Cited by 153Circadian rhythm and melatoninHeart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmias

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Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats

Scheer, F. A. J. L., Ter Horst, G. J., van der Vliet, J., Buijs, R. M.·2001·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.2001.280.3.h1391

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Abstract

The suprachiasmatic nucleus (SCN) is the mammalian biological clock that generates the daily rhythms in physiology and behavior. Light can phase shift the rhythm of the SCN but can also acutely affect SCN activity and output, e.g., output to the pineal. Recently, multisynaptic SCN connections to other organs were also demonstrated. Moreover, they were shown to affect those organs functionally. The aim of the present study was to investigate the role of the SCN in the regulation of the heart. First, we demonstrated that heart rate (HR) in SCN-intact, but not SCN-lesioned (SCNx), male Wistar rats had a clear circadian rhythm, which was not caused by locomotor activity. Second, we demonstrated that light at night reduces HR in intact but not in SCNx rats. Finally, we demonstrated the presence of a multisynaptic autonomic connection from SCN neurons to the heart with the retrograde pseudorabies virus tracing technique. Together, these results demonstrate that the SCN affects the heart in rats and suggest that this is mediated by a neuronal mechanism.

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Authors: Scheer, F. A. J. L., Ter Horst, G. J., van der Vliet, J., & Buijs, R. M.
Affiliations: Netherlands Institute for Neuroscience (NL)
Department of Biological Psychiatry, University and Academic Hospital of Groningen, 9700 RB Groningen, The Netherlands
Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, 1105 AZ Amsterdam; and
ORCID: Scheer, F. A. J. L.
Buijs, R. M.
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2001-03-01
Volume: 280
Issue: 3
Pages: H1391-H1399
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.2001.280.3.h1391
OpenAlex: W2400609677
Cited by: 153
References: 37
Citations by year: 2026: 2 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 7
FWCI: 2.23
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: suprachiasmatic nucleus, circadian rhythm, heart rate, autonomic regulation of the heart, light at night, SCN lesions, pineal gland, biological clock
MeSH terms: Animals, Autonomic Nervous System, Circadian Rhythm, Heart, Heart Rate, Lighting, Male, Herpesvirus 1, Suid, Suprachiasmatic Nucleus, Rats, Wistar, Rats

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Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats

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