The anabolic response to resistance exercise and a protein-rich meal is not diminished by age
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OBJECTIVES: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. SETTING: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. PARTICIPANTS: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. DESIGN: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum). MEASUREMENTS: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol∙kg(-1)min(-1)) of L- [ring-13C6] phenylalanine. RESULTS: Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073±0.008; post: 0.156±0.021(SE) %/h, p<0.001] and older adults (pre: 0.075±0.004; post: 0.152±0.017 %/h, p=0.003) following the meal and resistance exercise bout. CONCLUSION: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.
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The evidence points more convincingly toward protein change theory; creating a more pronounced change from habitual intake in older populations may be even more important than in younger populations.
“However, this would seem to point more convincingly toward protein change theory; perhaps creating a more pronounced change from habitual intake in older populations is even more important than in younger populations. New related data support this [37].”
From Dietary protein to maximize resistance training: a review and examination of protein spread and change theories (2012) · cites this paper as [37]
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- Authors
- Symonsi, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., & Paddon-Jones, D.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- ORCID
- Wolfe, R.R.
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 15
- Issue
- 5
- Pages
- 376-381
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC3280506
- OpenAlex
- W2085792315
- Cited by
- 112
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 8 · 2013: 7 · 2012: 12
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute on Aging (P30 AG17231, P60AG017231, P30AG024832)
- National Center for Research Resources (M01 RR-00073, UL1RR029876, M01RR000073)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- muscle protein synthesis, resistance training, protein intake, aging, older adults, sarcopenia, knee extension exercise, phenylalanine tracer, vastus lateralis
- MeSH terms
- Adult, Aged, Aging, Biopsy, Dietary Proteins, Female, Humans, Male, Meat, Muscle Proteins, Phenylalanine, Exercise, Quadriceps Muscle, Resistance Training
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