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Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Open accessAbstract
Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein–coupled seven-transmembrane signaling receptors is also critical for the generation of primary and secondary adaptive cellular and humoral immune responses. Recent studies demonstrate important roles for the chemokine system in the priming of naive T cells, in cell fate decisions such as effector and memory cell differentiation, and in regulatory T cell function. In this review, we focus on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.
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Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“Compared with TCM, TEM proliferate less and are skewed toward greater production of effector cytokines such as IFN-γ (203).”
BackgroundNeutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 2×
“These cells therefore preferentially migrate between the blood and spleen compartments and enter peripheral organs, such as the lung, liver, intestinal tract, and kidney (191, 192).”
BackgroundVictora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · cited 1×
“Although the preferential expression of these chemokine receptors is apparent in vitro, there is some overlapping expression in vivo, which is not surprising given the relative plasticity between the various CD4+ T cell subsets (178).”
BackgroundRapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331 · cited 1×
“For example, the development of CD8+ TRM in the skin during HSV infection is dependent upon localization of CD8+ TRM precursors to the epidermis by CXCR3-CXCL10 interactions, which counteract a CCR7-dependent tissue exit signal (209).”
BackgroundProduction of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079 · cited 3×
“CCL24 Eotaxin-2, MPIF-2 CCR3 Eosinophil and basophil migration CCL25 TECK CCR9 T cell homing to gut; thymocyte migration CCL26 Eotaxin-3 CCR3, CX3CR1 Eosinophil and basophil migration CCL27 CTAK CCR10 T cell homing to skin CCL28 MEC CCR3, CCR10 T cell and IgA plasma cell homing to mucosa XCL1 Lymphotactin α, SCM-1α XC…”
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Zhang, L., Yu, X., Zheng, L., Zhang, Y., Li, Y., Fang, Q., Gao, R., Kang, B., Zhang, Q., Huang, J. Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0694-x · Cited by 1,505
Xiong, Y., Liu, Y., Cao, L., Wang, D., Guo, M., Jiang, A., Guo, D., Hu, W., Yang, J., Tang, Z., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1747363 · Cited by 1,076
Dangaj, D., Bruand, M., Grimm, A. J., Ronet, C., Barras, D., Duttagupta, P. A., Lanitis, E., Duraiswamy, J., Tanyi, J. L., Benencia, F., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.004 · Cited by 875
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“CXCR3 on CD8 T Cells Is Essential for Anti-PD-1Mediated CD8 T Cell Activation CXCR3 is expressed not only on T cells but also on other hematopoietic cells, such as innate lymphocytes and plasmacytoid DCs (Griffith et al., 2014).”
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Zhu, S., Zhang, T., Zheng, L., Liu, H., Song, W., Liu, D., Li, Z., & Pan, C.-X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01164-5 · Cited by 654
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Kohli, K., Pillarisetty, V. G., & Kim, T. S. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-021-00303-x · Cited by 583
Bain, C. C., Hawley, C. A., Garner, H., Scott, C. L., Schridde, A., Steers, N. J., Mack, M., Joshi, A., Guilliams, M., Mowat, A. M. I., et al. (2016) · Nature Communications · doi:10.1038/ncomms11852 · Cited by 527
Mikucki, M. E., Fisher, D. T., Matsuzaki, J., Skitzki, J. J., Gaulin, N. B., Muhitch, J. B., Ku, A. W., Frelinger, J. G., Odunsi, K., Gajewski, T. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8458 · Cited by 512
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Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood · doi:10.1182/blood-2015-09-618538 · Cited by 413
Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385
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De Marco, S., Sichetti, M., Muradyan, D., Piccioni, M., Traina, G., Pagiotti, R., & Pietrella, D. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/1756308 · Cited by 297
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Do, T. H., Ma, F., Andrade, P. R., Teles, R., de Andrade Silva, B. J., Hu, C., Espinoza, A., Hsu, J.-E., Cho, C.-S., Kim, M., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo2787 · Cited by 139
“” These included proinflammatory chemokines and cytokines known to recruit and activate immune cells such as IL18, CCL5, CCL18, CXCL2, CXCL3, CXCL5, CXCL9, CXCL16, MIF, SPP1, TNFSF13B, and TNFSF14 (76) (table S13).”
BackgroundMitophagy and cGAS–STING crosstalk in neuroinflammation
Zhou, X., Wang, J., Yu, L., Qiao, G., Qin, D., Yuen-Kwan Law, B., Ren, F., Wu, J., & Wu, A. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.012 · Cited by 131
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Lv, J., Gao, H., Ma, J., Liu, J., Tian, Y., Yang, C., Li, M., Zhao, Y., Li, Z., Zhang, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1230266 · Cited by 48
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Fleischmann, R. M., Wagner, F., Kivitz, A. J., Mansikka, H. T., Khan, N., Othman, A. A., Khatri, A., Hong, F., Jiang, P., Ruzek, M., et al. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40319 · Cited by 32
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Yoh, S., Kawarai, Y., Hagiwara, S., Orita, S., Nakamura, J., Miyamoto, S., Suzuki, T., Akazawa, T., Shiko, Y., Kawasaki, Y., et al. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05454-y · Cited by 26
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Metadata
- Authors
- Griffith, J. W., Sokol, C. L., & Luster, A. D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 659-702
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2153960708
- Cited by
- 2,059
- References
- 19
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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