The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48
Open accessAbstract
A histone-binding protein that declines with age in the human dentate gyrus can reverse age-related memory deficits in mice.
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“BDNF plays roles in plasticity and cognitive improvement.”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [27]
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Park, J. H., Lee, T.-K., Kim, D. W., Park, C. W., Park, Y. E., Kim, B., Lee, J., Lee, H., Won, M., & Ahn, J. H. (2019) · Laboratory Animal Research · doi:10.1186/s42826-019-0011-3
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“Interestingly, it has recently been revealed that the decline of RBBP4 in humans causes cognitive aging and memory loss (Pavlopoulos et al., 2013).”
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“It is well understood that RbAp48 participates in the age-related DG dysfunction and the expression level decreases in ageing hippocampus of human and mice [12,18].”
BackgroundStructure-Function study of the chromatin remodelling complex NuRD
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Defining the Role of RBBP4 in Oocyte Maturation and Preimplantation Development Using Trim-Away
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“Experiments in mice have confirmed that the amount of RBBP4 is reduced in the brain of older animals, and furthermore the knockdown of RBBP4 in young animals led to defects in memory (Pavlopoulos et al., 2013).”
Background
Metadata
- Authors
- Pavlopoulos, E., Jones, S., Kosmidis, S., Close, M., Kim, C., Kovalerchik, O., Small, S. A., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Columbia University (US)
- Corresponding author
- Jones, Sidonie
- Kosmidis, Stylianos
- Small, Scott A.
- Kandel, Eric R.
- Venue
- Science Translational Medicine
- Published
- 2013-08-28
- Volume
- 5
- Issue
- 200
- Pages
- 200ra115-200ra115
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4940031
- OpenAlex
- W2104064321
- Cited by
- 109
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 22 · 2013: 5
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG034618, R01AG025161, P50AG008702)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- age-related memory decline, RbAp48, histone-binding proteins, histone acetylation, dentate gyrus, hippocampus, cognitive aging, Alzheimer's disease, gene expression profiling, hippocampal-dependent memory, entorhinal cortex, novel object recognition, Morris water maze
- MeSH terms
- Acetylation, Adult, Aged, Aged, 80 and over, Aging, Animals, Female, Genes, Dominant, Histones, Humans, Male, Membrane Proteins, Memory Disorders, Middle Aged, Organ Specificity, Phosphoproteins, Protein Binding, RNA, Messenger, Gene Expression Regulation, Developmental, Dentate Gyrus, Oligonucleotide Array Sequence Analysis, Mice, Histone Acetyltransferases, Retinoblastoma-Binding Protein 4
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