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Cited by 309Muscle metabolism and nutritionAnimal Nutrition and PhysiologyFood and Agricultural Sciences

Postprandial Kinetics of Dietary Amino Acids Are the Main Determinant of Their Metabolism after Soy or Milk Protein Ingestion in Humans

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Bos, Cécile, Gaudichon, Claire, Pueyo, Maria E., Morens, Céline, Tomé, Daniel, Metges, Cornelia C., Petzke, Klaus J., Everwand, Julia +1 more·2003·The Journal of Nutrition
DOI 10.1093/jn/133.5.1308
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Abstract

Soy proteins have been shown to result in lower postprandial nitrogen retention than milk proteins, but the mechanisms underlying these differences have not been elucidated. To investigate this question, we measured the postprandial kinetics of the appearance of individual (15)N-amino acids in the serum of healthy adults after the ingestion of either (15)N-soy (n = 8) or (15)N-milk proteins (n = 8) in a mixed single meal (46 kJ/kg). The kinetics of total and dietary amino acids (AA) in the peripheral circulation were characterized by an earlier and higher peak after soy protein ingestion. Dietary AA levels peaked at 2.5 h in the soy group vs. 3.9 h in the milk group (P < 0.02). This time interval difference between groups was associated with a faster transfer of dietary N into urea in the soy group (peak at 3 vs. 4.75 h in the milk group, P < 0.005) and a higher level of incorporation into the serum protein pool from 3 to 8 h after the soy meal. The dietary AA pattern in the peripheral blood closely reflected the dietary protein AA pattern. Postprandial glucose, insulin, and glucagon levels and profiles did not differ between groups. Soy AA were digested more rapidly and were directed toward both deamination pathways and liver protein synthesis more than milk AA. We conclude that differences in the metabolic postprandial fates of soy and milk proteins are due mainly to differences in digestion kinetics; however, the AA composition of dietary proteins may also play a role.

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  • Differences in absorption kinetics and the subsequent impact on muscle protein metabolism extend beyond the degree of hydrolysis and amino acid profiles.

    “differences in absorption kinetics, and the subsequent impact on muscle protein metabolism appear to extend beyond the degree of hydrolysis and amino acid profiles [69, 86, 90–92].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [90]

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Authors
Bos, C., Gaudichon, C., Pueyo, M. E., Morens, C., Tomé, D., Metges, C. C., Petzke, K. J., Everwand, J., & Benamouzig, R.
Affiliations
  • Physiologie de la Nutrition et du Comportement Alimentaire (FR)
  • German Institute of Human Nutrition (DE)
  • Hôpital Avicenne (FR)
Corresponding author
  • Gaudichon, Claire
  • Metges, Cornelia C.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2003-05
Volume
133
Issue
5
Pages
1308-1315
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/133.5.1308
OpenAlex
W1920613397
Cited by
309
References
4
Citations by year
2026: 8 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 31 · 2021: 18 · 2020: 21 · 2019: 14 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 18 · 2014: 8 · 2013: 13 · 2012: 14
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords
soy protein, milk protein, dietary amino acids, nitrogen retention, urea, serum protein synthesis, amino acid composition, insulin, glucagon, postprandial blood glucose
MeSH terms
Adult, Amino Acids, Body Height, Body Weight, Diet, Female, Food Analysis, Food Handling, Humans, Male, Milk Proteins, Body Mass Index, Postprandial Period, Soybean Proteins

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