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Cited by 249

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Human muscle protein synthesis and breakdown during and after exercise

Kumar, Vinod, Atherton, Philip, Smith, Kenneth, Rennie, Michael J.·2009·Journal of Applied Physiology
DOI 10.1152/japplphysiol.91481.2008
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Abstract

Skeletal muscle demonstrates extraordinary mutability in its responses to exercise of different modes, intensity, and duration, which must involve alterations of muscle protein turnover, both acutely and chronically. Here, we bring together information on the alterations in the rates of synthesis and degradation of human muscle protein by different types of exercise and the influences of nutrition, age, and sexual dimorphism. Where possible, we summarize the likely changes in activity of signaling proteins associated with control of protein turnover. Exercise of both the resistance and nonresistance types appears to depress muscle protein synthesis (MPS), whereas muscle protein breakdown (MPB) probably remains unchanged during exercise. However, both MPS and MPB are elevated after exercise in the fasted state, when net muscle protein balance remains negative. Positive net balance is achieved only when amino acid availability is increased, thereby raising MPS markedly. However, postexercise-increased amino acid availability is less important for inhibiting MPB than insulin, the secretion of which is stimulated most by glucose availability, without itself stimulating MPS. Exercise training appears to increase basal muscle protein turnover, with differential responses of the myofibrillar and mitochondrial protein fractions to acute exercise in the trained state. Aging reduces the responses of myofibrillar protein and anabolic signaling to resistance exercise. There appear to be few, if any, differences in the response of young women and young men to acute exercise, although there are indications that, in older women, the responses may be blunted more than in older men.

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Research works printed but not linked: 105

  1. 10.1172/JCI119282 · DOI
  2. 10.1042/bse0410173 · DOI
  3. 10.1152/ajpendo.2001.280.2.E203 · DOI
  4. 10.1093/gerona/58.2.B108 · DOI
  5. 10.1152/ajpendo.00774.2007 · DOI · Paper page
  6. 10.3945/jn.108.092924 · DOI · Paper page
  7. 10.1152/jappl.1993.74.3.1381 · DOI
  8. 10.1042/cs0760447 · DOI
  9. 10.1152/ajpendo.90428.2008 · DOI · Paper page
  10. 10.1007/PL00014265 · DOI
  11. 10.1152/ajpendo.1997.273.1.E122 · DOI · Paper page
  12. 10.2337/diabetes.48.5.949 · DOI · Paper page
  13. 10.1111/j.1469-7793.2001.0575f.x · DOI
  14. 10.1113/jphysiol.2003.047019 · DOI
  15. 10.1152/japplphysiol.00333.2003 · DOI
  16. 10.1152/ajpendo.00466.2001 · DOI · Paper page
  17. 10.1152/jappl.1998.85.5.1744 · DOI
  18. Brodsky IG , Balagopal P, Nair KS. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men–a clinical research center study. J Clin Endocrinol Metab 81 : 3469–3475, 1996. · DOI · Paper page
  19. 10.1152/ajpendo.1984.246.4.E297 · DOI
  20. 10.1113/expphysiol.2004.029462 · DOI
  21. 10.1152/ajpendo.1990.258.5.E821 · DOI
  22. 10.1152/ajpendo.1990.259.4.E470 · DOI · Paper page
  23. 10.1111/j.1365-2362.1985.tb00283.x · DOI
  24. 10.1152/jappl.1992.73.4.1383 · DOI · Paper page
  25. 10.1152/ajpendo.1996.270.1.E67 · DOI
  26. 10.2165/00007256-200737090-00001 · DOI · Paper page
  27. 10.1007/s00421-008-0786-7 · DOI
  28. 10.1016/0006-2944(82)90042-4 · DOI
  29. 10.1152/japplphysiol.00021.2008 · DOI
  30. 10.1152/japplphysiol.00635.2003 · DOI
  31. 10.1111/j.1469-7793.2001.00301.x · DOI · Paper page
  32. 10.1016/0026-0495(85)90196-9 · DOI
  33. Fujita S , Dreyer HC, Drummond MJ, Glynn EL, Volpi E, Rasmussen BB. Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance post-exercise muscle protein synthesis. J Appl Physiol. In press.
  34. 10.1152/ajpendo.00173.2006 · DOI
  35. 10.1152/ajpregu.00277.2005 · DOI
  36. 10.1152/ajpcell.1998.274.2.C406 · DOI
  37. 10.1113/jphysiol.2008.160333 · DOI · Paper page
  38. 10.1152/japplphysiol.90425.2008 · DOI · Paper page
  39. 10.1152/ajpendo.90411.2008 · DOI · Paper page
  40. Halliday D , McKeran RO. Measurement of muscle protein synthetic rate from serial muscle biopsies and total body protein turnover in man by continuous intravenous infusion of l -(α- 15 N)lysine. Clin Sci Mol Med 49 : 581–590, 1975. · DOI
  41. 10.1038/ijo.2008.116 · DOI
  42. 10.1093/ajcn/86.2.373 · DOI · Paper page
  43. Haus JM , Miller BF, Carroll CC, Weinheimer EM, Trappe TA. The effect of strenuous aerobic exercise on skeletal muscle myofibrillar proteolysis in humans. Scand J Med Sci Sports 17 : 260–266, 2007. · DOI
  44. 10.1096/fj.08-117200 · DOI
  45. 10.1055/s-2008-1025758 · DOI
  46. 10.1111/j.1365-2265.2005.02339.x · DOI · Paper page
  47. 10.1152/ajpendo.90586.2008 · DOI
  48. 10.1152/ajpendo.00430.2003 · DOI · Paper page
  49. 10.1152/japplphysiol.00221.2002 · DOI
  50. 10.1152/ajpendo.00413.2004 · DOI
  51. 10.1152/physiolgenomics.00151.2006 · DOI
  52. 10.1152/ajpendo.2001.280.6.E982 · DOI · Paper page
  53. 10.1016/0026-0495(95)90047-0 · DOI
  54. 10.1152/ajpendo.00195.2003 · DOI
  55. 10.1152/ajpendo.1994.267.6.E1010 · DOI
  56. 10.1113/jphysiol.1996.sp021433 · DOI
  57. 10.1111/j.1748-1716.2007.01712.x · DOI
  58. 10.1152/ajpendo.00300.2005 · DOI · Paper page
  59. 10.1249/01.MSS.0000053910.63105.45 · DOI · Paper page
  60. 10.1152/ajpendo.00370.2003 · DOI
  61. 10.1152/japplphysiol.01383.2003 · DOI
  62. 10.1139/y02-134 · DOI
  63. 10.1152/ajpendo.1997.273.1.E99 · DOI · Paper page
  64. 10.1093/jn/136.2.379 · DOI
  65. 10.1152/japplphysiol.90346.2008 · DOI
  66. 10.1113/jphysiol.2002.034850 · DOI · Paper page
  67. 10.1152/jappl.2000.88.2.386 · DOI · Paper page
  68. 10.1093/gerona/62.12.1407 · DOI
  69. 10.1017/S002966519900124X · DOI
  70. 10.1042/bst0080499 · DOI
  71. 10.1042/cs0630519 · DOI
  72. 10.1152/japplphysiol.90782.2008 · DOI
  73. 10.1073/pnas.93.26.15364 · DOI · Paper page
  74. 10.1113/jphysiol.2005.097154 · DOI
  75. 10.1016/j.bbrc.2004.05.020 · DOI
  76. 10.1152/japplphysiol.00167.2002 · DOI
  77. 10.1152/ajpendo.00358.2004 · DOI
  78. 10.1152/ajpendo.00334.2003 · DOI · Paper page
  79. 10.2337/diabetes.52.8.1888 · DOI · Paper page
  80. 10.1371/journal.pone.0001875 · DOI · Paper page
  81. 10.1152/ajpendo.1992.262.3.E372 · DOI
  82. 10.1016/S0950-351X(96)80651-3 · DOI
  83. 10.1139/H07-076 · DOI · Paper page
  84. 10.1152/ajpregu.00636.2007 · DOI
  85. 10.1152/japplphysiol.00811.2004 · DOI · Paper page
  86. 10.1152/ajpendo.00234.2002 · DOI · Paper page
  87. 10.1152/jappl.1996.81.5.2034 · DOI
  88. 10.1152/ajpendo.2001.281.2.E197 · DOI · Paper page
  89. 10.1152/ajpendo.2001.280.3.E496 · DOI
  90. 10.1152/ajpendo.1995.269.5.E820 · DOI · Paper page
  91. Volpi E , Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 85 : 4481–4490, 2000. · DOI · Paper page
  92. 10.1001/jama.286.10.1206 · DOI
  93. 10.1017/S0029665199001305 · DOI
  94. 10.1152/ajpendo.1993.264.5.E693 · DOI
  95. 10.1017/S0029665108007854 · DOI
  96. 10.1113/jphysiol.2008.153916 · DOI · Paper page
  97. 10.1093/ajcn/85.4.1031 · DOI · Paper page
  98. 10.1113/jphysiol.2005.103481 · DOI
  99. 10.1152/japplphysiol.01185.2004 · DOI · Paper page
  100. 10.1093/gerona/58.10.M918 · DOI · Paper page
  101. 10.1152/ajpendo.1992.262.3.E261 · DOI
  102. 10.1152/ajpendo.1999.277.1.E118 · DOI · Paper page
  103. 10.1002/bms.1200211004 · DOI
  104. 10.1152/ajpendo.1993.265.2.E210 · DOI · Paper page
  105. 10.1152/ajpendo.00053.2002 · DOI

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Metadata

Authors
Kumar, V., Atherton, P., Smith, K., & Rennie, M. J.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2009-06
Volume
106
Issue
6
Pages
2026-2039
ISSN
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.91481.2008
Cited by
249
References
24
Language
en

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