High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects

Lymphocyte Homing and Homeostasis

Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846 · see citing works

Exercise and the immune system: regulation, integration, and adaptation

Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710 · see citing works

The Role of the CD28 Receptor During T Cell Responses to Antigen

Linsley, P. S., & Ledbetter, J. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001203 · Cited by 1,298 · see citing works

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073 · see citing works

Cadherins in cancer: implications for invasion and metastasis

Takeichi, M. (1993) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(93)90029-p · Cited by 927 · see citing works

Regulation of the Natural Killer Cell Receptor Repertoire

Raulet, D. H., Vance, R. E., & McMahon, C. W. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.291 · Cited by 520 · see citing works

Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells

Picker, L. J., Treer, J. R., Ferguson-Darnell, B., Collins, P. A., Bergstresser, P. R., & Terstappen, L. W. M. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.3.1122 · Cited by 380 · see citing works

Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)

Voehringer, D., Koschella, M., & Pircher, H. (2002) · Blood · doi:10.1182/blood-2002-02-0657 · Cited by 352 · see citing works

Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition

Picker, L. J., Treer, J. R., Ferguson-Darnell, B., Collins, P. A., Buck, D., & Terstappen, L. W. M. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.3.1105 · Cited by 341 · see citing works

Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity

Ito, M., Maruyama, T., Saito, N., Koganei, S., Yamamoto, K., & Matsumoto, N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051986 · Cited by 260 · see citing works

Viral infections induce abundant numbers of senescent CD8 T cells

Voehringer, D., Blaser, C., Brawand, P., Raulet, D. H., Hanke, T., & Pircher, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4838 · Cited by 246 · see citing works

Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)

Ouyang, Q., Wagner, W. M., Voehringer, D., Wikby, A., Klatt, T., Walter, S., Müller, C. A., Pircher, H., & Pawelec, G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00134-7 · Cited by 238 · see citing works

Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon

Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L., Swick, N. S., Utter, A. C., Vinci, D. M., Opiela, S. J., & Morrow, J. D. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00961.2001 · Cited by 198 · see citing works

Adhesion Molecules, Catecholamines and Leucocyte Redistribution During and Following Exercise

Shephard, R. J. (2003) · Sports Medicine · doi:10.2165/00007256-200333040-00002 · Cited by 163 · see citing works

Strenuous Exercise and Immunological Changes

Shek, P. N., Sabiston, B. H., Buguet, A., & Radomski, M. W. (1995) · International Journal of Sports Medicine · doi:10.1055/s-2007-973039 · Cited by 159 · see citing works

Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung.

Saltini, C., Kirby, M., Trapnell, B. C., Tamura, N., & Crystal, R. G. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.4.1123 · Cited by 157 · see citing works

Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype

Nociari, M., Telford, W. G., & Russo, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3327 · Cited by 154 · see citing works

Effect of High- Versus Moderate-Intensity Exercise on Lymphocyte Subpopulations and Proliferative Response

Nieman, D. C., Miller, A., Henson, D. A., Warren, B. J., Gusewitch, G., Johnson, R., Davis, J., Butterworth, D. E., Herring, J., & Nehlsen‐Cannarella, S. L. (1994) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021047 · Cited by 154 · see citing works

Replicative senescence of CD8 T cells: Effect on human ageing

Effros, R. B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.024 · Cited by 127 · see citing works

Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes

Steensberg, A., Morrow, J. D., Toft, D., Brüünsgaard, H., & Pedersen, K. (2002) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0584-6 · Cited by 118 · see citing works

The Route of Antigen Entry Determines the Requirement for L-selectin during Immune Responses

Catalina, M. D., Carroll, M. C., Arizpe, H. M., Takashima, A., Estess, P., & Siegelman, M. H. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2341 · Cited by 104 · see citing works

The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53

Simpson, R. J., Florida-James, G. D., Whyte, G. P., & Guy, K. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0146-4 · Cited by 99 · see citing works

Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system

van Baarle, D., Tsegaye, A., Miedema, F. F., & Akbar, A. N. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.003 · Cited by 91 · see citing works

Effect of glutamine supplementation on exercise-induced changes in lymphocyte function

Krzywkowski, K., Petersen, E. W., Ostrowski, K., Kristensen, J. H., Bozá, J., & Pedersen, B. K. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.4.c1259 · Cited by 84 · see citing works

Regulation of lymphocyte traffic by adhesion molecules

Fabbri, M., Bianchi, E., Fumagalli, L., & Pardi, R. (1999) · Inflammation Research · doi:10.1007/s000110050454 · Cited by 77 · see citing works

Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans

Brüünsgaard, H., Jensen, M. S., Schjerling, P., Halkjær-Kristensen, J., Ogawa, K., Skinhøj, P., & Pedersen, B. K. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00531-7 · Cited by 70 · see citing works

Peripheral human CD8+CD28+T lymphocytes give rise to CD28–progeny, but IL-4 prevents loss of CD28 expression

Labalette, M., Leteurtre, E., Thumerelle, C., Grutzmacher, C., Tourvieille, B., & Dessaint, J. (1999) · International Immunology · doi:10.1093/intimm/11.8.1327 · Cited by 47 · see citing works

Exercise and T-lymphocyte function: a comparison of proliferation in PBMC and NK cell-depleted PBMC culture

Green, K. J., ROWBOTTOM, D. G., & MACKINNON, L. T. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00926.2001 · Cited by 45 · see citing works

Adhesion molecules during immune response to exercise

Gabriel, H. H. W., & Kindermann, W. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-5-512 · Cited by 40 · see citing works

Differential cell adhesion molecule expression and lymphocyte mobilisation during prolonged aerobic exercise

Gannon, G. A., Rhind, S. G., Shek, P. N., & Shephard, R. J. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210000374 · Cited by 31 · see citing works

Adhesion molecules during immune response to exercise

Gabriel, H. H. W., & Kindermann, W. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y98-067 · Cited by 25 · see citing works

Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan

Campbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 692 · see citing works

Exercise and the Regulation of Immune Functions

Simpson, R. J., Kunz, H., Agha, N. H., & Graff, R. M. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.08.001 · Cited by 606 · see citing works

Biomarkers of peripheral muscle fatigue during exercise

Finsterer, J. (2012) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-13-218 · Cited by 314 · see citing works

Exercise and the aging immune system

Simpson, R. J., Lowder, T. W., Spielmann, G., Bigley, A. B., LaVoy, E. C., & Kunz, H. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.003 · Cited by 281 · see citing works

CD57+ T lymphocytes and functional immune deficiency

Focosi, D., Bestagno, M., Burrone, Ó. R., & Petrini, M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809566 · Cited by 253 · see citing works

Selective Mobilization of Cytotoxic Leukocytes by Epinephrine

Dimitrov, S., Lange, T., & Jan Born, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902189 · Cited by 235 · see citing works

Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype

Campbell, J. P., Riddell, N. E., Burns, V. E., Turner, M., van Zanten, J. J. C. S. V., Drayson, M. T., & Bosch, J. A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.02.011 · Cited by 220 · see citing works

Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells

Bigley, A. B., Rezvani, K., Chew, C., Sekine, T., Pistillo, M., Crucian, B. E., Bollard, C. M., & Simpson, R. J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.030 · Cited by 172 · see citing works

β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans

Graff, R. M., Kunz, H. E., Agha, N. H., Baker, F. L., Laughlin, M., Bigley, A. B., Markofski, M. M., LaVoy, E. C., Katsanis, E., Bond, R. A., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.08.017 · Cited by 145 · see citing works

Aging, Persistent Viral Infections, and Immunosenescence: Can Exercise "Make Space"?

Simpson, R. (2011) · Exercise and sport sciences reviews · doi:10.1097/jes.0b013e318201f39d · Cited by 154 · see citing works

Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans

Simpson, R. J., McFarlin, B. K., McSporran, C., Spielmann, G., Hartaigh, B. Ó., & Guy, K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.013 · Cited by 125 · see citing works

Is immunosenescence influenced by our lifetime “dose” of exercise?

Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works

The Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells

Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 110 · see citing works

Mobilization of γδ T lymphocytes in response to psychological stress, exercise, and β-agonist infusion

Anane, L. H., Edwards, K. M., Burns, V. E., Drayson, M. T., Riddell, N. E., Zanten, J. V., Wallace, G. R., Mills, P. J., & Bosch, J. A. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.03.003 · Cited by 110 · see citing works

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise

Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.11.002 · Cited by 99 · see citing works

Terrestrial stress analogs for spaceflight associated immune system dysregulation

Crucian, B. E., Simpson, R. J., Mehta, S. K., Stowe, R., Choukèr, A., Hwang, S., Actor, J. K., Salam, A. P., Pierson, D. L., & Sams, C. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.011 · Cited by 98 · see citing works

Immunity and ageing in man: Annual review 2006/2007

Pawelec, G., & Larbi, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.09.009 · Cited by 94 · see citing works

Aging and immunity – Impact of behavioral intervention

Müller, L., & Pawelec, G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.11.015 · Cited by 93 · see citing works

Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise

Turner, J. E., Aldred, S., Witard, O. C., Drayson, M. T., Moss, P. M., & Bosch, J. A. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.07.239 · Cited by 90 · see citing works

Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation

Rooney, B. V., Bigley, A. B., LaVoy, E. C. P., Laughlin, M. S., Pedlar, C. R., & Simpson, R. J. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.06.008 · Cited by 86 · see citing works

Antioxidant regulatory mechanisms in neutrophils and lymphocytes after intense exercise

Ferrer, M. D., Tauler, P., Sureda, A., Tur, J. A., & Pons, A. (2008) · Journal of Sports Sciences · doi:10.1080/02640410802409683 · Cited by 86 · see citing works

Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans.

Simpson, R. J., Cosgrove, C., Chee, M. M., McFarlin, B. K., Bartlett, D. B., Spielmann, G., O’Connor, D. P., Pircher, H., & Shiels, P. G. (2010) · PubMed · Cited by 77 · see citing works

Coupling Aging Immunity with a Sedentary Lifestyle: Has the Damage Already Been Done? – A Mini-Review

Simpson, R. J., & Guy, K. (2009) · Gerontology · doi:10.1159/000270905 · Cited by 74 · see citing works

Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review

Dinh, H. C., Beyer, I., Mets, T. F., Onyema, O. O., Njemini, R., Renmans, W., Waele, M. D., Jochmans, K., Meeren, S. V., & Bautmans, I. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0212-9 · Cited by 73 · see citing works

The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans

Spielmann, G., Bollard, C. M., Bigley, A. B., Hanley, P. J., Blaney, J. W., LaVoy, E. C. P., Pircher, H., & Simpson, R. J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.05.003 · Cited by 66 · see citing works

γ/δ T cell subsets in human aging using the classical α/β T cell model

Vasudev, A., Ying, C., Ayyadhury, S., Puan, K. J., Andiappan, A. K., Nyunt, M. S. Z., Shadan, N. B., Mustafa, S., Low, I., Rötzschke, O., et al. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a1213-650rr · Cited by 63 · see citing works

Physical and Immunological Aspects of Exercise in Chronic Diseases

Apostolopoulos, V., Borkoles, E., Polman, R. C. J., & Stojanovska, L. (2014) · Immunotherapy · doi:10.2217/imt.14.76 · Cited by 51 · see citing works

Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes

Onyema, O. O., Njemini, R., Forti, L. N., Bautmans, I., Aerts, J. L., Waele, M. D., & Mets, T. F. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.08.007 · Cited by 45 · see citing works

Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise

Campbell, J. P., Guy, K., Cosgrove, C., Florida-James, G. D., & Simpson, R. J. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.09.001 · Cited by 43 · see citing works

Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

Brown, F. F., Bigley, A. B., Sherry, C., Neal, C. M., Witard, O. C., Simpson, R. J., & Galloway, S. D. R. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.031 · Cited by 42 · see citing works

T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans

Clifford, T., Wood, M. J., Stocks, P., Howatson, G., Stevenson, E., & Hilkens, C. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3667-0 · Cited by 38 · see citing works

Targeting ß2 adrenergic receptors regulate human T cell function directly and indirectly

Zalli, A., Bosch, J. A., Goodyear, O. C., Riddell, N. E., McGettrick, H. M., Moss, P. A. H., & Wallace, G. R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.001 · Cited by 40 · see citing works

Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study

Onyema, O. O., Decoster, L., Njemini, R., Forti, L. N., Bautmans, I., Waele, M. D., & Mets, T. F. (2015) · BMC Cancer · doi:10.1186/s12885-015-2013-3 · Cited by 38 · see citing works

A single exercise bout augments adenovirus-specific T-cell mobilization and function

Kunz, H., Spielmann, G., Agha, N. H., O’Connor, D. P., Bollard, C. M., & Simpson, R. J. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.04.035 · Cited by 39 · see citing works

Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise

Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. D. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.018 · Cited by 38 · see citing works

Special issue on exercise immunology: Current perspectives on aging, health and extreme performance

Simpson, R. J., & Bosch, J. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.006 · Cited by 37 · see citing works

NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection

Bigley, A. B., Lowder, T., Spielmann, G., Rector, J. L., Pircher, H., Woods, J. A., & Simpson, R. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.004 · Cited by 36 · see citing works

Acute aerobic exercise in humans increases cytokine expression in CD27− but not CD27+ CD8+ T-cells

LaVoy, E. C., Bosch, J. A., Lowder, T. W., & Simpson, R. J. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.09.006 · Cited by 33 · see citing works

Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men

Wang, J., & Weng, T. (2011) · Clinical Science · doi:10.1042/cs20110032 · Cited by 32 · see citing works

Exercise, Immunity, and Illness

Jones, A. W., & Davison, G. (2018) · Muscle and Exercise Physiology · doi:10.1016/b978-0-12-814593-7.00015-3 · Cited by 37 · see citing works

Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancers

Sun, Z., Nyberg, R., Wu, Y., Bernard, B. M., & Redmond, W. L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247238 · Cited by 31 · see citing works

T‐cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection

LaVoy, E. C. P., Hussain, M. R., Reed, J., Kunz, H., Pistillo, M., Bigley, A. B., & Simpson, R. J. (2017) · Physiological Reports · doi:10.14814/phy2.13070 · Cited by 31 · see citing works

Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise

Wang, J.-S., & Lin, C.-T. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1231-2 · Cited by 29 · see citing works

The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood

Cosgrove, C., Galloway, S. D. R., Neal, C., Hunter, A. M., McFarlin, B. K., Spielmann, G., & Simpson, R. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2273-9 · Cited by 26 · see citing works

The effects of acute exercise and inflammation on immune function in early-stage prostate cancer

Schauer, T., Djurhuus, S. S., Simonsen, C., Brasso, K., & Christensen, J. F. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100508 · Cited by 25 · see citing works

Analysis of selected T cell subsets in peripheral blood after exhaustive effort among elite soccer players

Kostrzewa‐Nowak, D., & Nowak, R. (2018) · Biochemia Medica · doi:10.11613/bm.2018.030707 · Cited by 23 · see citing works

Caffeine ingestion and antigen‐stimulated human lymphocyte activation after prolonged cycling

Fletcher, D. K., & BISHOP, N. C. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2010.01223.x · Cited by 23 · see citing works

Circulating angiogenic cell response to sprint interval and continuous exercise

O’Carroll, L., Wardrop, B., Murphy, R. P., Ross, M., & Harrison, M. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-018-04065-7 · Cited by 22 · see citing works

Changes in naïve and memory T-cells in elite swimmers during a winter training season

Teixeira, A. M., Rama, L., Carvalho, H. M., Borges, G., Carvalheiro, T., Gleeson, M., Alves, F., Trindade, H., & Paiva, A. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.01.002 · Cited by 20 · see citing works

Exercise-induced β2-adrenergic receptor activation enhances effector lymphocyte mobilization in humans and suppresses lymphoma growth in mice through NK-cells

Smith, K. A., Batatinha, H., Niemiro, G. M., Baker, F. L., Zúñiga, T. M., Diak, D. M., Mylabathula, P. L., Kistner, T. M., Davini, D. W., Hoffman, E. A., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.04.040 · Cited by 20 · see citing works

Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project

Schlabe, S., Vogel, M., Boesecke, C., Schwarze‐Zander, C., Rockstroh, J. K., Körner, C., Brixius, K., & Wasmuth, J. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2651-y · Cited by 20 · see citing works

Repeated high-intensity Wingate cycle bouts influence markers of lymphocyte migration but not apoptosis

Friedman, R. A., Navalta, J. W., Fedor, E. A., Kell, H. B., Lyons, S., Arnett, S. W., & Schafer, M. A. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-156 · Cited by 20 · see citing works

The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer

Koivula, T., Lempiäinen, S., Neuvonen, J., Norha, J., Hollmén, M., Sundberg, C. J., Rundqvist, H., Minn, H. R. I., Rinne, P., & HEINONEN, I. H. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1394420 · Cited by 21 · see citing works

Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D‐deficient men, independent of age

Lithgow, H., Florida‐James, G., Ross, M., Duncan, G., & Leggate, M. (2021) · Experimental Physiology · doi:10.1113/ep089480 · Cited by 16 · see citing works

Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells

Wang, J., & Wu, C. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00687.2009 · Cited by 16 · see citing works

Adoptive Cellular Therapy of Cancer: Exploring Innate and Adaptive Cellular Crosstalk to Improve Anti-Tumor Efficacy

Payne, K. K., Bear, H. D., & Manjili, M. H. (2014) · Future Oncology · doi:10.2217/fon.14.97 · Cited by 15 · see citing works

The role of T cells in vascular aging, hypertension, and atherosclerosis

DeConne, T. M., Buckley, D. J., Trott, D. W., & Martens, C. R. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00570.2024 · Cited by 15 · see citing works

Radiosensitivity of CD3−CD8+CD56+ NK cells

Vokurková, D., Vávrová, J., Šinkora, J., Stoklasova, A., Bláha, V., & Řezáčová, M. (2010) · Radiation Measurements · doi:10.1016/j.radmeas.2010.07.028 · Cited by 13 · see citing works

Comparison of selected CD45+ cell subsets’ response and cytokine levels on exhaustive effort among soccer players

Kostrzewa‐Nowak, D., Buryta, R., & Nowak, R. (2018) · Journal of Medical Biochemistry · doi:10.2478/jomb-2018-0029 · Cited by 12 · see citing works

Older men display elevated levels of senescence-associated exercise-responsive CD28 null angiogenic T cells compared with younger men

Ross, M., Ingram, L. A., Taylor, G., Malone, E. M., Simpson, R. J., West, D. J., & Florida-James, G. D. (2018) · Physiological Reports · doi:10.14814/phy2.13697 · Cited by 12 · see citing works

Single-cell sequencing of immune cells after marathon and symptom-limited cardiopulmonary exercise

Yu, Y., Zhang, X., Chen, Y., Li, Y., Bian, S., Yang, Y., Song, H., Zhang, C., Dong, Z., Li, G., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106532 · Cited by 11 · see citing works

CMV Amplifies T-cell Redeployment to Acute Exercise Independently of HSV-1 Serostatus

LaVoy, E. C. P., Bigley, A. B., Spielmann, G., Rector, J. L., Morrison, M. R., O’Connor, D. P., & Simpson, R. J. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a5a0fb · Cited by 11 · see citing works

The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise

Kunz, H., Agha, N. H., Hussain, M. R., LaVoy, E. C. P., Smith, K. A., Mylabathula, P. L., Diak, D. M., Baker, F. L., O’Connor, D. P., Bond, R. A., et al. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01136-7 · Cited by 11 · see citing works

Effect of 6-day intense Kendo training on lymphocyte counts and its expression of CD95

Tanimura, Y., Kon, M., Shimizu, K., Kimura, F., Kono, I., & Ajisaka, R. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1119-1 · Cited by 11 · see citing works

Effects of High-Intensity Interval Training on Melatonin Function and Cellular Lymphocyte Apoptosis in Sedentary Middle-Aged Men

Al‐Rawaf, H. A., Gabr, S. A., Iqbal, A., & Alghadir, A. H. (2023) · Medicina · doi:10.3390/medicina59071201 · Cited by 10 · see citing works

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males

Ross, M., Tormey, P., Ingram, L. A., Simpson, R. J., Malone, E. M., & Florida-James, G. D. (2016) · Experimental Physiology · doi:10.1113/ep085771 · Cited by 9 · see citing works

Acute Hematological and Inflammatory Responses to High-intensity Exercise Tests: Impact of Duration and Mode of Exercise

Minuzzi, L., Carvalho, H. M., Brunelli, D., Rosado, F., Cavaglieri, C., Gonçalves, C., Gaspar, J., Rama, L., & Teixeira, A. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0042-117723 · Cited by 8 · see citing works

The acute leukocyte and cytokine response of older adults to resistance exercise in normobaric hypoxia

Allsopp, G. L., Addinsall, A. B., Stephenson, G. L., Basheer, F., Gatta, P. A. D., Hoffmann, S. M., Russell, A. P., & Wright, C. R. (2022) · Biology of Sport · doi:10.5114/biolsport.2023.116005 · Cited by 8 · see citing works

Acute high-intensity exercise enhances T cell proliferation compared to moderate-intensity exercise

Siedlik, J. A., Deckert, J. A., Dunbar, A. J., Bhatta, A., Gigliotti, N. M., Chan, M. A., Benedict, S. H., Bubak, M. P., Vardiman, J. P., & Gallagher, P. M. (2025) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2024-0420 · Cited by 5 · see citing works

Immunological Alterations Used to Predict Infections in Response to Strenuous Physical Training

Ekblom, Ö. B., Ekblom, B. T., & Malm, C. (2011) · Military Medicine · doi:10.7205/milmed-d-10-00427 · Cited by 5 · see citing works

Effect of Moderate Exercise on the Level of Melatonin Hormone and Lymphocyte Apoptosis in Healthy Subjects

Jaafar, I. F., Jassim, H. A., & Hussein, A. G. (2010) · Iraqi postgraduate Medical Journal · Cited by 5 · see citing works

Effects of hypobaric Endurance Training on Graded Exercise Induced Lymphocyte Mobilization, Senescence and Their Surface Thiol Levels in Elite Male Athletes

Alamdari, K. A., & Bashiri, J. (2018) · International Journal of Applied Exercise Physiology · doi:10.22631/ijaep.v7i1.227 · Cited by 5 · see citing works

Long-term physical training in adolescent sprint and middle distance swimmers alters the composition of circulating T and NK cells which correlates with soluble ICAM-1 serum concentrations

Notbohm, H. L., Schumann, M., Fuhrmann, S., Klocke, J., Theurich, S., & Bloch, W. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04660-1 · Cited by 4 · see citing works

Common Markers of Muscle Damage Are Associated with Divergent Gene Expression Patterns after Eccentric Contractions

Deyhle, M. R., Tiede, D., XIN, L., Hyldahl, R. D., & Hubal, M. J. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003399 · Cited by 4 · see citing works

An ultra-endurance event leads to changes in circulating regulatory T-cells, CD4+ naïve and CD8+ effector memory T-cells in the 48 h post-race recovery period

Lithgow, H., Gibson, L., Wilson, R., Guthrie, N., Ingram-Sills, L., Clifford, T., & Ross, M. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05677-y · Cited by 3 · see citing works

Aging Immunity and the Impact of Physical Exercise

Bigley, A. B., Baker, F. L., Spielmann, G., & Simpson, R. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_165 · Cited by 3 · see citing works

Aging Immunity and the Impact of Physical Exercise

Spielmann, G., Bigley, A. B., LaVoy, E. C. P., & Simpson, R. J. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_26 · Cited by 4 · see citing works

Lifestyle Interventions to Improve Immunesenescence

Bartlett, D. B., & Huffman, K. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_10 · Cited by 3 · see citing works

Examining the effect of intermittent cycling throughout a 3-h period on peripheral blood concentrations of haemopoietic stem and progenitor cells and cytolytic natural killer cells

Cox, P. A., Pradana, F., Noble, E., Lucas, S. J. E., Pratt, G., Drayson, M. T., Amin, K., Kinsella, F. A. M., & Wadley, A. J. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04261-1 · Cited by 1 · see citing works

Exercício agudo versus imunossupressão: talvez apenas outro mecanismo homeostático

Nunes, E. A., & Fernandes, L. C. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1 · see citing works

T cell immunity and caregiving stress in young and older caregivers

Vitlić, A., Lord, J. M., Arlt, W., Oliver, C., & Phillips, A. C. (2015) · Healthy Aging Research · doi:10.12715/har.2015.4.15 · Cited by 1 · see citing works

CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation

Riddell, N. E. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1 · see citing works

The impact of exercise, adiposity and persistent viral infection on blood T-Cell phenotype and function

Spielmann, G. (2026) · Edinburgh Napier Research Repository (Edinburgh Napier University) · doi:10.17869/enu.192070

Alterações cardiovasculares após maratona: marcadores de injúria e fadiga cardíaca

Sierra, A. (2015) · doi:10.11606/d.39.2015.tde-08042015-080152

Exercise and Immunosenescence

Simpson, R. J., & Spielmann, G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_10

The effect of B2 agonists on the immune function

Zalli, A. A. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)

Exercise stress, nutrition and novel measures of in vivo immunity

Diment, B. C. (2015) · Bangor University Research Portal (Bangor University)

Biomarkers of peripheral muscle fatigue during

Finsterer, J. (2012)

Equine High-Intensity Exercise, Articular Biochemistry, and Nutritional Antioxidant Supplementation

MacNicol, J. L. (2017) · The Atrium (University of Guelph)

Impact of Psychological and Physical Stressors on the Exercise-Induced Immune Response in Collegiate Swimmers

Kuremsky, C. A. (2018) · doi:10.31390/gradschool_theses.4845

Chronic stress and ageing : effects on immune function

Vitlić, A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Immunity, Aging, and the Works of V.M. Dilman

Polevshchikov, A. V., & Nazarov, P. G. (2021) · Advances in Gerontology · doi:10.1134/s2079057021030103

Effects of Physical Activity Status and Exercise Modality on the T-Cell and Monocyte Response to Acute Exercise in Older Adults

Levine, R. G. (2020)

Impact of physical activity on immune function and inflammation in the elderly

Bartlett, D. B. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Aging Immunity and the Impact of Physical Exercise

Bigley, A. B., Baker, F. L., Spielmann, G., & Simpson, R. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_165-1

KLRC4, KLRG1, and Natural Cytotoxicity Receptors

Gupta, R. K., & Gupta, G. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1065-2_32

Severe Hypoxia Enhances Lymphocyte Apoptosis Induced by Oxidative Stress during Moderate Exercise

Lin, C., & Wang, J. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1173.5

Effects of bovine colostrum on immune responses to prolonged exercise and upper respiratory illness in active males

Jones, A. W. (2014)

Markers of immunosenescence and oxidative stress in healthy adults

Turner, J. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham)

The effect of moderate physical activity on NK cells populations and cytotoxic T lymphocytes in young, healthy women

Tubek-Krokosz, A., Baran, J., Galbarczyk, A., Gałuszka-Bulaga, A., Klimek, M., Miłkowska, K., Les, K., Słojewska, K., Ścibor, M., & Grazyna Jasienska, A. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349215

High-Intensity Exercise Mobilises Senescent T-lymphocytes into the Peripheral Blood Compartment in Young and Old Subjects

Simpson, R. J., Cosgrove, C., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000273140.61651.0b

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise

Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.11.002 · Cited by 99 · see citing works

T-Lymphocyte Activation is Not Affected by the Mobilization of Senescent T-Cells into the Peripheral Blood Following an Acute Bout of Exercise

Bartlett, D. B., Cosgrove, C., Spielmann, G., Guy, K., & Simpson, R. J. (2009) · TopSCHOLAR (Western Kentucky University)

Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans

Pircher, H., Cosgrove, C., Chee, M., McFarlin, B., Bartlett, D., Spielmann, G., O'Connor, D., Pircher, H., & Shiels, P. G. (2026) · Universitätsbibliothek Gießen · doi:10.22029/eir.2010.1650 · Cited by 1 · see citing works

HIGHLIGHTED TOPIC Exercise and Inflammation

Simpson, R. J., Florida-james, G. D., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H., & Guy, K. (2007)