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Cited by 130Muscle metabolism and nutritionSports Performance and TrainingMuscle Physiology and Disorders

Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men

Tang, Jason E., Manolakos, Joshua J., Kujbida, Greg W., Lysecki, Paul J., Moore, Daniel R., Phillips, Stuart M.·2007·Applied Physiology, Nutrition, and Metabolism
DOI 10.1139/h07-076
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Abstract

Whey protein is a supplemental protein source often used by athletes, particularly those aiming to gain muscle mass; however, direct evidence for its efficacy in stimulating muscle protein synthesis (MPS) is lacking. We aimed to determine the impact of consuming whey protein on skeletal muscle protein turnover in the post-exercise period. Eight healthy resistance-trained young men (age = 21 ± 1 .0 years; BMI = 26.8 ± 0.9 kg/m 2 (means ± SE)) participated in a double-blind randomized crossover trial in which they performed a unilateral leg resistance exercise workout (EX: 4 sets of knee extensions and 4 sets of leg press; 8–10 repetitions/set; 80% of maximal), such that one leg was not exercised and acted as a rested (RE) comparator. After exercise, subjects consumed either an isoenergetic whey protein plus carbohydrate beverage (WHEY: 10 g protein and 21 g fructose) or a carbohydrate-only beverage (CHO: 21 g fructose and 10 g maltodextran). Subjects received pulse-tracer injections of l-[ring-2 H 5]phenylalanine and l-[15 N]phenylalanine to measure MPS. Exercise stimulated a rise in MPS in the WHEY-EX and CHO-EX legs, which were greater than MPS in the WHEY-RE leg and the CHO-RE leg (all p < 0.05), respectively. The rate of MPS in the WHEY-EX leg was greater than in the CHO-EX leg (p < 0.001). We conclude that a small dose (10 g) of whey protein with carbohydrate (21 g) can stimulate a rise in MPS after resistance exercise in trained young men that would be supportive of a positive net protein balance, which, over time, would lead to hypertrophy.

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  • Intact protein supplements such as egg, whey, casein, beef, soy and whole milk can evoke an anabolic response similar or greater in magnitude to free form amino acids, assuming ingestion of equal EAA amounts.

    “it is now clear that intact protein supplements such as egg, whey, casein, beef, soy and even whole milk can evoke an anabolic response that can be similar or greater in magnitude to free form amino acids, assuming ingestion of equal EAA amounts [62–64].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [63]

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Authors
Tang, J. E., Manolakos, J. J., Kujbida, G. W., Lysecki, P. J., Moore, D. R., & Phillips, S. M.
Affiliations
  • McMaster University (CA)
  • Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.
ORCID
Venue
Applied Physiology, Nutrition, and Metabolism
Publisher
Canadian Science Publishing
Published
2007-12
Volume
32
Issue
6
Pages
1132-1138
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/h07-076
OpenAlex
W2056504048
Cited by
130
References
14
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 9 · 2012: 14
FWCI
4.00
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
whey protein, muscle protein synthesis, resistance training, carbohydrate supplementation, post-exercise recovery, skeletal muscle protein turnover, net protein balance, muscle hypertrophy, phenylalanine tracer
MeSH terms
Whey Proteins, Adult, Algorithms, Beverages, Blood Glucose, Dietary Carbohydrates, Humans, Insulin, Kinetics, Male, Milk Proteins, Muscle Proteins, Phenylalanine, Weight Lifting, Exercise, Muscle, Skeletal

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