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Cited by 83

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates

Kilroe, Sean P., Fulford, Jonathan, Holwerda, Andrew M., Jackman, Sarah R., Lee, Benjamin P., Gijsen, Annemie P., van Loon, Luc J. C., Wall, Benjamin T.·2020·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00360.2019
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Abstract

Short-term muscle disuse has been reported to lower both postabsorptive and postprandial myofibrillar protein synthesis rates. This study assessed the impact of disuse on daily myofibrillar protein synthesis rates following short-term (2 and 7 days) muscle disuse under free living conditions. Thirteen healthy young men (age: 20 ± 1 yr; BMI: 23 ± 1 kg/m−2) underwent 7 days of unilateral leg immobilization via a knee brace, with the nonimmobilized leg acting as a control. Four days before immobilization participants ingested 400 mL of 70% deuterated water, with 50-mL doses consumed daily thereafter. Upper leg bilateral MRI scans and muscle biopsies were collected before and after 2 and 7 days of immobilization to determine quadriceps volume and daily myofibrillar protein synthesis rates. Immobilization reduced quadriceps volume in the immobilized leg by 1.7 ± 0.3 and 6.7 ± 0.6% after 2 and 7 days, respectively, with no changes in the control leg. Over the 1-wk immobilization period, myofibrillar protein synthesis rates were 36 ± 4% lower in the immobilized (0.81 ± 0.04%/day) compared with the control (1.26 ± 0.04%/day) leg ( P < 0.001). Myofibrillar protein synthesis rates in the control leg did not change over time ( P = 0.775), but in the immobilized leg they were numerically lower during the 0- to 2-day period (16 ± 6%, 1.11 ± 0.09%/day, P = 0.153) and were significantly lower during the 2- to 7-day period (44 ± 5%, 0.70 ± 0.06%/day, P < 0.001) when compared with the control leg. We conclude that 1 wk of muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates in healthy young men.

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Metadata

Authors
Kilroe, S. P., Fulford, J., Holwerda, A. M., Jackman, S. R., Lee, B. P., Gijsen, A. P., van Loon, L. J. C., & Wall, B. T.
Affiliations
  • Department of Sport and Health Sciences, College of Life and Environmental Science, University of Exeter, Exeter, United Kingdom
  • Peninsula National Institute for Health Research Clinical Research Facility, College of Medicine and Health, University of Exeter, Exeter, United Kingdom
  • Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, United Kingdom
ORCID
Jackman, Sarah R.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2020-02-01
Volume
318
Issue
2
Pages
E117-E130
ISSN
  • 0193-1849
  • 1522-1555
DOI
10.1152/ajpendo.00360.2019
Cited by
83
References
11
Language
en
Funders
  • National institute health research (CRF/2016/10027)
  • Royal Society

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CoChat. (2026). Citation check: Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. https://app.cochat.ai/papers/10.1152/ajpendo.00360.2019
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Kilroe, S. P., Fulford, J., Holwerda, A. M., Jackman, S. R., Lee, B. P., Gijsen, A. P., van Loon, L. J. C., & Wall, B. T. (2020). Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00360.2019

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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