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Effect of acute sleep deprivation on vascular function in healthy subjects
Abstract
Sleep disorders are associated with inflammation and sympathetic activation, which are suspected to induce endothelial dysfunction, a key factor in the increased risk of cardiovascular disease. Less is known about the early effects of acute sleep deprivation on vascular function. We evaluated microvascular reactivity and biological markers of endothelial activation during continuous 40 h of total sleep deprivation (TSD) in 12 healthy men (29 +/- 3 yr). The days before [day 1 (D1)] and during TSD (D3), at 1200 and 1800, endothelium-dependent and -independent cutaneous vascular conductance was assessed by iontophoresis of acetylcholine and sodium nitroprusside, respectively, coupled to laser-Doppler flowmetry. At 0900, 1200, 1500, and 1800, heart rate (HR) and instantaneous blood pressure (BP) were recorded in the supine position. At D1, D3, and the day after one night of sleep recovery (D4), markers of vascular endothelial cell activation, including soluble intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, and interleukin-6 were measured from blood samples at 0800. Compared with D1, plasma levels of E-selectin were raised at D3, whereas intercellular adhesion molecule-1 and interleukin-6 were raised at D4 (P < 0.05). The endothelium-dependent and -independent CVC were significantly decreased after 29 h of TSD (P < 0.05). By contrast, HR, systolic BP, and the normalized low-frequency component of HR variability (0.04-0.15 Hz), a marker of the sympathetic activity, increased significantly within 32 h of TSD (P < 0.05). In conclusion, acute exposure to 40 h of TSD appears to cause vascular dysfunction before the increase in sympathetic activity and systolic BP.
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“a single night of sleep loss induces an activation of vascular endothelial markers (ie, E-selectin, s-intercellular adhesion molecule, s-ICAM-1) (Frey et al, 2007;Sauvet et al, 2010).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Sauvet et al, 2010
In the citing paper
“Similarly, acute total sleep deprivation (TSD) also altered endothelial-dependent arterial [77] and microvascular activities [78] in healthy participants.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [78]
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“Activation of vascular endothelial markers (i.e., E-selectin, sICAM-1), which typically follows increases in inflammation, also occurs after a single night of sleep loss (Frey et al. 2007, Sauvet et al. 2010).”
BackgroundThe role of sleep in emotional brain function
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“Congruently, sleep deprivation also increases sympathetic dominance of the autonomic nervous system, indexed by changes in heart rate variability (Sauvet et al 2010, Zhong et al 2005).”
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Metadata
- Authors
- Sauvet, F., Leftheriotis, G., Gomez-Merino, D., Langrume, C., Drogou, C., Van Beers, P., Bourrilhon, C., Florence, G., & Chennaoui, M.
- Affiliations
- Institut de Recherche Biomédicale des Armées, Département des Environnements Opérationnels, Brétigny sur Orge; and
- Université d'Angers, Unité Mixte Centre National de la Recherche Scientifique 6214-Institut National de la Santé et de la Recherche Médicale 771, Angers, France
- Corresponding author
- Sauvet, Fabien
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-01
- Volume
- 108
- Issue
- 1
- Pages
- 68-75
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2063737450
- Cited by
- 268
- References
- 53
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 19 · 2023: 19 · 2022: 12 · 2021: 15 · 2020: 20 · 2019: 16 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 19 · 2014: 15 · 2013: 13 · 2012: 15
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Délégation Générale pour l'Armement
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- acute sleep deprivation, total sleep deprivation, vascular function, endothelial dysfunction, cutaneous vascular conductance, endothelial activation markers, E-selectin, interleukin-6, soluble intercellular adhesion molecule-1, VCAM-1, sympathetic activity, heart rate variability, blood pressure, microvascular reactivity, sleep disorders, cardiovascular risk
- MeSH terms
- Acute Disease, Adult, Endothelium, Vascular, Humans, Male, Reference Values, Sleep Deprivation, Vasculitis, Cytokines
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