Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men
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Aging impairs the sensitivity of skeletal muscle to anabolic stimuli, such as amino acids and resistance exercise. Beef is a nutrient-rich source of dietary protein capable of stimulating muscle protein synthesis (MPS) rates in older men at rest. To date, the dose–response of myofibrillar protein synthesis to graded ingestion of protein-rich foods, such as beef, has not been determined. We aimed to determine the dose–response of MPS with and without resistance exercise to graded doses of beef ingestion. Thirty-five middle-aged men (59 ± 2 years) ingested 0 g, 57 g (2 oz; 12 g protein), 113 g (4 oz; 24 g protein), or 170 g (6 oz; 36 g protein) of (15% fat) ground beef (n = 7 per group). Subjects performed a bout of unilateral resistance exercise to allow measurement of the fed state and the fed plus resistance exercise state within each dose. A primed constant infusion of l-[1-13 C]leucine was initiated to measure leucine oxidation and of l-[ring-13 C 6]phenylalanine was initiated to measure myofibrillar MPS. Myofibrillar MPS was increased with ingestion of 170 g of beef to a greater extent than all other doses at rest and after resistance exercise. There was more leucine oxidation with ingestion of 113 g of beef than with 0 g and 57 g, and it increased further after ingestion of 170 g of beef (all p < 0.05). Ingestion of 170 g of beef protein is required to stimulate a rise in myofibrillar MPS over and above that seen with lower doses. An isolated bout of resistance exercise was potent in stimulating myofibrillar MPS, and acted additively with feeding.
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There is a dose-responsive relationship between protein intake and muscle protein synthesis.
“the observation of a dose-responsive relationship between protein intake and MPS82–85”
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Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792 · see citing works
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works
Moore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973 · see citing works
Self-citationKatsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works
An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
Biolo, G., Tipton, K. D., Klein, S., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e122 · Cited by 825 · see citing works
Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · see citing works
Wilkinson, S. B., Tarnopolsky, M. A., MacDonald, M. J., MacDonald, J. R., Armstrong, D., & Phillips, S. M. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1031 · Cited by 530 · see citing works
Self-citationTipton, K. D., Rasmussen, B. B., Miller, S. L., Wolf, S. E., Owens-Stovall, S. K., Petrini, B. E., & Wolfe, R. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e197 · Cited by 526 · see citing works
Rasmussen, B. B., Tipton, K. D., Miller, S. L., Wolf, S. E., & Wolfe, R. R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.386 · Cited by 523 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield‐Moore, M., Aarsland, A. A., & Wolfe, R. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1065 · Cited by 504 · see citing works
Yang, Y., Breen, L., Burd, N. A., Hector, A. J., Churchward-Venne, T. A., Josse, A. R., Tarnopolsky, M. A., & Phillips, S. M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007422 · Cited by 480 · see citing works
Self-citationVolpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464 · see citing works
Dreyer, H. C., Drummond, M. J., Pennings, B., Fujita, S., Glynn, E. L., Chinkes, D. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2007 · Cited by 447 · see citing works
Essential amino acids and muscle protein recovery from resistance exercise
Børsheim, E., Tipton, K. D., Wolf, S. E., & Wolfe, R. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00466.2001 · Cited by 422 · see citing works
Glover, E. I., Phillips, S. M., Oates, B. R., Tang, J. E., Tarnopolsky, M. A., Selby, A., Smith, K., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160333 · Cited by 414 · see citing works
Self-citationRieu, I., Balage, M., Sornet, C., Giraudet, C., Pujos, E., Grizard, J., Mosoni, L., & Dardevet, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110742 · Cited by 410 · see citing works
Haley, S. M., Jette, A. M., Coster, W. J., Kooyoomjian, J. T., Levenson, S., Heeren, T., & Ashba, J. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.4.m217 · Cited by 409 · see citing works
Yarasheski, K. E., Zachwieja, J. J., & Bier, D. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.2.e210 · Cited by 406 · see citing works
Drummond, M. J., Dreyer, H. C., Pennings, B., Fry, C. S., Dhanani, S., Dillon, E. L., Sheffield‐Moore, M., Volpi, E., & Rasmussen, B. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00021.2008 · Cited by 391 · see citing works
Moderating the portion size of a protein-rich meal improves anabolic efficiency in young and elderly
Symons, T., Sheffield-Moore, M., Wolfe, R. R., & Paddon-Jones, D. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.06.369 · Cited by 352 · see citing works
Pennings, B., Groen, B., de Lange, A., Gijsen, A. P., Zorenc, A. H., Senden, J. M. G., & van Loon, L. J. C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00517.2011 · Cited by 326 · see citing works
Moore, D. R., Tang, J. E., Burd, N. A., Rerecich, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164087 · Cited by 322 · see citing works
Self-citationChurchward‐Venne, T. A., Burd, N. A., Mitchell, C. J., West, D. W. D., Philp, A., Marcotte, G. R., Baker, S. K., Baar, K., & Phillips, S. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.228833 · Cited by 314 · see citing works
Self-citationBurd, N. A., Holwerda, A. M., Selby, K. C., West, D. W. D., Staples, A. W., Cain, N. E., Cashaback, J. G. A., Potvin, J. R., Baker, S. K., & Phillips, S. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.192856 · Cited by 312 · see citing works
Self-citationPennings, B., Koopman, R., Beelen, M., Senden, J. M., Saris, W. H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29649 · Cited by 311 · see citing works
Moore, D. R., Phillips, S. M., Babraj, J. A., Smith, K., & Rennie, M. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2004 · Cited by 268 · see citing works
Self-citationAging does not impair the anabolic response to a protein-rich meal
Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.451 · Cited by 240 · see citing works
Dietary protein and muscle in older persons
Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 203 · see citing works
Sheffield-Moore, M., Yeckel, C. W., Volpi, E., Wolf, S. E., Morio, B., Chinkes, D. L., Paddon-Jones, D., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00334.2003 · Cited by 197 · see citing works
Linking age-related changes in skeletal muscle mass and composition with metabolism and disease.
Janssen, I., & Ross, R. (2006) · PubMed · Cited by 169 · see citing works
Recent Advances in Methods of Assessing Dietary Amino Acid Requirements for Adult Humans
Zello, G. A., Wykes, L., Ball, R. O., & Pencharz, P. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.12.2907 · Cited by 146 · see citing works
Chernoff, R. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719434 · Cited by 133 · see citing works
Tang, J. E., Manolakos, J. J., Kujbida, G. W., Lysecki, P. J., Moore, D. R., & Phillips, S. M. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-076 · Cited by 130 · see citing works
Self-citationThe anabolic response to resistance exercise and a protein-rich meal is not diminished by age
Symonsi, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., & Paddon-Jones, D. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0319-z · Cited by 112 · see citing works
Welle, S. L., & Thornton, C. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.4.e677 · Cited by 103 · see citing works
Dietary strategies to recover from exercise-induced muscle damage
Sousa, M., Teixeira, V. H., & Soares, J. M. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.849662 · Cited by 91 · see citing works
Inclusion of red meat in healthful dietary patterns.
McNeill, S. (2014) · Meat Science · doi:10.1016/j.meatsci.2014.06.028 · Cited by 87 · see citing works
Dideriksen, K., Reitelseder, S., Petersen, S. G., Hjort, M., Helmark, I. C., Kjær, M., & Holm, L. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01318.x · Cited by 87 · see citing works
Resistance Exercise Increases Postprandial Muscle Protein Synthesis in Humans
Witard, O. C., Tieland, M., Beelen, M., Tipton, K. D., van Loon, L. J. C., & Koopman, R. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181844e79 · Cited by 80 · see citing works
Burd, N. A., West, D. W. D., Rerecich, T., Prior, T., Baker, S. K., & Phillips, S. M. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-15 · Cited by 66 · see citing works
Self-citationDietary protein considerations to support active aging
Wall, B. T., Cermak, N. M., & van Loon, L. J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0258-7 · Cited by 56 · see citing works
Optimizing the Benefits of Exercise on Physical Function in Older Adults
Buford, T., Anton, S. D., Clark, D. J., Higgins, T. J., & Cooke, M. B. (2013) · PM & R : the journal of injury, function, and rehabilitation · doi:10.1016/j.pmrj.2013.11.009 · Cited by 56 · see citing works
Daly, R. M., Gianoudis, J., Prosser, M., Kidgell, D. J., Ellis, K. A., O’Connell, S. L., & Nowson, C. A. (2015) · Trials · doi:10.1186/s13063-015-0884-x · Cited by 49 · see citing works
Smith, G. I., Villareal, D., Lambert, C., Reeds, D. N., Mohammed, B., & Mittendorfer, B. (2010) · Journal of applied physiology · doi:10.1152/japplphysiol.00957.2009 · Cited by 27 · see citing works
Negro, M., Vandoni, M., Ottobrini, S., Codrons, E., Correale, L., Buonocore, D., & Marzatico, F. (2014) · Nutrients · doi:10.3390/nu6083040 · Cited by 21 · see citing works
Margolis, L. M., & Rivas, D. A. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9921-0 · Cited by 17 · see citing works
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Protein content and amino acid composition of commercially available plant-based protein isolates
Gorissen, S. H. M., Crombag, J. J. R., Senden, J. M. G., Waterval, W. A. H., Bierau, J., Verdijk, L. B., & van Loon, L. J. C. (2018) · Amino Acids · doi:10.1007/s00726-018-2640-5 · Cited by 1,169 · see citing works
Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., Aragon, A. A., Devries, M. C., Banfield, L., Krieger, J. W., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097608 · Cited by 1,154 · see citing works
Self-citationThe Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption
van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651 · see citing works
Self-citationWitard, O. C., Jackman, S. R., Breen, L., Smith, K., Selby, A., & Tipton, K. D. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055517 · Cited by 517 · see citing works
Self-citationPaddon-Jones, D., Campbell, W., Jacques, P., Kritchevsky, S., Moore, L., Rodriguez, N., & van Loon, L. V. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.084061 · Cited by 255 · see citing works
Traylor, D. A., Gorissen, S., & Phillips, S. M. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy003 · Cited by 208 · see citing works
Self-citationGorissen, S. H. M., & Witard, O. C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s002966511700194x · Cited by 221 · see citing works
Loenneke, J. P., Loprinzi, P. D., Murphy, C. H., & Phillips, S. M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.04.002 · Cited by 208 · see citing works
Self-citationDaly, R. M., O’Connell, S. L., Mundell, N. L., Grimes, C. A., Dunstan, D. W., & Nowson, C. A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.064154 · Cited by 205 · see citing works
Dietary protein and muscle in older persons
Paddon‐Jones, D., & Leidy, H. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000011 · Cited by 203 · see citing works
Church, D. D., Hirsch, K. R., Park, S., Kim, I., Gwin, J. A., Pasiakos, S. M., Wolfe, R. R., & Ferrando, A. A. (2020) · Nutrients · doi:10.3390/nu12123717 · Cited by 185 · see citing works
Kim, I.-Y., Schutzler, S., Schrader, A., Spencer, H., Kortebein, P., Deutz, N. E. P., Wolfe, R. R., & Ferrando, A. A. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00382.2014 · Cited by 171 · see citing works
The anabolic response to plant-based protein ingestion
Pinckaers, P. J. M., Trommelen, J., Snijders, T., & van Loon, L. J. C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01540-8 · Cited by 170 · see citing works
The impact of protein quality on the promotion of resistance exercise-induced changes in muscle mass
Phillips, S. M. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0124-8 · Cited by 168 · see citing works
Self-citationPennings, B., Groen, B. B., van Dijk, J.-W., de Lange, A., Kiskini, A., Kuklinski, M., Senden, J. M., & van Loon, L. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051201 · Cited by 167 · see citing works
The Health Benefits of Egg Protein
Puglisi, M., & Fernández, M. (2022) · Nutrients · doi:10.3390/nu14142904 · Cited by 157 · see citing works
Muscle Protein Synthesis after Protein Administration in Critical Illness
Chapple, L. S., Kouw, I. W. K., Summers, M. J., Weinel, L. M., Gluck, S., Raith, E. P., Slobodian, P., Soenen, S., Deane, A. M., van Loon, L. J. C., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202112-2780oc · Cited by 153 · see citing works
Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia
Phillips, S. M. (2015) · Advances in Nutrition · doi:10.3945/an.115.008367 · Cited by 144 · see citing works
Self-citationProtein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults
Witard, O., Wardle, S., Macnaughton, L., Hodgson, A., & Tipton, K. (2016) · Nutrients · doi:10.3390/nu8040181 · Cited by 132 · see citing works
Burd, N. A., Beals, J. W., Martinez, I. G., Salvador, A. F., & Skinner, S. K. (2019) · Sports Medicine · doi:10.1007/s40279-018-1009-y · Cited by 127 · see citing works
Self-citationReidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128 · see citing works
Murphy, C. H., Churchward-Venne, T. A., Mitchell, C. J., Kolar, N. M., Kassis, A., Karagounis, L. G., Burke, L. M., Hawley, J. A., & Phillips, S. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00550.2014 · Cited by 124 · see citing works
Self-citationChurchward-Venne, T., Breen, L., & Phillips, S. M. (2014) · Biofactors · doi:10.1002/biof.1138 · Cited by 116 · see citing works
Self-citationPre-Sleep Protein Ingestion to Improve the Skeletal Muscle Adaptive Response to Exercise Training
Trommelen, J., & Van Loon, L. (2016) · Nutrients · doi:10.3390/nu8120763 · Cited by 116 · see citing works
Monteyne, A. J., Coelho, M. O., Porter, C., Abdelrahman, D. R., Jameson, T. S., Jackman, S. R., Blackwell, J. R., Finnigan, T. J., Stephens, F. B., Dirks, M. L., et al. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa092 · Cited by 110 · see citing works
Kim, I.-Y., Schutzler, S., Schrader, A., Spencer, H. J., Azhar, G., Ferrando, A. A., & Wolfe, R. R. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00365.2015 · Cited by 109 · see citing works
Tezze, C., Sandri, M., & Tessari, P. (2023) · Nutrients · doi:10.3390/nu15184073 · Cited by 103 · see citing works
Kouw, I. W. K., Holwerda, A. M., Trommelen, J., Kramer, I. F., Bastiaanse, J., Halson, S. L., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2017) · Journal of Nutrition · doi:10.3945/jn.117.254532 · Cited by 107 · see citing works
The impact of exercise and nutrition on the regulation of skeletal muscle mass
McGlory, C., van Vliet, S., Stokes, T., Mittendorfer, B., & Phillips, S. M. (2018) · The Journal of Physiology · doi:10.1113/jp275443 · Cited by 101 · see citing works
Self-citationBeals, J. W., Sukiennik, R. A., Nallabelli, J., Emmons, R. S., van Vliet, S., Young, J. R., Ulanov, A. V., Li, Z., Paluska, S. A., De Lisio, M., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.130385 · Cited by 99 · see citing works
Self-citationResearch progress in the role and mechanism of Leucine in regulating animal growth and development
Rehman, S. U., Ali, R., Zhang, H., Zafar, M. H., & Wang, M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1252089 · Cited by 97 · see citing works
Growing older with health and vitality: a nexus of physical activity, exercise and nutrition
Witard, O. C., McGlory, C., Hamilton, D. L., & Phillips, S. M. (2016) · Biogerontology · doi:10.1007/s10522-016-9637-9 · Cited by 91 · see citing works
Self-citationThe muscle protein synthetic response to food ingestion
Gorissen, S. H. M., Rémond, D., & van Loon, L. J. C. (2015) · Meat Science · doi:10.1016/j.meatsci.2015.05.009 · Cited by 90 · see citing works
Holwerda, A. M., Paulussen, K. J. M., Overkamp, M., Goessens, J. P. B., Kramer, I. F., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2019) · Journal of Nutrition · doi:10.1093/jn/nxy263 · Cited by 91 · see citing works
Dietary strategies to recover from exercise-induced muscle damage
Sousa, M., Teixeira, V. H., & Soares, J. M. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.849662 · Cited by 91 · see citing works
Gwin, J. A., Church, D. D., Wolfe, R. R., Ferrando, A. A., & Pasiakos, S. M. (2020) · Nutrients · doi:10.3390/nu12082457 · Cited by 89 · see citing works
Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise
Beals, J. W., Burd, N. A., Moore, D. R., & van Vliet, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00087 · Cited by 88 · see citing works
Self-citationMitchell, C., McGregor, R., D’Souza, R., Thorstensen, E., Markworth, J., Fanning, A., Poppitt, S., & Cameron-Smith, D. (2015) · Nutrients · doi:10.3390/nu7105420 · Cited by 87 · see citing works
Inclusion of red meat in healthful dietary patterns.
McNeill, S. (2014) · Meat Science · doi:10.1016/j.meatsci.2014.06.028 · Cited by 87 · see citing works
Churchward-Venne, T. A., Holwerda, A. M., Phillips, S. M., & van Loon, L. J. C. (2016) · Sports Medicine · doi:10.1007/s40279-016-0504-2 · Cited by 71 · see citing works
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Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates
TROMMELEN, J., HOLWERDA, A. M., KOUW, I. W. K., LANGER, H., HALSON, S. L., ROLLO, I., VERDIJK, L. B., & VAN LOON, L. J. C. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001045 · Cited by 69 · see citing works
Smeuninx, B., Greig, C. A., & Breen, L. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00025 · Cited by 69 · see citing works
Self-citationMarshall, R. N., Smeuninx, B., Morgan, P. T., & Breen, L. (2020) · Nutrients · doi:10.3390/nu12051533 · Cited by 63 · see citing works
Self-citationPhillips, S. M., & Martinson, W. (2018) · Nutrition reviews · doi:10.1093/nutrit/nuy062 · Cited by 64 · see citing works
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Horstman, A. M. H., & Huppertz, T. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2078782 · Cited by 59 · see citing works
Churchward-Venne, T. A., Cotie, L. M., MacDonald, M. J., Mitchell, C. J., Prior, T., Baker, S. K., & Phillips, S. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00096.2014 · Cited by 58 · see citing works
Self-citationGranic, A., Dismore, L. L., Hurst, C., Robinson, S. M., & Sayer, A. A. (2020) · Nutrients · doi:10.3390/nu12082257 · Cited by 58 · see citing works
Dietary protein considerations to support active aging
Wall, B. T., Cermak, N. M., & van Loon, L. J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0258-7 · Cited by 56 · see citing works
Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
Hudson, J., Bergia, R. E., & Campbell, W. W. (2020) · Nutrients · doi:10.3390/nu12051441 · Cited by 56 · see citing works
Optimizing the Benefits of Exercise on Physical Function in Older Adults
Buford, T., Anton, S. D., Clark, D. J., Higgins, T. J., & Cooke, M. B. (2013) · PM & R : the journal of injury, function, and rehabilitation · doi:10.1016/j.pmrj.2013.11.009 · Cited by 56 · see citing works
Van Vliet, S., Beals, J. W., Martinez, I. G., Skinner, S. K., & Burd, N. A. (2018) · Nutrients · doi:10.3390/nu10020224 · Cited by 56 · see citing works
Self-citationDietary protein supplementation in the elderly for limiting muscle mass loss
Lancha, A., Zanella, R., Tanabe, S. G. O., Andriamihaja, M., & Blachier, F. (2016) · Amino Acids · doi:10.1007/s00726-016-2355-4 · Cited by 59 · see citing works
Churchward‐Venne, T. A., Snijders, T., Linkens, A. M. A., Hamer, H. M., van Kranenburg, J. M. X., & van Loon, L. J. C. (2015) · Journal of Nutrition · doi:10.3945/jn.115.213710 · Cited by 54 · see citing works
Daly, R. M., Gianoudis, J., Prosser, M., Kidgell, D. J., Ellis, K. A., O’Connell, S. L., & Nowson, C. A. (2015) · Trials · doi:10.1186/s13063-015-0884-x · Cited by 49 · see citing works
McDonald, C. J., Ankarfeldt, M. Z., Capra, S. M., Bauer, J. D., Raymond, K., & Heitmann, B. L. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000611 · Cited by 48 · see citing works
Formica, M., Gianoudis, J., Nowson, C. A., O’Connell, S. L., Milte, C. M., Ellis, K. A., & Daly, R. M. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa104 · Cited by 45 · see citing works
Alternative dietary protein sources to support healthy and active skeletal muscle aging
van der Heijden, I., Monteyne, A. J., Stephens, F. B., & Wall, B. T. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuac049 · Cited by 45 · see citing works
Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes
Deane, C. S., Bass, J. J., Crossland, H., Phillips, B. E., & Atherton, P. J. (2020) · Nutrients · doi:10.3390/nu12092670 · Cited by 46 · see citing works
Buffière, C., Gaudichon, C., Hafnaoui, N., Migné, C., Scislowski, V., Khodorova, N., Mosoni, L., Blot, A., Boirie, Y., Dardevet, D. P., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.158113 · Cited by 38 · see citing works
Valenzuela, P. L., Ordóñez, F. M., Morales, J. S., Castillo‐García, A., & Lucía, A. (2019) · Nutrients · doi:10.3390/nu11061429 · Cited by 41 · see citing works
Dietary protein and amino acid intakes for mitigating sarcopenia in humans
He, W., Connolly, E. D., Cross, H. R., & Wu, G. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2348549 · Cited by 37 · see citing works
Lower Integrated Muscle Protein Synthesis in Masters Compared with Younger Athletes
Doering, T. M., Jenkins, D. G., Reaburn, P. R. J., Borges, N. R., Hohmann, E., & Phillips, S. M. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000935 · Cited by 30 · see citing works
Self-citationHannaian, S. J., Hodson, N. W., Sawan, S. A., Mazzulla, M., Kato, H., Matsunaga, K., Waskiw‐Ford, M., Duncan, J., Kumbhare, D. A., & Moore, D. R. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00241.2020 · Cited by 25 · see citing works
Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves
Moore, D. R. (2021) · Sports Medicine · doi:10.1007/s40279-021-01510-0 · Cited by 30 · see citing works
Mielgo‐Ayuso, J., Calleja-González, J., Refoyo, I., León-Guereño, P., Córdova, A., & Coso, J. D. (2020) · Nutrients · doi:10.3390/nu12020316 · Cited by 26 · see citing works
Pikosky, M. A., Cifelli, C. J., Agarwal, S., & Fulgoni, V. L. I. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.873512 · Cited by 24 · see citing works
A New Method for Calculating Protein Content and Determining Appropriate Protein Levels in FoodsPreprint
Forouzesh, A., Forouzesh, F., Foroushani, S. S., & Forouzesh, A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4133566 · Cited by 24 · see citing works
How to Overcome Anabolic Resistance in Dialysis-Treated Patients?
Garibotto, G., Saio, M., Aimasso, F., Russo, E., Picciotto, D., Viazzi, F. C., Verzola, D., Laudon, A., Esposito, P. B., & Brunori, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.701386 · Cited by 23 · see citing works
Holwerda, A., Lenaerts, K., Bierau, J., & van Loon, L. V. (2016) · Nutrients · doi:10.3390/nu8040221 · Cited by 19 · see citing works
Naclerio, F., Seijo, M., Larumbe‐Zabala, E., & Earnest, C. P. (2017) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0003 · Cited by 21 · see citing works
Acute Effects of Cheddar Cheese Consumption on Circulating Amino Acids and Human Skeletal Muscle
de Hart, N. M. M. P., Mahmassani, Z. S., Reidy, P. T., Kelley, J. J., McKenzie, A. I., Petrocelli, J. J., Bridge, M. J., Baird, L. M., Bastian, E. D., Ward, L. S., et al. (2021) · Nutrients · doi:10.3390/nu13020614 · Cited by 21 · see citing works
Negro, M., Vandoni, M., Ottobrini, S., Codrons, E., Correale, L., Buonocore, D., & Marzatico, F. (2014) · Nutrients · doi:10.3390/nu6083040 · Cited by 21 · see citing works
Hsu, T.-H., Chiu, C.-C., Wang, Y.-C., Chen, T.-H., Chen, Y.-H., Lee, Y.-P., Hung, S.-W., Wu, C.-P., & Chuang, H.-L. (2018) · Nutrients · doi:10.3390/nu10111740 · Cited by 20 · see citing works
Exercise and Physical Activity for Older Adults
Avers, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-60912-8.00008-7 · Cited by 21 · see citing works
Betik, A. C., Aguila, J., McConell, G. K., McAinch, A. J., & Mathai, M. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152562 · Cited by 17 · see citing works
Margolis, L. M., & Rivas, D. A. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9921-0 · Cited by 17 · see citing works
Dehnavi, Z., Barghchi, H., Esfehani, A. J., Barati, M., Khorasanchi, Z., Farsi, F., Ostad, A. N., Ranjbar, G., Rezvani, R., Rezaie, M., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3417 · Cited by 16 · see citing works
Protein metabolism and physical training: any need for amino acid supplementation?
POORTMANS, J. R., & Carpentier, A. (2016) · Nutrire · doi:10.1186/s41110-016-0022-x · Cited by 14 · see citing works
Nutrition for Master Athletes: Is There a Need for Specific Recommendations?
Louis, J. B., Vercruyssen, F., Dupuy, O., & Bernard, T. (2019) · Journal of Aging and Physical Activity · doi:10.1123/japa.2019-0190 · Cited by 14 · see citing works
Nickels, M., Blythe, R. D., White, N. M., Ali, A., Aitken, L. M., Heyland, D. K., & McPhail, S. (2023) · Australian Critical Care · doi:10.1016/j.aucc.2022.12.015 · Cited by 12 · see citing works
Bendtsen, L. Q., Thorning, T. K., Reitelseder, S., Ritz, C., Hansen, E. T., van Hall, G., Astrup, A. V., Sjödin, A. M., & Holm, L. (2019) · Nutrients · doi:10.3390/nu11050989 · Cited by 11 · see citing works
Salvador, A. F., McKenna, C. F., Paulussen, K. J. M., Keeble, A. R., Askow, A. T., Fang, H., Li, Z., ULANOV, A. V., Paluska, S. A., Moore, D. R., et al. (2021) · The Journal of Physiology · doi:10.1113/jp281907 · Cited by 11 · see citing works
Self-citationYimam, M. A., Andreini, M., Carnevale, S., & Muscaritoli, M. (2025) · Nutrients · doi:10.3390/nu17020211 · Cited by 10 · see citing works
Hudson, J., Paddon‐Jones, D., & Campbell, W. W. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.09.007 · Cited by 10 · see citing works
Larsen, M. S., Witard, O. C., Holm, L., Scaife, P. J., Hansen, R., Smith, K., Tipton, K. D., Mose, M., Bengtsen, M. B., Lauritsen, K. M., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.08.011 · Cited by 11 · see citing works
Detzel, C. J., Petschow, B., Johnson, N., & Weaver, E. (2016) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v6i10.308 · Cited by 9 · see citing works
Muscle Protein Synthesis and Muscle Mass in Healthy Older Men
Tomé, D. (2017) · Journal of Nutrition · doi:10.3945/jn.117.263491 · Cited by 8 · see citing works
Davies, R. W., Lynch, A. E., Kumar, U., & Jakeman, P. M. (2024) · Translational Sports Medicine · doi:10.1155/2024/3184356 · Cited by 6 · see citing works
Valenzuela, P. L., Montalvo, Z., Ordóñez, F. M., González-Navarro, M., Larumbe‐Zabala, E., & Naclerio, F. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1727377 · Cited by 5 · see citing works
Nutrition for master athletes: from challenges to optimisation strategies
Louis, J. B., Vercruyssen, F., Dupuy, O., & Bernard, T. (2019) · Movement & Sport Sciences - Science & Motricité · doi:10.1051/sm/2019019 · Cited by 5 · see citing works
Lorenzetti, R. L. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-8phw-q520 · Cited by 3 · see citing works
Carvalho, J., Marques, E. A., & Moreira, P. A. M. (2015) · Wiley eBooks · doi:10.1002/9781118823408.ch7
Churchward‐Venne, T. A. (2013) · MacSphere (McMaster University) · doi:10.71548/9052
Dietary factors modulating postprandial protein handling
Gorissen, S. H. M. (2016) · doi:10.26481/dis.20160623sg
Molecular Regulation of Muscle Protein Synthesis at Rest and Following Endurance Exercise
Sawan, S. A. (2017) · TSpace (University of Toronto)
Nutrition for Strength Adaptations
Zbinden, H., Avey, A. M., & Baar, K. (2018) · Nutrition and Enhanced Sports Performance · doi:10.1016/b978-0-12-813922-6.00029-1
- Authors
- Robinson, M. J., Burd, N. A., Breen, L., Rerecich, T., Yang, Y., Hector, A. J., Baker, S. K., & Phillips, S. M.
- Affiliations
- McMaster University (CA)
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2013-02
- Volume
- 38
- Issue
- 2
- Pages
- 120-125
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2071076747
- Cited by
- 109
- References
- 47
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 7
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Cattlemen's Beef Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- myofibrillar protein synthesis, resistance training, dose-response relationship, dietary protein, leucine oxidation, skeletal muscle anabolism, middle-aged men, aging, fed state
- MeSH terms
- Amino Acids, Animals, Cattle, Gene Expression Regulation, Humans, Male, Meat, Middle Aged, Muscle Proteins, Exercise
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