapy

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Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway

Yuan, C., Fan, R., Zhu, K., Wang, Y., Xie, W., & Liang, Y. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231220670 · Cited by 36

Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology

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Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers

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Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids

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PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

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The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer

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DNA damage and metabolic mechanisms of cancer drug resistance

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Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis

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Suppression of the SLC7A11/glutathione axis causes ferroptosis and apoptosis and alters the mitogen-activated protein kinase pathway in nasopharyngeal carcinoma

Wang, H., Fan, S., Zhan, Y., Peng, S., & Wang, W. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127976 · Cited by 35

ER remodeling via lipid metabolism

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NIR Fluorescent/Photoacoustic Bimodal Imaging of Ferroptosis in Pancreatic Cancer Using Biothiols-Activable Probes

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Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila

Davidson, A. J., Heron, R., Das, J., Overholtzer, M., & Wood, W. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01450-7 · Cited by 41

Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer

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HDAC6 inhibitors sensitize non-mesenchymal triple-negative breast cancer cells to cysteine deprivation

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Oxidase Mimic Graphdiyne for Efficient Superoxide Generation in Wide pH Ranges

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The dark side of ferroptosis in pancreatic cancer

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Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency

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From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

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Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma

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Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells

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Ferroptosis As Ultimate Target of Cancer Therapy

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Glutamine deprivation induces ferroptosis in pancreatic cancer cells

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METTL9-SLC7A11 axis promotes hepatocellular carcinoma progression through ferroptosis inhibition

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A single mitochondria-targetable fluorescent probe for visualizing cysteine and glutathione in ferroptosis of myocardial ischemia/reperfusion injury

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Unique assembly of carbonylpyridinium and chromene reveals mitochondrial thiol starvation under ferroptosis and novel ferroptosis inducer

Ma, K., Yang, H., Shen, T., Yue, Y., Zhao, L., Liu, X., Huo, F., & Yin, C. (2022) · Chemical Science · doi:10.1039/d2sc00328g · Cited by 33

Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF /Nrf2/ HO ‐1 signaling, the microbiota‐gut‐brain axis, and hippocampal neuron ferroptosis

Ji, C., Guo, P., Han, M., Chen, K., Qin, J., & Yang, F. (2023) · Phytotherapy Research · doi:10.1002/ptr.7807 · Cited by 33

The Ubiquitin–Proteasome System in Tumor Metabolism

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Dehydroascorbic acid sensitizes cancer cells to system xc- inhibition-induced ferroptosis by promoting lipid droplet peroxidation

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Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations

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A guide to ferroptosis in cancer

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Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis

Shen, X., Chen, Y., Tang, Y., Lu, P., Liu, M., Mao, T., Weng, Y., Yu, F., Liu, Y., Tang, Y., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101928 · Cited by 33

MOMP: A critical event in cell death regulation and anticancer treatment

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A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer

Yan, Y., Cai, J., Huang, Z., Cao, X., Tang, P., Wang, Z., Zhang, F., Xia, S., & Shen, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.712230 · Cited by 33

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, A. N., Golán, I., Campisano, S., Gélabert, C., Moustakas, A., Sancho, P., & Caja, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.723798 · Cited by 33

Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)

Zuzčák, M., & Trnka, J. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5383 · Cited by 33

Dynamic Ginsenoside-Sheltered Nanocatalysts for Safe Ferroptosis-Apoptosis Combined Therapy

Zhao, X., Wu, J., Guo, D., Hu, S., Chen, X. '., Hong, L., Wang, J., Ma, J., Jiang, Y., Niu, T., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.026 · Cited by 32

Ferroptosis: Shedding Light on Mechanisms and Therapeutic Opportunities in Liver Diseases

You, H., Wang, L., Bu, F., Meng, H., Huang, C., Fang, G.-Y., & Li, J. (2022) · Cells · doi:10.3390/cells11203301 · Cited by 33

A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022

Miao, Y., Quan, W., Dong, X., Gan, J., Ji, C.-F., Wang, J., & Zhang, F. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01421-1 · Cited by 33

A biomimetic nanoreactor for combinational chemo/chemodynamic therapy of choriocarcinoma through synergistic apoptosis and ferroptosis strategy

Yu, H., Zhao, H., Zhang, Y., Hou, Y., Li, R., Li, C., Zhang, M., Li, C., Zhao, J., Zhang, M., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.144690 · Cited by 32

CD98 heavy chain as a prognostic biomarker and target for cancer treatment

Pu, X., & Dubrovska, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1251100 · Cited by 35

Multiple myeloma with high expression of SLC7A11 is sensitive to erastin-induced ferroptosis

Zhang, W., Li, Q., Zhang, Y., Wang, Z., Yuan, S., Zhang, X., Zhao, M., Zhuang, W., & Li, B.-Z. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01909-2 · Cited by 31

The crosstalk between oncogenic signaling and ferroptosis in cancer

Pang, Q., Tang, Z., & Luo, L. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104349 · Cited by 32

Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy

Gao, J., Zhang, X., Liu, Y., & Gu, X. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.007 · Cited by 34

Programmed cell death network in cancer drug resistance: A framework for therapeutic intervention

Guo, D., Guo, Y., Zhu, C., Liao, Y., Lin, Z., Zhang, H., Zhang, W., & Zou, Z. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101387 · Cited by 36

High expression of the ferroptosis‐associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma

Yan, J., Ye, G., & Shao, Y. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24317 · Cited by 31

Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis

Qiu, C., Liu, T., Luo, D., Luan, D., Cheng, L., & Wang, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.746030 · Cited by 33

Mitochondrial regulatory mechanisms in spinal cord injury: A narrative review

Chengjiang, L., Liu, Y., Ma, B., Zhou, M., Zhao, X., Fu, X., Kan, S.-L., Hu, W., & Zhu, R. (2022) · Medicine · doi:10.1097/md.0000000000031930 · Cited by 31

Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy

Bao, J., Yan, Y., Zuo, D., Zhuo, Z., Sun, T., Lin, H., Han, Z., Zhao, Z., & Yu, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1178573 · Cited by 33

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Mao, Z., Gao, Z., Pan, S.-K., Liu, D., Liu, Z., & Wu, P. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02000-8 · Cited by 30

Targeting Metabolic–Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy

Wang, Y., He, J., Lian, S., Zeng, Y., He, S., Xu, J., Luo, L., Yang, W., & Jiang, J. (2024) · Antioxidants · doi:10.3390/antiox13070828 · Cited by 32

Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer

Li, Y., Liu, C.-Y., Fang, B., Chen, X., Wang, K., Xin, H., Yang, S., & Yang, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05881-6 · Cited by 33

Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation

Gu, L., Sun, Y., Bai, T., Shao, S., Tang, S., Xue, P., Cai, W., Qin, X., Zeng, X., & Yan, S. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03284-3 · Cited by 34

Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer

Amrutkar, M., & Gladhaug, I. P. (2021) · Cancers · doi:10.3390/cancers13040601 · Cited by 31

Reduction-sensitive polymeric micelles as amplifying oxidative stress vehicles for enhanced antitumor therapy

Xia, H., Liang, Y., Chen, K., Guo, C., Wang, M., Cao, J., Han, S., Ma, Q., Sun, Y., & He, B. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111733 · Cited by 30

Ferroptosis Meets Cell–Cell Contacts

Dietrich, C., & Hofmann, T. G. (2021) · Cells · doi:10.3390/cells10092462 · Cited by 30

Mechanisms of ferroptosis in chronic kidney disease

Zhuo, W.-Q., Wen, Y., Luo, H., Luo, Z., & Wang, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.975582 · Cited by 29

New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke

Wei, Z., Xie, Y., Wei, M., Zhao, H., Ren, K., Feng, Q., & Xu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1020918 · Cited by 34

Ferroptosis: A New Promising Target for Ovarian Cancer Therapy

Zhao, H., Xu, Y., & Shang, H. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.76480 · Cited by 30

Ferroptosis: A New Mechanism in Diabetic Cardiomyopathy

Song, Z., Wang, J., & Zhang, L. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.88476 · Cited by 30

Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation

Zhi, S., Cui, Y., Liu, Y., Zhang, J., Li, X.-J., Sheng, B., Chen, X.-X., Yan, C., Li, W., Mao, J.-N., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155940 · Cited by 30

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

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Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis

Wang, Y., Peng, X., Zhang, M., Jia, Y., Yu, B., & Tian, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9738143 · Cited by 30

Molecular Therapeutics of Pancreatic Ductal Adenocarcinoma: Targeted Pathways and the Role of Cancer Stem Cells

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Downregulation of Cx43 reduces cisplatin-induced acute renal injury by inhibiting ferroptosis

Yu, M., Lin, Z., Tian, X., Chen, S., Liang, X., Qin, M., Zhu, Q., Wu, Y., & Zhong, S. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112672 · Cited by 29

The Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer

Wang, Y., Huang, Z., Li, B., Liu, L., & Huang, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.863541 · Cited by 30

Fe/Ni layered double hydroxide biocatalysts inhibit tumor growth through ROS and ferroptosis signaling pathway

Pan, Q., Lin, F., Liu, R., Li, Y., Zhang, X., Luo, R., Cai, L., Liu, Y., Deng, W., & He, L. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.142962 · Cited by 30

Mitochondrial Regulation of Ferroptosis in Cancer Therapy

Cheng, X., Zhang, J., Xiao, Y., Wang, Z., He, J., Ke, M., Liu, S., Wang, Q., & Zhang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210037 · Cited by 29

Organic Selenium induces ferroptosis in pancreatic cancer cells

Noè, R., Inglese, N., Romani, P., Serafini, T., Paoli, C., Calciolari, B., Fantuz, M., Zamborlin, A., Surdo, N. C., Spada, V., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102962 · Cited by 30

Advances in Nanodelivery Systems Based on Metabolism Reprogramming Strategies for Enhanced Tumor Therapy.

Zhang, Z.-Q., Liang, X.-Y., Yang, X., Liu, Y., Zhou, X., & Li, C.-H. (2024) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.3c15686 · Cited by 26

Metal ions-anchored bacterial outer membrane vesicles for enhanced ferroptosis induction and immune stimulation in targeted antitumor therapy

Sun, Y., Ma, Y., Shangguan, S., Ruan, Y., Bai, T., Xue, P., Zhuang, H., Cao, W., Cai, H., Tang, E., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02747-3 · Cited by 28

Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy

Sahoo, S. S., & Manna, D. (2025) · Small · doi:10.1002/smll.202412462 · Cited by 28

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Shi, X., Li, Q., Zhang, C., Pei, H., Wang, G., Zhou, H., Fan, L., Yang, K., Jiang, B., Wang, F., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01083-0 · Cited by 28

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

Almeida‐Silva, J., Menezes, D., Fernandes, J. M. P., de Almeida, M. C., Vasco-dos-Santos, D. R., Saraiva, R. M., Viçosa, A. L., Perez, S. A. C., Andrade, S. G., Suarez-Fontes, A. M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.926699 · Cited by 30

Current insights into the regulation of programmed cell death by TP53 mutation in cancer

Su, Y., Sai, Y., Zhou, L., Liu, Z., Du, P., Wu, J., & Zhang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1023427 · Cited by 29

Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine

Wang, H., Wen, N., Li, P., Xiu, T., Shang, S., Zhang, W., Zhang, W., Qiao, J., & Tang, B. (2023) · Talanta · doi:10.1016/j.talanta.2023.125532 · Cited by 28

Ferroptotic cell death and cancer

Kiberstis, P. A. (2020) · Science · doi:10.1126/science.368.6486.42-m · Cited by 1

Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer

(2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2020-054 · Cited by 2

“Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import”Preprint

Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/827972 · Cited by 2

Abstract 5711: Therapeutic induction of tumor-selective ferroptosis in models of pancreatic cancer

Badgley, M. A., DelGiorno, K. E., Wahl, G. M., Lyssiotis, C. A., & Olive, K. P. (2020) · Cancer Research · doi:10.1158/1538-7445.am2020-5711

The critical role of cysteine import and metabolism in pancreatic cancer

Badgley, M. A. (2017) · doi:10.7916/d8db8dhx