The effects of exercise on the neuronal response to food cues
Open accessAbstract
Increased physical activity is associated with successful long-term weight loss maintenance due to mechanisms likely more complex than simply increased energy expenditure. The impact of physical activity on the central regulation of food intake may be an important mechanism of this effect. The objective of this study was to examine the effects of exercise training and acute exercise on the neuronal response to food cues as well as eating behaviors. fMRI was performed in the fasted state at baseline and again after a 6 month progressive exercise intervention (supervised, 5 days/wk) both with and without an acute exercise bout in 12 overweight/obese (5 women, 7 men; BMI 33 ± 4 kg/m(2)) healthy adults. fMRI data were acquired while subjects were presented with visual stimuli of foods of high hedonic value as compared to neutral control objects. Questionnaires on eating behaviors, ratings of appeal and desire for foods, and ratings of appetite (hunger, satiety, prospective intake) using visual analog scales were also performed at baseline and again after the 6-month exercise intervention. While only a trend was observed for a reduction in body weight (102 ± 5 to 99 ± 6 kg, p=0.09), a significant reduction in fat mass was observed (36.4 ± 2.8 to 33.7 ± 3.2 kg, p=0.04), although as expected changes in fat mass were variable (-10.0 to +3.7 kg). Chronic exercise was associated with a reduction in the neuronal response to food, primarily in the posterior attention network and insula. A significant positive correlation between the change in fat/body mass and the change in insula response to food cues with chronic exercise was observed. An acute exercise bout attenuated the effects of chronic exercise. The exercise intervention, however, did not impact any of the measures of appetitive behavior. In summary, despite no effects on behavioral measures of appetite, chronic exercise training was associated with attenuation in the response to visual food cues in brain regions known to be important in food intake regulation. The insula, in particular, appears to play an important role in the potential exercise-induced weight loss and weight loss maintenance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Behavioral training exercise may diminish participant SN reactivity to salient food cues, particularly within the ventral striatum and insula.
“This work suggests that behavioral training exercise may diminish participant SN reactivity to salient food cues, particularly within the ventral striatum and insula (84).”
From The Role of Exercise in Management of Mental Health Disorders: An Integrative Review (2021) · cites this paper as [84]
Reductions in weight were associated with reduced insular activation among overweight/obese adults following a 6-month exercise trial.
“Similarly, Cornier and colleagues (84) found that reductions in weight were associated with reduced insular activation among overweight/obese adults following a 6-month exercise trial.”
From The Role of Exercise in Management of Mental Health Disorders: An Integrative Review (2021) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats
Flores, M. B. S., Fernandes, M. F., Ropelle, E. R., Faria, M. C., Ueno, M., Velloso, L. A., Saad, M. J. A., & Carvalheira, J. B. C. (2006) · Diabetes · doi:10.2337/db05-1622 · Cited by 153 · see citing works
RetractedCentral Exercise Action Increases the AMPK and mTOR Response to Leptin
Ropelle, E. R., Fernandes, M. F., Flores, M. B. S., Ueno, M., Rocco, S. A., Marin, R., Cintra, D. E., Velloso, L. A., Franchini, K. G., Saad, M. J. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003856 · Cited by 62 · see citing works
RetractedS<scp>UCCESSFUL</scp> W<scp>EIGHT</scp> L<scp>OSS</scp> M<scp>AINTENANCE</scp>
Wing, R. R., & Hill, J. O. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.323 · Cited by 1,382 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · see citing works
“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677 · see citing works
Images of desire: food-craving activation during fMRI
Pelchat, M. L., Johnson, A., Chan, R., Valdez, J., & Ragland, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.023 · Cited by 667 · see citing works
van der Laan, L. N., de Ridder, D. T. D., Viergever, M. A., & Smeets, P. A. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.055 · Cited by 602 · see citing works
Individual Differences in Reward Drive Predict Neural Responses to Images of Food
Beaver, J. D., Lawrence, A. D., van Ditzhuijzen, J., Davis, M. H., Woods, A., & Calder, A. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0350-06.2006 · Cited by 594 · see citing works
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
Tataranni, P. A., Gautier, J., Chen, K., Uecker, A., Bandy, D. J., Salbe, A. D., Pratley, R. E., Lawson, M. A., Reiman, E. M., & Ravussin, É. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4569 · Cited by 592 · see citing works
Cortical and limbic activation during viewing of high- versus low-calorie foods
Killgore, W. D. S., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun-Todd, D. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00191-5 · Cited by 581 · see citing works
Pictures of appetizing foods activate gustatory cortices for taste and reward
Simmons, W. K., Martin, A., & Barsalou, L. W. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi038 · Cited by 569 · see citing works
Hunger selectively modulates corticolimbic activation to food stimuli in humans
LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.493 · Cited by 444 · see citing works
ROSENBAUM, M. S., Sy, M., Pavlovich, K. H., Leibel, R. L., & Joy Hirsch, C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35055 · Cited by 408 · see citing works
Appetite and adiposity in children: evidence for a behavioral susceptibility theory of obesity
Carnell, S., & Wardle, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.22 · Cited by 406 · see citing works
Exposure to appetitive food stimuli markedly activates the human brain
Wang, G.-J., Volkow, N. D., Telang, F., Jayne, M., Ma, J., Rao, M., Zhu, W., Wong, C. T., Pappas, N. R., Geliebter, A., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.026 · Cited by 402 · see citing works
Baskin, D. G., Lattemann, D. F., Seeley, R. J., Woods, S. C., Porte, D., & Schwartz, M. W. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01974-5 · Cited by 398 · see citing works
Siep, N., Roefs, A., Roebroeck, A., Havermans, R., Bonte, M. L., & Jansen, A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.035 · Cited by 375 · see citing works
King, N. A., Burley, V. J., & Blundell, J. E. (1994) · PubMed · Cited by 327 · see citing works
Metabolic and Behavioral Compensatory Responses to Exercise Interventions: Barriers to Weight Loss
King, N. A., Caudwell, P., Hopkins, M., Byrne, N. M., Colley, R., Hills, A. P., Stubbs, J. R., & Blundell, J. E. (2007) · Obesity · doi:10.1038/oby.2007.164 · Cited by 322 · see citing works
Blundell, J. E., Stubbs, R. J., Hughes, D. A., Whybrow, S., & King, N. A. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003286 · Cited by 299 · see citing works
Exercise-induced suppression of acylated ghrelin in humans
Broom, D. R., Stensel, D. J., Bishop, N. C., Burns, S. F., & Miyashita, M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2006 · Cited by 294 · see citing works
Zheng, H., Lenard, N. R., Shin, A. C., & Berthoud, H. R. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.65 · Cited by 286 · see citing works
Mind versus metabolism in the control of food intake and energy balance
Berthoud, H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.034 · Cited by 259 · see citing works
Cerebral processing of food-related stimuli: effects of fasting and gender
Uher, R., Treasure, J., Heining, M., Brammer, M. J., & Campbell, I. C. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.12.008 · Cited by 258 · see citing works
A review of the effects of exercise on appetite regulation: an obesity perspective
Martins, C., Morgan, L., & Truby, H. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.98 · Cited by 254 · see citing works
King, N. A., Caudwell, P. P., Hopkins, M., Stubbs, J. R., Naslund, E., & Blundell, J. E. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27706 · Cited by 226 · see citing works
Brain activity in hunger and satiety: an exploratory visually stimulated fMRI study
Führer, D., Zysset, S., & Stumvoll, M. (2008) · Obesity · doi:10.1038/oby.2008.33 · Cited by 218 · see citing works
Polak, J., Klimčáková, E., Moro, C., Viguerie, N., Berlan, M., Hejnová, J., Richterova, B., Kraus, I., Langin, D., & Štich, V. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.008 · Cited by 213 · see citing works
Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.
Baicy, K., London, E. D., Monterosso, J., Wong, M.-L., Delibasi, T., Sharma, A., & Licinio, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706481104 · Cited by 212 · see citing works
Effect of Satiation on Brain Activity in Obese and Lean Women
Gautier, J., Parigi, A. D., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2001) · Obesity Research · doi:10.1038/oby.2001.92 · Cited by 207 · see citing works
Effect of long-term changes in diet and exercise on plasma leptin concentrations
Reseland, J. E., Anderssen, S. A., Solvoll, K., Hjermann, I., Urdal, P., Holme, I., & Drevon, C. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.240 · Cited by 205 · see citing works
Sex-based differences in the behavioral and neuronal responses to food
Cornier, M.-A., Salzberg, A. K., Endly, D. C., Bessesen, D. H., & Tregellas, J. R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.008 · Cited by 196 · see citing works
Self-citationThe Effect of Physical Activity on Body Weight
Jakicic, J. M. (2009) · Obesity · doi:10.1038/oby.2009.386 · Cited by 184 · see citing works
Effects of exercise on energy-regulating hormones and appetite in men and women
Hagobian, T. A., Sharoff, C. G., Stephens, B. R., Wade, G. N., Silva, J. E., Chipkin, S. R., & Braun, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90671.2008 · Cited by 173 · see citing works
Manoach, D. S., Halpern, E. F., Kramer, T. S., Chang, Y., GOFF, D. C., Rauch, S. L., Kennedy, D. N., & Gollub, R. L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.955 · Cited by 173 · see citing works
Schur, E. A., Kleinhans, N. M., Goldberg, J. H., Buchwald, D., Schwartz, M. W., & Maravilla, K. R. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.56 · Cited by 170 · see citing works
Neural contributions to the motivational control of appetite in humans
Hinton, E. C., Parkinson, J. A., Holland, A. J., Arana, F. S., Roberts, A., & Owen, A. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03589.x · Cited by 169 · see citing works
King, N. A., Horner, K., Hills, A. P., Byrne, N. M., Wood, R. E., Bryant, E., Caudwell, P., Finlayson, G., Gibbons, C., Hopkins, M., et al. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsm.2010.082495 · Cited by 169 · see citing works
Subjective feeling of appetite modulates brain activity
Porubská, K., Veit, R., Preissl, H. T., Fritsche, A., & Birbaumer, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.216 · Cited by 162 · see citing works
Effects of overfeeding on the neuronal response to visual food cues
Cornier, M.-A., Von Kaenel, S. S., Bessesen, D. H., & Tregellas, J. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.965 · Cited by 160 · see citing works
Self-citationEffect of satiety on brain activation during chocolate tasting in men and women
Smeets, P. A. M., de Graaf, C., Stafleu, A., van Osch, M. J. P., Nievelstein, R. A. J., & van der Grond, J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1297 · Cited by 159 · see citing works
King, J. A., Wasse, L. K., Ewens, J., Crystallis, K., Emmanuel, J. J., Batterham, R. L., & Stensel, D. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2735 · Cited by 159 · see citing works
Cornier, M., Salzberg, A. K., Endly, D. C., Bessesen, D. H., Rojas, D. C., & Tregellas, J. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006310 · Cited by 154 · see citing works
Self-citationCentral Nervous System Regulation of Food Intake
Schwartz, M. W. (2006) · Obesity · doi:10.1038/oby.2006.275 · Cited by 146 · see citing works
The effect of exercise training on leptin levels in obese males
Pasman, W. J., Westerterp‐Plantenga, M. S., & Saris, W. H. M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e280 · Cited by 138 · see citing works
The role of physical activity in prevention and treatment of body weight gain in adults
Jakicic, J. M. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3826s · Cited by 118 · see citing works
Acute effect of walking on energy intake in overweight/obese women
Unick, J. L., Otto, A. D., Goodpaster, B. H., Helsel, D. L., Pellegrini, C. A., & Jakicic, J. M. (2010) · Appetite · doi:10.1016/j.appet.2010.07.012 · Cited by 106 · see citing works
Patterson, C. M., Bouret, S. G., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90859.2008 · Cited by 101 · see citing works
Watts, A. G. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1581 · Cited by 98 · see citing works
Leidy, H. J., Lepping, R. J., Savage, C. R., & Harris, C. T. (2011) · Obesity · doi:10.1038/oby.2011.108 · Cited by 94 · see citing works
Sex differences in cerebral responses to images of high versus low-calorie food
Killgore, W. D. S., & Yurgelun-Todd, D. A. (2010) · Neuroreport · doi:10.1097/wnr.0b013e32833774f7 · Cited by 81 · see citing works
The Effect of Physical Activity on 18‐Month Weight Change in Overweight Adults
Jakicic, J. M., Otto, A. D., Lang, W., Semler, L., Winters, C., Polzien, K. M., & Mohr, K. I. (2010) · Obesity · doi:10.1038/oby.2010.122 · Cited by 78 · see citing works
Human Cortical Specialization for Food: a Functional Magnetic Resonance Imaging Investigation
St‐Onge, M., Sy, M., Heymsfield, S. B., & Joy Hirsch, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1014 · Cited by 76 · see citing works
Assessing food appeal and desire to eat: the effects of portion size & energy density
Burger, K. S., Cornier, M. A., Ingebrigtsen, J. P., & Johnson, S. L. (2011) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-8-101 · Cited by 68 · see citing works
Self-citationTaste Memory Induces Brain Activation as Revealed by Functional MRI
Levy, L. M., Henkin, R. I., Lin, C. S., Finley, A., & Schellinger, D. (1999) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199907000-00002 · Cited by 53 · see citing works
Heini, A. F., Kirk, K. A., Lara‐Castro, C., & Weinsier, R. L. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00341.x · Cited by 29 · see citing works
Mussell (2000) · doi:10.1002/(sici)1098-108x(200003)27:2
Flagged first, then by citations
Cited by
Sorted by citations
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407 · see citing works
The Role of Exercise in Management of Mental Health Disorders: An Integrative Review
Smith, P. J., & Merwin, R. M. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-060619-022943 · Cited by 360 · see citing works
Dorling, J. L., Broom, D. R., Burns, S. F., Clayton, D. J., Deighton, K., James, L. J., King, J. A., Miyashita, M., Thackray, A. E., Batterham, R. L., et al. (2018) · Nutrients · doi:10.3390/nu10091140 · Cited by 235 · see citing works
Neural vulnerability factors that increase risk for future weight gain
Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179 · see citing works
Ruffault, A., Czernichow, S., Hagger, M. S., Ferrand, M., Erichot, N., Carette, C., Boujut, E., & Flahault, C. (2017) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2016.09.002 · Cited by 173 · see citing works
Beaulieu, K., Hopkins, M., Blundell, J. E., & Finlayson, G. (2016) · Sports Medicine · doi:10.1007/s40279-016-0518-9 · Cited by 165 · see citing works
Neural Responses to Visual Food Cues: Insights from Functional Magnetic Resonance Imaging
García‐García, I., Narberhaus, A., Marqués‐Iturria, I., Garolera, M., Rădoi, A., Segura, B., Pueyo, R., Ariza, M., & Jurado, M. Á. (2013) · European Eating Disorders Review · doi:10.1002/erv.2216 · Cited by 166 · see citing works
Neural vulnerability factors for obesity
Stice, E. M., & Burger, K. S. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.12.002 · Cited by 155 · see citing works
Aerobic exercise reduces neuronal responses in food reward brain regions
Evero, N., Hackett, L. C., Clark, R. D., Phelan, S., & Hagobian, T. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01365.2011 · Cited by 150 · see citing works
Devoto, F., Zapparoli, L., Bonandrini, R., Berlingeri, M., Ferrulli, A., Luzi, L., Banfi, G., & Paulesu, E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.017 · Cited by 140 · see citing works
Obesity, Appetite, and the Prefrontal Cortex
Gluck, M. E., Viswanath, P., & Stinson, E. J. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0289-0 · Cited by 140 · see citing works
Adolescent obesity and dietary decision making—a brain-health perspective
Lowe, C. J., Morton, J. B., & Reichelt, A. C. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(19)30404-3 · Cited by 141 · see citing works
Killgore, W. D. S., Olson, E. A., & Weber, M. (2013) · Scientific Reports · doi:10.1038/srep03457 · Cited by 117 · see citing works
Campos, A., Port, J. D., & Acosta, A. J. (2022) · Brain Sciences · doi:10.3390/brainsci12040431 · Cited by 115 · see citing works
A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior
Burger, K. S., & Berner, L. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.025 · Cited by 110 · see citing works
Weight regaining: From statistics and behaviors to physiology and metabolism
Anastasiou, C. A., Karfopoulou, E., & Yannakoulia, M. (2015) · Metabolism · doi:10.1016/j.metabol.2015.08.006 · Cited by 108 · see citing works
Training motor responses to food: A novel treatment for obesity targeting implicit processes
Stice, E. M., Lawrence, N., Kemps, E., & Veling, H. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.06.005 · Cited by 111 · see citing works
Beaulieu, K., Oustric, P., & Finlayson, G. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00372-3 · Cited by 93 · see citing works
Legget, K. T., Cornier, M., Melanson, E. L., Bechtell, J. L., & Tregellas, J. R. (2013) · Neuroreport · doi:10.1097/wnr.0000000000000013 · Cited by 94 · see citing works
Self-citationEffects of High-Intensity Intermittent Exercise Training on Appetite Regulation
Sim, A. Y., Wallman, K. E., Fairchild, T. J., & Guelfi, K. J. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000687 · Cited by 80 · see citing works
Hinkle, W., Cordell, M., Leibel, R. L., ROSENBAUM, M. S., & Joy Hirsch, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059114 · Cited by 79 · see citing works
Washburn, R. A., Szabo, A. N., Lambourne, K., Willis, E. A., Ptomey, L. T., Honas, J. J., Herrmann, S. D., & Donnelly, J. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109849 · Cited by 74 · see citing works
Cornier, M., Legget, K. T., Thomas, E. A., Bechtell, J. L., Eichman, L. C., Bessesen, D. H., & Tregellas, J. R. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.01.002 · Cited by 76 · see citing works
Self-citationThe effects of high-intensity exercise on neural responses to images of food
Crabtree, D. R., Chambers, E. S., Hardwick, R. M., & Blannin, A. K. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071381 · Cited by 75 · see citing works
Hume, D. J., Yokum, S., & Stice, E. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.127753 · Cited by 70 · see citing works
Stice, E. M., Rohde, P., Shaw, H. E., & Desjardins, C. D. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa146 · Cited by 69 · see citing works
Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart, S., Veldhuizen, M. G., Geha, P., & Small, D. M. (2012) · Appetite · doi:10.1016/j.appet.2012.09.032 · Cited by 63 · see citing works
Exercise-Trained Men and Women: Role of Exercise and Diet on Appetite and Energy Intake
Howe, S. M., Hand, T. M., & Manore, M. M. (2014) · Nutrients · doi:10.3390/nu6114935 · Cited by 62 · see citing works
Frodl, T., Strehl, K., Carballedo, A., Tozzi, L., Doyle, M., Amico, F., Gormley, J., Lavelle, G., & O’Keane, V. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00088-6 · Cited by 63 · see citing works
Beaulieu, K., Blundell, J. E., van Baak, M. A., Battista, F., Busetto, L., Carraça, E. V., Dicker, D., Encantado, J., Ermolao, A., Farpour‐Lambert, N. J., et al. (2021) · Obesity Reviews · doi:10.1111/obr.13251 · Cited by 59 · see citing works
Burger, K. S., & Stice, E. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055285 · Cited by 56 · see citing works
Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet
Wasinski, F., Bacurau, R. F. P., Moraes, M. R., Haro, A. S., Moraes‐Vieira, P. M., Estrela, G. R., Paredes‐Gamero, E. J., Barros, C. C., de Almeida, S. S., Câmara, N. O. S., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/395672 · Cited by 52 · see citing works
Li, G., Ji, G., Hu, Y., Xu, M., Jin, Q., Liu, L., von Deneen, K. M., Zhao, J., Chen, A., Cui, G., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24320 · Cited by 51 · see citing works
Tozzi, L., Carballedo, A., Lavelle, G., Doolin, K., Doyle, M., Amico, F., McCarthy, H., Gormley, J., Lord, A., O’Keane, V., et al. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13222 · Cited by 49 · see citing works
Dorton, H. M., LUO, S. H., Monterosso, J. R., & Page, K. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00297 · Cited by 48 · see citing works
Fearnbach, S. N., Silvert, L., Keller, K., Genin, P. M., Morio, B., Pereira, B., Duclos, M., Boirie, Y., & Thivel, D. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.215 · Cited by 47 · see citing works
Verdú, E., Homs, J., & Boadas‐Vaello, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182413333 · Cited by 54 · see citing works
Yang, Y., Wu, Q., & Morys, F. (2021) · Brain Sciences · doi:10.3390/brainsci11121587 · Cited by 44 · see citing works
Kahathuduwa, C. N., Davis, T. H., O’Boyle, M. W., Boyd, L. A., Chin, S.-H., Paniukov, D., & Binks, M. (2017) · Appetite · doi:10.1016/j.appet.2017.09.025 · Cited by 42 · see citing works
Zheng, L., Miao, M., & Gan, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104721 · Cited by 41 · see citing works
Yokum, S., & Stice, E. M. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz204 · Cited by 39 · see citing works
Exercise Training Reduces Reward for High-Fat Food in Adults with Overweight/Obesity
Beaulieu, K., Hopkins, M., Gibbons, C., Oustric, P., Caudwell, P., Blundell, J. E., & Finlayson, G. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002205 · Cited by 38 · see citing works
Drummen, M., Dorenbos, E., Vreugdenhil, A. C. E., Raben, A., Westerterp‐Plantenga, M. S., & Adam, T. C. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy252 · Cited by 37 · see citing works
Appetite and Energy Intake Regulation in Response to Acute Exercise
Halliday, T. M., White, M. H., Hild, A., Conroy, M. B., Melanson, E. L., & Cornier, M. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002678 · Cited by 37 · see citing works
Self-citationAppetite, Satiety, and Food Reward in Obese Individuals: A Behavioral Phenotype Approach
Dalton, M., Finlayson, G., Esdaile, E. K., & King, N. A. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0060-4 · Cited by 36 · see citing works
Aerobic exercise modulates anticipatory reward processing via the μ‐opioid receptor system
Saanijoki, T., Nummenmaa, L., Tuulari, J. J., Tuominen, L. J., Arponen, E., Kalliokoski, K. K., & Hirvonen, J. (2018) · Human Brain Mapping · doi:10.1002/hbm.24224 · Cited by 35 · see citing works
Fearnbach, S. N., Silvert, L., Pereira, B., Boirie, Y., Duclos, M., Keller, K., & Thivel, D. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.06.006 · Cited by 34 · see citing works
Physical exercise and brain responses to images of high-calorie food
Killgore, W. D. S., Kipman, M., Schwab, Z. J., Tkachenko, O. N., Preer, L. A., Gogel, H., Bark, J. S., Mundy, E. A., Olson, E. A., & Weber, M. (2013) · Neuroreport · doi:10.1097/wnr.0000000000000029 · Cited by 34 · see citing works
Thivel, D., Finlayson, G., & Blundell, J. E. (2018) · Obesity Reviews · doi:10.1111/obr.12782 · Cited by 32 · see citing works
Hopkins, M., Gibbons, C., Caudwell, P., Webb, D., Hellström, P. M., Näslund, E. B., Blundell, J. E., & Finlayson, G. (2014) · International Journal of Endocrinology · doi:10.1155/2014/323728 · Cited by 29 · see citing works
Luo, S., O’Connor, S. G., Belcher, B. R., & Page, K. A. (2018) · Obesity · doi:10.1002/oby.22107 · Cited by 28 · see citing works
An Exploration of the Role of Sugar-Sweetened Beverage in Promoting Obesity and Health Disparities
Sigala, D. M., & Stanhope, K. L. (2021) · Current Obesity Reports · doi:10.1007/s13679-020-00421-x · Cited by 28 · see citing works
Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms
Zhang, Y., Wang, R., Liu, T., & Wang, R. (2024) · Metabolites · doi:10.3390/metabo14110589 · Cited by 27 · see citing works
A Motivational Pathway Linking Physical Activity to Body-Related Eating Cues
Carraça, E. V., Rodrigues, B., & Teixeira, D. (2020) · Journal of Nutrition Education and Behavior · doi:10.1016/j.jneb.2020.08.003 · Cited by 27 · see citing works
Johnson, K. O., Holliday, A., Mistry, N., Cunniffe, A., Howard, K., Stanger, N., O’Mahoney, L. L., Matu, J., & Ispoglou, T. (2021) · Nutrients · doi:10.3390/nu13010141 · Cited by 26 · see citing works
Microbiota–gut–brain axis: the mediator of exercise and brain health
Kang, P., & Wang, A. (2024) · Psychoradiology · doi:10.1093/psyrad/kkae007 · Cited by 31 · see citing works
Ruffault, A., Carette, C., Puerto, K. L. I., Juge, N., Beauchet, A., Benoliel, J. J., Lacorte, J., Fournier, J., Czernichow, S., & Flahault, C. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.06.012 · Cited by 25 · see citing works
Drenowatz, C. J., Evensen, L. H., Ernstsen, L., Blundell, J. E., Hand, G. A., Shook, R. P., Hébert, J. R., Burgess, S., & Blair, S. N. (2017) · Appetite · doi:10.1016/j.appet.2017.08.006 · Cited by 25 · see citing works
Neural Vulnerability Factors That Predict Future Weight Gain
Stice, E. M., & Yokum, S. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00455-9 · Cited by 25 · see citing works
Li, G., Xia, H., Teng, G., & Chen, A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106008 · Cited by 24 · see citing works
Oh, H., & Taylor, A. H. (2013) · Appetite · doi:10.1016/j.appet.2013.07.015 · Cited by 24 · see citing works
Rocha, J., Paxman, J. R., Dalton, C., Winter, E., & Broom, D. R. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0189 · Cited by 23 · see citing works
Aerobic Fitness Is Associated with Cerebral μ-Opioid Receptor Activation in Healthy Humans
Saanijoki, T., Kantonen, T., Pekkarinen, L., Kalliokoski, K. K., Hirvonen, J., Malén, T., Tuominen, L. J., Tuulari, J. J., Arponen, E., Nuutila, P., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002895 · Cited by 23 · see citing works
Chen, S., Dong, D., Jackson, T., Su, Y., & Chen, H. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.06.036 · Cited by 22 · see citing works
Impact of imposed exercise on energy intake in children at risk for overweight
Fearnbach, S. N., Masterson, T. D., Schlechter, H., Ross, A. J., Rykaczewski, M. J., Loken, E., Downs, D. S., Thivel, D., & Keller, K. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0206-5 · Cited by 22 · see citing works
Watanabe, Y. (2013) · Medical Science Monitor · doi:10.12659/msm.889234 · Cited by 22 · see citing works
Exercise-related changes in between-network connectivity in overweight/obese adults
Legget, K. T., Wylie, K. P., Cornier, M., Melanson, E. L., Paschall, C. J., & Tregellas, J. R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.031 · Cited by 22 · see citing works
Self-citationZhang, D., Gao, J., Yan, X., Tang, M., Zhe, X., Cheng, M., Chen, W., & Zhang, X. (2020) · Brain and Behavior · doi:10.1002/brb3.1725 · Cited by 21 · see citing works
Brain reactivity to visual food stimuli after moderate-intensity exercise in children
Masterson, T. D., Kirwan, C. B., Davidson, L. E., Larson, M. J., Keller, K., Fearnbach, S. N., Evans, A., & LeCheminant, J. D. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9766-z · Cited by 20 · see citing works
Wang, H., Chen, Y., Li, X., Wang, J., Zhou, Y., & Zhou, C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00400 · Cited by 17 · see citing works
Exercise and Weight Loss: What Is the Evidence of Sex Differences?
Hagobian, T. A., & Evero, N. (2012) · Current Obesity Reports · doi:10.1007/s13679-012-0035-6 · Cited by 17 · see citing works
Dietary Intake and Energy Expenditure in Breast Cancer Survivors: A Review
Purcell, S. A., Marker, R. J., Cornier, M., & Melanson, E. L. (2021) · Nutrients · doi:10.3390/nu13103394 · Cited by 16 · see citing works
Self-citationZapparoli, L., Devoto, F., Giannini, G., Zonca, S., Gallo, F., & Paulesu, E. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103179 · Cited by 16 · see citing works
Balbim, G. M., Ajilore, O., Erickson, K. I., Lamar, M., Aguiñaga, S., Bustamante, E. E., & Márquez, D. X. (2020) · Journal of Cognitive Enhancement · doi:10.1007/s41465-020-00185-1 · Cited by 14 · see citing works
Sayer, R. D., Tamer, G. G., Chen, N., Tregellas, J. R., Cornier, M., Kareken, D. A., Talavage, T. M., McCrory, M. A., & Campbell, W. W. (2016) · Obesity · doi:10.1002/oby.21603 · Cited by 15 · see citing works
Self-citationCarbine, K. A., Anderson, J., Larson, M. J., LeCheminant, J. D., & Bailey, B. W. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.10.011 · Cited by 15 · see citing works
Yoshikawa, T., Tanaka, M., Ishii, A., & Watanabe, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.021 · Cited by 15 · see citing works
Mitchell, J. J., Dicken, S. J., Kale, D., Herbeć, A., Beard, E., & Shahab, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273530 · Cited by 13 · see citing works
Dera, A. M., Shen, T., Thackray, A. E., Hinton, E. C., King, J. A., James, L. J., Morgan, P. S., Rush, N., Miyashita, M., Batterham, R. L., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105247 · Cited by 14 · see citing works
Sayer, R. D., Dhillon, J., Tamer, G. G., Cornier, M., Chen, N., Wright, A. J., Campbell, W. W., & Mattes, R. D. (2017) · Nutrients · doi:10.3390/nu9080807 · Cited by 14 · see citing works
Self-citationEffects of an acute bout of physical exercise on reward functioning in healthy adults
Wardle, M. C., Lopez-Gamundi, P., & LaVoy, E. C. P. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.07.010 · Cited by 14 · see citing works
Ren, Y., Xu, M., von Deneen, K. M., He, Y., Li, G., Yang, Z., Zhang, W., Li, X., Han, Y., Cui, G., et al. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111047 · Cited by 13 · see citing works
Balcetis, E., Cole, S., & Duncan, D. T. (2020) · Policy Insights from the Behavioral and Brain Sciences · doi:10.1177/2372732220939135 · Cited by 12 · see citing works
Rostamzadeh, N., & Sheikholeslami‐Vatani, D. (2021) · Sport Sciences for Health · doi:10.1007/s11332-021-00781-4 · Cited by 12 · see citing works
Jackson, T., Gao, X., & Chen, H. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.245 · Cited by 12 · see citing works
Alberga, A. S., Edache, I. Y., Sigal, R. J., von Ranson, K. M., Russell‐Mayhew, S., Kenny, G. P., Doucette, S. P., Prud’homme, D., Hadjiyannakis, S., Cameron, J. D., et al. (2022) · Obesity Science & Practice · doi:10.1002/osp4.620 · Cited by 11 · see citing works
Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010
Kilpatrick, L. A., An, H. M., Pawar, S., Sood, R., & Gupta, A. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00498-0 · Cited by 11 · see citing works
Behavioral interventions in health neuroscience
Dutcher, J. M., & Creswell, J. D. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13913 · Cited by 11 · see citing works
Lv, N., Lefferts, W. K., Xiao, L., Goldstein‐Piekarski, A. N., Wielgosz, J., Lavori, P. W., Simmons, J. M., Smyth, J. M., Stetz, P. C., Venditti, E. M., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab280 · Cited by 11 · see citing works
Vartanian, M., Jahanitabesh, A., Christensen, J. F., Staub, H., Jensen, D. E. A., Villringer, A., & Witte, A. V. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106301 · Cited by 9 · see citing works
Neuroadaptive processes associated with palatable food intake: present data and future directions
Gilbert, J. R., & Burger, K. S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.02.033 · Cited by 9 · see citing works
Zhou, Y., Stubbs, R. J., & Finlayson, G. (2022) · Appetite · doi:10.1016/j.appet.2022.106446 · Cited by 9 · see citing works
Dion, C., Tanner, J. J., Crowley, S. J., Wiggins, M. E., Mareci, T. H., Ding, M., Price, C. C., & Manini, T. M. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111470 · Cited by 8 · see citing works
Li, Y., Xia, X., Yu, A., Xu, H., & Zhang, C. (2022) · Appetite · doi:10.1016/j.appet.2022.105955 · Cited by 7 · see citing works
Compton, S., Larson, M. J., LeCheminant, J. D., Tucker, L. A., & Bailey, B. W. (2022) · Brain and Behavior · doi:10.1002/brb3.2590 · Cited by 4 · see citing works
Brain-Based Etiology of Weight Regulation
Burger, K. S., Shearrer, G. E., & Sanders, A. J. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0667-5 · Cited by 5 · see citing works
Emotional eating is related to carbohydrate intake in active women
Quaresma, M. V. L. D. S., de Melo, C. M., Rosa, J. P. P., da Silva, E. V. A., Lima, G. H. O., del Re, M. P., Tufik, S. B., & de Mello, M. T. (2016) · Motriz Revista de Educação Física · doi:10.1590/s1980-6574201600040020 · Cited by 5 · see citing works
Review and analysis of physical exercise at hormonal and brain level, and its influence on appetite
Escribano, L. G., Casas, A. G., Fernández-Marcote, A. R. E., López, P. T., & Marcos, L. T. (2017) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.10.001 · Cited by 5 · see citing works
Functional imaging in obese children responding to long-term sports therapy
Kinder, M., Lotze, M., Davids, S., Domín, M., Thoms, K., Wendt, J., Hirschfeld, H., Hamm, A. O., & Lauffer, H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.037 · Cited by 5 · see citing works
Li, G., Liu, Y., Liu, C., Li, H., Tang, W., & Chen, A. (2025) · Trends in Neuroscience and Education · doi:10.1016/j.tine.2025.100274 · Cited by 4 · see citing works
- Authors
- Cornier, M.-A., Melanson, E. L., Salzberg, A. K., Bechtell, J. L., & Tregellas, J. R.
- Affiliations
- University of Colorado Anschutz (US)
- Denver VA Medical Center (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 105
- Issue
- 4
- Pages
- 1028-1034
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC3260391
- OpenAlex
- W2038554756
- Cited by
- 144
- References
- 58
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 12 · 2016: 16 · 2015: 8 · 2014: 8 · 2013: 18 · 2012: 7
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NCRR Colorado CTSI (UL1 RR025780)
- NIH/NIDDK Clinical Nutrition Research Unit (DK48520)
- NIH/NIDDK (R01DK07708, R01DK089095, R01DK072174)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- exercise training, acute exercise, food cues, insula, appetite, dietary habits, weight loss maintenance, obesity, overweight, fat mass, food intake regulation
- MeSH terms
- Adult, Appetite, Appetite Regulation, Brain, Brain Mapping, Cerebral Cortex, Cues, Feeding Behavior, Female, Food, Humans, Magnetic Resonance Imaging, Male, Obesity, Photic Stimulation, Exercise, Leptin, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
