Basal forebrain contributes to default mode network regulation
Open accessAbstract
The default mode network (DMN) is a collection of cortical brain regions that is active during states of rest or quiet wakefulness in humans and other mammalian species. A pertinent characteristic of the DMN is a suppression of local field potential gamma activity during cognitive task performance as well as during engagement with external sensory stimuli. Conversely, gamma activity is elevated in the DMN during rest. Here, we document that the rat basal forebrain (BF) exhibits the same pattern of responses, namely pronounced gamma oscillations during quiet wakefulness in the home cage and suppression of this activity during active exploration of an unfamiliar environment. We show that gamma oscillations are localized to the BF and that gamma-band activity in the BF has a directional influence on a hub of the rat DMN, the anterior cingulate cortex, during DMN-dominated brain states. The BF is well known as an ascending, activating, neuromodulatory system involved in wake–sleep regulation, memory formation, and regulation of sensory information processing. Our findings suggest a hitherto undocumented role of the BF as a subcortical node of the DMN, which we speculate may be important for switching between internally and externally directed brain states. We discuss potential BF projection circuits that could underlie its role in DMN regulation and highlight that certain BF nuclei may provide potential target regions for up- or down-regulation of DMN activity that might prove useful for treatment of DMN dysfunction in conditions such as epilepsy or major depressive disorder.
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The default mode network is regulated in part by PV-INs.
“Furthermore, abnormalities in the default mode network, which is regulated in part by PV-INs [27], have been observed in AD patients [28][29][30][31][32].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [27]
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- Authors
- Nair, J., Klaassen, A.-L., Arato, J., Vyssotski, A. L., Harvey, M., & Rainer, G.
- Affiliations
- University of Fribourg (CH)
- Department of Cognitive Science, Central European University, 1051 Budapest, Hungary;
- ETH Zurich (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-01-23
- Volume
- 115
- Issue
- 6
- Pages
- 1352-1357
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5819396
- OpenAlex
- W2785023327
- Cited by
- 77
- References
- 79
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 2
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (143390, 141786, 168602)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- default mode network, basal forebrain, gamma oscillations, anterior cingulate cortex, quiet wakefulness, exploratory behavior, neuromodulation, epilepsy, major depressive disorder, rats
- MeSH terms
- Animals, Behavior, Animal, Exploratory Behavior, Gyrus Cinguli, Locomotion, Male, Nerve Net, Task Performance and Analysis, Wakefulness, Rats, Long-Evans, Basal Forebrain
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