The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Therapy for Fibrotic Diseases: Nearing the Starting Line
Abstract
An emerging consensus indicates that fibrotic diseases in lung, liver, and kidney exhibit common underlying mechanisms, which can be targeted therapeutically.
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“Although tissue-specific features of fibrogenesis appear to exist, there is increasing appreciation of common pathways of fibrosis that are conserved among tissues, including transforming growth factor–β (TGFβ), connective tissue growth factor (CTGF), interleukin-4 (IL-4), IL-13, platelet-derived growth factor (PDGF), and osteopontin (19).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [19]
Citations
Cites
1 retracted
RETRACTED: Lysyl Oxidase-like 2 Deaminates Lysine 4 in Histone H3
Herranz, N., Dave, N., Millanes‐Romero, A., Morey, L., Diaz, V. M., Lorenz, V., Gallego, R. G., Jerónimo, C., Croce, L. D., de Herreros, A. G., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.002 · Cited by 73
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Self-citationTRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,264
Flagged first, then by citations
Research works printed but not linked: 3
- 10.1053/j.gastro.2012.06.036 · DOI · Paper page
- 10.1016/j.jhep.2011.09.021 · DOI
- 10.1111/j.1476-5381.2011.01247.x · DOI
Cited by
Sorted by citations
Items 101–118 of 118
Liu, L., Yu, H., Zhao, H., Wu, Z., Long, Y., Zhang, J., Yan, X., You, Z., Zhou, L., Xia, T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910650117 · Cited by 94
Hepatic Stellate Cells and Liver Fibrosis
Puche, J. E., Saiman, Y., & Friedman, S. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00529.x · Cited by 89
Self-citationCollagen Prolyl 4-Hydroxylase as a Therapeutic Target: Miniperspective
Vasta, J. D., & Raines, R. T. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00822 · Cited by 82
Su, T.-H., Shiau, C.-W., Jao, P., Liu, C.-H., Liu, C.-J., Tai, W.-T., Jeng, Y.-M., Yang, H.-C., Tseng, T.-C., Huang, H.-P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507499112 · Cited by 78
Kramann, R., & Schneider, R. K. (2018) · Blood · doi:10.1182/blood-2018-02-834820 · Cited by 62
Liu, M., Hu, Y., Yuan, Y., Tian, Z., & Zhang, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00477 · Cited by 65
Zhang, H., Ma, Y., Cheng, X., Wu, D., Huang, X., Chen, B., Ren, Y., Jiang, W., Tang, X., Bai, T., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1206 · Cited by 65
Self-citationThe Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities
Binatti, E., Gerussi, A., Barisani, D., & Invernizzi, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126649 · Cited by 62
Zhao, S., Dejanovic, D., Yao, P., Bhilocha, S., Sadler, T., Schirbel, A., West, G., Doyon, G., Lopez, R., Mao, R., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0259-9 · Cited by 59
Modelling and targeting mechanical forces in organ fibrosis
Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00144-3 · Cited by 59
Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0118 · Cited by 59
A two-way street - cellular metabolism and myofibroblast contraction
Noom, A., Sawitzki, B., Knaus, P., & Duda, G. N. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00359-x · Cited by 31
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
Yoon, I., Kim, S., Cho, M., You, K. A., Son, J., Lee, C., Suh, J. H., Bae, D., Kim, J. M., Oh, S., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216940 · Cited by 22
Treatment of systemic sclerosis: is there any hope for the future?
Allanore, Y., Matucci-Cerinic, M., & Distler, O. (2016) · RMD Open · doi:10.1136/rmdopen-2016-000260 · Cited by 19
Cyclic Stretching of Fibrotic Microtissue Array for Evaluation of Anti-Fibrosis Drugs
Asmani, M., Kotei, C., Hsia, I., Marecki, L., Wang, T., Zhou, C., & Zhao, R. (2019) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-019-00590-3 · Cited by 16
Collagen-targeted molecular imaging in diffuse liver diseases
Zhou, I. Y., Tanabe, K. K., Fuchs, B. C., & Caravan, P. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02677-2 · Cited by 14
Hsia, I., Asmani, M., & Zhao, R. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115194 · Cited by 12
Jiang, X., Peng, Y., Liu, L., Wang, Y., Li, M., Li, W., Huang, F., Zheng, C., Xu, F., Hu, Q., et al. (2022) · Liver International · doi:10.1111/liv.15445 · Cited by 12
Metadata
- Authors
- Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Biogen (United States) (US)
- Corresponding author
- Friedman, Scott L.
- Venue
- Science Translational Medicine
- Published
- 2013-01-09
- Volume
- 5
- Issue
- 167
- Pages
- 167sr1-167sr1
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2121339421
- Cited by
- 655
- References
- 209
- Citations by year
- 2026: 17 · 2025: 29 · 2024: 38 · 2023: 38 · 2022: 55 · 2021: 48 · 2020: 64 · 2019: 55 · 2018: 50 · 2017: 52 · 2016: 50 · 2015: 62 · 2014: 62 · 2013: 30
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA020709, AA020709)
- National Heart, Lung, and Blood Institute (P01HL108794, HL108794, HL53949, R01HL102292, HL102292)
- National Institute of Allergy and Infectious Diseases (AI0774349)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK93493, DK94768, R01DK084077, R24DK094768, DK 56621, R01DK093493, DK84077)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- fibrosis, antifibrotic therapy, pulmonary fibrosis, renal fibrosis, liver cirrhosis, extracellular matrix, epithelial damage, fibrogenesis, biomarkers, drug development
- MeSH terms
- Extracellular Matrix, Fibrosis, Humans, Signal Transduction
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