Cited by 284Epigenetics and DNA MethylationStress Responses and CortisolTreatment of Major Depression

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Epigenetic Mechanisms of Depression and Antidepressant Action

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Vialou, Vincent, Feng, Jian, Robison, Alfred J., Nestler, Eric J.·2013·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev-pharmtox-010611-134540PMC PMC3711377

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Abstract

Epigenetic mechanisms, which control chromatin structure and function, mediate changes in gene expression that occur in response to diverse stimuli. Recent research has established that environmental events and behavioral experience induce epigenetic changes at particular gene loci and that these changes help shape neuronal plasticity and function and hence behavior. Some of these changes can be stable and can even persist for a lifetime. Increasing evidence supports the hypothesis that aberrations in chromatin remodeling and subsequent effects on gene expression within limbic brain regions contribute to the pathogenesis of depression and other stress-related disorders such as post-traumatic stress disorder and other anxiety syndromes. Likewise, the gradually developing but persistent therapeutic effects of antidepressant medications may be achieved in part via epigenetic mechanisms. This review discusses recent advances in our understanding of the epigenetic regulation of stress-related disorders and focuses on three distinct aspects of stress-induced epigenetic pathology: the effects of stress and antidepressant treatment during adulthood, the lifelong effects of early-life stress on subsequent stress vulnerability, and the possible transgenerational transmission of stress-induced abnormalities.

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Authors: Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Nestler, Eric J.
ORCID: Vialou, Vincent
Feng, Jian
Robison, Alfred J.
Nestler, Eric J.
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2013-01-06
Volume: 53
Issue: 1
Pages: 59-87
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev-pharmtox-010611-134540
PMC: PMC3711377
OpenAlex: W2130374405
Cited by: 277
References: 216
Citations by year: 2026: 9 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 14 · 2019: 26 · 2018: 26 · 2017: 25 · 2016: 32 · 2015: 32 · 2014: 26 · 2013: 21
FWCI: 1.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH096890, R01MH051399)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: epigenetics, depression, antidepressant mechanism, chromatin remodeling, neuroplasticity, limbic system, post-traumatic stress disorder, anxiety, early life stress, stress vulnerability, transgenerational transmission, gene expression regulation
MeSH terms: Animals, Antidepressive Agents, Depression, Humans, Gene Expression, DNA Methylation, Epigenesis, Genetic

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Epigenetic Mechanisms of Depression and Antidepressant Action

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