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Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Open accessAbstract
, or pharmacological stimulation using 6-formylindolo (3,2-b) carbazole (Ficz) decreased immunopathology in NOD/DQ8 mice exposed to gluten. We then determined AhR ligand production by the fecal microbiota and AhR activation in patients with active celiac disease compared to nonceliac control individuals. Patients with active celiac disease demonstrated reduced AhR ligand production and lower intestinal AhR pathway activation. These results highlight gut microbiota-dependent modulation of the AhR pathway in celiac disease and suggest a new therapeutic strategy for treating this disorder.
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“the importance of the GM’s ability to metabolize tryptophan into aryl hydrocarbon receptor ligands and, therefore, modulate gut inflammation, was demonstrated in patients with celiac disease (202).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [202]
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Metadata
- Authors
- Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., McCarville, J. L., Bermudez Brito, M., Planchais, J., Rolhion, N., Murray, J. A., Langella, P., Loonen, L. M. P., Wells, J. M., Bercik, P., Sokol, H., & Verdu, E. F.
- Affiliations
- McMaster University (CA)
- Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- AgroParisTech (FR)
- Inserm (FR)
- Mayo Clinic (US)
- Wageningen University & Research (NL)
- Corresponding author
- Lamas, Bruno
- Sokol, Harry
- Verdu, Elena F.
- ORCID
- Lamas, Bruno
- Galipeau, Heather J.
- Constante, Marco
- Clarizio, Alexandra
- Jury, Jennifer
- Breyner, Natalia M.
- Caminero, Alberto
- Rueda, Gaston
- Hayes, Christina L.
- McCarville, Justin L.
- Planchais, Julien
- Rolhion, Nathalie
- Murray, Joseph A.
- Langella, Philippe
- Loonen, Linda M. P.
- Wells, Jerry M.
- Bercik, Premysl
- Sokol, Harry
- Verdu, Elena F.
- Venue
- Science Translational Medicine
- Published
- 2020-10-21
- Volume
- 12
- Issue
- 566
- Pages
- eaba0624
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3094545640
- Cited by
- 179
- References
- 59
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 33 · 2023: 27 · 2022: 43 · 2021: 27 · 2020: 3
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Joint Programming Initiative A healthy diet for a healthy life (ANR-15-HDIM-0001-1, JPI-HDHL 50-52905-98-601)
- Canadian Institutes of Health Research (CIHR-143922, 168840)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- aryl hydrocarbon receptor, celiac disease, gut microbiota, intestinal inflammation, gluten, FICZ, fecal microbiota, immunopathology
- MeSH terms
- Gastrointestinal Microbiome, Animals, Celiac Disease, Humans, Inflammation, Ligands, RNA, Ribosomal, 16S, Receptors, Aryl Hydrocarbon, Mice
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