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Cellular barcoding to decipher clonal dynamics in disease

Sankaran, Vijay G., Weissman, Jonathan S., Zon, Leonard I.·2022·Science
DOI 10.1126/science.abm5874PMC PMC10111813
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Abstract

Cellular barcodes are distinct DNA sequences that enable one to track specific cells across time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes, paired with single-cell readouts of cell state, have markedly increased our knowledge of clonal dynamics and genealogies of the cells that compose a variety of tissues and organs. These advances hold promise to redefine our view of human disease. Here, we provide an overview of cellular barcoding approaches, discuss applications to gain new insights into disease mechanisms, and provide an outlook on future applications. We discuss unanticipated insights gained through barcoding in studies of cancer and blood cell production and describe how barcoding can be applied to a growing array of medical fields, particularly with the increasing recognition of clonal contributions in human diseases.

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Metadata

Authors
Sankaran, V. G., Weissman, J. S., & Zon, L. I.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-10-14
Volume
378
Issue
6616
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.abm5874
PMC
PMC10111813
Cited by
93
References
22
Language
en

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