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CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
Open accessAbstract
Effective clearance of an infection requires that the immune system rapidly detects and neutralizes invading parasites while strictly avoiding self-antigens that would result in autoimmunity. The cellular machinery and complex signaling pathways that coordinate an effective immune response have generally been considered properties of the eukaryotic immune system. However, a surprisingly sophisticated adaptive immune system that relies on small RNAs for sequence-specific targeting of foreign nucleic acids was recently discovered in bacteria and archaea. Molecular vaccination in prokaryotes is achieved by integrating short fragments of foreign nucleic acids into a repetitive locus in the host chromosome known as a CRISPR (clustered regularly interspaced short palindromic repeat). Here we review the mechanisms of CRISPR-mediated immunity and discuss the ecological and evolutionary implications of these adaptive defense systems.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 5,947
CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III
Deltcheva, E., Chylinski, K., Sharma, C. M., Gonzales, K., Chao, Y., Pirzada, Z. A., Eckert, M. R., Vogel, J., & Charpentier, E. (2011) · Nature · doi:10.1038/nature09886 · Cited by 2,563
CRISPR/Cas, the Immune System of Bacteria and Archaea
Horvath, P., & Barrangou, R. (2010) · Science · doi:10.1126/science.1179555 · Cited by 2,471
Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
Brouns, S. J. J., Jore, M. M., Lundgren, M., Westra, E. R., Slijkhuis, R. J. H., Snijders, A. P. L., Dickman, M. J., Makarova, K. S., Koonin, E. V., & van der Oost, J. (2008) · Science · doi:10.1126/science.1159689 · Cited by 2,460
Ishino, Y., Shinagawa, H., Makino, K., Amemura, M., & Nakata, A. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.12.5429-5433.1987 · Cited by 2,421
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Garneau, J. E., Dupuis, M.-È., Villion, M., Romero, D. A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A. H., & Moineau, S. (2010) · Nature · doi:10.1038/nature09523 · Cited by 2,336
Evolution and classification of the CRISPR–Cas systems
Makarova, K. S., Haft, D. H., Barrangou, R., Brouns, S. J. J., Charpentier, E., Horvath, P., Moineau, S., Mojica, F. J. M., Wolf, Y. I., Yakunin, A. F., et al. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2577 · Cited by 2,331
Suttle, C. A. (2005) · Nature · doi:10.1038/nature04160 · Cited by 2,186
Research works printed but not linked: 1
- Hankin EH, 1896, Ann. Inst. Pasteur, 10, 511
Cited by
Sorted by citations
Items 101–200 of 669
Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complexPreprint
Hale, C. R., Cocozaki, A. I., Li, H., Terns, R. M., & Terns, M. P. (2014) · Genes & Development · doi:10.1101/gad.250712.114 · Cited by 113
Wei, Y., Chesne, M. T., Terns, R. M., & Terns, M. P. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1407 · Cited by 105
CRISPR-based technologies: prokaryotic defense weapons repurposed
Terns, R. M., & Terns, M. P. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.01.003 · Cited by 112
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
Ivanov, I. E., Wright, A. V., Cofsky, J. C., Aris, K., Doudna, J. A., & Bryant, Z. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913445117 · Cited by 109
Erdoğan, İ., Keskin, B. C., Bilir, Ö., Hong, Y., & Tör, M. (2023) · Biology · doi:10.3390/biology12071037 · Cited by 126
Breurec, S., Criscuolo, A., Diancourt, L., Rendueles, O., Vandenbogaert, M., Passet, V., Caro, V., Rocha, E. P. C., Touchon, M., & Brisse, S. (2016) · Scientific Reports · doi:10.1038/srep30379 · Cited by 106
Sampson, T. R., Napier, B. A., Schroeder, M. R., Louwen, R., Zhao, J., Chin, C., Ratner, H. K., Llewellyn, A. C., Jones, C. L., Laroui, H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323025111 · Cited by 105
Engineering RNA Virus Interference via the CRISPR/Cas13 Machinery in Arabidopsis
Aman, R. A., Mahas, A., Butt, H., Ali, Z., Aljedaani, F., & Mahfouz, M. M. (2018) · Viruses · doi:10.3390/v10120732 · Cited by 105
Coupling immunity and programmed cell suicide in prokaryotes: Life‐or‐death choices
Koonin, E. V., & Zhang, F. (2016) · BioEssays · doi:10.1002/bies.201600186 · Cited by 98
CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers
Wimmer, F., & Beisel, C. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03078 · Cited by 105
Genomics Approaches For Improving Salinity Stress Tolerance in Crop Plants
Nongpiur, R. C., Singla-Pareek, S. L., & Pareek, A. (2016) · Current Genomics · doi:10.2174/1389202917666160331202517 · Cited by 99
Gene drive inhibition by the anti-CRISPR proteins AcrIIA2 and AcrIIA4 in Saccharomyces cerevisiae
Basgall, E. M., Goetting, S. C., Goeckel, M. E., Giersch, R. M., Roggenkamp, E., Schrock, M. N., Halloran, M., & Finnigan, G. C. (2018) · Microbiology · doi:10.1099/mic.0.000635 · Cited by 98
Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins
Zhang, H., Li, Z., Daczkowski, C. M., Gabel, C. A., Mesecar, A. D., & Chang, L. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.004 · Cited by 99
Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria
de Lima, R., Fiol, F. D. S. D., & Balcão, V. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00692 · Cited by 98
Stimuli-responsive DNA-based hydrogels for biosensing applications
Chen, M., Wang, Y., Zhang, J., Peng, Y., Li, S., Han, D., Ren, S., Qin, K., Li, S., & Gao, Z. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01242-x · Cited by 96
Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3
Gong, B., Shin, M., Sun, J., Jung, C., Bolt, E. L., John van der, O. O. S. T., & Kim, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410806111 · Cited by 100
Genome Editing in Clostridium saccharoperbutylacetonicum N1-4 with the CRISPR-Cas9 System
Wang, S., Dong, S., Wang, P., Tao, Y., & Wang, Y. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00233-17 · Cited by 97
Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex
Blosser, T. R., Loeff, L., Westra, E. R., Vlot, M., Künne, T., Sobota, M., Dekker, C., Brouns, S. J. J., & Joo, C. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.028 · Cited by 92
Carte, J. M., Christopher, R. T., Smith, J. T., Olson, S., Barrangou, R., Moineau, S., Glover, C. V. C., Graveley, B. R., Terns, R. M., & Terns, M. P. (2014) · Molecular Microbiology · doi:10.1111/mmi.12644 · Cited by 95
Transcription control engineering and applications in synthetic biology
Engstrom, M. D., & Pfleger, B. F. (2017) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2017.09.003 · Cited by 96
Characterization of Streptomycin Resistance in Isolates of Erwinia amylovora in California
Forster, H., McGhee, G. C., Sundin, G. W., & Adaskaveg, J. E. (2015) · Phytopathology · doi:10.1094/phyto-03-15-0078-r · Cited by 90
Polintons, virophages and transpovirons: a tangled web linking viruses, transposons and immunity
Koonin, E. V., & Krupovìč, M. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.06.008 · Cited by 85
Rollins, M. F., Schuman, J. T., Paulus, K., Bukhari, H. S. T., & Wiedenheft, B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv094 · Cited by 87
A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses
Jackson, R. N., & Wiedenheft, B. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.023 · Cited by 86
Planting the seed: target recognition of short guide RNAs
Künne, T., Swarts, D. C., & Brouns, S. J. J. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2013.12.003 · Cited by 86
Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex
Dillard, K. E., Brown, M. W., Johnson, N. V., Xiao, Y., Dolan, A. E., Hernandez, E. T., Dahlhauser, S. D., Kim, Y., Myler, L. R., Anslyn, E. V., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.039 · Cited by 86
Rahman, S. U., McCoy, E., Raza, G., Ali, Z., Mansoor, S., & Amin, I. U. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00456-6 · Cited by 92
Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System
Qazi, S., Miettinen, H. M., Wilkinson, R. A., McCoy, K., Douglas, T., & Wiedenheft, B. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00822 · Cited by 87
Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases
Garcia‐Doval, C., & Jínek, M. (2017) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2017.10.015 · Cited by 85
Further analysis of barley MORC 1 using a highly efficient RNA ‐guided Cas9 gene‐editing system
Kumar, N., Galli, M., Ordon, J., Stuttmann, J., Kogel, K., & Imani, J. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.12924 · Cited by 87
Genome Editing for Sustainable Crop Improvement and Mitigation of Biotic and Abiotic Stresses
Hamdan, M. F., Karlson, C. K. S., Teoh, E. Y., Lau, S.-E., & Tan, B. C. (2022) · Plants · doi:10.3390/plants11192625 · Cited by 91
Verma, H., Kumar, R., Oldach, P., Sangwan, N., Khurana, J. P., Gilbert, J. A., & Lal, R. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1014 · Cited by 85
Establishment and application of a CRISPR–Cas12a assisted genome-editing system in Zymomonas mobilis
Shen, W., Zhang, J., Geng, B., Qiu, M., Hu, M., Yang, Q., Bao, W., Xiao, Y., Zheng, Y., Peng, W., et al. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1219-5 · Cited by 83
Target site selection and remodelling by type V CRISPR-transposon systems
Querques, I., Schmitz, M., Oberli, S., Chanez, C., & Jínek, M. (2021) · Nature · doi:10.1038/s41586-021-04030-z · Cited by 83
El‐Sayed, A. S. A., Abdel‐Ghany, S. E., & Ali, G. S. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8263-z · Cited by 86
Plant–pathogen interactions: toward development of next-generation disease-resistant plants
Nejat, N., Rookes, J. E., Mantri, N. L., & Cahill, D. M. (2016) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2015.1134437 · Cited by 86
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
Hochstrasser, M. L., Taylor, D. W., Kornfeld, J. E., Nogales, E., & Doudna, J. A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.07.027 · Cited by 82
Munck, C., Sheth, R. U., Freedberg, D. E., & Wang, H. H. (2020) · Nature Communications · doi:10.1038/s41467-019-14012-5 · Cited by 83
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9
Eggers, A. R., Chen, K., Soczek, K. M., Tuck, O. T., Doherty, E. E., Xu, B., Trinidad, M. I., Thornton, B. W., Yoon, P. H., & Doudna, J. A. (2024) · Cell · doi:10.1016/j.cell.2024.04.031 · Cited by 76
The CRISPR-Cas system in Enterobacteriaceae
Medina-Aparicio, L., Dávila‐Ramos, S., Rebollar-Flores, J. E., Calva, E., & Hernández-Lucas, I. (2018) · Pathogens and Disease · doi:10.1093/femspd/fty002 · Cited by 80
Impacts of insect oral secretions on defoliation-induced plant defense
Schmelz, E. A. (2015) · Current Opinion in Insect Science · doi:10.1016/j.cois.2015.04.002 · Cited by 77
Hooton, S. P. T., & Connerton, I. F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00744 · Cited by 77
Hupfeld, M., Trasanidou, D., Ramazzini, L., Klumpp, J., Loessner, M. J., & Kilcher, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky544 · Cited by 77
Patterson, A. G., Chang, J. T., Taylor, C., & Fineran, P. C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv517 · Cited by 76
The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease
Sheppard, N. F., Glover, C. V. C., Terns, R. M., & Terns, M. P. (2015) · RNA · doi:10.1261/rna.039842.113 · Cited by 75
Precision genome engineering in lactic acid bacteria
van Pijkeren, J. P., & Britton, R. A. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s10 · Cited by 78
Genetic engineering approaches to understanding drought tolerance in plants
Shinwari, Z. K., Jan, S. A., Nakashima, K., & Yamaguchi‐Shinozaki, K. (2020) · Plant Biotechnology Reports · doi:10.1007/s11816-020-00598-6 · Cited by 77
Development and Application of CRISPR/Cas in Microbial Biotechnology
Ding, W., Zhang, Y., & Shi, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00711 · Cited by 81
Metagenomic reconstructions of bacterial CRISPR loci constrain population histories
Sun, C. L., Thomas, B. C., Barrangou, R., & Banfield, J. F. (2015) · The ISME Journal · doi:10.1038/ismej.2015.162 · Cited by 69
Chen, M., Zhang, J., Peng, Y. Y., Bai, J., Li, S., Han, D., Ren, S., Qin, K., Zhou, H., Han, T., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114792 · Cited by 74
Structural basis for the assembly of the type V CRISPR-associated transposon complex
Schmitz, M., Querques, I., Oberli, S., Chanez, C., & Jínek, M. (2022) · Cell · doi:10.1016/j.cell.2022.11.009 · Cited by 76
Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile
Boudry, P., Semenova, E., Monot, M., Datsenko, K. A., Lopatina, A., Sekulović, O., Ospina-Bedoya, M., Fortier, L., Severinov, K., Dupuy, B., et al. (2015) · mBio · doi:10.1128/mbio.01112-15 · Cited by 79
Fitting CRISPR-associated Cas3 into the Helicase Family Tree
Jackson, R. N., Lavin, M., Carter, J. J., & Wiedenheft, B. (2014) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2014.01.001 · Cited by 72
Applications of genome editing in insects
Reid, W. R., & O’Brochta, D. A. (2015) · Current Opinion in Insect Science · doi:10.1016/j.cois.2015.11.001 · Cited by 72
Exploiting CRISPR–Cas immune systems for genome editing in bacteria
Barrangou, R., & van Pijkeren, J. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.10.003 · Cited by 75
Classification of CRISPR/Cas system and its application in tomato breeding
Chaudhuri, A., Halder, K., & Datta, A. (2022) · Theoretical and Applied Genetics · doi:10.1007/s00122-021-03984-y · Cited by 77
A CRISPR design for next-generation antimicrobials
Beisel, C. L., Gomaa, A. A., & Barrangou, R. (2014) · Genome biology · doi:10.1186/s13059-014-0516-x · Cited by 71
Genome scale engineering techniques for metabolic engineering
Liu, R., Bassalo, M. C., Zeitoun, R. I., & Gill, R. T. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.09.013 · Cited by 71
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease
Zhang, H., Li, Z., Xiao, R., & Chang, L. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0499-0 · Cited by 70
Cas9-Based Tools for Targeted Genome Editing and Transcriptional Control
Xu, T., Li, Y., Nostrand, J. D. V., He, Z., & Zhou, J. Z. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03786-13 · Cited by 71
Boosting plant immunity with CRISPR/Cas
Chaparro‐Garcia, A., Kamoun, S., & Nekrasov, V. (2015) · Genome biology · doi:10.1186/s13059-015-0829-4 · Cited by 68
Clostridioides difficile phage biology and application
Heuler, J., Fortier, L., & Sun, X. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab012 · Cited by 75
Akram, F., Sahreen, S., Aamir, F., Haq, I. U., Malik, K. A., Imtiaz, M., Naseem, W., Nasir, N., & Waheed, H. M. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00501-4 · Cited by 72
Do all creatures possess an acquired immune system of some sort?
Rimer, J., Cohen, I. R., & Friedman, N. (2014) · BioEssays · doi:10.1002/bies.201300124 · Cited by 74
Targeted Genome Editing via CRISPR in the Pathogen Cryptococcus neoformans
Arras, S. D. M., Chua, S. M. H., Wizrah, M. S. I., Faint, J. A., Yap, A. S., & Fraser, J. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164322 · Cited by 67
Higo, A., Isu, A., Fukaya, Y., Ehira, S., & Hisabori, T. (2017) · Plant and Cell Physiology · doi:10.1093/pcp/pcx166 · Cited by 64
Structural insights into a high fidelity variant of SpCas9
Guo, M., Ren, K., Zhu, Y., Tang, Z., Wang, Y., Zhang, B., & Huang, Z. (2019) · Cell Research · doi:10.1038/s41422-018-0131-6 · Cited by 65
Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut
Li, R., Wang, Y., Hu, H., Tan, Y. Q., & Ma, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-35735-y · Cited by 63
Systems biology perspectives on minimal and simpler cells
Xavier, J. C., Patil, K. R., & Rocha, I. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00050-13 · Cited by 58
Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficile
Maikova, A., Kreis, V., Boutserin, A., Severinov, K., & Soutourina, O. A. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.01416-19 · Cited by 67
Staying on target with CRISPR-Cas
Carroll, D. (2013) · Nature Biotechnology · doi:10.1038/nbt.2684 · Cited by 60
Triticale (x Triticosecale Wittmack) Breeding
Mergoum, M., Sapkota, S., ElDoliefy, A. E. A., Naraghi, S. M., Pirseyedi, S. M., Alamri, M., & AbuHammad, W. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-23108-8_11 · Cited by 59
Systematic strategies for developing phage resistant Escherichia coli strains
Zou, X., Xiao, X., Mo, Z., Ge, Y., Jiang, X. Y., Huang, R., Li, M., Deng, Z., Chen, S., Wang, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31934-9 · Cited by 62
Recent developments in genome editing and applications in plant breeding
Jung, C., Capistrano-Gossmann, G. G., Braatz, J., Sashidhar, N., & Melzer, S. (2017) · Plant Breeding · doi:10.1111/pbr.12526 · Cited by 58
Cryo-EM structure of the RNA-guided ribonuclease Cas12g
Li, Z., Zhang, H., Xiao, R., Han, R., & Chang, L. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00721-2 · Cited by 55
Role of platelets and megakaryocytes in adaptive immunity
Marcoux, G., Laroche, A., Romero, J. E., & Boilard, É. (2020) · Platelets · doi:10.1080/09537104.2020.1786043 · Cited by 57
CRISPR-based gene expression control for synthetic gene circuits
Santos‐Moreno, J., & Schaerli, Y. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200020 · Cited by 59
CRISPR/Cas and Argonaute-Based Biosensors for Pathogen Detection
Yang, Z., Mao, S., Wang, L., Fu, S., Dong, Y., Jaffrezic-Renault, N. J., & Guo, Z. (2023) · ACS Sensors · doi:10.1021/acssensors.3c01232 · Cited by 61
Prykhozhij, S. V., Steele, S. L., Razaghi, B., & Berman, J. N. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026765 · Cited by 57
Engineering the Caenorhabditis elegans genome with CRISPR/Cas9
Waaijers, S., & Boxem, M. (2014) · Methods · doi:10.1016/j.ymeth.2014.03.024 · Cited by 54
Gene regulation at transcriptional and post‐transcriptional levels to combat salt stress in plants
Singh, A., & Roychoudhury, A. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13502 · Cited by 55
New Insights for Biosensing: Lessons from Microbial Defense Systems
Wan, Y., Zong, C., Li, X., Wang, A., Li, Y., Yang, T., Bao, Q., DuBow, M. S., Yang, M., Ledesma‐Amaro, R., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01063 · Cited by 58
CRISPR Assays for Disease Diagnosis: Progress to and Barriers Remaining for Clinical Applications
Huang, Z. J., Lyon, C. J., Wang, J., Lu, S., & Hu, Y. (2023) · Advanced Science · doi:10.1002/advs.202301697 · Cited by 60
Advances in Plant Epigenome Editing Research and Its Application in Plants
Qi, Q., Hu, B., Jiang, W., Wang, Y., Yan, J., Ma, F., Guan, Q., & Xu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043442 · Cited by 58
Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs
Jacobsen, T. L., Ttofali, F., Liao, C., Manchalu, S., Gray, B. N., & Beisel, C. L. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa272 · Cited by 55
Mechanism of CRISPR-RNA guided recognition of DNA targets inEscherichia coli
van Erp, P. B. G., Jackson, R. N., Carter, J. J., Golden, S. M., Bailey, S., & Wiedenheft, B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv793 · Cited by 53
40 Years of archaeal virology: Expanding viral diversity
Snyder, J. C., Bolduc, B., & Young, M. (2015) · Virology · doi:10.1016/j.virol.2015.03.031 · Cited by 55
Achigar, R., Magadán, A. H., Tremblay, D. M., Pianzzola, M. J., & Moineau, S. (2017) · Scientific Reports · doi:10.1038/srep43438 · Cited by 55
Uppada, V., Gokara, M., & Rasineni, G. K. (2018) · Gene · doi:10.1016/j.gene.2018.02.066 · Cited by 54
Li, S., & Xia, L. (2019) · aBIOTECH · doi:10.1007/s42994-019-00009-7 · Cited by 55
Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition
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Metadata
- Authors
- Sorek, R., Lawrence, C. M., & Wiedenheft, B.
- Affiliations
- Weizmann Institute of Science (IL)
- Montana State University (US)
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2013-06-02
- Volume
- 82
- Issue
- 1
- Pages
- 237-266
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2131157113
- Cited by
- 668
- References
- 158
- Citations by year
- 2026: 12 · 2025: 32 · 2024: 52 · 2023: 54 · 2022: 46 · 2021: 44 · 2020: 58 · 2019: 42 · 2018: 46 · 2017: 59 · 2016: 53 · 2015: 67 · 2014: 79 · 2013: 23
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0628732, 0920312)
- Leona M. and Harry B. Helmsley Charitable Trust
- Deutsche Forschungsgemeinschaft
- Israel Science Foundation (1303/12)
- National Institutes of Health
- National Institute of General Medical Sciences (GM-103500, R01GM108888, P20GM103500)
- National Center for Research Resources
- FP7 Ideas: European Research Council (260432)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Keywords
- CRISPR, adaptive immunity, bacteria, archaea, small RNA, autoimmunity, immune evasion, evolutionary implications, ecological implications
- MeSH terms
- Archaea, Bacteria, RNA, Bacterial, Signal Transduction, RNA, Archaeal, Inverted Repeat Sequences, Adaptive Immunity
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