Cited by 109Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study

Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin‐immunoreactive neurons

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Disney, Anita A., Aoki, Chiye·2008·Journal of Comparative Neurology

Abstract

Acetylcholine (ACh) is believed to underlie mechanisms of arousal and attention in mammals. ACh also has a demonstrated functional effect in visual cortex that is both diverse and profound. We have reported previously that cholinergic modulation in V1 of the macaque monkey is strongly targeted toward GABAergic interneurons. Here we examine the localization of m1 and m2 muscarinic receptor subtypes across subpopulations of GABAergic interneurons—identified by their expression of the calcium‐binding proteins parvalbumin, calbindin, and calretinin—using dual‐immunofluorescence confocal microscopy in V1 of the macaque monkey. In doing so, we find that the vast majority (87%) of parvalbumin‐immunoreactive neurons express m1‐type muscarinic ACh receptors. m1 receptors are also expressed by 60% of calbindin‐immunoreactive neurons and 40% of calretinin‐immunoreactive neurons. m2 AChRs, on the other hand, are expressed by only 31% of parvalbumin neurons, 23% of calbindin neurons, and 25% of calretinin neurons. Parvalbumin‐immunoreactive cells comprise ≈75% of the inhibitory neuronal population in V1 and included in this large subpopulation are neurons known to veto and regulate the synchrony of principal cell spiking. Through the expression of m1 ACh receptors on nearly all of these PV cells, the cholinergic system avails itself of powerful control of information flow through and processing within the network of principal cells in the cortical circuit. J. Comp. Neurol. 507:1748–1762, 2008. © 2008 Wiley‐Liss, Inc.

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Crossref · 10.1002/cne.21616

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  • Cholinergic receptors are expressed by inhibitory and excitatory cortical neurons and on the terminals of thalamocortical neurons.

    “Cholinergic receptors are expressed by inhibitory and excitatory cortical neurons119,124,158–164, as well as on the terminals of thalamocortical neurons165–169.”

    From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [159]

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Authors
Disney, A. A., & Aoki, C.
Affiliations
New York University (US)
Corresponding author
Disney, Anita A.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2008-02-08
Volume
507
Issue
5
Pages
1748-1762
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
OpenAlex
W1992057648
Cited by
109
References
67
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 13 · 2017: 7 · 2016: 1 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 10
FWCI
2.45
Type
journal article
Language
en
Open access
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Eye Institute (P30 EY-13079, R01EY013145, R01EY13145, P30EY013079)
  • National Institute of Neurological Disorders and Stroke (R01 NS41091, R01NS041091, R25NS080686)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
muscarinic receptors, M1 muscarinic receptor, M2 muscarinic receptor, parvalbumin, GABAergic interneurons, visual cortex, macaque, calbindin, calretinin, calcium-binding proteins, cholinergic modulation, principal cells, neuronal synchronization
MeSH terms
Acetylcholine, Animals, Fluorescent Antibody Technique, gamma-Aminobutyric Acid, Immunohistochemistry, Interneurons, Macaca mulatta, Male, Parvalbumins, Receptors, Muscarinic, Visual Cortex, Microscopy, Confocal, Calbindins, S100 Calcium Binding Protein G

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