REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
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Abstract
A beneficial cocktail: Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics. Studies in humanized mice and convalescent humans led to the development of a cocktail of two potent antibodies that simultaneously bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent the virus from entering host cells. Baum et al. evaluated the efficacy of this cocktail, REGN-COV2, in rhesus macaques, which may model mild disease, and in golden hamsters, which present more severe symptoms. The antibody cocktail provided benefits in both models when administered either prophylactically or therapeutically and is currently in clinical trials. Science , this issue p. 1110
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The frequency distributions of human IGVK and IgVL genes differed significantly between vaccinees and the Sequence Read Archive dataset SRP010970.
“Two-sided binomial tests with unequal variance were used to compare the frequency distributions., significant differences are denoted with stars (* p < 0.05, ** p < 0.01, *** p < 0.001, **** = p < 0.0001).”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [65]
Passive transfer of nAbs limits respiratory tract infection and protects against infection in animal models.
“passive transfer of nAbs limits respiratory tract infection and protects against infection in animal models (16–20)”
From mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection (2021) · cites this paper as [19]
Passive transfer of neutralizing antibodies before SARS-CoV-2 exposure can prevent or limit upper respiratory tract infection, lung infection, and symptomatic disease in animal models.
“passive transfer of neutralizing antibodies in advance of SARS-CoV-2 infection (mimicking the conditions of 2° infection) can effectively prevent or limit URT infection, lung infection, and symptomatic disease in animal models”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Baum et al., 2020
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- Authors
- Baum, A., Ajithdoss, D., Copin, R., Zhou, A., Lanza, K., Negron, N., Ni, M., Wei, Y., Mohammadi, K., Musser, B., Atwal, G. S., Oyejide, A., Goez-Gazi, Y., Dutton, J., Clemmons, E., Staples, H. M., Bartley, C., Klaffke, B., Alfson, K., Gazi, M., Gonzalez, O., Dick, E., Carrion, R., Pessaint, L., Porto, M., Cook, A., Brown, R., Ali, V., Greenhouse, J., Taylor, T., Andersen, H., Lewis, M. G., Stahl, N., Murphy, A. J., Yancopoulos, G. D., & Kyratsous, C. A.
- Affiliations
- Regeneron (United States) (US)
- Texas Biomedical Research Institute (US)
- Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.
- Bioqual (US)
- BIOQUAL, Rockville, MD 20850, USA.
- Corresponding author
- Kyratsous, Christos A.
- ORCID
- Baum, Alina
- Ajithdoss, Dharani
- Copin, Richard
- Zhou, Anbo
- Ni, Min
- Wei, Yi
- Mohammadi, Kusha
- Musser, Bret
- Atwal, Gurinder S.
- Oyejide, Adelekan
- Dutton, John
- Clemmons, Elizabeth
- Staples, Hilary M.
- Bartley, Carmen
- Alfson, Kendra
- Gonzalez, Olga
- Dick, Edward
- Carrion, Ricardo
- Pessaint, Laurent
- Porto, Maciel
- Cook, Anthony
- Brown, Renita
- Ali, Vaneesha
- Greenhouse, Jack
- Taylor, Tammy
- Andersen, Hanne
- Lewis, Mark G.
- Stahl, Neil
- Murphy, Andrew J.
- Kyratsous, Christos A.
- Venue
- Science
- Published
- 2020-11-27
- Volume
- 370
- Issue
- 6520
- Pages
- 1110-1115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7857396
- OpenAlex
- W3092503590
- Cited by
- 517
- References
- 38
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 42 · 2023: 60 · 2022: 110 · 2021: 237 · 2020: 39
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Biomedical Advanced Research and Development Authority (HHSO100201700020C)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- neutralizing antibodies, SARS-CoV-2, COVID-19 pandemic, antibody therapy, prophylaxis, treatment efficacy, rhesus monkeys, golden hamster, spike protein epitopes, viral load, pneumonia, animal model of COVID-19
- MeSH terms
- COVID-19, Animals, Drug Combinations, Macaca mulatta, Mesocricetus, Antibodies, Neutralizing, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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