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Therapy for Fibrotic Diseases: Nearing the Starting Line
Abstract
An emerging consensus indicates that fibrotic diseases in lung, liver, and kidney exhibit common underlying mechanisms, which can be targeted therapeutically.
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“Although tissue-specific features of fibrogenesis appear to exist, there is increasing appreciation of common pathways of fibrosis that are conserved among tissues, including transforming growth factor–β (TGFβ), connective tissue growth factor (CTGF), interleukin-4 (IL-4), IL-13, platelet-derived growth factor (PDGF), and osteopontin (19).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [19]
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Metadata
- Authors
- Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Biogen (United States) (US)
- Corresponding author
- Friedman, Scott L.
- Venue
- Science Translational Medicine
- Published
- 2013-01-09
- Volume
- 5
- Issue
- 167
- Pages
- 167sr1-167sr1
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2121339421
- Cited by
- 655
- References
- 209
- Citations by year
- 2026: 17 · 2025: 29 · 2024: 38 · 2023: 38 · 2022: 55 · 2021: 48 · 2020: 64 · 2019: 55 · 2018: 50 · 2017: 52 · 2016: 50 · 2015: 62 · 2014: 62 · 2013: 30
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA020709, AA020709)
- National Heart, Lung, and Blood Institute (P01HL108794, HL108794, HL53949, R01HL102292, HL102292)
- National Institute of Allergy and Infectious Diseases (AI0774349)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK93493, DK94768, R01DK084077, R24DK094768, DK 56621, R01DK093493, DK84077)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- fibrosis, antifibrotic therapy, pulmonary fibrosis, renal fibrosis, liver cirrhosis, extracellular matrix, epithelial damage, fibrogenesis, biomarkers, drug development
- MeSH terms
- Extracellular Matrix, Fibrosis, Humans, Signal Transduction
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