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Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB
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“The AKT activation of NF-κB is due to stimulation of IKKs and is independent of MEKK1 and NIK, providing an alternate pathway allowing growth factors such as platelet-derived growth factor to activate NF-κB (81-83”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [83]
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Cites
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“Oncogenic Ras has been demonstrated to induce both proapoptotic and antiapoptotic signals (40, 51), and we have shown previously that oncogenic Ras stimulates the transcriptional activity of NF-kB to overcome H-Ras(V12)-induced apoptosis (41).”
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Metadata
- Authors
- Madrid, L. V., Wang, C.-Y., Guttridge, D. C., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-03-01
- Volume
- 20
- Issue
- 5
- Pages
- 1626-1638
- ISSN
- 1098-5549
- Cited by
- 540
- References
- 4
- Language
- en
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