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Epigenetic Mechanisms of Depression and Antidepressant Action
Open accessAbstract
Epigenetic mechanisms, which control chromatin structure and function, mediate changes in gene expression that occur in response to diverse stimuli. Recent research has established that environmental events and behavioral experience induce epigenetic changes at particular gene loci and that these changes help shape neuronal plasticity and function and hence behavior. Some of these changes can be stable and can even persist for a lifetime. Increasing evidence supports the hypothesis that aberrations in chromatin remodeling and subsequent effects on gene expression within limbic brain regions contribute to the pathogenesis of depression and other stress-related disorders such as post-traumatic stress disorder and other anxiety syndromes. Likewise, the gradually developing but persistent therapeutic effects of antidepressant medications may be achieved in part via epigenetic mechanisms. This review discusses recent advances in our understanding of the epigenetic regulation of stress-related disorders and focuses on three distinct aspects of stress-induced epigenetic pathology: the effects of stress and antidepressant treatment during adulthood, the lifelong effects of early-life stress on subsequent stress vulnerability, and the possible transgenerational transmission of stress-induced abnormalities.
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In the citing paper
“In genetically susceptible models of treatment-resistant depression, SAHA inhibits HDAC2, restores histone acetylation and BDNF levels, and reverses antidepressant non-responsiveness (Meylan et al., 2016; Vialou et al., 2013).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Vialou et al., 2013
Experimental — accuracy not yet measuredIn the citing paper
“This maintains that depressed mood reflects an adaptive, risk-averse approach to social interaction that reduces the likelihood of further aversive outcomes by: (1) increasing our cognitive sensitivity to (sensory) cues of social risk; (2) reducing our (behavioural) propensity for taking social risks; and (3) initiating signalling behaviours that elicit support and defuse conflict [32].”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“This maintains that depressed mood reflects an adaptive, risk-averse approach to social interaction that reduces the likelihood of further aversive outcomes by: (1) increasing our cognitive sensitivity to (sensory) cues of social risk; (2) reducing our (behavioural) propensity for taking social risks; and (3) initiating signalling behaviours that elicit support and defuse conflict [32].”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“This maintains that depressed mood reflects an adaptive, risk-averse approach to social interaction that reduces the likelihood of further aversive outcomes by: (1) increasing our cognitive sensitivity to (sensory) cues of social risk; (2) reducing our (behavioural) propensity for taking social risks; and (3) initiating signalling behaviours that elicit support and defuse conflict [32].”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“This maintains that depressed mood reflects an adaptive, risk-averse approach to social interaction that reduces the likelihood of further aversive outcomes by: (1) increasing our cognitive sensitivity to (sensory) cues of social risk; (2) reducing our (behavioural) propensity for taking social risks; and (3) initiating signalling behaviours that elicit support and defuse conflict [32].”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“The depressive response is adaptive when changes in mood state and behaviour reduce uncertainty in the face of socio-environmental change, and lead to re-engagement with that environment when volatility abates (which should, at least in part, be brought about by depressive behaviours; see [32]).”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“Notably, the exacerbation of normative depressed states into severe, dysfunctional forms is also likely when depressive changes fail to alleviate social stress, creating a self-perpetuating cycle arising from heightened and prolonged arousal of ineffectual attempts to reduce socio-environmental volatility [32].”
From The depressed brain: an evolutionary systems theory (2017) · cites this paper as [32]
In the citing paper
“Cholinergic innervation has been known for a long time to regulate critical period plasticity209.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [209]
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Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Molecular Mechanisms of Long Noncoding RNAs
Wang, K., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.018 · Cited by 4,462
Research works printed but not linked: 2
- Anisman H, 2008, J. Psychiatry Neurosci., 33, 131
- Weinstock M, 2010, Isr. J. Psychiatry Relat. Sci., 47, 36
Cited by
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Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Management of Depression in Older Adults: A Review
Kok, R. M., & Reynolds, C. F. (2017) · JAMA · doi:10.1001/jama.2017.5706 · Cited by 890
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748
Self-citationThe organization of the stress system and its dysregulation in depressive illness
Gold, P. W. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.163 · Cited by 654
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Self-citationEpigenetic mechanisms of chronic pain
Descalzi, G., Ikegami, D., Ushijima, T., Nestler, E. J., Zachariou, V., & Narita, M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.02.001 · Cited by 402
Self-citationEpigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353
Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights
Kremer, M., Salvat, É., Muller, A., Yalçın, İ., & Barrot, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.057 · Cited by 333
The Potential of HDAC Inhibitors as Cognitive Enhancers
Gräff, J., & Tsai, L. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140216 · Cited by 306
Neuronal plasticity and neurotrophic factors in drug responses
Castrén, E., & Antila, H. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.61 · Cited by 284
Epigenetic mechanisms of depression
Nestler, E. J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4291 · Cited by 217
Self-citationAdapting to Stress: Understanding the Neurobiology of Resilience
Osório, C., Probert, T., Jones, E., Young, A. H., & Robbins, I. (2016) · Behavioral Medicine · doi:10.1080/08964289.2016.1170661 · Cited by 206
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197
A new perspective on the anterior cingulate cortex and affective pain
Xiao, X., & Zhang, Y.-Q. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.022 · Cited by 197
Epigenetic programming by early‐life stress: Evidence from human populations
Vaiserman, A. M. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24211 · Cited by 193
The Glutathione System: A New Drug Target in Neuroimmune Disorders
Morris, G., Anderson, G., Dean, O. M., Berk, M., Gałecki, P., Martín-Subero, M., & Maes, M. H. J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8705-x · Cited by 194
The depressed brain: an evolutionary systems theory
Badcock, P. B., Davey, C. G., Whittle, S., Allen, N. B., & Friston, K. J. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.005 · Cited by 190
Neural Substrates of Depression and Resilience
Han, M., & Nestler, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0527-x · Cited by 185
Self-citationKundaković, M., Lim, S. C., Gudsnuk, K. M., & Champagne, F. A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00078 · Cited by 179
Wei, J., Yuen, E. Y., Liu, W., Li, X., Zhong, P., Karatsoreos, I. N., McEwen, B. S., & Yan, Z. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.83 · Cited by 176
Badcock, P. B., Friston, K. J., Ramstead, M. J. D., Ploeger, A., & Hohwy, J. (2019) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-019-00721-3 · Cited by 175
Vaillancourt, T., Hymel, S. C., & McDougall, P. (2013) · Theory Into Practice · doi:10.1080/00405841.2013.829726 · Cited by 167
Animal models of post-traumatic stress disorder: face validity
Goswami, S., Rodríguez-Sierra, O. E., Cascardi, M. A., & Paré, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00089 · Cited by 165
Epigenetic Signaling in Psychiatric Disorders
Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163
Self-citationNeuronal correlates of depression
Chaudhury, D., Liu, H., & Han, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 150
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149
Epigenetics and depression: return of the repressed
Dalton, V. S., Kolshus, E., & McLoughlin, D. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.028 · Cited by 142
Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness
Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139
Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression
Dempster, E. L., Wong, C. C. Y., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. S., & Eley, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.013 · Cited by 132
Amare, A. T., Schubert, K. O., & Baune, B. T. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0112-8 · Cited by 132
Zheleznyakova, G. Y., Cao, H., & Schiöth, H. B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0101-4 · Cited by 131
Epigenetic Modifications of Major Depressive Disorder
Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 129
Melas, P. A., Scherma, M., Fratta, W., Cifani, C., & Fadda, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041863 · Cited by 127
Biomarkers for major depressive disorder
Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 123
Liu, Z., Li, X., Sun, N., Xu, Y. J., Meng, Y.-Q., Yang, C., Wang, Y., & Zhang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093388 · Cited by 123
Antypa, N., Drago, A., & Serretti, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.006 · Cited by 120
Epigenetics in Personality Disorders: Today's Insights
Gescher, D. M., Kahl, K. G., Hillemacher, T., Frieling, H., Kuhn, J., & Frodl, T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00579 · Cited by 115
Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111
Gassen, N. C., Fries, G. R., Zannas, A. S., Hartmann, J., Zschocke, J., Hafner, K., Carrillo‐Roa, T., Steinbacher, J., Preißinger, S. N., Hoeijmakers, L., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aac7695 · Cited by 109
Glover, M. E., & Clinton, S. M. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.04.008 · Cited by 109
Athira, K. V., Bandopadhyay, S., Samudrala, P. K., Naidu, V. G. M., Lahkar, M., & Chakravarty, S. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191001142934 · Cited by 110
Role of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108
Self-citationExploration of Epigenetics for Improvement of Drought and Other Stress Resistance in Crops: A Review
Sun, C., Ali, K., Yan, K., Fiaz, S., Dormatey, R., Bi, Z., & Bai, J. (2021) · Plants · doi:10.3390/plants10061226 · Cited by 108
Blood biomarkers and treatment response in major depression
Mora, C., Zonca, V., Riva, M. A., & Cattaneo, A. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1470927 · Cited by 107
Regulation of chromatin states by drugs of abuse
Walker, D. M., Cates, H. M., Heller, E. A., & Nestler, E. J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.11.002 · Cited by 106
Self-citationRobison, A. J., Vialou, V., Sun, H.-S., Labonte, B., A Golden, S., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.319 · Cited by 105
Self-citationMarrocco, J., Reynaert, M., Gatta, E., Gabriel, C., Mocaër, E., Prisco, S. D., Merega, E., Pittaluga, A., Nicoletti, F., Maccari, S., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4131-13.2014 · Cited by 105
Epigenetics, chromatin and genome organization: recent advances from the ENCODE project
Siggens, L., & Ekwall, K. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12231 · Cited by 105
Duclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101
Neuroepigenetics and addiction
Walker, D. M., & Nestler, E. J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00048-x · Cited by 101
Self-citationEarly-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?
Vaiserman, A. M., & Koliada, A. K. (2017) · Human Genomics · doi:10.1186/s40246-017-0129-z · Cited by 99
Sex Differences in Stress Response: Classical Mechanisms and Beyond
Hodes, G. E., Bangasser, D. A., Sotiropoulos, I., Kokras, N., & Dalla, C. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231005090134 · Cited by 103
Antidepressant action of HDAC inhibition in the prefrontal cortex
Covington, H. E., Maze, I., Vialou, V., & Nestler, E. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.030 · Cited by 97
Self-citationTransgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction?
Nestler, E. J. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002426 · Cited by 94
Self-citationDissecting early life stress-induced adolescent depression through epigenomic approach
Ochi, S., & Dwivedi, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01907-x · Cited by 94
Tomaz, V. D. S., Filho, A. J. M. C., Cordeiro, R. C., Jucá, P. M., Soares, M. V. R., Barroso, P. N., Cristino, L. M. F., Jiang, W., Teixeira, A. L., de Lucena, D. F., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.022 · Cited by 92
Boulle, F., Massart, R., Stragier, E., Païzanis, E., Zaidan, L., Marday, S., Gabriel, C., Mocaer, E., Mongeau, R., & Lanfumey, L. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.125 · Cited by 91
Susceptibility and Resilience to Posttraumatic Stress Disorder–like Behaviors in Inbred Mice
Daws, S. E., Joseph, N. F., Jamieson, S., King, M. L., Chévere-Torres, I., Fuentes, I., Shumyatsky, G. P., Brantley, A. F., Rumbaugh, G., & Miller, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.030 · Cited by 89
Meylan, E. M., Halfon, O., Magistretti, P. J., & Cardinaux, J.-R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.012 · Cited by 87
Understanding the epigenetic basis of sex differences in depression
Hodes, G. E., Walker, D. M., Labonté, B., Nestler, E. J., & Russo, S. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23876 · Cited by 87
Self-citationAhmed, A. A., Ma, W., Ni, Y., Zhou, Q., & Zhao, R. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.12.002 · Cited by 87
Advance in Stress for Depressive Disorder
Ding, Y., & Dai, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_8 · Cited by 86
Athira, K. V., Madhana, R. M., Indu Chandran, J. S., Lahkar, M., Sinha, S., & Naidu, V. G. M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.009 · Cited by 85
Na, K.-S., Won, E., Kang, J., Chang, H. S., Yoon, H.-K., Tae, W. S., Kim, Y.-K., Lee, M.-S., Joe, S.-H., Kim, H., et al. (2016) · Scientific Reports · doi:10.1038/srep21089 · Cited by 84
Long Non-Coding RNA: Potential Diagnostic and Therapeutic Biomarker for Major Depressive Disorder
Cui, X., Sun, X., Niu, W., Kong, L., He, M., Zhong, A., Chen, S., Jiang, K., Zhang, L.-Y., & Cheng, Z. (2016) · Medical Science Monitor · doi:10.12659/msm.899372 · Cited by 82
Genetic and epigenetic factors associated with depression: an updated overview
Alshaya, D. S. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103311 · Cited by 81
A methylation study of long-term depression risk
Clark, S. L., Hattab, M. W., Chan, R. F., Shabalin, A. A., Han, L. K. M., Zhao, M., Smit, J. H., Jansen, R., Milaneschi, Y., Xie, L. Y., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0516-z · Cited by 82
Boulle, F., Pawluski, J. L., Homberg, J. R., Machiels, B. M., Kroeze, Y., Kumar, N., Steinbusch, H. W. M., Kenis, G., & van den Hove, D. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.017 · Cited by 80
Biomarkers Predicting Antidepressant Treatment Response: How Can We Advance the Field?
Labermaier, C., Masana, M., & Müller, M. B. (2013) · Disease Markers · doi:10.1155/2013/984845 · Cited by 80
Biomarkers for Psychiatric Disorders: Where Are We Standing?
Martins‐de‐Souza, D. (2013) · Disease Markers · doi:10.1155/2013/321071 · Cited by 78
Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S. F., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014977 · Cited by 76
Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress
Vialou, V., Thibault, M., Kaska, S., Cooper, S., Gajewski, P. A., Eagle, A. L., Mazei‐Robison, M. S., Nestler, E. J., & Robison, A. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.005 · Cited by 74
Self-citationAberg, K. A., Dean, B., Shabalin, A. A., Chan, R. F., Han, L. K. M., Zhao, M., van Grootheest, G., Xie, L. Y., Milaneschi, Y., Clark, S. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0247-6 · Cited by 73
Albert, P. R., François, B. L., & Vahid-Ansari, F. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180209 · Cited by 73
François, B. L., Soo, J., Millar, A., Daigle, M., Guisquet, A. L., Leman, S., Minier, F., Belzung, C., & Albert, P. R. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.002 · Cited by 73
Logan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-015-0041-y · Cited by 73
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 72
Lisoway, A. J., Zai, C. C. H., Tiwari, A. K., & Kennedy, J. L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.071 · Cited by 71
The importance of long non-coding RNAs in neuropsychiatric disorders
Hosseini, E., Bagheri‐Hosseinabadi, Z., Toma, I. D., Jafarisani, M., & Sadeghi, I. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.07.004 · Cited by 71
Understanding epigenetic architecture of suicide neurobiology: A critical perspective
Roy, B., & Dwivedi, Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.031 · Cited by 70
Kaut, O., Schmitt, I., Hofmann, A., Hoffmann, P., Schlaepfer, T. E., Wüllner, U., & Hurlemann, R. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0572-y · Cited by 68
Gemmel, M., Bögi, E., Ragan, C. M., Hazlett, M. F., Dubovický, M., van den Hove, D., Oberlander, T. F., Charlier, T. D., & Pawluski, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.023 · Cited by 68
Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1
Kabir, Z. D., Lee, A. S., Burgdorf, C. E., Fischer, D. K., Rajadhyaksha, A. M., Lee, F., Rizzo, B. K., Rice, R. C., Singh, K., Ota, K. T., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.271 · Cited by 66
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Sales, A. J., & Joca, S. R. L. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.40 · Cited by 62
Barde, S. S., Rüegg, J., Prud’homme, J., Ekström, T. J., Palkovits, M., Turecki, G., Bagdy, G., Ihnatko, R., Theodorsson, E., Juhász, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617824113 · Cited by 61
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Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.6 · Cited by 58
Self-citationKim, T.-K., Lee, J. E., Kim, J., Park, J. Y., Choi, J., Kim, H., Lee, E. H., & Han, P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9160-z · Cited by 58
Ampuero, E., Luarte, A., Santibáñez, M., Varas‐Godoy, M., Toledo, J. A., Díaz‐Véliz, G., Cavada, G., Rubio, F. J., & Wyneken, Ú. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv038 · Cited by 57
Zhou, J., Li, M., Wang, X., He, Y., Xia, Y., Sweeney, J. A., Kopp, R. F., Liu, C., & Chen, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.674273 · Cited by 56
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Ku, S. M., & Han, M.-H. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0538-7 · Cited by 54
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Decoding neural transcriptomes and epigenomes via high-throughput sequencing
Shin, J., Ming, G., & Song, H. (2014) · Nature Neuroscience · doi:10.1038/nn.3814 · Cited by 53
Pirooznia, S. K., & Elefant, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00030 · Cited by 53
Andaloussi, Z. I. L., Taghzouti, K., & Abboussi, O. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.007 · Cited by 53
Shen, E., Jiang, Y., Javidfar, B., Kassim, B. S., Loh, Y. E., Ma, Q., Mitchell, A., Pothula, V., Stewart, A. F., Ernst, P., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.144 · Cited by 53
Schiele, M. A., Zwanzger, P., Schwarte, K., Arolt, V., Baune, B. T., & Domschke, K. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa081 · Cited by 51
Swaab, D. F., Wolff, S. E. C., & Bao, A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00031-2 · Cited by 51
Metadata
- Authors
- Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2013-01-06
- Volume
- 53
- Issue
- 1
- Pages
- 59-87
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- PMC
- PMC3711377
- OpenAlex
- W2130374405
- Cited by
- 277
- References
- 216
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 14 · 2019: 26 · 2018: 26 · 2017: 25 · 2016: 32 · 2015: 32 · 2014: 26 · 2013: 21
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Annual Review of Pharmacology and Toxicology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH096890, R01MH051399)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- epigenetics, depression, antidepressant mechanism, chromatin remodeling, neuroplasticity, limbic system, post-traumatic stress disorder, anxiety, early life stress, stress vulnerability, transgenerational transmission, gene expression regulation
- MeSH terms
- Animals, Antidepressive Agents, Depression, Humans, Gene Expression, DNA Methylation, Epigenesis, Genetic
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