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Cited by 319

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Role of Dietary Proteins and Amino Acids in the Pathogenesis of Insulin Resistance

Tremblay, Frédéric, Lavigne, Charles, Jacques, Hélène, Marette, André·2007·Annual Review of Nutrition
DOI 10.1146/annurev.nutr.25.050304.092545
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Abstract

Dietary proteins and amino acids are important modulators of glucose metabolism and insulin sensitivity. Although high intake of dietary proteins has positive effects on energy homeostasis by inducing satiety and possibly increasing energy expenditure, it has detrimental effects on glucose homeostasis by promoting insulin resistance and increasing gluconeogenesis. Varying the quality rather than the quantity of proteins has been shown to modulate insulin resistance induced by Western diets and has revealed that proteins derived from fish might have the most desirable effects on insulin sensitivity. In vitro and in vivo data also support an important role of amino acids in glucose homeostasis through modulation of insulin action on muscle glucose transport and hepatic glucose production, secretion of insulin and glucagon, as well as gene and protein expression in various tissues. Moreover, amino acid signaling is integrated by mammalian target of rapamycin, a nutrient sensor that operates a negative feedback loop toward insulin receptor substrate 1 signaling, promoting insulin resistance for glucose metabolism. This integration suggests that modulating dietary proteins and the flux of circulating amino acids generated by their consumption and digestion might underlie powerful new approaches to treat various metabolic diseases such as obesity and diabetes.

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Metadata

Authors
Tremblay, F., Lavigne, C., Jacques, H., & Marette, A.
Venue
Annual Review of Nutrition
Publisher
Annual Reviews
Published
2007-08-01
Volume
27
Issue
1
Pages
293-310
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
DOI
10.1146/annurev.nutr.25.050304.092545
OpenAlex
W2130753873
Cited by
319
References
19
FWCI
1.79
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Role of Dietary Proteins and Amino Acids in the Pathogenesis of Insulin Resistance. https://app.cochat.ai/papers/10.1146/annurev.nutr.25.050304.092545
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Tremblay, F., Lavigne, C., Jacques, H., & Marette, A. (2007). Role of Dietary Proteins and Amino Acids in the Pathogenesis of Insulin Resistance. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.25.050304.092545

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