Race-dependent association of sulfidogenic bacteria with colorectal cancer
Open accessAbstract
OBJECTIVE: Colorectal cancer (CRC) incidence is higher in African Americans (AAs) compared with non-Hispanic whites (NHWs). A diet high in animal protein and fat is an environmental risk factor for CRC development. The intestinal microbiota is postulated to modulate the effects of diet in promoting or preventing CRC. Hydrogen sulfide, produced by autochthonous sulfidogenic bacteria, triggers proinflammatory pathways and hyperproliferation, and is genotoxic. We hypothesised that sulfidogenic bacterial abundance in colonic mucosa may be an environmental CRC risk factor that distinguishes AA and NHW. DESIGN: Colonic biopsies from uninvolved or healthy mucosa from CRC cases and tumour-free controls were collected prospectively from five medical centres in Chicago for association studies. Sulfidogenic bacterial abundance in uninvolved colonic mucosa of AA and NHW CRC cases was compared with normal mucosa of AA and NHW controls. In addition, 16S rDNA sequencing was performed in AA cases and controls. Correlations were examined among bacterial targets, race, disease status and dietary intake. RESULTS: was more abundant in AA cases than controls. Linear discriminant analysis of 16S rRNA gene sequences revealed five sulfidogenic genera that were more abundant in AA cases. Fat and protein intake and daily servings of meat were significantly higher in AAs compared with NHWs, and multiple dietary components correlated with a higher abundance of sulfidogenic bacteria. CONCLUSIONS: These results implicate sulfidogenic bacteria as a potential environmental risk factor contributing to CRC development in AAs.
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Several sulfidogenic bacteria, including Fusobacterium, Bilophila wadsworthia, and genera Lactococcus, Porphyromonas, Odoribacter, Bilophila, and Pyramidobacter, are enriched in tissue samples from colorectal cancer patients.
“Several sulfidogenic bacteria were found to be enriched in tissue samples from patients with CRC, including Fusobacterium, Bilophila wadsworthia, and the genera Lactococcus, Porphyromonas, Odoribacter, Bilophila, and Pyramidobacter.165, 166”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [166]
Sulfidogenic bacteria could help explain why African Americans have more colorectal cancer than Caucasians.
“Sulfidogenic bacteria might therefore contribute to the higher incidence of CRC in African Americans than Caucasians.166”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [166]
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- Authors
- Yazici, C., Wolf, P. G., Kim, H., Cross, T.-W. L., Vermillion, K., Carroll, T., Augustus, G. J., Mutlu, E., Tussing-Humphreys, L., Braunschweig, C., Xicola, R. M., Jung, B., Llor, X., Ellis, N. A., & Gaskins, H. R.
- Affiliations
- Division of Gastroenterology and Hepatology, University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA
- University of Illinois Urbana-Champaign (US)
- University of Illinois Chicago (US)
- University of Arizona (US)
- Rush University Medical Center (US)
- Yale University (US)
- Corresponding author
- Gaskins, H Rex
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2017-02-02
- Volume
- 66
- Issue
- 11
- Pages
- 1983-1994
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC5575988
- OpenAlex
- W2585923386
- Cited by
- 215
- References
- 64
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 27 · 2023: 29 · 2022: 21 · 2021: 25 · 2020: 23 · 2019: 24 · 2018: 16 · 2017: 12
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (5t32dk007788-15, UL1TR001863)
- National Cancer Institute (U01CA153060, R01CA141057, T32CA009213, R01CA204808, P30CA023074)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK-007788)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- colorectal cancer, sulfidogenic bacteria, racial disparities, African Americans, non-Hispanic whites, hydrogen sulfide, meat consumption, environmental risk factors, 16S rRNA gene sequencing
- MeSH terms
- Adenocarcinoma, Adult, Aged, Black or African American, Chicago, Colon, Diet, Dietary Fats, Dietary Proteins, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Prospective Studies, Risk Factors, Colorectal Neoplasms, Case-Control Studies, Sulfur-Reducing Bacteria, White People, Health Status Disparities, Real-Time Polymerase Chain Reaction
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