Cited by 518SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studiesvaccines and immunoinformatics approaches

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Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera

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Muik, Alexander, Wallisch, Ann-Kathrin, Sänger, Bianca, Swanson, Kena A., Mühl, Julia, Chen, Wei, Cai, Hui, Maurus, Daniel, Sarkar, Ritu, Türeci, Özlem, Dormitzer, Philip R., Şahin, Uğur·2021·Science

DOI 10.1126/science.abg6105PMC PMC7971771

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Abstract

Vaccine protects against B1.1.7 variant: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B1.1.7 (VOC 202012/01) variant that emerged in late 2020 in the United Kingdom has many changes in the spike protein gene. Three of these are associated with enhanced infectivity and transmissibility, and there are concerns that B.1.1.7 might compromise the effectiveness of the vaccine. Muik et al. compared the neutralization efficacy of sera from 40 subjects immunized with the BioNTech-Pfizer mRNA vaccine BNT162b2 against a pseudovirus bearing the Wuhan reference strain or the lineage B.1.1.7 spike protein (see the Perspective by Altmann et al. ). Serum was derived from 40 subjects in two age groups 21 days after the booster shot. The vaccine remained effective against B.1.1.7 with a slight but significant decrease in neutralization that was more apparent in participants under 55 years of age. Thus, the vaccine provides a significant “cushion” of protection against this variant. Science , this issue p. 1152 ; see also p. 1103

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Method
Early effectiveness of COVID-19 vaccination with BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector vaccine on symptomatic disease, hospitalisations and mortality in older adults in England
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“This is supported by recent evidence that sera from vaccinated individuals elicits equivalent neutralising titres to VOC 202012/01 and similar variants to that seen with previous strains.(32, 33)”
Result
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes
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Self-citation
Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals
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Self-citation
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Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?
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Immunity to SARS-CoV-2 variants of concern
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SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera
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Two Years into the COVID-19 Pandemic: Lessons Learned
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Antibody and B cell responses to SARS-CoV-2 infection and vaccination
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Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination
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mRNA-Based Vaccines
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“While it is reassuring that mRNA-1273 and BNT162b2 vaccines provide protection against these two emerging SARS-CoV-2 variants, it is equally reassuring to know that the flexibility provided by mRNA-based vaccine technology enables the periodic reformulation of vaccines so that they better match circulating viral varia…”
Background
The emerging SARS-CoV-2 variants of concern
Sanyaolu, A. O., Okorie, C., Marinkovic, A., Haider, N., Abbasi, A. F., Jaferi, U., Prakash, S., & Balendra, V. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211024372 · Cited by 122
Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum
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Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike
Tong, P., Gautam, A. K., Windsor, I. W., Travers, M. E., Chen, Y., Garcia, N., Whiteman, N. B., McKay, L. G. A., Storm, N., Malsick, L. E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.025 · Cited by 115
“…to early and relatively homogeneous variants circulating well before emergence of the B.1.1.7 and B.1.351 strains first reported in December 2020, and probably before the spread in New England of the D614G variant that did not substantially alter antigenicity (Muik et al., 2021; Xie et al., 2021).”
Influential
Emerging SARS-CoV-2 Variants of Concern (VOCs): An Impending Global Crisis
Thye, A. Y.-K., Law, J. W., Pusparajah, P., Letchumanan, V., Chan, K., & Lee, L. (2021) · Biomedicines · doi:10.3390/biomedicines9101303 · Cited by 121
“7 is mostly complete without adverse effects from current vaccines is also consistent with several other studies [79,159,160].”
BackgroundResult
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
Zhou, Y., Xie, Y., Tang, L., Pu, D., Zhu, Y., Liu, J., & Ma, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00733-x · Cited by 116
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Mengist, H. M., Kombe, A. J. K., Mekonnen, D. S., Abebaw, A., Getachew, M., & Jin, T. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101533 · Cited by 115
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
Caniels, T. G., Bontjer, I., van der Straten, K., Poniman, M., Burger, J. A., Appelman, B., Lavell, A. H. A., Oomen, M., Godeke, G.-J., Valle, C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj5365 · Cited by 107
mRNA vaccines for COVID-19 and diverse diseases
Hussain, A., Yang, H., Zhang, M., Liu, Q., Alotaibi, G., Irfan, M. F., He, H., Chang, J. K., Liang, X., Weng, Y., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.032 · Cited by 121
Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants
Gushchin, V. А., Dolzhikova, I. V., Shchetinin, A. M., Odintsova, A. S., Siniavin, A. E., Nikiforova, M. A., Pochtovyi, A. A., Shidlovskaya, E. V., Kuznetsova, N. A., Burgasova, O., et al. (2021) · Vaccines · doi:10.3390/vaccines9070779 · Cited by 110
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“7 had little effect on sera from 16 subjects who received Pfizer vaccine injections [91].”
Background
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants
Ikegame, S., Siddiquey, M. N. A., Hung, C.-T., Haas, G. D., Brambilla, L., Oguntuyo, K. Y., Kowdle, S., Chiu, H.-P., Stevens, C. S., Vilardo, A. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24909-9 · Cited by 141
The Emerging Concern and Interest SARS-CoV-2 Variants
Janik, E., Niemcewicz, M., Podogrocki, M., Majsterek, I., & Bijak, M. (2021) · Pathogens · doi:10.3390/pathogens10060633 · Cited by 113
CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
Redd, A. D., Nardin, A., Kared, H., Bloch, E. M., Pekosz, A. S., Laeyendecker, O. B., Abel, B., Fehlings, M., Quinn, T. C., & Tobian, A. A. R. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab143 · Cited by 105
Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host
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“The neutralizing activity of vaccine-elicited sera against pseudoviruses carrying E484K, N501Y, and K417N/E484K/N501Y cluster has been found to be decreased (85).”
Background
COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions
Khan, W. H., Hashmi, Z., Goel, A., Ahmad, R., Gupta, K., Khan, N., Alam, I., Ahmed, F., & Ansari, M. A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.690621 · Cited by 105
“…convalescent and postvaccination sera (Arif, 2021; CDC, 2021b; Collier et al., 2021; Edara et al., 2021; Emary et al., 2021; Galloway et al., 2021; Muik et al., 2021; Ostrov, 2021; Planas et al., 2021; Shen et al., 2021; Wang et al., 2021a; Wu et al., 2021) VOC GH/ 501Y.V2 (B.1.351) South…”
Influential

Authors: Muik, A., Wallisch, A.-K., Sänger, B., Swanson, K. A., Mühl, J., Chen, W., Cai, H., Maurus, D., Sarkar, R., Türeci, Ö., Dormitzer, P. R., & Şahin, U.
Affiliations: BioNTech (Germany) (DE)
Pfizer (United States) (US)
Johannes Gutenberg University Mainz (DE)
Corresponding author: Şahin, Uğur
ORCID: Muik, Alexander
Wallisch, Ann-Kathrin
Sänger, Bianca
Swanson, Kena A.
Mühl, Julia
Chen, Wei
Cai, Hui
Maurus, Daniel
Türeci, Özlem
Dormitzer, Philip R.
Şahin, Uğur
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2021-03-12
Volume: 371
Issue: 6534
Pages: 1152-1153
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.abg6105
PMC: PMC7971771
OpenAlex: W3123108673
Semantic Scholar: a28b6633cf65c49f1251702b8e3e3c1b85e19236
Cited by: 515
References: 12
Citations by year: 2026: 4 · 2025: 8 · 2024: 17 · 2023: 34 · 2022: 152 · 2021: 298
FWCI: 39.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Science (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Pfizer
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords: SARS-CoV-2, B.1.1.7 lineage, BNT162b2, mRNA vaccines, neutralizing antibodies, spike protein mutations, vaccine escape, pseudovirus neutralization
MeSH terms: COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Adult, Aged, Antibodies, Viral, China, Female, United Kingdom, Humans, Male, Middle Aged, Neutralization Tests, Young Adult, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus

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Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera

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