CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Barrangou, R., Fremaux, C., Deveau, H., Richards, M., Boyaval, P., Moineau, S., Romero, D. A., & Horvath, P. (2007) · Science · doi:10.1126/science.1138140 · Cited by 5,947

CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III

Deltcheva, E., Chylinski, K., Sharma, C. M., Gonzales, K., Chao, Y., Pirzada, Z. A., Eckert, M. R., Vogel, J., & Charpentier, E. (2011) · Nature · doi:10.1038/nature09886 · Cited by 2,563

CRISPR/Cas, the Immune System of Bacteria and Archaea

Horvath, P., & Barrangou, R. (2010) · Science · doi:10.1126/science.1179555 · Cited by 2,471

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

Brouns, S. J. J., Jore, M. M., Lundgren, M., Westra, E. R., Slijkhuis, R. J. H., Snijders, A. P. L., Dickman, M. J., Makarova, K. S., Koonin, E. V., & van der Oost, J. (2008) · Science · doi:10.1126/science.1159689 · Cited by 2,460

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

Ishino, Y., Shinagawa, H., Makino, K., Amemura, M., & Nakata, A. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.12.5429-5433.1987 · Cited by 2,421

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

Garneau, J. E., Dupuis, M.-È., Villion, M., Romero, D. A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A. H., & Moineau, S. (2010) · Nature · doi:10.1038/nature09523 · Cited by 2,336

Evolution and classification of the CRISPR–Cas systems

Makarova, K. S., Haft, D. H., Barrangou, R., Brouns, S. J. J., Charpentier, E., Horvath, P., Moineau, S., Mojica, F. J. M., Wolf, Y. I., Yakunin, A. F., et al. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2577 · Cited by 2,331

Viruses in the sea

Suttle, C. A. (2005) · Nature · doi:10.1038/nature04160 · Cited by 2,186

CRISPR Craft: DNA Editing the Reconstructive Ladder

Roh, D. S., Li, E. B. H., & Liao, E. C.-W. (2018) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000004863 · Cited by 23

Essentiality of the glnA gene in Haloferax mediterranei: gene conversion and transcriptional analysis

Rodríguez-Herrero, V., Payá, G., Bautista, V., Vegara, A., Molina, M. C., Camacho, M. L., Esclapez, J., & Bonete, M.-J. (2020) · Extremophiles · doi:10.1007/s00792-020-01169-x · Cited by 24

Research Progress and Application of Miniature CRISPR-Cas12 System in Gene Editing

Xuan, Q., Wang, J., Nie, Y., Fang, C., & Liang, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312686 · Cited by 22

Nonconventional Therapeutics against Staphylococcus aureus

Grunenwald, C. M., Bennett, M. R., & Skaar, E. P. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0047-2018 · Cited by 22

Diagnostics of COVID-19 Based on CRISPR–Cas Coupled to Isothermal Amplification: A Comparative Analysis and Update

Hernández-García, A., Morales-Moreno, M. D., Valdés-Galindo, E. G., Jimenez-Nieto, E. P., & Quezada, A. (2022) · Diagnostics · doi:10.3390/diagnostics12061434 · Cited by 22

Pathogen-Specific Bactericidal Method Mediated by Conjugative Delivery of CRISPR-Cas13a Targeting Bacterial Endogenous Transcripts

Song, Z., Yu, Y., Bai, X., Jia, Y., Tian, J., Gu, K., Zhao, M., Zhou, C., Zhang, X., Wang, H., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01300-22 · Cited by 22

Future Directions for Adrenal Insufficiency: Cellular Transplantation and Genetic Therapies

Graves, L. E., Torpy, D. J., Coates, P. T., Alexander, I. E., Bornstein, S. R., & Clarke, B. M. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac751 · Cited by 23

CRISPR-Cas effector specificity and cleavage site determine phage escape outcomes

Schelling, M. A., Nguyen, G. T., & Sashital, D. G. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002065 · Cited by 22

New Insights Into Functions and Possible Applications of Clostridium difficile CRISPR-Cas System

Maikova, A. S., Severinov, K., & Soutourina, O. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01740 · Cited by 21

Cupriavidus metallidurans Strains with Different Mobilomes and from Distinct Environments Have Comparable Phenomes

Houdt, R. V., Provoost, A., Assche, A. V., Leys, N., Lievens, B., Mijnendonckx, K., & Monsieurs, P. (2018) · Genes · doi:10.3390/genes9100507 · Cited by 22

Developing a genetic manipulation system for the Antarctic archaeon, Halorubrum lacusprofundi: investigating acetamidase gene function

Liao, Y., Williams, T. J., Walsh, J. C., Ji, M., Poljak, A., Curmi, P. M. G., Duggin, I. G., & Cavicchioli, R. (2016) · Scientific Reports · doi:10.1038/srep34639 · Cited by 22

A review on advanced methods in plant gene targeting

Sanagala, R., Moola, A. K., & Diana, R. K. B. (2017) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2017.07.004 · Cited by 22

Cyclic Tetra-Adenylate (cA4) Recognition by Csa3; Implications for an Integrated Class 1 CRISPR-Cas Immune Response in Saccharolobus solfataricus

Charbonneau, A. A., Eckert, D. M., Gauvin, C. C., Lintner, N. G., & Lawrence, C. M. (2021) · Biomolecules · doi:10.3390/biom11121852 · Cited by 21

Multiple homologous genes knockout (KO) by CRISPR/Cas9 system in rabbit

Liu, H., Sui, T., Liu, D., Liu, T., Chen, M., Deng, J., Xu, Y., & Li, Z. (2018) · Gene · doi:10.1016/j.gene.2018.01.044 · Cited by 21

Transcriptional profiles of Haloferax mediterranei based on nitrogen availability

Esclapez, J., Pire, C., Camacho, M. L., Bautista, V., Martínez‐Espinosa, R. M., Zafrilla, B., Vegara, A., Alcaraz, L. A., & Bonete, M.-J. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.11.018 · Cited by 21

A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebrafish Using CRISPR/Cas9

Prykhozhij, S. V., Rajan, V., & Berman, J. N. (2015) · Zebrafish · doi:10.1089/zeb.2015.1158 · Cited by 20

Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System

Dou, C. R., Yu, M., Gu, Y., Wang, J., Yin, K., Nie, C., Zhu, X., Qi, S., Wei, Y., & Cheng, W. (2018) · iScience · doi:10.1016/j.isci.2018.04.001 · Cited by 20

Energy- and cost-effective non-sterilized fermentation of 2,3-butanediol by an engineered Klebsiella pneumoniae OU7 with an anti-microbial contamination system

Guo, Z., Ou, X., Xu, P., Gao, H., Zhang, L., Zong, M., & Lou, W. (2020) · Green Chemistry · doi:10.1039/d0gc03044a · Cited by 20

History and Classification of CRISPR/Cas System

Khan, Z., Ali, Z., Khan, A. A., Sattar, T., Zeshan, A., Saboor, T., & Binyamin, B. (2022) · Springer eBooks · doi:10.1007/978-981-16-6305-5_2 · Cited by 21

CRISPR-based microalgal genome editing and the potential for sustainable aquaculture: a comprehensive review

Ambily, B., Mol, V. P. L., Sini, H., & Nevin, K. G. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03376-x · Cited by 22

CRISPR-Cas immunity and mobile DNA: a new superfamily of DNA transposons encoding a Cas1 endonuclease

Hickman, A. B., & Dyda, F. (2014) · Mobile DNA · doi:10.1186/1759-8753-5-23 · Cited by 20

What rheumatologists need to know about CRISPR/Cas9

GIBSON, G. J., & Yang, M. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.6 · Cited by 20

CRF: detection of CRISPR arrays using random forest

Wang, K., & Liang, C. (2017) · PeerJ · doi:10.7717/peerj.3219 · Cited by 20

CRISPR RNA and anti-CRISPR protein binding to the Xanthomonas albilineans Csy1-Csy2 heterodimer in the type I-F CRISPR-Cas system

Hong, S., Ka, D., Yoon, S. J., Suh, N., Jeong, M., Suh, J., & Bae, E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001611 · Cited by 20

Csx3 is a cyclic oligonucleotide phosphodiesterase associated with type III CRISPR–Cas that degrades the second messenger cA4

Brown, S., Gauvin, C. C., Charbonneau, A. A., Burman, N., & Lawrence, C. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014099 · Cited by 20

CRISPR-based assays for low-resource settings

Huang, Z. J., Lyon, C. J., & Hu, Y. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00026-8 · Cited by 19

Draft Genome Sequence of the Iron-Oxidizing Acidophile Leptospirillum ferriphilum Type Strain DSM 14647

Cárdenas, J. P., Lazcano, M., Ossandon, F. J., Corbett, M. K., Holmes, D. S., & Watkin, E. L. J. (2014) · Genome Announcements · doi:10.1128/genomea.01153-14 · Cited by 19

CRISPR/Cas9 system and its applications in human hematopoietic cells

Hu, X. (2016) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2016.09.003 · Cited by 22

CRISPR-Cas system presents multiple transcriptional units including antisense RNAs that are expressed in minimal medium and upregulated by pH in Salmonella enterica serovar Typhi

Medina-Aparicio, L., Rebollar-Flores, J. E., America, A. B., Vázquez, A., Gutiérrez-Ríos, R.-M., Olvera, L., Calva, E., & Hernández-Lucas, I. (2016) · Microbiology · doi:10.1099/mic.0.000414 · Cited by 20

Elimination of the cryptic plasmid in Leuconostoc citreum by CRISPR/Cas9 system

Jang, Y.-J., Seo, S.-O., Kim, S.-A., Li, L., Kim, T., Kim, S. C., Jin, Y., & Han, N. S. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.04.018 · Cited by 19

Curing the endogenous megaplasmid in Clostridium saccharoperbutylacetonicum N1-4 (HMT) using CRISPR-Cas9 and preliminary investigation of the role of the plasmid for the strain metabolism

Gu, Y., Feng, J., Zhang, Z.-T., Wang, S., Guo, L., Wang, Y., & Wang, Y. (2018) · Fuel · doi:10.1016/j.fuel.2018.09.030 · Cited by 19

Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model

Wiechert, J., Filipchyk, A., Hünnefeld, M., Gätgens, C., Brehm, J., Heermann, R., & Frunzke, J. (2020) · mBio · doi:10.1128/mbio.02273-19 · Cited by 19

Recruiting a Phosphite Dehydrogenase/Formamidase-Driven Antimicrobial Contamination System in Bacillus subtilis for Nonsterilized Fermentation of Acetoin

Guo, Z., Ou, X., Liang, S. L., Gao, H., Zhang, L., Zong, M., & Lou, W. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00312 · Cited by 19

Dynamics changes of CRISPR-Cas9 systems induced by high fidelity mutations

Zheng, L., Shi, J., & Mu, Y. (2018) · Physical Chemistry Chemical Physics · doi:10.1039/c8cp04226h · Cited by 19

Genome-resolved metagenomics provides insights into the functional complexity of microbial mats in Blue Holes, Shark Bay

Kindler, G. S., Wong, H. L., Larkum, A. W. D., Johnson, M. S., MacLeod, F. I., & Burns, B. P. (2021) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiab158 · Cited by 21

Exploiting the Type I-B CRISPR Genome Editing System in Thermoanaerobacterium aotearoense SCUT27 and Engineering the Strain for Enhanced Ethanol Production

Dai, K., Fu, H., Guo, X., Qu, C., Lan, Y., & Wang, J. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.00751-22 · Cited by 18

Methods of Evaluating the Efficiency of CRISPR/Cas Genome Editing

Lomov, N. A., Viushkov, V. S., Petrenko, A. P., Syrkina, M. S., & Rubtsov, M. A. (2019) · Molecular Biology · doi:10.1134/s0026893319060116 · Cited by 20

First Experimental Evidence for the Presence of a CRISPR Toxin in Sulfolobus

He, F., Chen, L., & Peng, X. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.09.016 · Cited by 18

Classification of a Violacein-Producing Psychrophilic Group of Isolates Associated with Freshwater in Antarctica and Description of Rugamonas violacea sp. nov.

Sedláček, I., Holochová, P., Sobotka, R., Busse, H., Švec, P., Králová, S., Šedo, O., Pilný, J., Staňková, E., Koublová, V., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00452-21 · Cited by 17

Platinum nanoparticles (PtNPs)-based CRISPR/Cas12a platform for detection of nucleic acid and protein in clinical samples

Liang, J., Teng, P., Hu, L., He, G., Song, Q., Zhang, Y., Peng, B., Li, G., Xiao, W., Cao, D., et al. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.340203 · Cited by 18

Types I and V Anti-CRISPR Proteins: From Phage Defense to Eukaryotic Synthetic Gene Circuits

Yu, L., & Marchisio, M. A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.575393 · Cited by 18

Probing the structural dynamics of the CRISPR‐Cas9 RNA‐guided DNA‐cleavage system by coarse‐grained modeling

Zheng, W. (2016) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.25229 · Cited by 17

Advances in improving tomato fruit quality by gene editing

Yuan, L., Gai, W.-X., Xuan, X., Ahiakpa, J. K., Li, F., Ge, P., Zhang, X., Tao, J., Yang, Y., & Zhang, Y. (2024) · Horticultural Plant Journal · doi:10.1016/j.hpj.2024.04.008 · Cited by 19

Advances in CRISPR-based gene editing technology and its application in nucleic acid detection

Chen, L., LI, J., Chen, J., Duan, L., Hu, Z., Li, K., Liao, D., & HE, N. (2024) · Biocell · doi:10.32604/biocell.2024.056698 · Cited by 16

The CRISPR-Cas system in Lactiplantibacillus plantarum strains: identification and characterization using a genome mining approach

Rostampour, M., Panahi, B., & Jahandizi, R. M. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1394756 · Cited by 16

A Type I Restriction Modification System Influences Genomic Evolution Driven by Horizontal Gene Transfer in Paenibacillus polymyxa

Chen, Z., Shen, M., Mao, C., Wang, C., Yuan, P., Wang, T., & Sun, D. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.709571 · Cited by 16

Protospacer-Adjacent Motif Specificity during Clostridioides difficile Type I-B CRISPR-Cas Interference and Adaptation

Maikova, A. S., Boudry, P., Shiriaeva, A., Vasileva, A., Boutserin, A., Medvedeva, S., Semenova, E., Severinov, K., & Soutourina, O. A. (2021) · mBio · doi:10.1128/mbio.02136-21 · Cited by 16

Mouse knockout models for HIV-1 restriction factors

Rehwinkel, J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1646-8 · Cited by 18

Catalytically Enhanced Cas9 Through Directed Protein Evolution

Hand, T. H., Roth, M. O., Smith, C. L., Shiel, E. A., Klein, K. N., Gilbert, D. M., & Li, H. (2021) · The CRISPR Journal · doi:10.1089/crispr.2020.0092 · Cited by 15

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application

Du, P., Lou, C., Zhao, X., Wang, Q., Ji, X., & Wei, W. (2021) · Life · doi:10.3390/life11111255 · Cited by 16

Ruminal Viruses (Bacteriophages, Archaeaphages)

Gilbert, R. A., & Klieve, A. V. (2015) · Springer eBooks · doi:10.1007/978-81-322-2401-3_9 · Cited by 16

Structural and mechanistic insights into the CRISPR inhibition of AcrIF7

Kim, I., Koo, J., An, S. Y., Hong, S., Ka, D., Kim, E., Bae, E., & Suh, J. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa690 · Cited by 16

Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector

Huo, Y., Zhao, H., Dong, Q., & Jiang, T. (2023) · Nature Microbiology · doi:10.1038/s41564-022-01316-4 · Cited by 15

Genome editing with natural and engineered CjCas9 orthologs

Gao, S., Wang, Y., Qi, T., Wei, J., Hu, Z., Liu, J., Sun, S., Liu, H., & Wang, Y. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.029 · Cited by 16

Motif depletion in bacteriophages infecting hosts with CRISPR systems

Kupczok, A., & Bollback, J. P. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-663 · Cited by 15

Yeast Still a Beast: Diverse Applications of CRISPR/Cas Editing Technology in S. cerevisiae.

Giersch, R. M., & Finnigan, G. C. (2017) · PubMed Central · Cited by 15

Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage

Yang, D., Wang, Z., Ma, J., Fu, Q., Wu, L., Wang, H., Wang, S., Yan, Y., & Sun, J. (2020) · Viruses · doi:10.3390/v12010090 · Cited by 15

Histone-like Nucleoid-Structuring Protein (H-NS) Paralogue StpA Activates the Type I-E CRISPR-Cas System against Natural Transformation in Escherichia coli

Sun, D., Mao, X., Fei, M., Chen, Z., Zhu, T., & Qiu, J. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.00731-20 · Cited by 15

Label-free dual-mode sensing platform based on target-regulated CRISPR–Cas12a activity for ochratoxin A in Morinda officinalis

Xu, H., Pan, R., Huang, W., & Zhu, X. (2023) · Analytical Methods · doi:10.1039/d3ay01025b · Cited by 14

Advances in miniature CRISPR-Cas proteins and their applications in gene editing

Wu, H., Sun, Y., Wang, Y., Li, L., & Song, Y. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03962-0 · Cited by 13

Directed evolution studies of a thermophilic Type II-C Cas9

Hand, T. H., Das, A., & Li, H. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.10.029 · Cited by 12

Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species

Watanabe, T., Shibasaki, M., Maruyama, F., Sekizaki, T., & Nakagawa, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183752 · Cited by 14

Chemical transformation mediated CRISPR/Cas9 genome editing in Escherichia coli

Sun, D., Wang, L., Mao, X., Fei, M., Chen, Y., Shen, M., & Qiu, J. (2018) · Biotechnology Letters · doi:10.1007/s10529-018-02639-1 · Cited by 14

Phenotypic and genomic analysis of isopropanol and 1,3-propanediol producer Clostridium diolis DSM 15410

Sedlář, K., Vasylkivska, M., Musilová, J., Branská, B., Provazník, I., & Patáková, P. (2020) · Genomics · doi:10.1016/j.ygeno.2020.11.007 · Cited by 14

Expansion of the CRISPR/Cas Genome-Sculpting Toolbox: Innovations, Applications and Challenges

Batool, A., Malik, F. A., & Andrabi, K. I. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00500-8 · Cited by 14

Global transcription of CRISPR loci in the human oral cavity

Lum, A. G., Ly, M., Santiago-Rodríguez, T. M., Naidu, M., Boehm, T. K., & Pride, D. T. (2015) · BMC Genomics · doi:10.1186/s12864-015-1615-0 · Cited by 14

Current advances in CRISPR-Cas-mediated gene editing and regulation in cyanobacteria

Dong, Z., Chen, L., Wang, Y., Sun, T., & Zhang, W. (2024) · Blue Biotechnology · doi:10.1186/s44315-024-00009-3 · Cited by 16

Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research

Niu, D., Zhao, Q., Xu, L., & Lin, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212360 · Cited by 14

Exploiting the Potential of Spherical PAM Antenna for Enhanced CRISPR-Cas12a: A Paradigm Shift toward a Universal Amplification-Free Nucleic Acid Test Platform

Dai, J., Wu, B., Ai, F., Yang, Z., Lu, Y., Zinian, C., Zeng, K., & Zhang, Z. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04871 · Cited by 13

Recognition of a pseudo-symmetric RNA tetranucleotide by Csx3, a new member of the CRISPR associated Rossmann fold superfamily

Topuzlu, E., & Lawrence, C. M. (2016) · RNA Biology · doi:10.1080/15476286.2015.1130209 · Cited by 13

Gene editing to investigate the role of conceptus factors in the establishment of pregnancy in the pig

Geisert, R. D., Meyer, A. E., Pfeiffer, C. A., Johns, D. N., Lee, K., Wells, K. D., Spencer, T. E., & Prather, R. S. (2021) · Reproduction · doi:10.1530/rep-20-0604 · Cited by 13

Fluorescence-based methods for measuring target interference by CRISPR–Cas systems

Phan, P. T., Schelling, M. A., Xue, C., & Sashital, D. G. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.10.027 · Cited by 13

Cas9 regulated gene expression and pathogenicity in Riemerella anatipestifer

Wang, Y., Yin, X., Zhou, Z., Hu, S., Li, S., Liu, M., Wang, X., Xiao, Y., Shi, D., Bi, D., et al. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103706 · Cited by 13

Genome editing in the nematode Caenorhabditis briggsae using the CRISPR/Cas9 system

Culp, E. J., Richman, C. M., Sharanya, D., Jhaveri, N. S., van den Berg, W., & Gupta, B. P. (2020) · Biology Methods and Protocols · doi:10.1093/biomethods/bpaa003 · Cited by 14

CRISPR-Cas systems in the marine actinomycete Salinispora: linkages with phage defense, microdiversity and biogeography

Wietz, M., Millán‐Aguiñaga, N., & Jensen, P. R. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-936 · Cited by 13

Molecular Improvement of Grain: Target Traits for a Changing World

Singer, S. D., Foroud, N. A., & Laurie, J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22439-6 · Cited by 13

Plant–Pathogen Interactions and Global Food Security

Ezrari, S., Legrifi, I., Taoussi, M., Khadiri, M., Belabess, Z., & Lahlali, R. (2023) · Springer eBooks · doi:10.1007/978-981-99-4890-1_2 · Cited by 12

Методы оценки эффективности работы систем CRISPR/Cas при геномном редактировании

Lomov, N. A., Viushkov, V. S., Petrenko, A. P., Syrkina, M. S., & Rubtsov, M. A. (2019) · Molecular Biology · doi:10.1134/s0026898419060119 · Cited by 12

Physiology of the read–write genome

Shapiro, J. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.271130 · Cited by 12

CRISPR/Transposon gene integration (CRITGI) can manage gene expression in a retrotransposon-dependent manner

Hanasaki, M., & Masumoto, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-51891-6 · Cited by 13

Four thermostatic steps: A novel CRISPR-Cas12-based system for the rapid at-home detection of respiratory pathogens

Fang, J., Liu, J., Cheng, N., Kang, X., Huang, Z., Wang, G., Xiong, X., Tian, L., Gong, Z., Huang, Z., et al. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12568-3 · Cited by 11

Advances in Diversity, Evolutionary Dynamics and Biotechnological Potential of Restriction-Modification Systems

Chen, C., Zhang, Y., Wu, H., Qiao, J., & Caiyin, Q. (2025) · Microorganisms · doi:10.3390/microorganisms13051126 · Cited by 12

Pseudo-chaotic oscillations in CRISPR-virus coevolution predicted by bifurcation analysis

Berezovskaya, F., Wolf, Y. I., Koonin, E. V., & Karev, G. P. (2014) · Biology Direct · doi:10.1186/1745-6150-9-13 · Cited by 11

Diversity and Evolution of Clostridium beijerinckii and Complete Genome of the Type Strain DSM 791T

Sedlář, K., Nykrýnová, M., Bezdíček, M., Branská, B., Lengerová, M., Patáková, P., & Škutková, H. (2021) · Processes · doi:10.3390/pr9071196 · Cited by 11

The use of CRISPR-Cas-based systems in bacterial cell factories

Kolasinliler, G., Aagre, M. M., Akkale, C., & Kaya, H. B. (2023) · Biochemical Engineering Journal · doi:10.1016/j.bej.2023.108880 · Cited by 11

Whole genome sequencing and characterization of Pantoea agglomerans DBM 3797, endophyte, isolated from fresh hop (Humulus lupulus L.)

Patáková, P., Vasylkivska, M., Sedlář, K., Jureckova, K., Bezdíček, M., Lovecká, P., Branská, B., Kaštánek, P., & Krofta, K. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1305338 · Cited by 10

Improving the use of CRISPR/Cas9 gene editing machinery as a cancer therapeutic tool with the help of nanomedicine

Fatima, H., Singh, D., Muhammad, H., Acharya, S., & Aziz, M. A. (2024) · 3 Biotech · doi:10.1007/s13205-024-04186-1 · Cited by 12

Adaptive loss of tRNA gene expression leads to phage resistance in a marine Synechococcus cyanobacterium

Zborowsky, S., Tahan, R., & Lindell, D. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01877-6 · Cited by 12

TstI, a Type II restriction–modification protein with DNA recognition, cleavage and methylation functions in a single polypeptide

Smith, R. M., Pernstich, C., & Halford, S. E. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku187 · Cited by 10

Genome engineering and disease modeling via programmable nucleases for insulin gene therapy; promises of CRISPR/Cas9 technology

Ekşi, Y. E., Şanlioğlu, A. D., Akkaya, B., Öztürk, B. E., & Şanlıoğlu, S. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i6.485 · Cited by 10

Pseudomonas petrae sp. nov. isolated from regolith samples in Antarctica

Nováková, D., Koublová, V., Sedlář, K., Staňková, E., Králová, S., Švec, P., Neumann‐Schaal, M., Wolf, J., Koudelková, S., Barták, M., et al. (2023) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2023.126424 · Cited by 10

CRISPR-Cas- and Aptamer-based Systems for Diagnosing Pathogens: A Review

Yu, H., Jing, W., & Cheng, X. (2023) · Zoonoses · doi:10.15212/zoonoses-2023-0008 · Cited by 10

Challenges of metagenomics and single-cell genomics approaches for exploring cyanobacterial diversity

Davison, M. R., Hall, E., Zare, R. N., & Bhaya, D. (2014) · Photosynthesis Research · doi:10.1007/s11120-014-0066-9 · Cited by 10

Challenging the Therapy/Enhancement Distinction in CRISPR Gene Editing

Gouw, A. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-93907-0_38 · Cited by 11

Construction of Traf3 knockout liver cancer cell line using CRISPR/Cas9 system

Hu, W., Guo, G., Chi, Y., & Li, F. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28753 · Cited by 10

Chondrogenic differentiation followed IGFBP3 loss in human endometrial mesenchymal stem cells

Ushakov, R. E., Skvortsova, E. V., Vitte, M. A., Vassilieva, I. O., Shatrova, A. N., Kotova, A. V., Kenis, V. M., & Burova, E. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.064 · Cited by 10

Dominant short repeated sequences in bacterial genomes

Avershina, E., & Rudi, K. (2015) · Genomics · doi:10.1016/j.ygeno.2014.12.009 · Cited by 10

Mechanism of spacer integration links the CRISPR/Cas system to transposition as a form of mobile DNA

Dyda, F., & Hickman, A. B. (2015) · Mobile DNA · doi:10.1186/s13100-015-0039-3 · Cited by 10

Structural and dynamic insights into the role of conformational switching in the nuclease activity of the Xanthomonas albilineans Cas2 in CRISPR-mediated adaptive immunity

Ka, D., Hong, S., Jeong, U., Jeong, M., Suh, N., Suh, J., & Bae, E. (2017) · Structural Dynamics · doi:10.1063/1.4984052 · Cited by 10

Facilitated diffusion of Argonaute-mediated target search

Cui, T. J., & Joo, C. (2019) · RNA Biology · doi:10.1080/15476286.2019.1616353 · Cited by 11

CRISPR adaptive immunity systems of prokaryotes

Pougach, K., Lopatina, A., & Severinov, K. (2012) · Molecular Biology · doi:10.1134/s0026893312020136 · Cited by 6

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature · doi:10.1038/nature10886 · Cited by 1,851

The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea

Karginov, F. V., & Hannon, G. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.12.033 · Cited by 384

Crispr‐Cas, The Prokaryotic Adaptive Immune System

Marraffini, L. A. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.107.1 · Cited by 2

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Dimitriu, T., Szczelkun, M. D., & Westra, E. R. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.028 · Cited by 105