Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons
Open accessAbstract
Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability by increasing inhibitory tone. Studies using cholinergic agonists in anesthetized primate V1 have yielded conflicting evidence for such a proposal. Here we investigated how muscarinic or nicotinic receptor blockade affect neuronal excitability and contrast response functions in awake macaque area V1. Muscarinic or nicotinic receptor blockade caused reduced activity for all contrasts tested, without affecting the contrast where neurons reach their half maximal response (c50). The activity reduction upon muscarinic and nicotinic blockade resulted in reduced neuronal contrast sensitivity, as assessed through neurometric functions. In the majority of cells receptor blockade was best described by a response gain model (a multiplicative scaling of responses), indicating that ACh is involved in signal enhancement, not saliency filtering in macaque V1.
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Effects of cholinergic modulation on neuronal response gain may vary across classes of excitatory neurons.
“However, the effects of cholinergic modulation on neuronal response gain may vary across classes of excitatory neurons172.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [172]
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- Authors
- Herrero, J. L., Gieselmann, M. A., & Thiele, A.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Thiele, Alexander
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2017-12-19
- Volume
- 11
- Pages
- 106-106
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC5742228
- OpenAlex
- W2779382641
- Cited by
- 25
- References
- 75
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Wellcome Trust (093104)
- Biotechnology and Biological Sciences Research Council (BB/F021399/1)
- Human Frontier Science Program
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- acetylcholine, muscarinic receptors, nicotinic acetylcholine receptors, contrast sensitivity, primary visual cortex, macaque, cholinergic modulation, neuronal excitability
- MeSH terms
- Action Potentials, Animals, Macaca mulatta, Male, Mecamylamine, Microelectrodes, Models, Neurological, Neurons, Neuropsychological Tests, Photic Stimulation, Receptors, Muscarinic, Receptors, Nicotinic, Scopolamine, Visual Cortex, Contrast Sensitivity, Muscarinic Antagonists, Nicotinic Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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