Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

Pavis, George F.; Jameson, Tom S. O.; Dirks, Marlou L.; Lee, Benjamin P.; Abdelrahman, Doaa R.; Murton, Andrew J.; Porter, Craig; Alamdari, Nima; Mikus, Catherine R.; Wall, Benjamin T.; Stephens, Francis B.

doi:10.1152/ajpendo.00454.2020

Cited by 37Muscle metabolism and nutritionMuscle Physiology and DisordersExercise and Physiological Responses

Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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Pavis, George F., Jameson, Tom S. O., Dirks, Marlou L., Lee, Benjamin P., Abdelrahman, Doaa R., Murton, Andrew J., Porter, Craig, Alamdari, Nima +3 more·2021·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00454.2020PMC PMC8260377

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Abstract

The present study investigated the contribution of myofibrillar protein synthesis (MyoPS) and associated gene signaling to recovery from 300 muscle-damaging, eccentric contractions. Measured with D2O, MyoPS rates were elevated during recovery and observed alongside expression of inflammatory and regenerative signaling pathways. A nutritional intervention accelerated recovery; however, MyoPS and gene signaling were unchanged compared with placebo. These data indicate that MyoPS and associated signaling do not explain accelerated recovery from muscle damage.

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Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1-7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans.
“Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1–7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans (57–61).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [61]

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When a study control is not properly selected, the data generated may be skewed and this could have implications for the study’s conclusions
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Additional file 1 of Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients
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Reducing NF-κB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage
Jameson, T. S. O., Pavis, G. F., Dirks, M. L., Lee, B. P., Abdelrahman, D. R., Murton, A. J., Porter, C., Alamdari, N., Mikus, C. R., Wall, B. T., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab106 · Cited by 25 · see citing works
Dynamic Proteomic Responses to Skeletal Muscle Damage and Repair in Mice
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Letter to the Editor From Constantin-Teodosiu: “Reducing NF-κB Signaling Nutritionally Is Associated With Expedited Recovery of Skeletal Muscle Function After Damage”
Constantin‐Teodosiu, D. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac052 · Cited by 1 · see citing works
Leucine-Enriched Essential Amino Acids Improve Recovery from Post-Exercise Muscle Damage Independent of Increases in Integrated Myofibrillar Protein Synthesis in Young Men
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Muscle damage and inflammation during recovery from exercise
Peake, J. M., Neubauer, O., Gatta, P. A. D., & Nosaka, K. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00971.2016 · Cited by 829 · see citing works

Authors: Pavis, G. F., Jameson, T. S. O., Dirks, M. L., Lee, B. P., Abdelrahman, D. R., Murton, A. J., Porter, C., Alamdari, N., Mikus, C. R., Wall, B. T., & Stephens, F. B.
Affiliations: University of Exeter (GB)
The University of Texas Medical Branch at Galveston (US)
Beachbody LLC, Santa Monica, California
Corresponding author: Stephens, Francis B.
ORCID: Pavis, George F.
Jameson, Tom S. O.
Dirks, Marlou L.
Lee, Benjamin P.
Abdelrahman, Doaa R.
Murton, Andrew J.
Porter, Craig
Alamdari, Nima
Wall, Benjamin T.
Stephens, Francis B.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2021-02-01
Volume: 320
Issue: 2
Pages: E291-E305
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00454.2020
PMC: PMC8260377
OpenAlex: W3112962555
Cited by: 37
References: 72
Citations by year: 2026: 7 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 7
FWCI: 2.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Funders: Beachbody LLC
University of Exeter
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: skeletal muscle injury, eccentric exercise, muscle recovery, myofibrillar protein synthesis, inflammatory gene expression, dietary supplementation, muscle protein synthesis, exercise-induced muscle damage
MeSH terms: Adult, Athletic Injuries, Female, Humans, Inflammation, Male, Muscle Proteins, Muscular Diseases, Myofibrils, Regeneration, Protein Biosynthesis, Signal Transduction, Exercise, Gene Expression, Muscle, Skeletal, Recovery of Function, Resistance Training, Young Adult

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Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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