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Sterol Regulation of Metabolism, Homeostasis, and Development

Wollam, Joshua, Antebi, Adam·2011·Annual Review of Biochemistry
DOI 10.1146/annurev-biochem-081308-165917
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Abstract

Sterol metabolites are critical signaling molecules that regulate metabolism, development, and homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate sterol-responsive nuclear hormone receptors to control these processes through feed-forward and feedback mechanisms. These signaling pathways are conserved from simple invertebrates to mammals. Indeed, results from various model organisms have yielded fundamental insights into cholesterol and BA homeostasis, lipid and glucose metabolism, protective mechanisms, tissue differentiation, development, reproduction, and even aging. Here, we review how sterols act through evolutionarily ancient mechanisms to control these processes.

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Cited by

Metadata

Authors
Wollam, J., & Antebi, A.
Affiliations
Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2011-07-07
Volume
80
Issue
1
Pages
885-916
ISSN
  • 0066-4154
  • 1545-4509
DOI
10.1146/annurev-biochem-081308-165917
Cited by
158
References
19
Language
en

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